Details for: SH3KBP1

Gene ID: 30011

Symbol: SH3KBP1

Ensembl ID: ENSG00000147010

Description: SH3 domain containing kinase binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 316.9657
    Cell Significance Index: -49.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.6510
    Cell Significance Index: -45.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.6350
    Cell Significance Index: -44.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.6277
    Cell Significance Index: -48.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.3589
    Cell Significance Index: -50.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.1805
    Cell Significance Index: -46.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.2448
    Cell Significance Index: -49.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.3496
    Cell Significance Index: -56.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.5510
    Cell Significance Index: -38.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.8080
    Cell Significance Index: -30.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7013
    Cell Significance Index: -50.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 3.7264
    Cell Significance Index: 541.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1799
    Cell Significance Index: 437.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9416
    Cell Significance Index: 696.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7581
    Cell Significance Index: 77.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6307
    Cell Significance Index: 192.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6057
    Cell Significance Index: 60.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4005
    Cell Significance Index: 90.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3336
    Cell Significance Index: 131.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1049
    Cell Significance Index: 997.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0664
    Cell Significance Index: 19.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0551
    Cell Significance Index: 209.3900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.0375
    Cell Significance Index: 13.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9428
    Cell Significance Index: 27.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9358
    Cell Significance Index: 57.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8543
    Cell Significance Index: 24.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8267
    Cell Significance Index: 63.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8004
    Cell Significance Index: 53.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7722
    Cell Significance Index: 20.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6825
    Cell Significance Index: 74.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5940
    Cell Significance Index: 14.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5343
    Cell Significance Index: 86.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4842
    Cell Significance Index: 9.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4768
    Cell Significance Index: 897.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4737
    Cell Significance Index: 258.6900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.4479
    Cell Significance Index: 1.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2382
    Cell Significance Index: 16.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2330
    Cell Significance Index: 316.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1630
    Cell Significance Index: 22.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1328
    Cell Significance Index: 25.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0874
    Cell Significance Index: 161.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0808
    Cell Significance Index: 1.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0434
    Cell Significance Index: 66.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0205
    Cell Significance Index: 13.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0149
    Cell Significance Index: -11.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0184
    Cell Significance Index: -11.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0282
    Cell Significance Index: -0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0387
    Cell Significance Index: -1.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0454
    Cell Significance Index: -8.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0605
    Cell Significance Index: -26.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0616
    Cell Significance Index: -45.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0660
    Cell Significance Index: -37.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0810
    Cell Significance Index: -36.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0985
    Cell Significance Index: -10.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1046
    Cell Significance Index: -4.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1187
    Cell Significance Index: -3.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1384
    Cell Significance Index: -17.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1433
    Cell Significance Index: -30.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1479
    Cell Significance Index: -18.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1503
    Cell Significance Index: -43.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1550
    Cell Significance Index: -26.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1666
    Cell Significance Index: -19.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1908
    Cell Significance Index: -3.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3352
    Cell Significance Index: -7.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3358
    Cell Significance Index: -43.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3374
    Cell Significance Index: -38.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3758
    Cell Significance Index: -21.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3787
    Cell Significance Index: -43.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3869
    Cell Significance Index: -11.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4210
    Cell Significance Index: -43.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4346
    Cell Significance Index: -13.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4362
    Cell Significance Index: -20.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4405
    Cell Significance Index: -9.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4453
    Cell Significance Index: -23.2000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4781
    Cell Significance Index: -6.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4834
    Cell Significance Index: -10.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5235
    Cell Significance Index: -10.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5288
    Cell Significance Index: -13.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5501
    Cell Significance Index: -41.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5660
    Cell Significance Index: -34.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5921
    Cell Significance Index: -31.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6062
    Cell Significance Index: -48.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6170
    Cell Significance Index: -12.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6181
    Cell Significance Index: -12.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6723
    Cell Significance Index: -14.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6834
    Cell Significance Index: -19.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6932
    Cell Significance Index: -36.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7128
    Cell Significance Index: -24.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7311
    Cell Significance Index: -10.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7688
    Cell Significance Index: -25.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7871
    Cell Significance Index: -55.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8232
    Cell Significance Index: -38.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8325
    Cell Significance Index: -52.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8333
    Cell Significance Index: -22.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9063
    Cell Significance Index: -19.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9131
    Cell Significance Index: -13.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9210
    Cell Significance Index: -13.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9254
    Cell Significance Index: -13.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9462
    Cell Significance Index: -27.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **SH3 domain**: SH3KBP1 contains a SH3 (Src homology 3) domain, a protein-protein interaction module that mediates interactions with other proteins. 2. **Kinase binding**: The gene encodes a protein that binds to kinases, facilitating their activation and regulation. 3. **Cellular localization**: SH3KBP1 is primarily localized to the cytoplasm, cytoskeleton, and plasma membrane, where it interacts with various signaling molecules and proteins. **Pathways and Functions:** 1. **Immune response**: SH3KBP1 is involved in the regulation of adaptive and innate immune responses, including the activation of B cells and the production of cytokines. 2. **Cell signaling**: The gene is a key regulator of signaling pathways, including those mediated by receptor tyrosine kinases (RTKs), such as EGFR and MET. 3. **Apoptosis**: SH3KBP1 is also involved in the regulation of apoptotic processes, influencing cell survival and death. 4. **Actin filament organization**: The gene plays a role in the organization and regulation of actin filaments, essential for cell migration, shape, and movement. 5. **Cargo recognition**: SH3KBP1 is involved in the recognition and binding of cargo proteins to clathrin-coated vesicles, facilitating endocytosis and membrane trafficking. **Signaling Pathways and Functions:** 1. **EGFR signaling**: SH3KBP1 interacts with EGFR, regulating its activation and downstream signaling. 2. **MET signaling**: The gene is also involved in MET signaling, influencing cell growth, migration, and survival. 3. **B cell receptor signaling**: SH3KBP1 regulates B cell receptor signaling, influencing B cell activation and antibody production. 4. **Neurotransmitter signaling**: The gene is involved in the regulation of neurotransmitter signaling, including those mediated by GABAergic interneurons. **Clinical Significance:** 1. **Infectious diseases**: SH3KBP1 plays a critical role in the regulation of immune responses to infectious diseases, such as bacterial and viral infections. 2. **Cancer**: The gene is involved in the regulation of cell growth, migration, and survival, making it a potential target for cancer therapy. 3. **Neurological disorders**: SH3KBP1 is involved in the regulation of neurotransmitter signaling, which is impaired in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Autoimmune diseases**: The gene is involved in the regulation of immune responses, which is dysregulated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, SH3KBP1 is a multifunctional gene that plays a critical role in various cellular processes, including immune response, cell signaling, and disease pathogenesis. Its dysregulation has been implicated in various pathological conditions, highlighting the need for further research into the molecular mechanisms underlying its functions and potential therapeutic applications.

Genular Protein ID: 1342839461

Symbol: SH3K1_HUMAN

Name: SH3 domain-containing kinase-binding protein 1

UniProtKB Accession Codes:

Q96B97 B7Z1D5 Q5JPT4 Q5JPT5 Q8IWX6 Q8IX98 Q96RN4 Q9NYR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10679202

Title: Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.

PubMed ID: 10679202

DOI: 10.1006/bbrc.2000.2147

PubMed ID: 12618476

Title: CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment but elicit divergent functional activities.

PubMed ID: 12618476

DOI: 10.1093/intimm/dxg032

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11474197

Title: Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization.

PubMed ID: 11474197

DOI: 10.1159/000056966

PubMed ID: 11071869

Title: Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes.

PubMed ID: 11071869

DOI: 10.1006/bbrc.2000.3760

PubMed ID: 12177062

Title: CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.

PubMed ID: 12177062

DOI: 10.1074/jbc.m205535200

PubMed ID: 11894095

Title: Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.

PubMed ID: 11894095

DOI: 10.1038/416183a

PubMed ID: 11894096

Title: The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.

PubMed ID: 11894096

DOI: 10.1038/416187a

PubMed ID: 12218189

Title: Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.

PubMed ID: 12218189

DOI: 10.1073/pnas.192462299

PubMed ID: 14596919

Title: Dab2 links CIN85 with clathrin-mediated receptor internalization.

PubMed ID: 14596919

DOI: 10.1016/s0014-5793(03)01111-6

PubMed ID: 12771190

Title: SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion.

PubMed ID: 12771190

DOI: 10.1242/jcs.00522

PubMed ID: 12690097

Title: Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.

PubMed ID: 12690097

DOI: 10.1074/jbc.m302540200

PubMed ID: 12734385

Title: Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization.

PubMed ID: 12734385

DOI: 10.1073/pnas.1031790100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15090612

Title: CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.

PubMed ID: 15090612

DOI: 10.1091/mbc.e03-09-0683

PubMed ID: 15456872

Title: Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.

PubMed ID: 15456872

DOI: 10.1128/mcb.24.20.8981-8993.2004

PubMed ID: 16256071

Title: CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.

PubMed ID: 16256071

DOI: 10.1016/j.bbrc.2005.10.032

PubMed ID: 15962011

Title: Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.

PubMed ID: 15962011

DOI: 10.1038/sj.embor.7400453

PubMed ID: 15707590

Title: CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis.

PubMed ID: 15707590

DOI: 10.1016/j.yexcr.2004.11.005

PubMed ID: 16177060

Title: CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function.

PubMed ID: 16177060

DOI: 10.4049/jimmunol.175.7.4208

PubMed ID: 16678097

Title: A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.

PubMed ID: 16678097

DOI: 10.1016/j.cell.2006.02.045

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16751601

Title: CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin.

PubMed ID: 16751601

DOI: 10.1093/jb/mvj105

PubMed ID: 16895919

Title: CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.

PubMed ID: 16895919

DOI: 10.1074/jbc.m605693200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20221403

Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.

PubMed ID: 20221403

DOI: 10.1371/journal.pone.0009588

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29636373

Title: Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency.

PubMed ID: 29636373

DOI: 10.1084/jem.20170534

PubMed ID: 31493651

Title: Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein.

PubMed ID: 31493651

DOI: 10.1016/j.virol.2019.08.022

PubMed ID: 16228008

Title: Cbl promotes clustering of endocytic adaptor proteins.

PubMed ID: 16228008

DOI: 10.1038/nsmb1000

Sequence Information:

  • Length: 665
  • Mass: 73126
  • Checksum: 3BD350FCDB14BD4C
  • Sequence:
    • MVEAIVEFDY QAQHDDELTI SVGEIITNIR KEDGGWWEGQ INGRRGLFPD NFVREIKKEM 
KKDPLTNKAP EKPLHEVPSG NSLLSSETIL RTNKRGERRR RRCQVAFSYL PQNDDELELK 
VGDIIEVVGE VEEGWWEGVL NGKTGMFPSN FIKELSGESD ELGISQDEQL SKSSLRETTG 
SESDGGDSSS TKSEGANGTV ATAAIQPKKV KGVGFGDIFK DKPIKLRPRS IEVENDFLPV 
EKTIGKKLPA TTATPDSSKT EMDSRTKSKD YCKVIFPYEA QNDDELTIKE GDIVTLINKD 
CIDVGWWEGE LNGRRGVFPD NFVKLLPPDF EKEGNRPKKP PPPSAPVIKQ GAGTTERKHE 
IKKIPPERPE MLPNRTEEKE RPEREPKLDL QKPSVPAIPP KKPRPPKTNS LSRPGALPPR 
RPERPVGPLT HTRGDSPKID LAGSSLSGIL DKDLSDRSND IDLEGFDSVV SSTEKLSHPT 
TSRPKATGRR PPSQSLTSSS LSSPDIFDSP SPEEDKEEHI SLAHRGVDAS KKTSKTVTIS 
QVSDNKASLP PKPGTMAAGG GGPAPLSSAA PSPLSSSLGT AGHRANSPSL FGTEGKPKME 
PAASSQAAVE ELRTQVRELR SIIETMKDQQ KREIKQLLSE LDEEKKIRLR LQMEVNDIKK 
ALQSK

Genular Protein ID: 1715262080

Symbol: A0A8V8TQF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TQF6

Database IDs:

ARBA 1 CDD 1 CTD 1 EMBL 5 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 444
  • Mass: 48575
  • Checksum: 90E8CE882A3610CA
  • Sequence:
    • MPTHGSNLPE QYLSQYQHAV ETIGKKLPAT TATPDSSKTE MDSRTKSKDY CKVIFPYEAQ 
NDDELTIKEG DIVTLINKDC IDVGWWEGEL NGRRGVFPDN FVKLLPPDFE KEGNRPKKPP 
PPSAPVIKQG AGTTERKHEI KKIPPERPEM LPNRTEEKER PEREPKLDLQ KPSVPAIPPK 
KPRPPKTNSL SRPGALPPRR PERPVGPLTH TRGDSPKIDL AGSSLSGILD KDLSDRSNDI 
DLEGFDSVVS STEKLSHPTT SRPKATGRRP PSQSLTSSSL SSPDIFDSPS PEEDKEEHIS 
LAHRGVDASK KTSKTVTISQ VSDNKASLPP KPGTMAAGGG GPAPLSSAAP SPLSSSLGTA 
GHRANSPSLF GTEGKPKMEP AASSQAAVEE LRTQVRELRS IIETMKDQQK REIKQLLSEL 
DEEKKIRLRL QMEVNDIKKA LQSK

Genular Protein ID: 3417608281

Symbol: B7Z6E8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6E8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 404
  • Mass: 44235
  • Checksum: F0E24DF007997102
  • Sequence:
    • MDSRTKSKDY CKVIFPYEAQ NDDELTIKEG DIVTLINKDC IDVGWWEGEL NGRRGVFPDN 
FVKLLPPDFE KEGNRPKKPP PPSAPVIKQG AGTTERKHEI KKIPPERPEM LPNRTEEKER 
PEREPKLDLQ KPSVPAIPPK KPRPPKTNSL SRPGALPPRR PERPVGPLTH TRGDSPKIDL 
AGSSLSGILD KDLSDRSNDI DLEGFDSVVS STEKLSHPTT SRPKATGRRP PSQSLTSSSL 
SSPDIFDSPS PEEDKEEHIS LAHRGVDASK KTSKTVTISQ VSDNKASLPP KPGTMAAGGG 
GPAPLSSAAP SPLSSSLGTA GHRANSPSLF GTEGKPKMEP AASSQAAVEE LRTQVRELRS 
IIETMKDQQK REIKQLLSEL DEEKKIRLRL QMEVNDIKKA LQSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.