Details for: HLA DRB1

Gene ID: 3123

Symbol: HLA DRB1

Ensembl ID: ENSG00000196126

Description: major histocompatibility complex, class II, DR beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 439.4863
    Cell Significance Index: -68.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.4646
    Cell Significance Index: -45.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 164.5547
    Cell Significance Index: -77.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 164.1182
    Cell Significance Index: -84.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.0628
    Cell Significance Index: -67.8900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 51.7400
    Cell Significance Index: 215.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.7336
    Cell Significance Index: -60.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.2310
    Cell Significance Index: -65.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.9420
    Cell Significance Index: -70.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 14.8698
    Cell Significance Index: 222.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.8034
    Cell Significance Index: -30.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.1697
    Cell Significance Index: 169.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.3571
    Cell Significance Index: 94.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.0642
    Cell Significance Index: 142.5100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 7.9354
    Cell Significance Index: 29.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 7.9338
    Cell Significance Index: 56.9800
  • Cell Name: centroblast (CL0009112)
    Fold Change: 7.8395
    Cell Significance Index: 18.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.7374
    Cell Significance Index: 912.4800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 6.7620
    Cell Significance Index: 116.1700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 6.0689
    Cell Significance Index: 27.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.3099
    Cell Significance Index: 278.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.8241
    Cell Significance Index: 112.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.6092
    Cell Significance Index: 55.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4672
    Cell Significance Index: 57.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7909
    Cell Significance Index: 1617.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3934
    Cell Significance Index: 151.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1492
    Cell Significance Index: 186.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1436
    Cell Significance Index: 30.5900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.9677
    Cell Significance Index: 6.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5592
    Cell Significance Index: 26.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4932
    Cell Significance Index: 373.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4679
    Cell Significance Index: 46.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4155
    Cell Significance Index: 51.1000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2611
    Cell Significance Index: 3.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2476
    Cell Significance Index: 47.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2108
    Cell Significance Index: 21.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1864
    Cell Significance Index: 11.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1482
    Cell Significance Index: 26.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1135
    Cell Significance Index: 50.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0777
    Cell Significance Index: 5.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0763
    Cell Significance Index: 41.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0673
    Cell Significance Index: 8.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0147
    Cell Significance Index: -0.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0236
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0254
    Cell Significance Index: -15.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0353
    Cell Significance Index: -66.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0464
    Cell Significance Index: -85.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0530
    Cell Significance Index: -39.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0532
    Cell Significance Index: -81.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0631
    Cell Significance Index: -85.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0969
    Cell Significance Index: -54.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0985
    Cell Significance Index: -72.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1034
    Cell Significance Index: -20.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1219
    Cell Significance Index: -77.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1714
    Cell Significance Index: -77.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1783
    Cell Significance Index: -63.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1820
    Cell Significance Index: -8.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1900
    Cell Significance Index: -40.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2313
    Cell Significance Index: -39.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2350
    Cell Significance Index: -30.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2938
    Cell Significance Index: -14.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3056
    Cell Significance Index: -35.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3323
    Cell Significance Index: -66.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4055
    Cell Significance Index: -55.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4607
    Cell Significance Index: -11.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4662
    Cell Significance Index: -54.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5099
    Cell Significance Index: -58.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5328
    Cell Significance Index: -77.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5340
    Cell Significance Index: -7.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5666
    Cell Significance Index: -23.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6794
    Cell Significance Index: -70.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7253
    Cell Significance Index: -44.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7496
    Cell Significance Index: -16.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8068
    Cell Significance Index: -57.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8252
    Cell Significance Index: -63.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8625
    Cell Significance Index: -64.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9015
    Cell Significance Index: -22.5400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.9808
    Cell Significance Index: -7.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0336
    Cell Significance Index: -81.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2086
    Cell Significance Index: -25.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.2255
    Cell Significance Index: -63.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2268
    Cell Significance Index: -64.4100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.2620
    Cell Significance Index: -25.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.2871
    Cell Significance Index: -35.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3127
    Cell Significance Index: -73.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3764
    Cell Significance Index: -86.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.5011
    Cell Significance Index: -69.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5418
    Cell Significance Index: -56.6000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.6255
    Cell Significance Index: -23.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6409
    Cell Significance Index: -72.5800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -1.8385
    Cell Significance Index: -4.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.8939
    Cell Significance Index: -82.3500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.9170
    Cell Significance Index: -37.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.9191
    Cell Significance Index: -72.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.9445
    Cell Significance Index: -67.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.9700
    Cell Significance Index: -51.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0007
    Cell Significance Index: -58.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.1459
    Cell Significance Index: -55.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.1625
    Cell Significance Index: -75.7600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -2.2057
    Cell Significance Index: -29.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA-DRB1 gene is a member of the MHC class II family, which is located on chromosome 6 in humans. It is one of the three genes that encode the alpha chain of the MHC II molecule, along with HLA-DRB3 and HLA-DRB4. The HLA-DRB1 gene is approximately 22 kb in length and consists of 10 exons. The protein product of the HLA-DRB1 gene is a transmembrane glycoprotein that forms a heterodimer with the beta-2 microglobulin (β2M) chain. **Pathways and Functions** The HLA-DRB1 gene is involved in several key pathways and functions, including: 1. **Antigen processing and presentation**: The HLA-DRB1 gene is responsible for encoding the alpha chain of the MHC II molecule, which presents peptide fragments from extracellular pathogens to CD4+ T cells. 2. **Adaptive immune system**: The HLA-DRB1 gene is essential for initiating an immune response against infections by presenting antigens to CD4+ T cells. 3. **Antigen presentation**: The HLA-DRB1 gene is involved in presenting antigens to CD4+ T cells, which is crucial for the activation of T cells and the initiation of an immune response. 4. **Cytokine signaling**: The HLA-DRB1 gene is involved in the signaling of CD4+ T cells, which is essential for the activation of T cells and the initiation of an immune response. 5. **Immune response regulation**: The HLA-DRB1 gene is involved in regulating the immune response by presenting antigens to CD4+ T cells and modulating the activity of T cells. **Clinical Significance** The HLA-DRB1 gene has significant clinical implications, including: 1. **Autoimmune diseases**: Variants of the HLA-DRB1 gene have been associated with several autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Transplant rejection**: The HLA-DRB1 gene is used to predict the risk of transplant rejection by matching donors and recipients based on their HLA typing. 3. **Infectious diseases**: The HLA-DRB1 gene is involved in presenting antigens from extracellular pathogens to CD4+ T cells, which is essential for initiating an immune response against infections. 4. **Cancer**: The HLA-DRB1 gene is involved in presenting antigens from tumor cells to CD4+ T cells, which is essential for the activation of T cells and the initiation of an immune response against cancer. In conclusion, the HLA-DRB1 gene plays a crucial role in the adaptive immune system by presenting peptide fragments from extracellular pathogens to CD4+ T cells. Its clinical significance extends to autoimmune diseases, transplant rejection, infectious diseases, and cancer.

Genular Protein ID: 2707570801

Symbol: DRB1_HUMAN

Name: HLA class II histocompatibility antigen, DRB1 beta chain

UniProtKB Accession Codes:

P01911 A0MWF2 A0N0W1 A2ICT1 A2TGX3 A4F5N0 A4ZXA5 A4ZXA6 A4ZY86 A5H000 A5HKN8 A7DZP9 A7LA26 A7UHG2 A7X5B1 A7X5B7 A7X5E0 A7X5E6 A7X5H8 A7X5J4 A7X5K7 A8K098 A8YQE9 A9JPG0 B0BK85 B0LUZ6 B0UYW1 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B3VTQ3 B5A8Y2 B5A8Y3 B5B8U0 B5B9V5 B5B9V6 B5LZ25 B5QSK8 B6VCX2 B6VEL9 B7UDB2 B9VRA4 B9X248 C0LAB5 O02876 O02930 O19585 O19717 O19718 O19739 O19788 O46699 O46793 O46872 O62869 O62889 O77969 O78047 O78210 O98212 P01912 P01914 P04229 P13758 P13759 P13760 P13761 P20039 P79545 Q06662 Q0PGR5 Q0PQ39 Q14280 Q14QT2 Q155F7 Q19AF2 Q19K86 Q1AP33 Q1G0Z9 Q1JRP3 Q1KLJ6 Q27PR6 Q27PR7 Q29673 Q29720 Q29722 Q29734 Q29770 Q29771 Q29772 Q29790 Q29792 Q29800 Q29806 Q29833 Q29874 Q29875

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 65 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 8 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 16 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 13 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6589154

Title: Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

PubMed ID: 6589154

DOI: 10.1002/j.1460-2075.1984.tb02026.x

PubMed ID: 2998758

Title: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

PubMed ID: 2998758

DOI: 10.1002/j.1460-2075.1985.tb04012.x

PubMed ID: 3875800

Title: Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants.

PubMed ID: 3875800

DOI: 10.1038/317166a0

PubMed ID: 3456344

Title: Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.

PubMed ID: 3456344

DOI: 10.1016/s0021-9258(17)35847-7

PubMed ID: 3571980

Title: cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope.

PubMed ID: 3571980

PubMed ID: 2885840

Title: HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

PubMed ID: 2885840

DOI: 10.1073/pnas.84.13.4591

PubMed ID: 3110774

Title: Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.

PubMed ID: 3110774

DOI: 10.1073/pnas.84.14.4929

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 3129499

Title: Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes.

PubMed ID: 3129499

PubMed ID: 2497068

Title: A cellular and functional split in the DRw8 haplotype is due to a single amino acid replacement (DR beta ser 57- asp 57).

PubMed ID: 2497068

DOI: 10.1007/bf00352840

PubMed ID: 9777332

Title: Complete cDNA sequence of the HLA-DRB1*09012 allele.

PubMed ID: 9777332

DOI: 10.1046/j.1365-2370.1998.00105.x

PubMed ID: 12652907

Title: Complete cDNA coding sequence of the HLA-DRB1*1405 allele.

PubMed ID: 12652907

DOI: 10.1080/1042517021000041822

PubMed ID: 12358860

Title: Complete cDNA sequences of the HLA-DRB1*0402 and DRB1*11041 alleles.

PubMed ID: 12358860

DOI: 10.1046/j.1365-2370.2002.00354.x

PubMed ID: 11972886

Title: Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404 alleles.

PubMed ID: 11972886

DOI: 10.1034/j.1399-0039.2002.590116.x

PubMed ID: 12028552

Title: Sequence of a new DR12 allele with two silent mutations that affect PCR-SSP typing.

PubMed ID: 12028552

DOI: 10.1034/j.1399-0039.2002.590221.x

PubMed ID: 15896200

Title: Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, - DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4.

PubMed ID: 15896200

DOI: 10.1111/j.1399-0039.2005.00407.x

PubMed ID: 17174751

Title: Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113.

PubMed ID: 17174751

DOI: 10.1016/j.humimm.2006.09.002

PubMed ID: 21388356

Title: Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population.

PubMed ID: 21388356

DOI: 10.1111/j.1399-0039.2010.01626.x

PubMed ID: 26396036

Title: Full-length HLA-DRB1 coding sequences generated by a hemizygous RNA-SBT approach.

PubMed ID: 26396036

DOI: 10.1111/tan.12654

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: 10.3389/fimmu.2018.02294

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 17345114

Title: Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles.

PubMed ID: 17345114

DOI: 10.1007/s00251-007-0196-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 6947956

Title: Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen.

PubMed ID: 6947956

PubMed ID: 6600932

Title: N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens.

PubMed ID: 6600932

DOI: 10.1021/bi00270a027

PubMed ID: 2658055

Title: Class II MHC molecules are specific receptors for staphylococcus enterotoxin A.

PubMed ID: 2658055

DOI: 10.1126/science.2658055

PubMed ID: 2210803

Title: Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins.

PubMed ID: 2210803

PubMed ID: 7479981

Title: Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1.

PubMed ID: 7479981

DOI: 10.1073/pnas.92.24.11289

PubMed ID: 8642306

Title: Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

PubMed ID: 8642306

DOI: 10.1084/jem.183.5.1965

PubMed ID: 9075930

Title: HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

PubMed ID: 9075930

DOI: 10.1016/s1074-7613(00)80332-5

PubMed ID: 9151859

Title: Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes.

PubMed ID: 9151859

DOI: 10.1128/jvi.71.6.4657-4662.1997

PubMed ID: 11070170

Title: Determination of the HLA-DM interaction site on HLA-DR molecules.

PubMed ID: 11070170

DOI: 10.1016/s1074-7613(00)00051-0

PubMed ID: 15265931

Title: Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

PubMed ID: 15265931

DOI: 10.4049/jimmunol.173.3.1966

PubMed ID: 16148104

Title: Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.

PubMed ID: 16148104

DOI: 10.4049/jimmunol.175.6.3603

PubMed ID: 17182262

Title: Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

PubMed ID: 17182262

DOI: 10.1016/j.immuni.2006.10.018

PubMed ID: 18305173

Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

PubMed ID: 18305173

DOI: 10.1073/pnas.0708874105

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19120973

Title: A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4(+) T cells.

PubMed ID: 19120973

DOI: 10.1111/j.1348-0421.2008.00080.x

PubMed ID: 19706888

Title: Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity.

PubMed ID: 19706888

DOI: 10.1182/blood-2009-03-208017

PubMed ID: 19830726

Title: Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.

PubMed ID: 19830726

DOI: 10.1002/eji.200939225

PubMed ID: 20356336

Title: Nomenclature for factors of the HLA system, 2010.

PubMed ID: 20356336

DOI: 10.1111/j.1399-0039.2010.01466.x

PubMed ID: 22327072

Title: Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire.

PubMed ID: 22327072

DOI: 10.4049/jimmunol.1102190

PubMed ID: 22929521

Title: Identification of a Wilms' tumor 1-derived immunogenic CD4(+) T-cell epitope that is recognized in the context of common Caucasian HLA-DR haplotypes.

PubMed ID: 22929521

DOI: 10.1038/leu.2012.248

PubMed ID: 23783831

Title: Exploring the MHC-peptide matrix of central tolerance in the human thymus.

PubMed ID: 23783831

DOI: 10.1038/ncomms3039

PubMed ID: 25413013

Title: Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

PubMed ID: 25413013

DOI: 10.1038/ncomms6369

PubMed ID: 27114505

Title: Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

PubMed ID: 27114505

DOI: 10.1073/pnas.1513918113

PubMed ID: 27591323

Title: Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.

PubMed ID: 27591323

DOI: 10.4049/jimmunol.1600663

PubMed ID: 30282837

Title: Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.

PubMed ID: 30282837

DOI: 10.1172/jci.insight.122467

PubMed ID: 31020640

Title: Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.

PubMed ID: 31020640

DOI: 10.1002/eji.201948126

PubMed ID: 31495665

Title: Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction.

PubMed ID: 31495665

DOI: 10.1016/j.immuni.2019.08.012

PubMed ID: 31308093

Title: Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells.

PubMed ID: 31308093

DOI: 10.4049/jimmunol.1900377

PubMed ID: 8145819

Title: Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.

PubMed ID: 8145819

DOI: 10.1038/368215a0

PubMed ID: 8152483

Title: Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.

PubMed ID: 8152483

DOI: 10.1038/368711a0

PubMed ID: 7477400

Title: The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

PubMed ID: 7477400

DOI: 10.1038/378457a0

PubMed ID: 9354468

Title: X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II.

PubMed ID: 9354468

DOI: 10.1016/s1074-7613(00)80369-6

PubMed ID: 9782128

Title: Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.

PubMed ID: 9782128

DOI: 10.1084/jem.188.8.1511

PubMed ID: 11432818

Title: Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence.

PubMed ID: 11432818

DOI: 10.1093/emboj/20.13.3306

PubMed ID: 11864610

Title: Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.

PubMed ID: 11864610

DOI: 10.1016/s1097-2765(02)00465-3

PubMed ID: 19303388

Title: T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.

PubMed ID: 19303388

DOI: 10.1016/j.immuni.2009.01.009

PubMed ID: 21900604

Title: Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.

PubMed ID: 21900604

DOI: 10.1073/pnas.1109438108

PubMed ID: 23260142

Title: Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

PubMed ID: 23260142

DOI: 10.1016/j.cell.2012.11.025

PubMed ID: 24190431

Title: A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.

PubMed ID: 24190431

DOI: 10.1084/jem.20131241

PubMed ID: 28467828

Title: Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

PubMed ID: 28467828

DOI: 10.1038/nature22329

PubMed ID: 29317506

Title: The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.

PubMed ID: 29317506

DOI: 10.1074/jbc.ra117.001013

PubMed ID: 29884618

Title: CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers.

PubMed ID: 29884618

DOI: 10.1126/sciimmunol.aat0687

PubMed ID: 31619516

Title: Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.

PubMed ID: 31619516

DOI: 10.1074/jbc.ra119.009437

PubMed ID: 32668259

Title: CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features.

PubMed ID: 32668259

DOI: 10.1016/j.celrep.2020.107885

PubMed ID: 14508706

Title: HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.

PubMed ID: 14508706

DOI: 10.1086/378097

PubMed ID: 21833088

Title: Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

PubMed ID: 21833088

DOI: 10.1038/nature10251

PubMed ID: 22286218

Title: Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

PubMed ID: 22286218

DOI: 10.1038/ng.1076

PubMed ID: 25559196

Title: High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

PubMed ID: 25559196

DOI: 10.1038/ng.3176

PubMed ID: 23510415

Title: Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

PubMed ID: 23510415

DOI: 10.1111/tan.12093

Sequence Information:

  • Length: 266
  • Mass: 29966
  • Checksum: 3B5912820A4654BE
  • Sequence:
    • MVCLKLPGGS CMTALTVTLM VLSSPLALSG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF 
YNQEESVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEQA RAAVDTYCRH NYGVVESFTV 
QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF RNQKGHSGLQ PTGFLS

Genular Protein ID: 2369487902

Symbol: Q5Y7D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7D1

Database IDs:

ARBA 11 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 35 Ensembl 3 GO 5 Gene3D 1 HGNC 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 17174751

Title: Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113.

PubMed ID: 17174751

DOI: 10.1016/j.humimm.2006.09.002

PubMed ID: 21388356

Title: Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population.

PubMed ID: 21388356

DOI: 10.1111/j.1399-0039.2010.01626.x

PubMed ID: 24355003

Title: HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing.

PubMed ID: 24355003

DOI: 10.1111/tan.12258

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 34410304

Title: CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope.

PubMed ID: 34410304

DOI: 10.1084/jem.20210785

Sequence Information:

  • Length: 266
  • Mass: 30120
  • Checksum: 37329B097C6BEEB4
  • Sequence:
    • MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT ERVRYLDRYF 
HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK RGRVDNYCRH NYGVVESFTV 
QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF RNQKGHSGLQ PRGFLS

Genular Protein ID: 1239327010

Symbol: A0A224MM52_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A224MM52

Database IDs:

ARBA 11 AlphaFoldDB 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 5 Gene3D 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 266
  • Mass: 30030
  • Checksum: 871CC341692ECA4D
  • Sequence:
    • MVCLKLPGGS CMTALTVTLM VLSSPLALAG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF 
YNQEESVRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR RAAVDTYCRH NYGVGESFTV 
QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF RNQKGHSGLQ PTGFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.