Details for: HLA DRB1

Gene ID: 3123

Symbol: HLA DRB1

Ensembl ID: ENSG00000196126

Description: major histocompatibility complex, class II, DR beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 22.55
    Marker Score: 23610
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.59
    Marker Score: 11714
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.56
    Marker Score: 3923.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.99
    Marker Score: 12687
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.78
    Marker Score: 2899.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.61
    Marker Score: 3690.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.3
    Marker Score: 6229
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.25
    Marker Score: 2195.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.15
    Marker Score: 4084
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.88
    Marker Score: 4434
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.74
    Marker Score: 2274
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.62
    Marker Score: 3236
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.62
    Marker Score: 3114
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.61
    Marker Score: 35780
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.55
    Marker Score: 198534
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.53
    Marker Score: 6880.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.34
    Marker Score: 21768.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.33
    Marker Score: 775
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.28
    Marker Score: 17249
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.23
    Marker Score: 8372
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.2
    Marker Score: 37149
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.18
    Marker Score: 9442
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.18
    Marker Score: 1373
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.17
    Marker Score: 1907
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.12
    Marker Score: 12975
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.05
    Marker Score: 1080
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.03
    Marker Score: 6054.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.01
    Marker Score: 77093
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.99
    Marker Score: 2810
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.96
    Marker Score: 5165.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.93
    Marker Score: 1445
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.84
    Marker Score: 4557
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.81
    Marker Score: 6774
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.78
    Marker Score: 2100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.77
    Marker Score: 1622.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.71
    Marker Score: 1966
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.71
    Marker Score: 27425.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.67
    Marker Score: 16252.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.64
    Marker Score: 4064
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.62
    Marker Score: 1737
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.56
    Marker Score: 3025.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.55
    Marker Score: 1928
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.54
    Marker Score: 7137
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.53
    Marker Score: 984
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.49
    Marker Score: 1213
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.46
    Marker Score: 1414
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.43
    Marker Score: 1012
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.35
    Marker Score: 5864
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.34
    Marker Score: 556
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.31
    Marker Score: 2505
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.28
    Marker Score: 3867
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.26
    Marker Score: 789
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.25
    Marker Score: 519
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.21
    Marker Score: 560
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.2
    Marker Score: 604
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.2
    Marker Score: 8985.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1510
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.19
    Marker Score: 8091
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.18
    Marker Score: 2181.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.17
    Marker Score: 3197
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.15
    Marker Score: 18709
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.13
    Marker Score: 13607
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.08
    Marker Score: 1751
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 2.06
    Marker Score: 626
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.03
    Marker Score: 9735
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.03
    Marker Score: 1007
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.01
    Marker Score: 3297.5
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2
    Marker Score: 579
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.98
    Marker Score: 3765
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.98
    Marker Score: 1041
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.97
    Marker Score: 921.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.96
    Marker Score: 1664
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.95
    Marker Score: 2690
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.92
    Marker Score: 1179
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.9
    Marker Score: 4804
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.9
    Marker Score: 5167
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.84
    Marker Score: 4165
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.83
    Marker Score: 2207
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.83
    Marker Score: 640
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.79
    Marker Score: 884
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.79
    Marker Score: 1823
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.76
    Marker Score: 608
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.76
    Marker Score: 563
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.75
    Marker Score: 633
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.75
    Marker Score: 1559
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.74
    Marker Score: 436
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.71
    Marker Score: 866
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.71
    Marker Score: 1139
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.71
    Marker Score: 478
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.7
    Marker Score: 1537.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.67
    Marker Score: 1116
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.66
    Marker Score: 424
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.66
    Marker Score: 624
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.63
    Marker Score: 391
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.61
    Marker Score: 1560
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.6
    Marker Score: 1781
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.58
    Marker Score: 1085
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.58
    Marker Score: 5612.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.58
    Marker Score: 1502
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.57
    Marker Score: 1580

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Other Information

**Key characteristics:** * The DRB1 gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of 1451 amino acids. * The DRB1 gene is expressed in a variety of cell types, including thymocytes, CD38-negative naive B cells, CD14-low monocytes, and alveolar capillary type 1 and 2 endothelial cells. * The DRB1 gene is also expressed in professional antigen-presenting cells (APCs), IgG-negative class switched memory B cells, and lung macrophages. **Pathways and functions:** * The DRB1 gene is involved in the adaptive immune system and the regulation of cell-mediated immunity. * DRB1 molecules are expressed on the surface of APCs, where they bind to MHC class I molecules loaded with peptide fragments derived from antigens. * This binding triggers the activation of T cells, which can then recognize and kill infected cells or activate antibody-dependent cell-mediated immunity. * The DRB1 gene is also involved in the regulation of inflammation and autoimmune diseases. **Clinical significance:** * Mutations in the DRB1 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, psoriasis, and lupus. * These mutations can lead to the production of aberrant DRB1 molecules that are not able to bind to MHC class I molecules. * This can lead to the activation of T cells and the development of autoimmune diseases.

Genular Protein ID: 2707570801

Symbol: DRB1_HUMAN

Name: HLA class II histocompatibility antigen, DRB1 beta chain

UniProtKB Accession Codes:

P01911 A0MWF2 A0N0W1 A2ICT1 A2TGX3 A4F5N0 A4ZXA5 A4ZXA6 A4ZY86 A5H000 A5HKN8 A7DZP9 A7LA26 A7UHG2 A7X5B1 A7X5B7 A7X5E0 A7X5E6 A7X5H8 A7X5J4 A7X5K7 A8K098 A8YQE9 A9JPG0 B0BK85 B0LUZ6 B0UYW1 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B3VTQ3 B5A8Y2 B5A8Y3 B5B8U0 B5B9V5 B5B9V6 B5LZ25 B5QSK8 B6VCX2 B6VEL9 B7UDB2 B9VRA4 B9X248 C0LAB5 O02876 O02930 O19585 O19717 O19718 O19739 O19788 O46699 O46793 O46872 O62869 O62889 O77969 O78047 O78210 O98212 P01912 P01914 P04229 P13758 P13759 P13760 P13761 P20039 P79545 Q06662 Q0PGR5 Q0PQ39 Q14280 Q14QT2 Q155F7 Q19AF2 Q19K86 Q1AP33 Q1G0Z9 Q1JRP3 Q1KLJ6 Q27PR6 Q27PR7 Q29673 Q29720 Q29722 Q29734 Q29770 Q29771 Q29772 Q29790 Q29792 Q29800 Q29806 Q29833 Q29874 Q29875

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 65 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 8 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 17 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 98 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 13 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 3 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6589154

Title: Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

PubMed ID: 6589154

DOI: 10.1002/j.1460-2075.1984.tb02026.x

PubMed ID: 2998758

Title: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

PubMed ID: 2998758

DOI: 10.1002/j.1460-2075.1985.tb04012.x

PubMed ID: 3875800

Title: Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants.

PubMed ID: 3875800

DOI: 10.1038/317166a0

PubMed ID: 3456344

Title: Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.

PubMed ID: 3456344

DOI: 10.1016/s0021-9258(17)35847-7

PubMed ID: 3571980

Title: cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope.

PubMed ID: 3571980

PubMed ID: 2885840

Title: HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

PubMed ID: 2885840

DOI: 10.1073/pnas.84.13.4591

PubMed ID: 3110774

Title: Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.

PubMed ID: 3110774

DOI: 10.1073/pnas.84.14.4929

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 3129499

Title: Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes.

PubMed ID: 3129499

PubMed ID: 2497068

Title: A cellular and functional split in the DRw8 haplotype is due to a single amino acid replacement (DR beta ser 57- asp 57).

PubMed ID: 2497068

DOI: 10.1007/bf00352840

PubMed ID: 9777332

Title: Complete cDNA sequence of the HLA-DRB1*09012 allele.

PubMed ID: 9777332

DOI: 10.1046/j.1365-2370.1998.00105.x

PubMed ID: 12652907

Title: Complete cDNA coding sequence of the HLA-DRB1*1405 allele.

PubMed ID: 12652907

DOI: 10.1080/1042517021000041822

PubMed ID: 12358860

Title: Complete cDNA sequences of the HLA-DRB1*0402 and DRB1*11041 alleles.

PubMed ID: 12358860

DOI: 10.1046/j.1365-2370.2002.00354.x

PubMed ID: 11972886

Title: Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404 alleles.

PubMed ID: 11972886

DOI: 10.1034/j.1399-0039.2002.590116.x

PubMed ID: 12028552

Title: Sequence of a new DR12 allele with two silent mutations that affect PCR-SSP typing.

PubMed ID: 12028552

DOI: 10.1034/j.1399-0039.2002.590221.x

PubMed ID: 15896200

Title: Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, - DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4.

PubMed ID: 15896200

DOI: 10.1111/j.1399-0039.2005.00407.x

PubMed ID: 17174751

Title: Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113.

PubMed ID: 17174751

DOI: 10.1016/j.humimm.2006.09.002

PubMed ID: 21388356

Title: Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population.

PubMed ID: 21388356

DOI: 10.1111/j.1399-0039.2010.01626.x

PubMed ID: 26396036

Title: Full-length HLA-DRB1 coding sequences generated by a hemizygous RNA-SBT approach.

PubMed ID: 26396036

DOI: 10.1111/tan.12654

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: 10.3389/fimmu.2018.02294

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 17345114

Title: Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles.

PubMed ID: 17345114

DOI: 10.1007/s00251-007-0196-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 6947956

Title: Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen.

PubMed ID: 6947956

PubMed ID: 6600932

Title: N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens.

PubMed ID: 6600932

DOI: 10.1021/bi00270a027

PubMed ID: 2658055

Title: Class II MHC molecules are specific receptors for staphylococcus enterotoxin A.

PubMed ID: 2658055

DOI: 10.1126/science.2658055

PubMed ID: 2210803

Title: Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins.

PubMed ID: 2210803

PubMed ID: 7479981

Title: Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1.

PubMed ID: 7479981

DOI: 10.1073/pnas.92.24.11289

PubMed ID: 8642306

Title: Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

PubMed ID: 8642306

DOI: 10.1084/jem.183.5.1965

PubMed ID: 9075930

Title: HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

PubMed ID: 9075930

DOI: 10.1016/s1074-7613(00)80332-5

PubMed ID: 9151859

Title: Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes.

PubMed ID: 9151859

DOI: 10.1128/jvi.71.6.4657-4662.1997

PubMed ID: 11070170

Title: Determination of the HLA-DM interaction site on HLA-DR molecules.

PubMed ID: 11070170

DOI: 10.1016/s1074-7613(00)00051-0

PubMed ID: 15265931

Title: Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

PubMed ID: 15265931

DOI: 10.4049/jimmunol.173.3.1966

PubMed ID: 16148104

Title: Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.

PubMed ID: 16148104

DOI: 10.4049/jimmunol.175.6.3603

PubMed ID: 17182262

Title: Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

PubMed ID: 17182262

DOI: 10.1016/j.immuni.2006.10.018

PubMed ID: 18305173

Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

PubMed ID: 18305173

DOI: 10.1073/pnas.0708874105

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19120973

Title: A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4(+) T cells.

PubMed ID: 19120973

DOI: 10.1111/j.1348-0421.2008.00080.x

PubMed ID: 19706888

Title: Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity.

PubMed ID: 19706888

DOI: 10.1182/blood-2009-03-208017

PubMed ID: 19830726

Title: Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.

PubMed ID: 19830726

DOI: 10.1002/eji.200939225

PubMed ID: 20356336

Title: Nomenclature for factors of the HLA system, 2010.

PubMed ID: 20356336

DOI: 10.1111/j.1399-0039.2010.01466.x

PubMed ID: 22327072

Title: Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire.

PubMed ID: 22327072

DOI: 10.4049/jimmunol.1102190

PubMed ID: 22929521

Title: Identification of a Wilms' tumor 1-derived immunogenic CD4(+) T-cell epitope that is recognized in the context of common Caucasian HLA-DR haplotypes.

PubMed ID: 22929521

DOI: 10.1038/leu.2012.248

PubMed ID: 23783831

Title: Exploring the MHC-peptide matrix of central tolerance in the human thymus.

PubMed ID: 23783831

DOI: 10.1038/ncomms3039

PubMed ID: 25413013

Title: Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

PubMed ID: 25413013

DOI: 10.1038/ncomms6369

PubMed ID: 27114505

Title: Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

PubMed ID: 27114505

DOI: 10.1073/pnas.1513918113

PubMed ID: 27591323

Title: Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.

PubMed ID: 27591323

DOI: 10.4049/jimmunol.1600663

PubMed ID: 30282837

Title: Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.

PubMed ID: 30282837

DOI: 10.1172/jci.insight.122467

PubMed ID: 31020640

Title: Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.

PubMed ID: 31020640

DOI: 10.1002/eji.201948126

PubMed ID: 31495665

Title: Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction.

PubMed ID: 31495665

DOI: 10.1016/j.immuni.2019.08.012

PubMed ID: 31308093

Title: Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells.

PubMed ID: 31308093

DOI: 10.4049/jimmunol.1900377

PubMed ID: 8145819

Title: Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.

PubMed ID: 8145819

DOI: 10.1038/368215a0

PubMed ID: 8152483

Title: Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.

PubMed ID: 8152483

DOI: 10.1038/368711a0

PubMed ID: 7477400

Title: The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

PubMed ID: 7477400

DOI: 10.1038/378457a0

PubMed ID: 9354468

Title: X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II.

PubMed ID: 9354468

DOI: 10.1016/s1074-7613(00)80369-6

PubMed ID: 9782128

Title: Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.

PubMed ID: 9782128

DOI: 10.1084/jem.188.8.1511

PubMed ID: 11432818

Title: Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence.

PubMed ID: 11432818

DOI: 10.1093/emboj/20.13.3306

PubMed ID: 11864610

Title: Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.

PubMed ID: 11864610

DOI: 10.1016/s1097-2765(02)00465-3

PubMed ID: 19303388

Title: T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.

PubMed ID: 19303388

DOI: 10.1016/j.immuni.2009.01.009

PubMed ID: 21900604

Title: Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.

PubMed ID: 21900604

DOI: 10.1073/pnas.1109438108

PubMed ID: 23260142

Title: Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

PubMed ID: 23260142

DOI: 10.1016/j.cell.2012.11.025

PubMed ID: 24190431

Title: A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.

PubMed ID: 24190431

DOI: 10.1084/jem.20131241

PubMed ID: 28467828

Title: Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

PubMed ID: 28467828

DOI: 10.1038/nature22329

PubMed ID: 29317506

Title: The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.

PubMed ID: 29317506

DOI: 10.1074/jbc.ra117.001013

PubMed ID: 29884618

Title: CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers.

PubMed ID: 29884618

DOI: 10.1126/sciimmunol.aat0687

PubMed ID: 31619516

Title: Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.

PubMed ID: 31619516

DOI: 10.1074/jbc.ra119.009437

PubMed ID: 32668259

Title: CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features.

PubMed ID: 32668259

DOI: 10.1016/j.celrep.2020.107885

PubMed ID: 14508706

Title: HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.

PubMed ID: 14508706

DOI: 10.1086/378097

PubMed ID: 21833088

Title: Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

PubMed ID: 21833088

DOI: 10.1038/nature10251

PubMed ID: 22286218

Title: Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

PubMed ID: 22286218

DOI: 10.1038/ng.1076

PubMed ID: 25559196

Title: High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

PubMed ID: 25559196

DOI: 10.1038/ng.3176

PubMed ID: 23510415

Title: Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

PubMed ID: 23510415

DOI: 10.1111/tan.12093

Sequence Information:

  • Length: 266
  • Mass: 29966
  • Checksum: 3B5912820A4654BE
  • Sequence:
    • MVCLKLPGGS CMTALTVTLM VLSSPLALSG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF 
YNQEESVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEQA RAAVDTYCRH NYGVVESFTV 
QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF RNQKGHSGLQ PTGFLS

Genular Protein ID: 2369487902

Symbol: Q5Y7D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7D1

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 37 Ensembl 3 GO 5 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 8 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 17174751

Title: Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113.

PubMed ID: 17174751

DOI: 10.1016/j.humimm.2006.09.002

PubMed ID: 21388356

Title: Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population.

PubMed ID: 21388356

DOI: 10.1111/j.1399-0039.2010.01626.x

PubMed ID: 24355003

Title: HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing.

PubMed ID: 24355003

DOI: 10.1111/tan.12258

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 34410304

Title: CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope.

PubMed ID: 34410304

DOI: 10.1084/jem.20210785

Sequence Information:

  • Length: 266
  • Mass: 30120
  • Checksum: 37329B097C6BEEB4
  • Sequence:
    • MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT ERVRYLDRYF 
HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK RGRVDNYCRH NYGVVESFTV 
QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF RNQKGHSGLQ PRGFLS

Genular Protein ID: 1239327010

Symbol: A0A224MM52_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A224MM52

Database IDs:

ARBA 11 AlphaFoldDB 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 5 Gene3D 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 266
  • Mass: 30030
  • Checksum: 871CC341692ECA4D
  • Sequence:
    • MVCLKLPGGS CMTALTVTLM VLSSPLALAG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF 
YNQEESVRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR RAAVDTYCRH NYGVGESFTV 
QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF RNQKGHSGLQ PTGFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.