Details for: ERVW 1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 15.4175
Cell Significance Index: 411.6700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 4.5758
Cell Significance Index: -1.8900 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.9844
Cell Significance Index: 12.3300 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.7812
Cell Significance Index: 6.3700 - Cell Name: germ cell (CL0000586)
Fold Change: 0.3986
Cell Significance Index: 3.0100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3658
Cell Significance Index: 19.0000 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.3401
Cell Significance Index: 2.1000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.3194
Cell Significance Index: 1.9300 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.2376
Cell Significance Index: 3.7700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1308
Cell Significance Index: 5.9300 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.0917
Cell Significance Index: 0.5000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.0718
Cell Significance Index: 2.2700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0582
Cell Significance Index: 7.4600 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.0579
Cell Significance Index: 0.5500 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.0504
Cell Significance Index: 0.5200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0469
Cell Significance Index: 0.6400 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0413
Cell Significance Index: 0.5800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0271
Cell Significance Index: 4.8800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.0190
Cell Significance Index: 0.3200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0149
Cell Significance Index: 0.7500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0140
Cell Significance Index: 1.7200 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0124
Cell Significance Index: 0.1800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0104
Cell Significance Index: 2.0900 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.0104
Cell Significance Index: 0.1200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0060
Cell Significance Index: 0.3800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0060
Cell Significance Index: 2.1600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0055
Cell Significance Index: 8.4900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0047
Cell Significance Index: 6.4300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0043
Cell Significance Index: 7.9200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0020
Cell Significance Index: 0.3900 - Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 0.0014
Cell Significance Index: 0.0100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0013
Cell Significance Index: 2.4800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0010
Cell Significance Index: 0.0600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0006
Cell Significance Index: 0.0700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0002
Cell Significance Index: -0.0100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0020
Cell Significance Index: -1.4900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0021
Cell Significance Index: -1.3200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0021
Cell Significance Index: -1.6300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0023
Cell Significance Index: -1.7200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0027
Cell Significance Index: -1.5100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0028
Cell Significance Index: -1.2700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0028
Cell Significance Index: -0.8200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0029
Cell Significance Index: -1.6000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0029
Cell Significance Index: -1.3000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0034
Cell Significance Index: -0.5000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0055
Cell Significance Index: -0.5600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0065
Cell Significance Index: -1.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0075
Cell Significance Index: -1.2800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0085
Cell Significance Index: -0.6600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0093
Cell Significance Index: -0.6600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0109
Cell Significance Index: -1.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0114
Cell Significance Index: -1.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0128
Cell Significance Index: -1.6500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0141
Cell Significance Index: -0.7400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0165
Cell Significance Index: -1.7200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0171
Cell Significance Index: -0.2500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0200
Cell Significance Index: -1.1200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0207
Cell Significance Index: -1.3900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0228
Cell Significance Index: -1.4700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0231
Cell Significance Index: -1.7200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0257
Cell Significance Index: -1.2000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0269
Cell Significance Index: -1.1900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0281
Cell Significance Index: -0.5200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0289
Cell Significance Index: -1.3600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0314
Cell Significance Index: -1.2900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0368
Cell Significance Index: -1.2900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0383
Cell Significance Index: -1.4500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0386
Cell Significance Index: -0.3600 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0413
Cell Significance Index: -0.4000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0420
Cell Significance Index: -1.0100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0427
Cell Significance Index: -1.1000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0433
Cell Significance Index: -1.3800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0440
Cell Significance Index: -1.2300 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0445
Cell Significance Index: -0.6200 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0460
Cell Significance Index: -0.5600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0467
Cell Significance Index: -1.5300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0493
Cell Significance Index: -1.3200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0509
Cell Significance Index: -1.0800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0511
Cell Significance Index: -1.0700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0512
Cell Significance Index: -1.7800 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.0523
Cell Significance Index: -0.2500 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0528
Cell Significance Index: -0.6900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0541
Cell Significance Index: -1.2500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0553
Cell Significance Index: -2.4000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0562
Cell Significance Index: -1.6100 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.0565
Cell Significance Index: -0.5900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0569
Cell Significance Index: -1.4200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0570
Cell Significance Index: -1.6800 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0577
Cell Significance Index: -0.7200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0578
Cell Significance Index: -2.0300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0580
Cell Significance Index: -2.1300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0581
Cell Significance Index: -1.4500 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0582
Cell Significance Index: -1.5300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0585
Cell Significance Index: -1.6700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0586
Cell Significance Index: -1.5700 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0591
Cell Significance Index: -0.5700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0592
Cell Significance Index: -1.7100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0600
Cell Significance Index: -1.2200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0606
Cell Significance Index: -1.3100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0610
Cell Significance Index: -1.2300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2613363424
Symbol: SYCY1_HUMAN
Name: Syncytin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9882319
Title: Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family.
PubMed ID: 9882319
PubMed ID: 10693809
Title: Syncytin is captive retroviral envelope protein involved in human placental morphogenesis.
PubMed ID: 10693809
DOI: 10.1038/35001608
PubMed ID: 10826480
Title: Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family.
PubMed ID: 10826480
PubMed ID: 14757826
Title: The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology.
PubMed ID: 14757826
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11990458
Title: The HERV-W/7q family in the human genome. Potential for protein expression and gene regulation.
PubMed ID: 11990458
PubMed ID: 9835022
Title: Endogenous retroviruses and multiple sclerosis. II. HERV-7q.
PubMed ID: 9835022
PubMed ID: 10708449
Title: An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor.
PubMed ID: 10708449
PubMed ID: 11238877
Title: Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope.
PubMed ID: 11238877
PubMed ID: 11531410
Title: Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation.
PubMed ID: 11531410
PubMed ID: 12050356
Title: The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors.
PubMed ID: 12050356
PubMed ID: 14557543
Title: Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.
PubMed ID: 14557543
PubMed ID: 12664292
Title: The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus.
PubMed ID: 12664292
PubMed ID: 12970426
Title: Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.
PubMed ID: 12970426
PubMed ID: 12620933
Title: Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta.
PubMed ID: 12620933
PubMed ID: 15254254
Title: Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation.
PubMed ID: 15254254
PubMed ID: 15452578
Title: Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.
PubMed ID: 15452578
DOI: 10.1038/nn1319
PubMed ID: 15827173
Title: Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope.
PubMed ID: 15827173
PubMed ID: 23492904
Title: A novel human endogenous retroviral protein inhibits cell-cell fusion.
PubMed ID: 23492904
DOI: 10.1038/srep01462
Sequence Information:
- Length: 538
- Mass: 59866
- Checksum: C54648A3C7043870
- Sequence:
MALPYHIFLF TVLLPSFTLT APPPCRCMTS SSPYQEFLWR MQRPGNIDAP SYRSLSKGTP TFTAHTHMPR NCYHSATLCM HANTHYWTGK MINPSCPGGL GVTVCWTYFT QTGMSDGGGV QDQAREKHVK EVISQLTRVH GTSSPYKGLD LSKLHETLRT HTRLVSLFNT TLTGLHEVSA QNPTNCWICL PLNFRPYVSI PVPEQWNNFS TEINTTSVLV GPLVSNLEIT HTSNLTCVKF SNTTYTTNSQ CIRWVTPPTQ IVCLPSGIFF VCGTSAYRCL NGSSESMCFL SFLVPPMTIY TEQDLYSYVI SKPRNKRVPI LPFVIGAGVL GALGTGIGGI TTSTQFYYKL SQELNGDMER VADSLVTLQD QLNSLAAVVL QNRRALDLLT AERGGTCLFL GEECCYYVNQ SGIVTEKVKE IRDRIQRRAE ELRNTGPWGL LSQWMPWILP FLGPLAAIIL LLLFGPCIFN LLVNFVSSRI EAVKLQMEPK MQSKTKIYRR PLDRPASPRS DVNDIKGTPP EEISAAQPLL RPNSAGSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.