Details for: HCLS1

Gene ID: 3059

Symbol: HCLS1

Ensembl ID: ENSG00000180353

Description: hematopoietic cell-specific Lyn substrate 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.5
    Marker Score: 40633.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.29
    Marker Score: 10380
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.27
    Marker Score: 182890
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.24
    Marker Score: 3131
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.22
    Marker Score: 6271
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.14
    Marker Score: 31059
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.92
    Marker Score: 3336
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.87
    Marker Score: 12295.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.84
    Marker Score: 150199
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.75
    Marker Score: 7713
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.72
    Marker Score: 3282
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.66
    Marker Score: 7887
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.63
    Marker Score: 3873
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.62
    Marker Score: 6394
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.59
    Marker Score: 16549
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.58
    Marker Score: 6238
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.58
    Marker Score: 4609.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.58
    Marker Score: 5052
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.56
    Marker Score: 7349.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.49
    Marker Score: 2344
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.49
    Marker Score: 2186
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.47
    Marker Score: 3412
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.46
    Marker Score: 1213
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.42
    Marker Score: 1045
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.41
    Marker Score: 4193
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.36
    Marker Score: 2365
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.33
    Marker Score: 3992
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.28
    Marker Score: 5677.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.27
    Marker Score: 1662
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.26
    Marker Score: 6246
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.26
    Marker Score: 2008
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.24
    Marker Score: 1757
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.24
    Marker Score: 6533
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.21
    Marker Score: 4633
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.19
    Marker Score: 2436.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.18
    Marker Score: 1572.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.16
    Marker Score: 1077.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.14
    Marker Score: 1622
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.09
    Marker Score: 1958
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.07
    Marker Score: 5360.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.06
    Marker Score: 3757
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.01
    Marker Score: 728
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.98
    Marker Score: 1193
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.96
    Marker Score: 1204
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.94
    Marker Score: 461
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.93
    Marker Score: 1727
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.93
    Marker Score: 1130
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.92
    Marker Score: 49299.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.91
    Marker Score: 579
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.91
    Marker Score: 591
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.91
    Marker Score: 1096
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9
    Marker Score: 19253
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.86
    Marker Score: 428
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.85
    Marker Score: 656
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.82
    Marker Score: 461
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.81
    Marker Score: 1308
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.8
    Marker Score: 1769
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.78
    Marker Score: 6985
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.75
    Marker Score: 7160
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.74
    Marker Score: 606
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.74
    Marker Score: 1461
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.73
    Marker Score: 2448
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.7
    Marker Score: 4620
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.7
    Marker Score: 1439.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.68
    Marker Score: 986.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.68
    Marker Score: 1022
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.67
    Marker Score: 1388
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.66
    Marker Score: 1206.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.65
    Marker Score: 1830
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.65
    Marker Score: 2199
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.64
    Marker Score: 1655
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.62
    Marker Score: 1118
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.61
    Marker Score: 1640
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.6
    Marker Score: 1213
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.59
    Marker Score: 9674
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.58
    Marker Score: 1293
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.56
    Marker Score: 1007
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.56
    Marker Score: 1035
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.56
    Marker Score: 859
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.52
    Marker Score: 785
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.51
    Marker Score: 485
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.51
    Marker Score: 615
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.49
    Marker Score: 492
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.48
    Marker Score: 1603
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.48
    Marker Score: 6128
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.47
    Marker Score: 1067
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.46
    Marker Score: 725
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166478
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.45
    Marker Score: 505
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.44
    Marker Score: 326
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.41
    Marker Score: 779
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.4
    Marker Score: 719
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.36
    Marker Score: 567
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.35
    Marker Score: 471
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.32
    Marker Score: 291
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.31
    Marker Score: 568
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.31
    Marker Score: 1459
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.29
    Marker Score: 324
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.27
    Marker Score: 1493
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.25
    Marker Score: 838

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * HCLS1 is a protein of the hemopoietic cell lineage. * It is a transmembrane protein with a SH3 domain and a cytoplasmic tail. * It is expressed in a variety of cell types, including blood cells, macrophages, and dendritic cells. * It is a key regulator of erythropoiesis, the process of blood cell production. * It is also involved in the regulation of other hematopoietic processes, such as granulocyte differentiation and macrophage differentiation. **Pathways and functions:** * HCLS1 is involved in the regulation of actin filament polymerization. * It is a key regulator of erythrocyte differentiation. * It is also involved in the regulation of granulocyte differentiation. * It is involved in the regulation of macrophage differentiation. * It is involved in the regulation of protein import into the nucleus. * It is involved in the regulation of tyrosine phosphorylation of stat protein. **Clinical significance:** * Mutations in HCLS1 have been linked to a number of human diseases, including beta-thalassemia, sickle cell anemia, and immune deficiencies. * HCLS1 is a potential target for the treatment of these diseases. * Studies of HCLS1 have shown that it can be used to treat experimental autoimmune diseases in mice. **Additional information:** * HCLS1 is a highly conserved protein. It is found in humans, mice, and rats. * It is a member of the hemopoietic cell-specific protein (HCLS) family of proteins. * HCLS1 is a relatively new protein, with most of the sequence being encoded by newly mapped genomic DNA sequences.

Genular Protein ID: 701386941

Symbol: HCLS1_HUMAN

Name: Hematopoietic lineage cell-specific protein

UniProtKB Accession Codes:

P14317 B4DQ69 Q53Y93 Q6IBK9 Q9UDK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2587259

Title: Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.

PubMed ID: 2587259

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7682714

Title: Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.

PubMed ID: 7682714

DOI: 10.1073/pnas.90.8.3631

PubMed ID: 8713105

Title: Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.

PubMed ID: 8713105

DOI: 10.1006/bbrc.1996.1082

PubMed ID: 8611520

Title: SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases.

PubMed ID: 8611520

DOI: 10.1021/bi9528614

PubMed ID: 9058808

Title: HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.

PubMed ID: 9058808

PubMed ID: 10066823

Title: Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.

PubMed ID: 10066823

DOI: 10.1074/jbc.274.11.7557

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 486
  • Mass: 54014
  • Checksum: 20AE72A28DA33DFB
  • Sequence:
    • MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 
VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 
GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE 
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGTRGLKA 
KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKRSPEAPQ PVIAMEEPAV PAPLPKKISS 
EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY 
EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA 
GAGAGAVALG ISAVAVYDYQ GEGSDELSFD PDDVITDIEM VDEGWWRGRC HGHFGLFPAN 
YVKLLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.