HDAC1 | ENSG00000116478 | NCBI 3065

Details for: HDAC1

Gene ID: 3065

Symbol: HDAC1

Ensembl ID: ENSG00000116478

Description: histone deacetylase 1

Associated with

Adipogenesis
(R-HSA-9843745)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Death receptor signaling
(R-HSA-73887)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Downregulation of smad2/3:smad4 transcriptional activity
(R-HSA-2173795)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
G0 and early g1
(R-HSA-1538133)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdacs deacetylate histones
(R-HSA-3214815)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of mecp2 binding ability to 5mc-dna
(R-HSA-9022538)
Mecp2 regulates neuronal receptors and channels
(R-HSA-9022699)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Metabolism of proteins
(R-HSA-392499)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr negatively regulates cell cycle via sc1
(R-HSA-193670)
Pervasive developmental disorders
(R-HSA-9005895)
Pip3 activates akt signaling
(R-HSA-1257604)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Potential therapeutics for sars
(R-HSA-9679191)
Pten regulation
(R-HSA-6807070)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitf-m-dependent genes involved in apoptosis
(R-HSA-9824594)
Regulation of mitf-m-dependent genes involved in cell cycle and proliferation
(R-HSA-9825892)
Regulation of pten gene transcription
(R-HSA-8943724)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Repression of wnt target genes
(R-HSA-4641265)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk
(R-HSA-201556)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Stat3 nuclear events downstream of alk signaling
(R-HSA-9701898)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of brown and beige adipocyte differentiation
(R-HSA-9843743)
Transcriptional regulation of brown and beige adipocyte differentiation by ebf2
(R-HSA-9844594)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 160.1463
Cell Significance Index: -24.9100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 96.9176
Cell Significance Index: -24.5800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 84.0231
Cell Significance Index: -34.1400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 79.4285
Cell Significance Index: -37.5000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 73.7968
Cell Significance Index: -37.9600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 56.0488
Cell Significance Index: -37.6100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.9311
Cell Significance Index: -34.3100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.4973
Cell Significance Index: -32.6700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.9931
Cell Significance Index: -26.7700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.8494
Cell Significance Index: -34.9200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.4423
Cell Significance Index: -25.9300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.9268
Cell Significance Index: -15.1600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.2292
Cell Significance Index: 262.8900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.8588
Cell Significance Index: 54.5900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.5017
Cell Significance Index: 96.8900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.4385
Cell Significance Index: 21.5600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2947
Cell Significance Index: 17.6700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2558
Cell Significance Index: 43.6400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2301
Cell Significance Index: 63.9000
Cell Name: kidney cell (CL1000497)
Fold Change: 1.1761
Cell Significance Index: 9.3900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1670
Cell Significance Index: 637.3000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1324
Cell Significance Index: 204.1300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0789
Cell Significance Index: 132.6600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0171
Cell Significance Index: 46.1000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.9997
Cell Significance Index: 27.2100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9375
Cell Significance Index: 186.0500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9370
Cell Significance Index: 25.0200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9078
Cell Significance Index: 124.6600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7990
Cell Significance Index: 21.4100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7920
Cell Significance Index: 150.7300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7436
Cell Significance Index: 16.1100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.7021
Cell Significance Index: 19.6200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5838
Cell Significance Index: 12.2200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5644
Cell Significance Index: 26.3200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5527
Cell Significance Index: 5.0900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4844
Cell Significance Index: 47.9200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4702
Cell Significance Index: 22.1000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4365
Cell Significance Index: 192.9700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4314
Cell Significance Index: 55.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3864
Cell Significance Index: 28.8000
Cell Name: peg cell (CL4033014)
Fold Change: 0.3168
Cell Significance Index: 7.3200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2380
Cell Significance Index: 164.6100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2308
Cell Significance Index: 82.7800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2217
Cell Significance Index: 7.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2142
Cell Significance Index: 15.1500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1910
Cell Significance Index: 5.1100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1867
Cell Significance Index: 24.1200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1224
Cell Significance Index: 1.3900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0794
Cell Significance Index: 0.4800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0679
Cell Significance Index: 11.6000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0663
Cell Significance Index: 2.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0457
Cell Significance Index: 3.5100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0231
Cell Significance Index: 43.4600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0016
Cell Significance Index: -0.7300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0040
Cell Significance Index: -7.3600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0075
Cell Significance Index: -5.5100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0102
Cell Significance Index: -15.6300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0119
Cell Significance Index: -0.6700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0128
Cell Significance Index: -9.7200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0163
Cell Significance Index: -22.1100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0173
Cell Significance Index: -12.7800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0218
Cell Significance Index: -13.8200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0240
Cell Significance Index: -4.8200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0299
Cell Significance Index: -18.6800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0314
Cell Significance Index: -0.5300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0381
Cell Significance Index: -21.5100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0711
Cell Significance Index: -10.3300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0726
Cell Significance Index: -1.9100
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0763
Cell Significance Index: -0.7700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0848
Cell Significance Index: -17.8600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0882
Cell Significance Index: -9.0100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0958
Cell Significance Index: -2.0400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1102
Cell Significance Index: -31.7200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1276
Cell Significance Index: -3.2600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1375
Cell Significance Index: -15.7600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1552
Cell Significance Index: -3.8800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1553
Cell Significance Index: -10.4400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1698
Cell Significance Index: -10.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2234
Cell Significance Index: -26.0300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2337
Cell Significance Index: -12.1800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2568
Cell Significance Index: -7.4000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2646
Cell Significance Index: -30.2100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3001
Cell Significance Index: -31.2500
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3767
Cell Significance Index: -3.9000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3779
Cell Significance Index: -23.2300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3795
Cell Significance Index: -30.0600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4794
Cell Significance Index: -25.1700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6048
Cell Significance Index: -37.0800
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.6156
Cell Significance Index: -5.0200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6310
Cell Significance Index: -16.2200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6546
Cell Significance Index: -33.0800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.6933
Cell Significance Index: -28.4100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.6989
Cell Significance Index: -8.9500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7235
Cell Significance Index: -21.3100
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7251
Cell Significance Index: -15.5000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7306
Cell Significance Index: -32.3200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.7472
Cell Significance Index: -13.8100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7671
Cell Significance Index: -28.1600
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.8156
Cell Significance Index: -11.4400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8330
Cell Significance Index: -31.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** HDAC1 is a member of the histone deacetylase family, which consists of 18 enzymes that share a conserved catalytic domain. HDAC1 is a hexameric enzyme, consisting of six catalytic subunits, which are responsible for the removal of acetyl groups from histones. The enzyme is highly specific for histones H3 and H4, and its activity is regulated by the presence of histone acetyltransferases, which compete with HDAC1 for histone binding sites. HDAC1 is also characterized by its ability to interact with various transcription factors and signaling pathways, including the Notch, Wnt, and TGF-β pathways. Its expression is tightly regulated by post-translational modifications, including ubiquitination and acetylation, which control its activity and localization. **Pathways and Functions** HDAC1 plays a crucial role in various cellular processes, including: 1. **Cell Cycle Regulation**: HDAC1 is involved in the regulation of the cell cycle, particularly in the G1/S transition, by repressing the expression of cell cycle-related genes. 2. **Apoptosis**: HDAC1 is involved in the regulation of apoptosis, particularly in the activation of the extrinsic pathway, by deacetylating and activating pro-apoptotic proteins. 3. **Immune Responses**: HDAC1 is involved in the regulation of immune responses, particularly in the activation of T cells, by deacetylating and activating transcription factors such as NF-κB. 4. **Chromatin Organization**: HDAC1 plays a crucial role in the regulation of chromatin organization, particularly in the compaction of chromatin, by deacetylating histones. 5. **Transcriptional Regulation**: HDAC1 is involved in the regulation of transcription, particularly in the repression of gene expression, by deacetylating histones. **Clinical Significance** HDAC1 has been implicated in various diseases, including: 1. **Cancer**: HDAC1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and its expression is associated with poor prognosis. 2. **Neurological Disorders**: HDAC1 is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Autoimmune Diseases**: HDAC1 is involved in the regulation of immune responses, particularly in the activation of T cells, and its dysregulation has been implicated in various autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. Overall, HDAC1 is a crucial enzyme involved in the regulation of gene expression and cellular processes, and its dysregulation has significant implications for human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein deacetylase HDAC1

Genular Protein ID: 3928366923

Symbol: HDAC1_HUMAN

Name: Protein deacetylase HDAC1

UniProtKB Accession Codes:

Q13547 Q92534

Database IDs:

Citations:

PubMed ID: 8602529

Title: A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

PubMed ID: 8602529

DOI: 10.1126/science.272.5260.408

PubMed ID: 8646880

Title: Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae.

PubMed ID: 8646880

DOI: 10.1159/000134323

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10487760

Title: MEF-2 function is modified by a novel co-repressor, MITR.

PubMed ID: 10487760

DOI: 10.1093/emboj/18.18.5085

PubMed ID: 10898795

Title: BCoR, a novel corepressor involved in BCL-6 repression.

PubMed ID: 10898795

PubMed ID: 10846170

Title: HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.

PubMed ID: 10846170

DOI: 10.1074/jbc.m000168200

PubMed ID: 11006275

Title: Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing.

PubMed ID: 11006275

DOI: 10.1074/jbc.m004821200

PubMed ID: 10669754

Title: Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.

PubMed ID: 10669754

DOI: 10.1128/mcb.20.5.1784-1796.2000

PubMed ID: 10655483

Title: Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5.

PubMed ID: 10655483

DOI: 10.1073/pnas.97.3.1056

PubMed ID: 10904264

Title: NuRD and SIN3 histone deacetylase complexes in development.

PubMed ID: 10904264

DOI: 10.1016/s0168-9525(00)02066-7

PubMed ID: 11602581

Title: Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.

PubMed ID: 11602581

DOI: 10.1074/jbc.m105590200

PubMed ID: 11331609

Title: Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.

PubMed ID: 11331609

DOI: 10.1101/gad.871201

PubMed ID: 11102443

Title: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.

PubMed ID: 11102443

DOI: 10.1074/jbc.m007372200

PubMed ID: 11427533

Title: TGIF2 interacts with histone deacetylase 1 and represses transcription.

PubMed ID: 11427533

DOI: 10.1074/jbc.m103377200

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 12032081

Title: The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.

PubMed ID: 12032081

DOI: 10.1093/emboj/21.11.2682

PubMed ID: 11960997

Title: SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.

PubMed ID: 11960997

DOI: 10.1074/jbc.m203690200

PubMed ID: 14633989

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

PubMed ID: 14633989

DOI: 10.1093/emboj/cdg595

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 12837748

Title: Acetylated SP3 is a transcriptional activator.

PubMed ID: 12837748

DOI: 10.1074/jbc.m305961200

PubMed ID: 12482978

Title: Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.

PubMed ID: 12482978

DOI: 10.1128/mcb.23.1.250-258.2003

PubMed ID: 12724404

Title: Identification and characterization of three new components of the mSin3A corepressor complex.

PubMed ID: 12724404

DOI: 10.1128/mcb.23.10.3456-3467.2003

PubMed ID: 12730668

Title: Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.

PubMed ID: 12730668

DOI: 10.1038/sj.onc.1206379

PubMed ID: 15451426

Title: Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex.

PubMed ID: 15451426

DOI: 10.1016/j.bbrc.2004.08.227

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 15273251

Title: Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.

PubMed ID: 15273251

DOI: 10.1074/jbc.m405129200

PubMed ID: 15199155

Title: SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.

PubMed ID: 15199155

DOI: 10.1128/mcb.24.13.6021-6028.2004

PubMed ID: 15361834

Title: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.

PubMed ID: 15361834

DOI: 10.1038/sj.onc.1208053

PubMed ID: 16285960

Title: STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.

PubMed ID: 16285960

DOI: 10.1053/j.gastro.2005.07.055

PubMed ID: 15701600

Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

PubMed ID: 15701600

DOI: 10.1074/jbc.m413492200

PubMed ID: 15927959

Title: Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PubMed ID: 15927959

DOI: 10.1074/jbc.m413687200

PubMed ID: 16166625

Title: Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.

PubMed ID: 16166625

DOI: 10.1128/mcb.25.19.8415-8429.2005

PubMed ID: 16569215

Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.

PubMed ID: 16569215

DOI: 10.1042/bj20051669

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16762839

Title: HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.

PubMed ID: 16762839

DOI: 10.1016/j.molcel.2006.04.019

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 16478997

Title: Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.

PubMed ID: 16478997

DOI: 10.1128/mcb.26.5.1770-1785.2006

PubMed ID: 17000776

Title: Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis.

PubMed ID: 17000776

DOI: 10.1128/mcb.00940-06

PubMed ID: 16820529

Title: SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.

PubMed ID: 16820529

DOI: 10.1093/nar/gkl401

PubMed ID: 17963697

Title: CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.

PubMed ID: 17963697

DOI: 10.1016/j.bbrc.2007.10.090

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17548428

Title: Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.

PubMed ID: 17548428

DOI: 10.1096/fj.07-8621com

PubMed ID: 17373667

Title: Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.

PubMed ID: 17373667

DOI: 10.1002/ijc.22673

PubMed ID: 17704056

Title: Regulation of E2F1 function by the nuclear corepressor KAP1.

PubMed ID: 17704056

DOI: 10.1074/jbc.m704757200

PubMed ID: 17872950

Title: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.

PubMed ID: 17872950

DOI: 10.1074/jbc.m703735200

PubMed ID: 17341466

Title: Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation.

PubMed ID: 17341466

DOI: 10.1093/nar/gkl1113

PubMed ID: 17369852

Title: SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

PubMed ID: 17369852

DOI: 10.1038/sj.onc.1210387

PubMed ID: 17996965

Title: The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.

PubMed ID: 17996965

DOI: 10.1016/j.bbamcr.2007.09.004

PubMed ID: 18279852

Title: Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.

PubMed ID: 18279852

DOI: 10.1016/j.yexcr.2008.01.006

PubMed ID: 18093978

Title: Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.

PubMed ID: 18093978

DOI: 10.1074/jbc.m706307200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19061646

Title: CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

PubMed ID: 19061646

DOI: 10.1016/j.molcel.2008.10.025

PubMed ID: 18438403

Title: Protein lysine methyltransferase G9a acts on non-histone targets.

PubMed ID: 18438403

DOI: 10.1038/nchembio.88

PubMed ID: 19081374

Title: A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression.

PubMed ID: 19081374

DOI: 10.1016/j.neuron.2008.09.040

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19049980

Title: SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

PubMed ID: 19049980

DOI: 10.1074/jbc.m808989200

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 19343227

Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

PubMed ID: 19343227

DOI: 10.1371/journal.pone.0005071

PubMed ID: 19182791

Title: Chfr is linked to tumour metastasis through the downregulation of HDAC1.

PubMed ID: 19182791

DOI: 10.1038/ncb1837

PubMed ID: 19729656

Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

PubMed ID: 19729656

DOI: 10.1126/science.1176709

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21030595

Title: HDAC3 is negatively regulated by the nuclear protein DBC1.

PubMed ID: 21030595

DOI: 10.1074/jbc.m110.153270

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 20081843

Title: Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

PubMed ID: 20081843

DOI: 10.1038/ncb2013

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21549307

Title: Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

PubMed ID: 21549307

DOI: 10.1016/j.molcel.2011.02.036

PubMed ID: 21041482

Title: A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci.

PubMed ID: 21041482

DOI: 10.1128/mcb.00840-10

PubMed ID: 21829689

Title: SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.

PubMed ID: 21829689

DOI: 10.1371/journal.pone.0023046

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25514493

Title: Pokemon (FBI-1) interacts with Smad4 to repress TGF-beta-induced transcriptional responses.

PubMed ID: 25514493

DOI: 10.1016/j.bbagrm.2014.12.008

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25653165

Title: Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.

PubMed ID: 25653165

DOI: 10.1093/nar/gkv068

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 27616479

Title: De novo mutations in CHD4, an ATP-dependent chromatin remodeler gene, cause an intellectual disability syndrome with distinctive dysmorphisms.

PubMed ID: 27616479

DOI: 10.1016/j.ajhg.2016.08.001

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 29656858

Title: A recurrent de novo PACS2 heterozygous missense variant causes neonatal-onset developmental epileptic encephalopathy, facial dysmorphism, and cerebellar dysgenesis.

PubMed ID: 29656858

DOI: 10.1016/j.ajhg.2018.03.005

PubMed ID: 30487602

Title: NP220 mediates silencing of unintegrated retroviral DNA.

PubMed ID: 30487602

DOI: 10.1038/s41586-018-0750-6

PubMed ID: 30110327

Title: The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish.

PubMed ID: 30110327

DOI: 10.1371/journal.pgen.1007578

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 36064715

Title: ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation.

PubMed ID: 36064715

DOI: 10.1038/s41419-022-05212-x

PubMed ID: 37179361

Title: The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase.

PubMed ID: 37179361

DOI: 10.1186/s13072-023-00494-7

Sequence Information:

Length: 482
Mass: 55103
Checksum: 4D35B7C1ED7838D6
Sequence:

MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN 
AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS 
AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG 
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI 
FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 
KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF 
SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK 
LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HDAC1

Associated with

Cells (max top 100)

Other Information

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. PubMed ID: 8602529

Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. PubMed ID: 8646880

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MEF-2 function is modified by a novel co-repressor, MITR. PubMed ID: 10487760

BCoR, a novel corepressor involved in BCL-6 repression. PubMed ID: 10898795

HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. PubMed ID: 10846170

Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. PubMed ID: 11006275

Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. PubMed ID: 10669754

Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. PubMed ID: 10655483

NuRD and SIN3 histone deacetylase complexes in development. PubMed ID: 10904264

Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. PubMed ID: 11602581

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. PubMed ID: 11331609

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. PubMed ID: 11102443

TGIF2 interacts with histone deacetylase 1 and represses transcription. PubMed ID: 11427533

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. PubMed ID: 11533236

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. PubMed ID: 12032081

SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. PubMed ID: 11960997

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. PubMed ID: 14633989

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. PubMed ID: 12670868

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. PubMed ID: 12493763

Acetylated SP3 is a transcriptional activator. PubMed ID: 12837748

Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. PubMed ID: 12482978

Identification and characterization of three new components of the mSin3A corepressor complex. PubMed ID: 12724404

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. PubMed ID: 12730668

Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. PubMed ID: 15451426

MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. PubMed ID: 15454082

Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1. PubMed ID: 15273251

SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. PubMed ID: 15199155

ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. PubMed ID: 15361834

STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. PubMed ID: 16285960

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. PubMed ID: 15701600

Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. PubMed ID: 15927959

Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. PubMed ID: 16166625

INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. PubMed ID: 16569215

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. PubMed ID: 16762839

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. PubMed ID: 16428440

Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. PubMed ID: 16478997

Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. PubMed ID: 17000776

SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. PubMed ID: 16820529

CR/periphilin is a transcriptional co-repressor involved in cell cycle progression. PubMed ID: 17963697

Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line. PubMed ID: 17487921

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. PubMed ID: 17548428

Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. PubMed ID: 17373667

Regulation of E2F1 function by the nuclear corepressor KAP1. PubMed ID: 17704056

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. PubMed ID: 17872950

Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation. PubMed ID: 17341466

SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. PubMed ID: 17369852

The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. PubMed ID: 17996965

Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU. PubMed ID: 18279852

Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. PubMed ID: 18093978

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. PubMed ID: 19061646

Protein lysine methyltransferase G9a acts on non-histone targets. PubMed ID: 18438403

A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. PubMed ID: 19081374

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells. PubMed ID: 19049980

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. PubMed ID: 19433865

FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PubMed ID: 19343227

Chfr is linked to tumour metastasis through the downregulation of HDAC1. PubMed ID: 19182791

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. PubMed ID: 19729656

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

HDAC3 is negatively regulated by the nuclear protein DBC1. PubMed ID: 21030595

CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. PubMed ID: 20523938

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. PubMed ID: 20081843

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. PubMed ID: 21549307

A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci. PubMed ID: 21041482

SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability. PubMed ID: 21829689

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569