Details for: EHD2

Gene ID: 30846

Symbol: EHD2

Ensembl ID: ENSG00000024422

Description: EH domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.6881
    Cell Significance Index: -22.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.9260
    Cell Significance Index: -20.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.9499
    Cell Significance Index: -19.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.5724
    Cell Significance Index: -22.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.4558
    Cell Significance Index: -19.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1434
    Cell Significance Index: -22.3700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 9.9538
    Cell Significance Index: 83.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2793
    Cell Significance Index: -18.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6614
    Cell Significance Index: -22.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6195
    Cell Significance Index: -17.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.3029
    Cell Significance Index: 276.2200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.3981
    Cell Significance Index: 27.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.1801
    Cell Significance Index: 38.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4375
    Cell Significance Index: 18.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0267
    Cell Significance Index: 21.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.0265
    Cell Significance Index: 12.9700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.9378
    Cell Significance Index: 4.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8630
    Cell Significance Index: 23.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7815
    Cell Significance Index: 107.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6399
    Cell Significance Index: 7.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4763
    Cell Significance Index: 58.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4411
    Cell Significance Index: 51.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3805
    Cell Significance Index: 10.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2399
    Cell Significance Index: 12.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1902
    Cell Significance Index: 84.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1807
    Cell Significance Index: 32.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1708
    Cell Significance Index: 2.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1665
    Cell Significance Index: 21.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1577
    Cell Significance Index: 2.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1554
    Cell Significance Index: 2.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1209
    Cell Significance Index: 2.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0851
    Cell Significance Index: 17.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0811
    Cell Significance Index: 0.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0667
    Cell Significance Index: 41.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0574
    Cell Significance Index: 4.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0112
    Cell Significance Index: 1.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0094
    Cell Significance Index: 7.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0078
    Cell Significance Index: 0.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0017
    Cell Significance Index: 1.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0135
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0182
    Cell Significance Index: -2.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0196
    Cell Significance Index: -10.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0258
    Cell Significance Index: -0.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0262
    Cell Significance Index: -9.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0292
    Cell Significance Index: -21.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0298
    Cell Significance Index: -18.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0320
    Cell Significance Index: -18.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0336
    Cell Significance Index: -15.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0453
    Cell Significance Index: -1.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0496
    Cell Significance Index: -9.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0596
    Cell Significance Index: -12.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0717
    Cell Significance Index: -20.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0736
    Cell Significance Index: -2.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0810
    Cell Significance Index: -4.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1185
    Cell Significance Index: -12.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1213
    Cell Significance Index: -8.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1275
    Cell Significance Index: -14.6100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1349
    Cell Significance Index: -0.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1392
    Cell Significance Index: -20.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1706
    Cell Significance Index: -19.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2008
    Cell Significance Index: -20.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2524
    Cell Significance Index: -11.7700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.2608
    Cell Significance Index: -1.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2736
    Cell Significance Index: -21.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3119
    Cell Significance Index: -20.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3401
    Cell Significance Index: -22.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3721
    Cell Significance Index: -22.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3799
    Cell Significance Index: -4.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3838
    Cell Significance Index: -23.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3943
    Cell Significance Index: -9.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3981
    Cell Significance Index: -20.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4487
    Cell Significance Index: -25.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4992
    Cell Significance Index: -22.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5221
    Cell Significance Index: -14.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5506
    Cell Significance Index: -19.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5535
    Cell Significance Index: -18.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5802
    Cell Significance Index: -21.9700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5863
    Cell Significance Index: -3.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5914
    Cell Significance Index: -18.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5995
    Cell Significance Index: -15.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6054
    Cell Significance Index: -12.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6083
    Cell Significance Index: -22.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6121
    Cell Significance Index: -21.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6570
    Cell Significance Index: -28.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6935
    Cell Significance Index: -18.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7722
    Cell Significance Index: -20.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7734
    Cell Significance Index: -22.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7751
    Cell Significance Index: -19.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7825
    Cell Significance Index: -22.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8108
    Cell Significance Index: -28.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8112
    Cell Significance Index: -23.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8207
    Cell Significance Index: -16.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8325
    Cell Significance Index: -20.7600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.8550
    Cell Significance Index: -4.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8578
    Cell Significance Index: -21.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Endocytic regulation**: EHD2 is involved in regulating endocytic trafficking, including the sorting of cargo proteins to recycling endosomes and the regulation of endocytic vesicle formation. 2. **Cytoskeleton organization**: EHD2 interacts with actin cytoskeleton proteins, influencing cortical actin cytoskeleton organization and membrane dynamics. 3. **Cell signaling**: EHD2 is involved in cell signaling pathways, including the regulation of endocytic recycling and the modulation of cellular responses to external stimuli. 4. **Membrane dynamics**: EHD2 regulates membrane dynamics, including the formation and remodeling of membrane tubules and the regulation of membrane fluidity. **Pathways and Functions** EHD2 is involved in various cellular pathways, including: 1. **Endocytic recycling**: EHD2 regulates the sorting of cargo proteins to recycling endosomes, influencing the efficiency of endocytic recycling and the maintenance of cellular homeostasis. 2. **Cortical actin cytoskeleton organization**: EHD2 interacts with actin cytoskeleton proteins, influencing cortical actin cytoskeleton organization and membrane dynamics. 3. **Caveola formation**: EHD2 is involved in the formation and regulation of caveolae, which are membrane invaginations involved in cell signaling and endocytic trafficking. 4. **Hemostasis**: EHD2 is involved in the regulation of hemostasis, including the modulation of platelet production and the regulation of blood clotting. **Clinical Significance** EHD2 has been implicated in various diseases, including: 1. **Immunological disorders**: EHD2 has been linked to immunological disorders, such as autoimmune diseases and cancers, where dysregulation of endocytic trafficking and cell signaling pathways can contribute to disease pathogenesis. 2. **Cardiovascular disease**: EHD2 has been implicated in cardiovascular disease, including the regulation of hemostasis and the modulation of blood clotting. 3. **Cancer**: EHD2 has been linked to cancer, including the regulation of endocytic trafficking and cell signaling pathways that contribute to tumor progression and metastasis. In conclusion, EHD2 is a multifunctional protein involved in various cellular processes, including endocytosis, cytoskeleton organization, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of EHD2 in maintaining cellular homeostasis and its potential as a therapeutic target for immunological disorders and other diseases.

Genular Protein ID: 3466517183

Symbol: EHD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NZN4 B2RDH9 B4DNU6 Q96CB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10673336

Title: EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.

PubMed ID: 10673336

DOI: 10.1006/geno.1999.6087

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17233914

Title: Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.

PubMed ID: 17233914

DOI: 10.1186/1471-2121-8-3

PubMed ID: 18502764

Title: The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion.

PubMed ID: 18502764

DOI: 10.1074/jbc.m802306200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22323287

Title: EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization.

PubMed ID: 22323287

DOI: 10.1091/mbc.e11-09-0787

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25588833

Title: Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.

PubMed ID: 25588833

DOI: 10.1242/jcs.161463

Sequence Information:

  • Length: 543
  • Mass: 61161
  • Checksum: 0EBF691B0A707359
  • Sequence:
    • MFSWLKRGGA RGQQPEAIRT VTSALKELYR TKLLPLEEHY RFGAFHSPAL EDADFDGKPM 
VLVAGQYSTG KTSFIQYLLE QEVPGSRVGP EPTTDCFVAV MHGDTEGTVP GNALVVDPDK 
PFRKLNPFGN TFLNRFMCAQ LPNQVLESIS IIDTPGILSG AKQRVSRGYD FPAVLRWFAE 
RVDLIILLFD AHKLEISDEF SEAIGALRGH EDKIRVVLNK ADMVETQQLM RVYGALMWAL 
GKVVGTPEVL RVYIGSFWSQ PLLVPDNRRL FELEEQDLFR DIQGLPRHAA LRKLNDLVKR 
ARLVRVHAYI ISYLKKEMPS VFGKENKKKQ LILKLPVIFA KIQLEHHISP GDFPDCQKMQ 
ELLMAHDFTK FHSLKPKLLE ALDEMLTHDI AKLMPLLRQE ELESTEVGVQ GGAFEGTHMG 
PFVERGPDEA MEDGEEGSDD EAEWVVTKDK SKYDEIFYNL APADGKLSGS KAKTWMVGTK 
LPNSVLGRIW KLSDVDRDGM LDDEEFALAS HLIEAKLEGH GLPANLPRRL VPPSKRRHKG 
SAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.