Details for: HIVEP2

Gene ID: 3097

Symbol: HIVEP2

Ensembl ID: ENSG00000010818

Description: HIVEP zinc finger 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.54
    Marker Score: 50512
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.52
    Marker Score: 13546
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.5
    Marker Score: 2880
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.5
    Marker Score: 5491
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.42
    Marker Score: 36187
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.41
    Marker Score: 18505
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.37
    Marker Score: 90002
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.36
    Marker Score: 1313
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.33
    Marker Score: 85903
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.29
    Marker Score: 77927
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.27
    Marker Score: 9422
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.18
    Marker Score: 11444
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20369
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.14
    Marker Score: 8267
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.13
    Marker Score: 621
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.12
    Marker Score: 3568
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.12
    Marker Score: 1634
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.08
    Marker Score: 6986
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.07
    Marker Score: 44135
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.06
    Marker Score: 1020
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125199
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.92
    Marker Score: 3690
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7794
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18046
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15940
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.84
    Marker Score: 1071
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.82
    Marker Score: 18820
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.8
    Marker Score: 1076
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.78
    Marker Score: 5090
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.72
    Marker Score: 539
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.71
    Marker Score: 7925
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.65
    Marker Score: 1759
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.62
    Marker Score: 1701
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.6
    Marker Score: 845
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.59
    Marker Score: 3918
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.59
    Marker Score: 2453
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.58
    Marker Score: 1741
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.55
    Marker Score: 6475.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.51
    Marker Score: 558
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.47
    Marker Score: 862
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.46
    Marker Score: 610
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.45
    Marker Score: 1558
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.41
    Marker Score: 1347
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.41
    Marker Score: 819
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.4
    Marker Score: 787
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.4
    Marker Score: 508.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.39
    Marker Score: 448
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.39
    Marker Score: 667
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.38
    Marker Score: 2004
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.37
    Marker Score: 826
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.37
    Marker Score: 1164
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.35
    Marker Score: 21626
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3141
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.33
    Marker Score: 502
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.33
    Marker Score: 1150
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.33
    Marker Score: 383
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.33
    Marker Score: 1653
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.32
    Marker Score: 507.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.32
    Marker Score: 9945
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.31
    Marker Score: 895
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20390
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.28
    Marker Score: 406
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.27
    Marker Score: 1570
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.22
    Marker Score: 1058
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2480
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.21
    Marker Score: 27041
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2
    Marker Score: 40461
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.19
    Marker Score: 378
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.12
    Marker Score: 640
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.12
    Marker Score: 306
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.12
    Marker Score: 993
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.11
    Marker Score: 416
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.11
    Marker Score: 376
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.1
    Marker Score: 1554
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.1
    Marker Score: 457
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.09
    Marker Score: 2511
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.08
    Marker Score: 3850
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.08
    Marker Score: 1584
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.06
    Marker Score: 594
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.05
    Marker Score: 55761
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.05
    Marker Score: 730
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.05
    Marker Score: 332
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.04
    Marker Score: 1255
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.03
    Marker Score: 5065.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.03
    Marker Score: 6172
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.02
    Marker Score: 495
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1
    Marker Score: 500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71679
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47905
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.99
    Marker Score: 1198
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.98
    Marker Score: 6285
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.97
    Marker Score: 329
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.97
    Marker Score: 2314
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.95
    Marker Score: 1011
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.94
    Marker Score: 934
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.94
    Marker Score: 3909.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * HIVEP2 is a zinc finger protein that is highly expressed in interneurons of the central nervous system. * It is a member of the HIVEP family of transcription factors, which are involved in the regulation of neuronal differentiation and survival. * HIVEP2 is a key regulator of the expression of many genes involved in neuronal development and function. * It is also involved in the regulation of synaptic plasticity and learning and memory. **Pathways and functions:** * HIVEP2 is involved in the regulation of gene expression through its interaction with the Rna polymerase II transcription complex. * It is a key regulator of neuronal differentiation and survival by promoting the expression of genes involved in these processes. * It is also involved in the regulation of synaptic plasticity and learning and memory. * HIVEP2 is a potential therapeutic target for a number of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Clinical significance:** * Mutations in HIVEP2 have been linked to a number of neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. * HIVEP2 is a potential therapeutic target for a number of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * Studies of HIVEP2 have also shown that it can be used to treat a variety of neuroinflammatory diseases, such as multiple sclerosis and spinal cord injury.

Genular Protein ID: 3105867179

Symbol: ZEP2_HUMAN

Name: Transcription factor HIVEP2

UniProtKB Accession Codes:

P31629 Q02646 Q5THT5 Q9NS05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 4 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2022670

Title: HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1.

PubMed ID: 2022670

DOI: 10.1016/s0021-9258(18)93015-2

PubMed ID: 1409593

Title: Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes.

PubMed ID: 1409593

DOI: 10.1073/pnas.89.19.8971

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 2247438

Title: Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

PubMed ID: 2247438

DOI: 10.1073/pnas.87.22.8707

PubMed ID: 10207097

Title: Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain.

PubMed ID: 10207097

DOI: 10.1128/mcb.19.5.3736

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23020937

Title: Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study.

PubMed ID: 23020937

DOI: 10.1016/s0140-6736(12)61480-9

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26153216

Title: Loss-of-function variants in HIVEP2 are a cause of intellectual disability.

PubMed ID: 26153216

DOI: 10.1038/ejhg.2015.151

Sequence Information:

  • Length: 2446
  • Mass: 269053
  • Checksum: 482E2C577EF9449A
  • Sequence:
    • MDTGDTALGQ KATSRSGETD KASGRWRQEQ SAVIKMSTFG SHEGQRQPQI EPEQIGNTAS 
AQLFGSGKLA SPSEVVQQVA EKQYPPHRPS PYSCQHSLSF PQHSLPQGVM HSTKPHQSLE 
GPPWLFPGPL PSVASEDLFP FPIHGHSGGY PRKKISSLNP AYSQYSQKSI EQAEEAHKKE 
HKPKKPGKYI CPYCSRACAK PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA 
HAIKAGLVPF TESAVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKMSPGPP 
IPLDIASRGG YHGSLEESLG GPMKVPILII PKSGIPLPNE SSQYIGPDML PNPSLNTKAD 
DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY FSRSESAEQQ ISPPNTNAKS 
YEEIIFGKYC RLSPRNALSV TTTSQERAAM GRKGIMEPLP HVNTRLDVKM FEDPVSQLIP 
SKGDVDPSQT SMLKSTKFNS ESRQPQIIPS SIRNEGKLYP ANFQGSNPVL LEAPVDSSPL 
IRSNSVPTSS ATNLTIPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS 
VQEGHVEVEH HGRMLKGISS SSLKEKKLSP GDRVGYDYDV CRKPYKKWED SETPKQNYRD 
ISCLSSLKHG GEYFMDPVVP LQGVPSMFGT TCENRKRRKE KSVGDEEDTP MICSSIVSTP 
VGIMASDYDP KLQMQEGVRS GFAMAGHENL SHGHTERFDP CRPQLQPGSP SLVSEESPSA 
IDSDKMSDLG GRKPPGNVIS VIQHTNSLSR PNSFERSESA ELVACTQDKA PSPSETCDSE 
ISEAPVSPEW APPGDGAESG GKPSPSQQVQ QQSYHTQPRL VRQHNIQVPE IRVTEEPDKP 
EKEKEAQSKE PEKPVEEFQW PQRSETLSQL PAEKLPPKKK RLRLADMEHS SGESSFESTG 
TGLSRSPSQE SNLSHSSSFS MSFEREETSK LSALPKQDEF GKHSEFLTVP AGSYSLSVPG 
HHHQKEMRRC SSEQMPCPHP AEVPEVRSKS FDYGNLSHAP VSGAAASTVS PSRERKKCFL 
VRQASFSGSP EISQGEVGMD QSVKQEQLEH LHAGLRSGWH HGPPAVLPPL QQEDPGKQVA 
GPCPPLSSGP LHLAQPQIMH MDSQESLRNP LIQPTSYMTS KHLPEQPHLF PHQETIPFSP 
IQNALFQFQY PTVCMVHLPA QQPPWWQAHF PHPFAQHPQK SYGKPSFQTE IHSSYPLEHV 
AEHTGKKPAE YAHTKEQTYP CYSGASGLHP KNLLPKFPSD QSSKSTETPS EQVLQEDFAS 
ANAGSLQSLP GTVVPVRIQT HVPSYGSVMY TSISQILGQN SPAIVICKVD ENMTQRTLVT 
NAAMQGIGFN IAQVLGQHAG LEKYPIWKAP QTLPLGLESS IPLCLPSTSD SVATLGGSKR 
MLSPASSLEL FMETKQQKRV KEEKMYGQIV EELSAVELTN SDIKKDLSRP QKPQLVRQGC 
ASEPKDGLQS GSSSFSSLSP SSSQDYPSVS PSSREPFLPS KEMLSGSRAP LPGQKSSGPS 
ESKESSDELD IDETASDMSM SPQSSSLPAG DGQLEEEGKG HKRPVGMLVR MASAPSGNVA 
DSTLLLTDMA DFQQILQFPS LRTTTTVSWC FLNYTKPNYV QQATFKSSVY ASWCISSCNP 
NPSGLNTKTT LALLRSKQKI TAEIYTLAAM HRPGTGKLTS SSAWKQFTQM KPDASFLFGS 
KLERKLVGNI LKERGKGDIH GDKDIGSKQT EPIRIKIFEG GYKSNEDYVY VRGRGRGKYI 
CEECGIRCKK PSMLKKHIRT HTDVRPYVCK LCNFAFKTKG NLTKHMKSKA HMKKCLELGV 
SMTSVDDTET EEAENLEDLH KAAEKHSMSS ISTDHQFSDA EESDGEDGDD NDDDDEDEDD 
FDDQGDLTPK TRSRSTSPQP PRFSSLPVNV GAVPHGVPSD SSLGHSSLIS YLVTLPSIRV 
TQLMTPSDSC EDTQMTEYQR LFQSKSTDSE PDKDRLDIPS CMDEECMLPS EPSSSPRDFS 
PSSHHSSPGY DSSPCRDNSP KRYLIPKGDL SPRRHLSPRR DLSPMRHLSP RKEAALRREM 
SQRDVSPRRH LSPRRPVSPG KDITARRDLS PRRERRYMTT IRAPSPRRAL YHNPPLSMGQ 
YLQAEPIVLG PPNLRRGLPQ VPYFSLYGDQ EGAYEHPGSS LFPEGPNDYV FSHLPLHSQQ 
QVRAPIPMVP VGGIQMVHSM PPALSSLHPS PTLPLPMEGF EEKKGASGES FSKDPYVLSK 
QHEKRGPHAL QSSGPPSTPS SPRLLMKQST SEDSLNATER EQEENIQTCT KAIASLRIAT 
EEAALLGPDQ PARVQEPHQN PLGSAHVSIR HFSRPEPGQP CTSATHPDLH DGEKDNFGTS 
QTPLAHSTFY SKSCVDDKQL DFHSSKELSS STEESKDPSS EKSQLH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.