Details for: HDAC1

Gene ID: 3065

Symbol: HDAC1

Ensembl ID: ENSG00000116478

Description: histone deacetylase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.09
    Marker Score: 6213.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.79
    Marker Score: 5634
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.78
    Marker Score: 7305.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.78
    Marker Score: 23908
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.74
    Marker Score: 11082
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.73
    Marker Score: 20154
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.72
    Marker Score: 10967.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.69
    Marker Score: 1700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.67
    Marker Score: 2369
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.66
    Marker Score: 3472
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.66
    Marker Score: 2888
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.64
    Marker Score: 56962
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.63
    Marker Score: 2395.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.62
    Marker Score: 3173
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.62
    Marker Score: 3837
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.61
    Marker Score: 16340
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.61
    Marker Score: 1175
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.61
    Marker Score: 791
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.59
    Marker Score: 6238
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.59
    Marker Score: 5871
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.58
    Marker Score: 13614
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.57
    Marker Score: 4275
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.57
    Marker Score: 1514
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.55
    Marker Score: 2639
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.54
    Marker Score: 573
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.52
    Marker Score: 1431
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.48
    Marker Score: 988
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.47
    Marker Score: 14587
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.47
    Marker Score: 1557
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.47
    Marker Score: 721
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.47
    Marker Score: 1409
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166427
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.44
    Marker Score: 760
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.44
    Marker Score: 6165
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.41
    Marker Score: 6752
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.38
    Marker Score: 1304
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.36
    Marker Score: 1026
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.35
    Marker Score: 321
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.35
    Marker Score: 316
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.34
    Marker Score: 2402
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.34
    Marker Score: 3770
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.34
    Marker Score: 985
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.34
    Marker Score: 3041
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.31
    Marker Score: 460
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.31
    Marker Score: 796
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.3
    Marker Score: 3603
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.3
    Marker Score: 870
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.3
    Marker Score: 1084
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.3
    Marker Score: 3269.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.3
    Marker Score: 68543
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.28
    Marker Score: 1707
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.28
    Marker Score: 482
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.28
    Marker Score: 1003
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.28
    Marker Score: 1327
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.27
    Marker Score: 2107
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.27
    Marker Score: 9421.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.26
    Marker Score: 858
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.26
    Marker Score: 786
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.26
    Marker Score: 3067.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.26
    Marker Score: 1102.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.25
    Marker Score: 3947
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.25
    Marker Score: 245
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.24
    Marker Score: 1139
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.23
    Marker Score: 2449
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.23
    Marker Score: 354
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.22
    Marker Score: 610
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.22
    Marker Score: 5264
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.22
    Marker Score: 1466.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.22
    Marker Score: 291
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.21
    Marker Score: 9454
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.21
    Marker Score: 666
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.21
    Marker Score: 1516
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.21
    Marker Score: 1281
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.21
    Marker Score: 873
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.2
    Marker Score: 700.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.19
    Marker Score: 382
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.19
    Marker Score: 266
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.18
    Marker Score: 864.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.18
    Marker Score: 15563
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.18
    Marker Score: 508.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.18
    Marker Score: 798
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.16
    Marker Score: 1247
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.16
    Marker Score: 1662
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.16
    Marker Score: 399
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 1.15
    Marker Score: 283
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.14
    Marker Score: 689.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.14
    Marker Score: 1198
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.13
    Marker Score: 289
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.13
    Marker Score: 297
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1456
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.13
    Marker Score: 844
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.13
    Marker Score: 1004
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.12
    Marker Score: 398
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.12
    Marker Score: 920
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.12
    Marker Score: 1117.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.12
    Marker Score: 579.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.12
    Marker Score: 751
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.11
    Marker Score: 1208.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.11
    Marker Score: 1629
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1
    Marker Score: 707

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Other Information

**Key characteristics:** * HDAC1 is a large protein with a molecular weight of approximately 170 kDa. * It is a member of the HDAC family of histone deacetylases. * HDAC1 is ubiquitinated by the E3 ubiquitin ligase RBR1 and is degraded by the proteasome. * It is a key regulator of the cell cycle and is involved in the regulation of cell proliferation, differentiation, and apoptosis. * HDAC1 also plays a role in inflammation and immune responses. **Pathways and functions:** * HDAC1 is involved in cell cycle regulation by deacetylating lysine residues on histone proteins, which allows them to be more accessible to transcription factors. * It is involved in the regulation of apoptosis by deacetylating the pro-apoptotic protein Apaf-1. * HDAC1 is involved in inflammation and immune responses by deacetylating inflammatory mediators, such as TNF-alpha and IL-1 beta. * It also plays a role in the regulation of cell growth and differentiation. **Clinical significance:** * Mutations in HDAC1 have been linked to a number of human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. * HDAC1 inhibitors are being investigated as potential therapeutics for these diseases. **Conclusion:** HDAC1 is a critical regulator of gene expression and immune responses. Its deregulation has been linked to a number of human diseases, highlighting its importance in maintaining cellular health and preventing disease.

Genular Protein ID: 3928366923

Symbol: HDAC1_HUMAN

Name: Protein deacetylase HDAC1

UniProtKB Accession Codes:

Q13547 Q92534

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 20 DrugCentral 1 EC 1 EMBL 3 EMDB 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 70 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 31 RefSeq 1 Rhea 12 SABIO-RK 1 SAM 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8602529

Title: A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

PubMed ID: 8602529

DOI: 10.1126/science.272.5260.408

PubMed ID: 8646880

Title: Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae.

PubMed ID: 8646880

DOI: 10.1159/000134323

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10487760

Title: MEF-2 function is modified by a novel co-repressor, MITR.

PubMed ID: 10487760

DOI: 10.1093/emboj/18.18.5085

PubMed ID: 10898795

Title: BCoR, a novel corepressor involved in BCL-6 repression.

PubMed ID: 10898795

PubMed ID: 10846170

Title: HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.

PubMed ID: 10846170

DOI: 10.1074/jbc.m000168200

PubMed ID: 11006275

Title: Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing.

PubMed ID: 11006275

DOI: 10.1074/jbc.m004821200

PubMed ID: 10669754

Title: Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.

PubMed ID: 10669754

DOI: 10.1128/mcb.20.5.1784-1796.2000

PubMed ID: 10655483

Title: Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5.

PubMed ID: 10655483

DOI: 10.1073/pnas.97.3.1056

PubMed ID: 11602581

Title: Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.

PubMed ID: 11602581

DOI: 10.1074/jbc.m105590200

PubMed ID: 11331609

Title: Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.

PubMed ID: 11331609

DOI: 10.1101/gad.871201

PubMed ID: 11102443

Title: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.

PubMed ID: 11102443

DOI: 10.1074/jbc.m007372200

PubMed ID: 11427533

Title: TGIF2 interacts with histone deacetylase 1 and represses transcription.

PubMed ID: 11427533

DOI: 10.1074/jbc.m103377200

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 12032081

Title: The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.

PubMed ID: 12032081

DOI: 10.1093/emboj/21.11.2682

PubMed ID: 11960997

Title: SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.

PubMed ID: 11960997

DOI: 10.1074/jbc.m203690200

PubMed ID: 14633989

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

PubMed ID: 14633989

DOI: 10.1093/emboj/cdg595

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 12837748

Title: Acetylated SP3 is a transcriptional activator.

PubMed ID: 12837748

DOI: 10.1074/jbc.m305961200

PubMed ID: 12482978

Title: Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.

PubMed ID: 12482978

DOI: 10.1128/mcb.23.1.250-258.2003

PubMed ID: 12724404

Title: Identification and characterization of three new components of the mSin3A corepressor complex.

PubMed ID: 12724404

DOI: 10.1128/mcb.23.10.3456-3467.2003

PubMed ID: 12730668

Title: Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.

PubMed ID: 12730668

DOI: 10.1038/sj.onc.1206379

PubMed ID: 15451426

Title: Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex.

PubMed ID: 15451426

DOI: 10.1016/j.bbrc.2004.08.227

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 15273251

Title: Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.

PubMed ID: 15273251

DOI: 10.1074/jbc.m405129200

PubMed ID: 15199155

Title: SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.

PubMed ID: 15199155

DOI: 10.1128/mcb.24.13.6021-6028.2004

PubMed ID: 15361834

Title: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.

PubMed ID: 15361834

DOI: 10.1038/sj.onc.1208053

PubMed ID: 10904264

Title: NuRD and SIN3 histone deacetylase complexes in development.

PubMed ID: 10904264

DOI: 10.1016/s0168-9525(00)02066-7

PubMed ID: 15701600

Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

PubMed ID: 15701600

DOI: 10.1074/jbc.m413492200

PubMed ID: 15927959

Title: Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PubMed ID: 15927959

DOI: 10.1074/jbc.m413687200

PubMed ID: 16166625

Title: Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.

PubMed ID: 16166625

DOI: 10.1128/mcb.25.19.8415-8429.2005

PubMed ID: 16569215

Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.

PubMed ID: 16569215

DOI: 10.1042/bj20051669

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16762839

Title: HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.

PubMed ID: 16762839

DOI: 10.1016/j.molcel.2006.04.019

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 16478997

Title: Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.

PubMed ID: 16478997

DOI: 10.1128/mcb.26.5.1770-1785.2006

PubMed ID: 17000776

Title: Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis.

PubMed ID: 17000776

DOI: 10.1128/mcb.00940-06

PubMed ID: 16820529

Title: SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.

PubMed ID: 16820529

DOI: 10.1093/nar/gkl401

PubMed ID: 17963697

Title: CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.

PubMed ID: 17963697

DOI: 10.1016/j.bbrc.2007.10.090

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17548428

Title: Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.

PubMed ID: 17548428

DOI: 10.1096/fj.07-8621com

PubMed ID: 17373667

Title: Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.

PubMed ID: 17373667

DOI: 10.1002/ijc.22673

PubMed ID: 17704056

Title: Regulation of E2F1 function by the nuclear corepressor KAP1.

PubMed ID: 17704056

DOI: 10.1074/jbc.m704757200

PubMed ID: 17872950

Title: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.

PubMed ID: 17872950

DOI: 10.1074/jbc.m703735200

PubMed ID: 17341466

Title: Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation.

PubMed ID: 17341466

DOI: 10.1093/nar/gkl1113

PubMed ID: 17369852

Title: SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

PubMed ID: 17369852

DOI: 10.1038/sj.onc.1210387

PubMed ID: 17996965

Title: The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.

PubMed ID: 17996965

DOI: 10.1016/j.bbamcr.2007.09.004

PubMed ID: 18279852

Title: Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.

PubMed ID: 18279852

DOI: 10.1016/j.yexcr.2008.01.006

PubMed ID: 18093978

Title: Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.

PubMed ID: 18093978

DOI: 10.1074/jbc.m706307200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19061646

Title: CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

PubMed ID: 19061646

DOI: 10.1016/j.molcel.2008.10.025

PubMed ID: 18438403

Title: Protein lysine methyltransferase G9a acts on non-histone targets.

PubMed ID: 18438403

DOI: 10.1038/nchembio.88

PubMed ID: 19081374

Title: A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression.

PubMed ID: 19081374

DOI: 10.1016/j.neuron.2008.09.040

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19049980

Title: SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

PubMed ID: 19049980

DOI: 10.1074/jbc.m808989200

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 19343227

Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

PubMed ID: 19343227

DOI: 10.1371/journal.pone.0005071

PubMed ID: 19182791

Title: Chfr is linked to tumour metastasis through the downregulation of HDAC1.

PubMed ID: 19182791

DOI: 10.1038/ncb1837

PubMed ID: 19729656

Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

PubMed ID: 19729656

DOI: 10.1126/science.1176709

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21030595

Title: HDAC3 is negatively regulated by the nuclear protein DBC1.

PubMed ID: 21030595

DOI: 10.1074/jbc.m110.153270

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 20081843

Title: Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

PubMed ID: 20081843

DOI: 10.1038/ncb2013

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21549307

Title: Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

PubMed ID: 21549307

DOI: 10.1016/j.molcel.2011.02.036

PubMed ID: 21829689

Title: SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.

PubMed ID: 21829689

DOI: 10.1371/journal.pone.0023046

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25514493

Title: Pokemon (FBI-1) interacts with Smad4 to repress TGF-beta-induced transcriptional responses.

PubMed ID: 25514493

DOI: 10.1016/j.bbagrm.2014.12.008

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25653165

Title: Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.

PubMed ID: 25653165

DOI: 10.1093/nar/gkv068

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 27616479

Title: De novo mutations in CHD4, an ATP-dependent chromatin remodeler gene, cause an intellectual disability syndrome with distinctive dysmorphisms.

PubMed ID: 27616479

DOI: 10.1016/j.ajhg.2016.08.001

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 29656858

Title: A recurrent de novo PACS2 heterozygous missense variant causes neonatal-onset developmental epileptic encephalopathy, facial dysmorphism, and cerebellar dysgenesis.

PubMed ID: 29656858

DOI: 10.1016/j.ajhg.2018.03.005

PubMed ID: 30487602

Title: NP220 mediates silencing of unintegrated retroviral DNA.

PubMed ID: 30487602

DOI: 10.1038/s41586-018-0750-6

PubMed ID: 30110327

Title: The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish.

PubMed ID: 30110327

DOI: 10.1371/journal.pgen.1007578

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 36064715

Title: ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation.

PubMed ID: 36064715

DOI: 10.1038/s41419-022-05212-x

Sequence Information:

  • Length: 482
  • Mass: 55103
  • Checksum: 4D35B7C1ED7838D6
  • Sequence:
    • MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN 
AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS 
AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG 
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI 
FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 
KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF 
SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK 
LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.