Details for: UBE2K

Gene ID: 3093

Symbol: UBE2K

Ensembl ID: ENSG00000078140

Description: ubiquitin conjugating enzyme E2 K

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 492.4934
    Cell Significance Index: -76.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 319.2277
    Cell Significance Index: -80.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 207.5871
    Cell Significance Index: -85.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 188.0761
    Cell Significance Index: -88.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 181.4860
    Cell Significance Index: -73.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 164.0405
    Cell Significance Index: -84.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 133.0657
    Cell Significance Index: -89.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 77.6125
    Cell Significance Index: -74.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 68.1330
    Cell Significance Index: -84.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.2965
    Cell Significance Index: -81.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.0691
    Cell Significance Index: -80.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.0840
    Cell Significance Index: -52.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.4402
    Cell Significance Index: -88.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.0233
    Cell Significance Index: 134.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.2385
    Cell Significance Index: 642.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.9357
    Cell Significance Index: 75.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4567
    Cell Significance Index: 492.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0723
    Cell Significance Index: 743.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0089
    Cell Significance Index: 112.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9120
    Cell Significance Index: 146.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8986
    Cell Significance Index: 53.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8065
    Cell Significance Index: 325.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7976
    Cell Significance Index: 195.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7607
    Cell Significance Index: 216.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1355
    Cell Significance Index: 51.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1268
    Cell Significance Index: 69.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9977
    Cell Significance Index: 690.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9288
    Cell Significance Index: 507.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8361
    Cell Significance Index: 369.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8218
    Cell Significance Index: 16.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7190
    Cell Significance Index: 20.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6679
    Cell Significance Index: 44.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6295
    Cell Significance Index: 29.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6183
    Cell Significance Index: 28.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5855
    Cell Significance Index: 80.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4194
    Cell Significance Index: 18.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4054
    Cell Significance Index: 21.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3679
    Cell Significance Index: 692.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3110
    Cell Significance Index: 11.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2678
    Cell Significance Index: 13.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2525
    Cell Significance Index: 18.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2382
    Cell Significance Index: 108.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2152
    Cell Significance Index: 331.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2137
    Cell Significance Index: 135.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2120
    Cell Significance Index: 34.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2031
    Cell Significance Index: 374.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1974
    Cell Significance Index: 23.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1855
    Cell Significance Index: 13.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1803
    Cell Significance Index: 3.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1742
    Cell Significance Index: 6.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1635
    Cell Significance Index: 3.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1633
    Cell Significance Index: 222.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1439
    Cell Significance Index: 24.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1353
    Cell Significance Index: 9.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0679
    Cell Significance Index: 8.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0032
    Cell Significance Index: 0.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0021
    Cell Significance Index: -0.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0075
    Cell Significance Index: -0.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0144
    Cell Significance Index: -0.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0160
    Cell Significance Index: -2.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0180
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0297
    Cell Significance Index: -18.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0400
    Cell Significance Index: -29.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0465
    Cell Significance Index: -34.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0589
    Cell Significance Index: -44.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0729
    Cell Significance Index: -41.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0863
    Cell Significance Index: -0.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1695
    Cell Significance Index: -17.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2152
    Cell Significance Index: -1.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2418
    Cell Significance Index: -5.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2555
    Cell Significance Index: -53.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2650
    Cell Significance Index: -76.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2753
    Cell Significance Index: -40.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4211
    Cell Significance Index: -26.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4419
    Cell Significance Index: -11.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4562
    Cell Significance Index: -7.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4719
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4865
    Cell Significance Index: -55.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5048
    Cell Significance Index: -26.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5097
    Cell Significance Index: -53.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5119
    Cell Significance Index: -59.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5657
    Cell Significance Index: -64.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6091
    Cell Significance Index: -8.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6370
    Cell Significance Index: -18.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6456
    Cell Significance Index: -9.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7493
    Cell Significance Index: -18.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7764
    Cell Significance Index: -46.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8127
    Cell Significance Index: -28.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8627
    Cell Significance Index: -68.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9197
    Cell Significance Index: -27.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9657
    Cell Significance Index: -14.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9710
    Cell Significance Index: -14.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0049
    Cell Significance Index: -16.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0604
    Cell Significance Index: -23.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1983
    Cell Significance Index: -14.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2236
    Cell Significance Index: -39.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.2325
    Cell Significance Index: -26.3500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.2441
    Cell Significance Index: -17.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2590
    Cell Significance Index: -77.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.4058
    Cell Significance Index: -20.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBE2K is a member of the E2 family of ubiquitin-conjugating enzymes, which are responsible for catalyzing the transfer of ubiquitin to lysine residues on target proteins. This process is a critical step in the UPS, which regulates protein degradation, protein modification, and protein-protein interactions. UBE2K is specifically involved in the conjugation of ubiquitin to proteins, facilitating their degradation by the proteasome or other ubiquitin-dependent processes. UBE2K has been shown to interact with various proteins, including ubiquitin ligases, proteasomal subunits, and signaling molecules, highlighting its central role in regulating protein homeostasis and immune responses. The gene is highly expressed in cells involved in immune responses, such as cortical cells of the adrenal gland, taste receptor cells, and Purkinje cells. **Pathways and Functions** UBE2K is involved in various cellular pathways, including: 1. **Adaptive Immune System**: UBE2K plays a crucial role in the regulation of immune responses, particularly in the processing and presentation of antigens by MHC class I molecules. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation**: UBE2K is involved in the conjugation of ubiquitin to antigens, facilitating their degradation by the proteasome and presentation by MHC class I molecules. 3. **Cellular Response to Interferon-Beta**: UBE2K is activated by interferon-beta, leading to the regulation of protein homeostasis and immune responses. 4. **Class I MHC Mediated Antigen Processing & Presentation**: UBE2K is involved in the processing and presentation of antigens by MHC class I molecules, regulating immune responses. 5. **Protein Modification**: UBE2K is involved in the conjugation of ubiquitin to proteins, regulating protein modification and degradation. **Clinical Significance** UBE2K has been implicated in various human diseases, including: 1. **Autoimmune Disorders**: UBE2K has been shown to play a role in the regulation of immune responses, and dysregulation of UBE2K has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: UBE2K has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, highlighting its potential as a therapeutic target. 3. **Neurological Disorders**: UBE2K has been implicated in the regulation of protein homeostasis in the brain, and dysregulation of UBE2K has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, UBE2K is a critical component of the ubiquitin-proteasome system, playing a vital role in regulating protein degradation, immune responses, and protein modification. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the functions and dysregulation of UBE2K.

Genular Protein ID: 3488550504

Symbol: UBE2K_HUMAN

Name: Ubiquitin-conjugating enzyme E2 K

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8702625

Title: Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.

PubMed ID: 8702625

DOI: 10.1074/jbc.271.32.19385

PubMed ID: 10634809

Title: Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis.

PubMed ID: 10634809

DOI: 10.1161/01.atv.20.1.128

PubMed ID: 10675012

Title: Regulation of macrophage-specific gene expression by degenerated lipoproteins.

PubMed ID: 10675012

DOI: 10.1002/(sici)1522-2683(20000101)21:2<338::aid-elps338>3.0.co;2-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16714285

Title: NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

PubMed ID: 16714285

DOI: 10.1074/jbc.m602089200

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 16868077

Title: E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.

PubMed ID: 16868077

DOI: 10.1073/pnas.0605215103

PubMed ID: 17873885

Title: E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.

PubMed ID: 17873885

DOI: 10.1038/nsmb1295

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 19906396

Title: Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis.

PubMed ID: 19906396

DOI: 10.1016/j.virol.2009.10.018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21532592

Title: UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

PubMed ID: 21532592

DOI: 10.1038/nature09966

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19407372

Title: Structure of full-length ubiquitin-conjugating enzyme E2-25K (Huntingtin-interacting protein 2).

PubMed ID: 19407372

DOI: 10.1107/s1744309109011117

Sequence Information:

  • Length: 200
  • Mass: 22407
  • Checksum: E40668099ED25828
  • Sequence:
  • MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 
    KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 
    EPDDPQDAVV ANQYKQNPEM FKQTARLWAH VYAGAPVSSP EYTKKIENLC AMGFDRNAVI 
    VALSSKSWDV ETATELLLSN

Genular Protein ID: 2535287320

Symbol: B3KSH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 97
  • Mass: 10667
  • Checksum: C6B08374B5889D0C
  • Sequence:
  • MTLRTVLLSL QALLAAAEPD DPQDAVVANQ YKQNPEMFKQ TARLWAHVYA GAPVSSPEYT 
    KKIENLCAMG FDRNAVIVAL SSKSWDVETA TELLLSN

Genular Protein ID: 1974678236

Symbol: B4DIZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 139
  • Mass: 15810
  • Checksum: ECCD8F30C4222872
  • Sequence:
  • MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 
    KIPETYPFNP PKYKQNPEMF KQTARLWAHV YAGAPVSSPE YTKKIENLCA MGFDRNAVIV 
    ALSSKSWDVE TATELLLSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.