Details for: OSGIN1

Gene ID: 29948

Symbol: OSGIN1

Ensembl ID: ENSG00000140961

Description: oxidative stress induced growth inhibitor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.4887
    Cell Significance Index: -6.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.2824
    Cell Significance Index: -6.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.6951
    Cell Significance Index: -5.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.3158
    Cell Significance Index: -6.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6125
    Cell Significance Index: -6.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.8951
    Cell Significance Index: 104.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5724
    Cell Significance Index: 55.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.2897
    Cell Significance Index: 65.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7575
    Cell Significance Index: -6.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1891
    Cell Significance Index: 53.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9730
    Cell Significance Index: 14.5800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6799
    Cell Significance Index: 7.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6672
    Cell Significance Index: 77.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6648
    Cell Significance Index: 39.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5029
    Cell Significance Index: 454.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4382
    Cell Significance Index: 47.6700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4293
    Cell Significance Index: 7.2200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4056
    Cell Significance Index: 6.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3983
    Cell Significance Index: 6.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3801
    Cell Significance Index: 75.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3045
    Cell Significance Index: 7.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2787
    Cell Significance Index: 19.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2720
    Cell Significance Index: 44.2400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2538
    Cell Significance Index: 1.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2446
    Cell Significance Index: 5.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2208
    Cell Significance Index: 7.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2132
    Cell Significance Index: 5.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2054
    Cell Significance Index: 5.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1975
    Cell Significance Index: 19.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1964
    Cell Significance Index: 2.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1573
    Cell Significance Index: 4.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1482
    Cell Significance Index: 7.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1241
    Cell Significance Index: 9.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1100
    Cell Significance Index: 20.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0583
    Cell Significance Index: 0.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0483
    Cell Significance Index: 1.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0475
    Cell Significance Index: 25.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0456
    Cell Significance Index: 3.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0415
    Cell Significance Index: 1.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0330
    Cell Significance Index: 1.5400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0276
    Cell Significance Index: 0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0188
    Cell Significance Index: 2.3200
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.0186
    Cell Significance Index: 0.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0160
    Cell Significance Index: 2.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0146
    Cell Significance Index: 2.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0092
    Cell Significance Index: 0.4800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0084
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0077
    Cell Significance Index: 1.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0050
    Cell Significance Index: 0.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0020
    Cell Significance Index: 0.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0010
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0010
    Cell Significance Index: -0.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0031
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0051
    Cell Significance Index: -3.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0055
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0080
    Cell Significance Index: -2.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0109
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0124
    Cell Significance Index: -1.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0139
    Cell Significance Index: -8.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0186
    Cell Significance Index: -3.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0211
    Cell Significance Index: -6.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0219
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0260
    Cell Significance Index: -3.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0278
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0337
    Cell Significance Index: -7.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0432
    Cell Significance Index: -2.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0516
    Cell Significance Index: -3.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0615
    Cell Significance Index: -7.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0625
    Cell Significance Index: -6.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0634
    Cell Significance Index: -0.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0699
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0843
    Cell Significance Index: -6.6800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0853
    Cell Significance Index: -0.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0868
    Cell Significance Index: -5.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0903
    Cell Significance Index: -3.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0914
    Cell Significance Index: -6.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1009
    Cell Significance Index: -1.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1018
    Cell Significance Index: -6.5700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1024
    Cell Significance Index: -1.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1058
    Cell Significance Index: -2.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1097
    Cell Significance Index: -6.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1198
    Cell Significance Index: -1.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1236
    Cell Significance Index: -1.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1264
    Cell Significance Index: -6.6400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1326
    Cell Significance Index: -1.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1436
    Cell Significance Index: -8.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1483
    Cell Significance Index: -6.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1564
    Cell Significance Index: -1.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1574
    Cell Significance Index: -6.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1585
    Cell Significance Index: -5.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Oxidative Stress Induction**: OSGIN1 is induced by oxidative stress, which suggests that this gene is a key player in the cellular response to oxidative damage. 2. **Growth Inhibition**: OSGIN1 inhibits cell growth and proliferation, particularly in the context of oxidative stress, highlighting its role as a growth regulator. 3. **Tissue-Specific Expression**: OSGIN1 is significantly expressed in various tissues, including cardiac muscle, cerebral cortex, and intestinal epithelium, indicating its functional importance in different cell types. 4. **Protein Binding**: OSGIN1 interacts with other proteins, suggesting its role in protein-protein interactions and signaling pathways. **Pathways and Functions:** 1. **Cell Differentiation**: OSGIN1 may regulate cellular differentiation by inhibiting cell growth and proliferation, allowing for the proper development and maturation of cells. 2. **Negative Regulation of Cell Growth**: OSGIN1 acts as a negative regulator of cell growth, preventing excessive cell proliferation and tumor formation. 3. **Regulation of Apoptotic Process**: OSGIN1 may modulate the apoptotic process, allowing for the controlled elimination of damaged or dysfunctional cells. 4. **Signal Transduction**: OSGIN1 interacts with other proteins, suggesting its role in signal transduction pathways and the regulation of cellular responses to oxidative stress. **Clinical Significance:** 1. **Oxidative Stress-Related Diseases**: OSGIN1's role in regulating oxidative stress-induced growth inhibition makes it a potential target for the development of novel therapeutic strategies to combat oxidative stress-related diseases, such as cancer, cardiovascular disease, and neurodegenerative disorders. 2. **Cancer Therapy**: OSGIN1's ability to inhibit cell growth and proliferation makes it a potential target for cancer therapy, particularly in the context of oxidative stress-related cancer. 3. **Neurodegenerative Disorders**: OSGIN1's role in regulating the apoptotic process and signal transduction pathways makes it a potential target for the development of novel therapeutic strategies to combat neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease**: OSGIN1's role in regulating cellular growth and differentiation makes it a potential target for the development of novel therapeutic strategies to combat cardiovascular disease. In conclusion, OSGIN1 is a key regulator of oxidative stress-induced growth inhibition, with significant implications for our understanding of cellular growth, differentiation, and survival in response to oxidative stress. Further research is needed to fully elucidate the mechanisms of OSGIN1 and its clinical significance, but its potential as a therapeutic target for oxidative stress-related diseases is promising.

Genular Protein ID: 2426576707

Symbol: OSGI1_HUMAN

Name: Ovary, kidney and liver protein 38

UniProtKB Accession Codes:

Q9UJX0 Q52M33 Q86UQ1 Q96S88 Q9BZ70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14570898

Title: Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis.

PubMed ID: 14570898

DOI: 10.1074/jbc.m308668200

PubMed ID: 15569677

Title: Bone marrow stromal cell-derived growth inhibitor inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis.

PubMed ID: 15569677

DOI: 10.1074/jbc.m408708200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11459809

Title: Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland.

PubMed ID: 11459809

DOI: 10.1210/endo.142.8.8297

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 477
  • Mass: 51992
  • Checksum: 29E936C20B23E7C0
  • Sequence:
    • MSSSRKDHLG ASSSEPLPVI IVGNGPSGIC LSYLLSGYTP YTKPDAIHPH PLLQRKLTEA 
PGVSILDQDL DYLSEGLEGR SQSPVALLFD ALLRPDTDFG GNMKSVLTWK HRKEHAIPHV 
VLGRNLPGGA WHSIEGSMVI LSQGQWMGLP DLEVKDWMQK KRRGLRNSRA TAGDIAHYYR 
DYVVKKGLGH NFVSGAVVTA VEWGTPDPSS CGAQDSSPLF QVSGFLTRNQ AQQPFSLWAR 
NVVLATGTFD SPARLGIPGE ALPFIHHELS ALEAATRVGA VTPASDPVLI IGAGLSAADA 
VLYARHYNIP VIHAFRRAVD DPGLVFNQLP KMLYPEYHKV HQMMREQSIL SPSPYEGYRS 
LPRHQLLCFK EDCQAVFQDL EGVEKVFGVS LVLVLIGSHP DLSFLPGAGA DFAVDPDQPL 
SAKRNPIDVD PFTYQSTRQE GLYAMGPLAG DNFVRFVQGG ALAVASSLLR KETRKPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.