Details for: CDIP1

Gene ID: 29965

Symbol: CDIP1

Ensembl ID: ENSG00000089486

Description: cell death inducing p53 target 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.5683
    Cell Significance Index: -26.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.7557
    Cell Significance Index: -22.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.2847
    Cell Significance Index: -26.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.4623
    Cell Significance Index: -26.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.7098
    Cell Significance Index: -25.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3146
    Cell Significance Index: -26.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8269
    Cell Significance Index: -24.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7130
    Cell Significance Index: -26.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7793
    Cell Significance Index: -10.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6662
    Cell Significance Index: -12.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0050
    Cell Significance Index: 53.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1989
    Cell Significance Index: 240.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1412
    Cell Significance Index: 15.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0538
    Cell Significance Index: 55.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.0072
    Cell Significance Index: 25.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7868
    Cell Significance Index: 710.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7622
    Cell Significance Index: 45.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6910
    Cell Significance Index: 19.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6544
    Cell Significance Index: 234.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5977
    Cell Significance Index: 40.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4878
    Cell Significance Index: 66.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4723
    Cell Significance Index: 76.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4635
    Cell Significance Index: 13.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4409
    Cell Significance Index: 87.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4107
    Cell Significance Index: 284.0400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3723
    Cell Significance Index: 2.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3471
    Cell Significance Index: 7.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3039
    Cell Significance Index: 21.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2746
    Cell Significance Index: 52.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2224
    Cell Significance Index: 5.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2072
    Cell Significance Index: 91.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2019
    Cell Significance Index: 19.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1789
    Cell Significance Index: 5.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1474
    Cell Significance Index: 18.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1459
    Cell Significance Index: 17.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1196
    Cell Significance Index: 20.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1093
    Cell Significance Index: 8.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0988
    Cell Significance Index: 17.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0706
    Cell Significance Index: 3.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0685
    Cell Significance Index: 3.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0680
    Cell Significance Index: 2.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0581
    Cell Significance Index: 4.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0550
    Cell Significance Index: 103.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0441
    Cell Significance Index: 2.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0394
    Cell Significance Index: 0.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0233
    Cell Significance Index: 1.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0134
    Cell Significance Index: 0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0057
    Cell Significance Index: 10.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0019
    Cell Significance Index: 3.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0030
    Cell Significance Index: -1.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0040
    Cell Significance Index: -0.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0123
    Cell Significance Index: -5.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0213
    Cell Significance Index: -0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0284
    Cell Significance Index: -15.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0320
    Cell Significance Index: -1.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0391
    Cell Significance Index: -2.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0393
    Cell Significance Index: -1.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0430
    Cell Significance Index: -6.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0447
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0657
    Cell Significance Index: -13.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0704
    Cell Significance Index: -3.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0821
    Cell Significance Index: -23.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0939
    Cell Significance Index: -10.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1089
    Cell Significance Index: -2.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1183
    Cell Significance Index: -13.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1199
    Cell Significance Index: -3.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1212
    Cell Significance Index: -4.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1269
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1513
    Cell Significance Index: -17.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1627
    Cell Significance Index: -19.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1647
    Cell Significance Index: -7.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1765
    Cell Significance Index: -4.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1784
    Cell Significance Index: -11.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2102
    Cell Significance Index: -5.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2253
    Cell Significance Index: -16.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2352
    Cell Significance Index: -24.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2399
    Cell Significance Index: -19.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2404
    Cell Significance Index: -11.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2598
    Cell Significance Index: -8.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2898
    Cell Significance Index: -6.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3554
    Cell Significance Index: -6.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3671
    Cell Significance Index: -3.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3693
    Cell Significance Index: -7.7300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3948
    Cell Significance Index: -5.5200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4033
    Cell Significance Index: -5.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4136
    Cell Significance Index: -8.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4308
    Cell Significance Index: -6.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4421
    Cell Significance Index: -23.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4502
    Cell Significance Index: -5.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4550
    Cell Significance Index: -14.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4561
    Cell Significance Index: -3.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4650
    Cell Significance Index: -13.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4692
    Cell Significance Index: -6.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4708
    Cell Significance Index: -9.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **p53 Target Gene:** CDIP1 is a direct target of the p53 protein, which is a key regulator of the cell cycle and apoptosis. 2. **Apoptosis Regulation:** CDIP1 is involved in the intrinsic apoptotic signaling pathway, which is activated in response to DNA damage. 3. **Nuclear Expression:** CDIP1 is primarily expressed in the nucleus, where it regulates gene expression and cell survival. 4. **Zinc Ion Binding:** CDIP1 contains zinc ion-binding motifs, which are involved in protein-protein interactions and regulation of gene expression. 5. **Cell Type-Specific Expression:** CDIP1 is significantly expressed in various neural cell types, including GABAergic amacrine cells, germ cells, dopaminergic neurons, and astrocytes of the cerebral cortex. **Pathways and Functions:** 1. **Intrinsic Apoptotic Signaling Pathway:** CDIP1 is involved in the intrinsic apoptotic signaling pathway, which is activated in response to DNA damage. 2. **p53-Mediated Gene Regulation:** CDIP1 is a target of p53, which regulates its expression and activity. 3. **Cell Survival and Death:** CDIP1 plays a critical role in regulating cell survival and death in the nervous system. 4. **DNA Damage Response:** CDIP1 is involved in the DNA damage response, which is a complex network of cellular pathways that respond to DNA damage. 5. **Protein-Protein Interactions:** CDIP1 interacts with other proteins, including p53, to regulate gene expression and cell survival. **Clinical Significance:** 1. **Neurological Disorders:** CDIP1 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer:** CDIP1 is also involved in the regulation of apoptosis and cell survival in cancer cells, making it a potential therapeutic target. 3. **Neurodevelopmental Disorders:** CDIP1 expression is altered in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 4. **Neurodegenerative Diseases:** CDIP1 dysregulation has been implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 5. **Therapeutic Potential:** CDIP1 is a potential therapeutic target for the treatment of neurological disorders, including cancer and neurodegenerative diseases. In conclusion, CDIP1 is a critical regulator of apoptosis and cell survival in the nervous system. Its dysregulation has been implicated in various neurological disorders, and it is a potential therapeutic target for the treatment of cancer and neurodegenerative diseases. Further research is needed to fully understand the mechanisms of CDIP1 and its role in the nervous system.

Genular Protein ID: 3451163586

Symbol: CDIP1_HUMAN

Name: Cell death-inducing p53-target protein 1

UniProtKB Accession Codes:

Q9H305 A8K7M1 B4DFU1 B4DY75 D3DUD6 Q96ID8 Q9H0Q4 Q9P112

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 10 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10570909

Title: C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain.

PubMed ID: 10570909

DOI: 10.1007/s100380050183

PubMed ID: 17599062

Title: CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.

PubMed ID: 17599062

DOI: 10.1038/sj.emboj.7601779

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27582497

Title: The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein.

PubMed ID: 27582497

DOI: 10.1042/bcj20160657

Sequence Information:

  • Length: 208
  • Mass: 21892
  • Checksum: 6C7334668A3C15A7
  • Sequence:
    • MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG PPPYEPPGHP 
MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY TPGPYPGPGG HTATVLVPSG 
AATTVTVLQG EIFEGAPVQT VCPHCQQAIT TKISYEIGLM NFVLGFFCCF MGCDLGCCLI 
PCLINDFKDV THTCPSCKAY IYTYKRLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.