Details for: UBE2K

Gene ID: 3093

Symbol: UBE2K

Ensembl ID: ENSG00000078140

Description: ubiquitin conjugating enzyme E2 K

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.66
    Marker Score: 47200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.64
    Marker Score: 2281
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.61
    Marker Score: 8559
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.59
    Marker Score: 5678
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.44
    Marker Score: 10193
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.43
    Marker Score: 1418
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.41
    Marker Score: 3239.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.39
    Marker Score: 80808
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.35
    Marker Score: 2708
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.32
    Marker Score: 46149
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.32
    Marker Score: 49483.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.32
    Marker Score: 2803
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.27
    Marker Score: 33955
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.26
    Marker Score: 4348
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.25
    Marker Score: 85270
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 17042
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.22
    Marker Score: 2515
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.22
    Marker Score: 5556
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.19
    Marker Score: 80789
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.19
    Marker Score: 1088
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.19
    Marker Score: 9074
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.19
    Marker Score: 2303
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.18
    Marker Score: 1275
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.15
    Marker Score: 1654
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.14
    Marker Score: 9894
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.08
    Marker Score: 2247
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.07
    Marker Score: 606
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.06
    Marker Score: 46076
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.04
    Marker Score: 856
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.03
    Marker Score: 8478.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.03
    Marker Score: 7847
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.02
    Marker Score: 2236
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.02
    Marker Score: 1924
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2
    Marker Score: 18813.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.99
    Marker Score: 630
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.99
    Marker Score: 966
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.99
    Marker Score: 122091.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.98
    Marker Score: 1100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.93
    Marker Score: 1155
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.92
    Marker Score: 19776
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.9
    Marker Score: 1687
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.9
    Marker Score: 1560
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.89
    Marker Score: 9933
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.89
    Marker Score: 1314
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.83
    Marker Score: 1145
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.83
    Marker Score: 17410
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.83
    Marker Score: 7437
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.82
    Marker Score: 898
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.82
    Marker Score: 957
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.8
    Marker Score: 666
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15380
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.79
    Marker Score: 2527
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.78
    Marker Score: 2592
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.78
    Marker Score: 651
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.78
    Marker Score: 995
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.78
    Marker Score: 2615
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.76
    Marker Score: 637
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.75
    Marker Score: 15093
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.73
    Marker Score: 2235
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.73
    Marker Score: 2156
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.72
    Marker Score: 1491
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.72
    Marker Score: 4116
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.72
    Marker Score: 1130
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.71
    Marker Score: 694
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7
    Marker Score: 27309
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.67
    Marker Score: 400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.67
    Marker Score: 3794
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.66
    Marker Score: 1680
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.65
    Marker Score: 476.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.65
    Marker Score: 618
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.65
    Marker Score: 451
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.65
    Marker Score: 8855.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.64
    Marker Score: 1118
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.63
    Marker Score: 518
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.63
    Marker Score: 1963
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.62
    Marker Score: 1105
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.62
    Marker Score: 55083
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.61
    Marker Score: 1483
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.61
    Marker Score: 1719
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.6
    Marker Score: 834.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.59
    Marker Score: 356
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.59
    Marker Score: 863
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.58
    Marker Score: 2808
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.58
    Marker Score: 12329
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.57
    Marker Score: 1670
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.57
    Marker Score: 640
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.56
    Marker Score: 531.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.56
    Marker Score: 540
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.56
    Marker Score: 982
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.55
    Marker Score: 3921
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.55
    Marker Score: 586
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.55
    Marker Score: 53812
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.55
    Marker Score: 539
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.53
    Marker Score: 389
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.53
    Marker Score: 790
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2341
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.5
    Marker Score: 4027
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.5
    Marker Score: 442
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5
    Marker Score: 5882
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.5
    Marker Score: 543

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Other Information

**Key characteristics** * UBE2K is a ubiquitin-conjugating enzyme that is involved in the processing and degradation of proteins. * It is a key regulator of adaptive immune responses, as it is expressed in cells that are activated by foreign antigens. * UBE2K is also involved in the regulation of inflammation and cell growth. **Pathways and functions** * UBE2K is involved in the adaptive immune system, where it helps to process and degrade antigens. * It is also involved in the regulation of inflammation, as it is expressed in cells that are activated by inflammatory stimuli. * UBE2K is involved in the regulation of cell growth, as it is expressed in cells that are dividing or proliferating. **Clinical significance** Mutations in the UBE2K gene have been linked to a number of human diseases, including autoimmune disorders, cancer, and inflammation. These diseases are characterized by the overactivation of the immune system, which can lead to tissue damage and inflammation. **Additional information** * UBE2K is a member of the E2 ubiquitin-conjugating enzyme family. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * UBE2K is a multi-domain protein, with a catalytic domain and a regulatory domain. * It is a key regulator of innate immune responses, and its activity is regulated by a variety of factors, including cytokines, hormones, and metabolites.

Genular Protein ID: 3488550504

Symbol: UBE2K_HUMAN

Name: Ubiquitin-conjugating enzyme E2 K

UniProtKB Accession Codes:

P61086 A6NJC1 A8K5Y9 B2RDF8 C9JGP1 O54806 P27924 Q16721 Q9CVV9 Q9Y2D3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 13 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8702625

Title: Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.

PubMed ID: 8702625

DOI: 10.1074/jbc.271.32.19385

PubMed ID: 10634809

Title: Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis.

PubMed ID: 10634809

DOI: 10.1161/01.atv.20.1.128

PubMed ID: 10675012

Title: Regulation of macrophage-specific gene expression by degenerated lipoproteins.

PubMed ID: 10675012

DOI: 10.1002/(sici)1522-2683(20000101)21:2<338::aid-elps338>3.0.co;2-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16714285

Title: NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

PubMed ID: 16714285

DOI: 10.1074/jbc.m602089200

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 16868077

Title: E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.

PubMed ID: 16868077

DOI: 10.1073/pnas.0605215103

PubMed ID: 17873885

Title: E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.

PubMed ID: 17873885

DOI: 10.1038/nsmb1295

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 19906396

Title: Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis.

PubMed ID: 19906396

DOI: 10.1016/j.virol.2009.10.018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21532592

Title: UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

PubMed ID: 21532592

DOI: 10.1038/nature09966

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19407372

Title: Structure of full-length ubiquitin-conjugating enzyme E2-25K (Huntingtin-interacting protein 2).

PubMed ID: 19407372

DOI: 10.1107/s1744309109011117

Sequence Information:

  • Length: 200
  • Mass: 22407
  • Checksum: E40668099ED25828
  • Sequence:
    • MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 
EPDDPQDAVV ANQYKQNPEM FKQTARLWAH VYAGAPVSSP EYTKKIENLC AMGFDRNAVI 
VALSSKSWDV ETATELLLSN

Genular Protein ID: 1974678236

Symbol: B4DIZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIZ2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Gene3D 2 GenomeRNAi 1 InterPro 5 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 139
  • Mass: 15810
  • Checksum: ECCD8F30C4222872
  • Sequence:
    • MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 
KIPETYPFNP PKYKQNPEMF KQTARLWAHV YAGAPVSSPE YTKKIENLCA MGFDRNAVIV 
ALSSKSWDVE TATELLLSN

Genular Protein ID: 2535287320

Symbol: B3KSH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSH4

Database IDs:

ARBA 2 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Gene3D 2 GenomeRNAi 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PROSITE 4 Pfam 2 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 97
  • Mass: 10667
  • Checksum: C6B08374B5889D0C
  • Sequence:
    • MTLRTVLLSL QALLAAAEPD DPQDAVVANQ YKQNPEMFKQ TARLWAHVYA GAPVSSPEYT 
KKIENLCAMG FDRNAVIVAL SSKSWDVETA TELLLSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.