Details for: HCLS1

Gene ID: 3059

Symbol: HCLS1

Ensembl ID: ENSG00000180353

Description: hematopoietic cell-specific Lyn substrate 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 138.4806
    Cell Significance Index: -21.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.1647
    Cell Significance Index: -33.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.3231
    Cell Significance Index: -34.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.6116
    Cell Significance Index: -12.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.8514
    Cell Significance Index: -22.0100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 11.8460
    Cell Significance Index: 27.6400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 8.4364
    Cell Significance Index: 22.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.3348
    Cell Significance Index: -25.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.2231
    Cell Significance Index: 115.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0496
    Cell Significance Index: -13.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8958
    Cell Significance Index: -23.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.2491
    Cell Significance Index: 154.1600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.6116
    Cell Significance Index: 23.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.5280
    Cell Significance Index: 416.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0659
    Cell Significance Index: 133.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7817
    Cell Significance Index: 47.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5939
    Cell Significance Index: 42.5600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.4067
    Cell Significance Index: 8.9800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.2189
    Cell Significance Index: 3.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5512
    Cell Significance Index: 104.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3230
    Cell Significance Index: 291.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2874
    Cell Significance Index: 28.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.1344
    Cell Significance Index: -0.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1314
    Cell Significance Index: 90.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1278
    Cell Significance Index: 20.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0705
    Cell Significance Index: 2.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0102
    Cell Significance Index: -19.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0134
    Cell Significance Index: -0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0162
    Cell Significance Index: -29.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0171
    Cell Significance Index: -10.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0176
    Cell Significance Index: -27.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0214
    Cell Significance Index: -3.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0227
    Cell Significance Index: -30.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0252
    Cell Significance Index: -14.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0280
    Cell Significance Index: -5.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0282
    Cell Significance Index: -3.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0285
    Cell Significance Index: -21.5500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0335
    Cell Significance Index: -0.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0336
    Cell Significance Index: -18.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0426
    Cell Significance Index: -8.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0444
    Cell Significance Index: -1.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0478
    Cell Significance Index: -35.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0504
    Cell Significance Index: -18.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0512
    Cell Significance Index: -32.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0565
    Cell Significance Index: -24.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0686
    Cell Significance Index: -31.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0699
    Cell Significance Index: -13.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0756
    Cell Significance Index: -7.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0813
    Cell Significance Index: -23.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0822
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0856
    Cell Significance Index: -14.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0902
    Cell Significance Index: -11.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1068
    Cell Significance Index: -4.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1108
    Cell Significance Index: -2.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1306
    Cell Significance Index: -2.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1316
    Cell Significance Index: -18.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1642
    Cell Significance Index: -8.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1676
    Cell Significance Index: -8.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1680
    Cell Significance Index: -11.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1856
    Cell Significance Index: -26.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1939
    Cell Significance Index: -4.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1986
    Cell Significance Index: -23.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2059
    Cell Significance Index: -23.5000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2127
    Cell Significance Index: -1.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2140
    Cell Significance Index: -22.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2346
    Cell Significance Index: -30.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2366
    Cell Significance Index: -30.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2404
    Cell Significance Index: -7.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2447
    Cell Significance Index: -18.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2581
    Cell Significance Index: -29.5700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.2595
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2681
    Cell Significance Index: -12.6000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2877
    Cell Significance Index: -4.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3078
    Cell Significance Index: -18.4800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3185
    Cell Significance Index: -5.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3252
    Cell Significance Index: -14.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3636
    Cell Significance Index: -24.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4056
    Cell Significance Index: -30.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4257
    Cell Significance Index: -26.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4519
    Cell Significance Index: -25.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4757
    Cell Significance Index: -29.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4805
    Cell Significance Index: -25.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4842
    Cell Significance Index: -19.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5276
    Cell Significance Index: -24.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5607
    Cell Significance Index: -24.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5613
    Cell Significance Index: -19.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5664
    Cell Significance Index: -11.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5843
    Cell Significance Index: -19.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5947
    Cell Significance Index: -16.6200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.5969
    Cell Significance Index: -5.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5988
    Cell Significance Index: -31.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6245
    Cell Significance Index: -19.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6478
    Cell Significance Index: -24.5300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6675
    Cell Significance Index: -8.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6708
    Cell Significance Index: -5.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6779
    Cell Significance Index: -10.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6791
    Cell Significance Index: -16.9400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.7228
    Cell Significance Index: -6.8700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.7340
    Cell Significance Index: -6.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HCLS1 is a gene that encodes a protein essential for the regulation of immune cell function. Key characteristics of HCLS1 include: 1. **Cell-specific expression**: HCLS1 is primarily expressed in hematopoietic cells, including blood cells, T cells, and monocytes. 2. **Signaling regulation**: HCLS1 modulates various signaling pathways, including those involved in cell proliferation, differentiation, and survival. 3. **Positive and negative regulation**: HCLS1 exhibits both positive and negative regulatory functions, depending on the context and cell type. 4. **Sh3 domain binding**: The protein contains a Sh3 domain, which is involved in protein-protein interactions and signaling. **Pathways and Functions** HCLS1 is involved in numerous signaling pathways, including: 1. **Actin filament organization**: HCLS1 regulates actin filament polymerization, which is essential for cell motility and morphology. 2. **Cytokine signaling**: HCLS1 modulates the response to cytokine stimuli, influencing immune cell activation and function. 3. **Apoptosis regulation**: HCLS1 negative regulates the apoptotic process, maintaining immune cell homeostasis. 4. **Transcription regulation**: HCLS1 positively regulates transcription by RNA polymerase II, influencing gene expression in immune cells. 5. **Phosphatidylinositol 3-kinase/protein kinase B signaling**: HCLS1 positively regulates the PI3K/PKB signaling pathway, which is involved in cell survival and proliferation. **Clinical Significance** Dysregulation of HCLS1 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: HCLS1 dysfunction may contribute to autoimmune conditions, such as rheumatoid arthritis and lupus. 2. **Cancer**: HCLS1 alterations have been linked to cancer development and progression, particularly in hematological malignancies. 3. **Immune deficiency**: HCLS1 mutations may lead to impaired immune function, increasing susceptibility to infections. 4. **Inflammatory disorders**: HCLS1 dysregulation may contribute to inflammatory conditions, such as atherosclerosis and inflammatory bowel disease. In conclusion, HCLS1 is a critical gene involved in the regulation of immune cell function and overall cellular homeostasis. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of HCLS1 in maintaining immune health.

Genular Protein ID: 701386941

Symbol: HCLS1_HUMAN

Name: Hematopoietic lineage cell-specific protein

UniProtKB Accession Codes:

P14317 B4DQ69 Q53Y93 Q6IBK9 Q9UDK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2587259

Title: Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.

PubMed ID: 2587259

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7682714

Title: Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.

PubMed ID: 7682714

DOI: 10.1073/pnas.90.8.3631

PubMed ID: 8713105

Title: Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.

PubMed ID: 8713105

DOI: 10.1006/bbrc.1996.1082

PubMed ID: 8611520

Title: SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases.

PubMed ID: 8611520

DOI: 10.1021/bi9528614

PubMed ID: 9058808

Title: HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.

PubMed ID: 9058808

PubMed ID: 10066823

Title: Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.

PubMed ID: 10066823

DOI: 10.1074/jbc.274.11.7557

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 486
  • Mass: 54014
  • Checksum: 20AE72A28DA33DFB
  • Sequence:
    • MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 
VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 
GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE 
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGTRGLKA 
KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKRSPEAPQ PVIAMEEPAV PAPLPKKISS 
EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY 
EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA 
GAGAGAVALG ISAVAVYDYQ GEGSDELSFD PDDVITDIEM VDEGWWRGRC HGHFGLFPAN 
YVKLLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.