Details for: HLA G

Gene ID: 3135

Symbol: HLA G

Ensembl ID: ENSG00000204632

Description: major histocompatibility complex, class I, G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.9591
    Cell Significance Index: -4.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.6913
    Cell Significance Index: -3.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 11.6827
    Cell Significance Index: 72.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.4679
    Cell Significance Index: -4.4700
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 4.3524
    Cell Significance Index: 10.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.7471
    Cell Significance Index: -4.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7827
    Cell Significance Index: 80.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.5107
    Cell Significance Index: -4.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1987
    Cell Significance Index: -4.7300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.9942
    Cell Significance Index: 10.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8226
    Cell Significance Index: 17.5200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7780
    Cell Significance Index: 11.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7523
    Cell Significance Index: 679.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5860
    Cell Significance Index: 8.7800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.5582
    Cell Significance Index: 1.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5316
    Cell Significance Index: 57.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4812
    Cell Significance Index: 28.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4663
    Cell Significance Index: 75.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3105
    Cell Significance Index: 21.4800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3030
    Cell Significance Index: 2.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2588
    Cell Significance Index: 7.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2297
    Cell Significance Index: 6.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2018
    Cell Significance Index: 19.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1954
    Cell Significance Index: 5.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1454
    Cell Significance Index: 3.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0852
    Cell Significance Index: 2.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0801
    Cell Significance Index: 15.2500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0674
    Cell Significance Index: 0.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0606
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0487
    Cell Significance Index: 5.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0447
    Cell Significance Index: 1.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0441
    Cell Significance Index: 0.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0200
    Cell Significance Index: 0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0167
    Cell Significance Index: 1.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0152
    Cell Significance Index: 0.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0150
    Cell Significance Index: 1.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0126
    Cell Significance Index: 2.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0053
    Cell Significance Index: 0.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0059
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0111
    Cell Significance Index: -5.0400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0123
    Cell Significance Index: -4.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0155
    Cell Significance Index: -0.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0160
    Cell Significance Index: -2.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0216
    Cell Significance Index: -4.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0218
    Cell Significance Index: -3.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0235
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0251
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0260
    Cell Significance Index: -5.4800
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -0.0296
    Cell Significance Index: -0.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0302
    Cell Significance Index: -4.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0343
    Cell Significance Index: -1.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0377
    Cell Significance Index: -4.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0397
    Cell Significance Index: -5.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0425
    Cell Significance Index: -0.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0524
    Cell Significance Index: -2.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0556
    Cell Significance Index: -3.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0589
    Cell Significance Index: -3.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0599
    Cell Significance Index: -4.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0653
    Cell Significance Index: -3.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0687
    Cell Significance Index: -5.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0698
    Cell Significance Index: -4.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0728
    Cell Significance Index: -0.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0770
    Cell Significance Index: -1.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0799
    Cell Significance Index: -1.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0846
    Cell Significance Index: -4.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0910
    Cell Significance Index: -2.6800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0997
    Cell Significance Index: -2.4900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1115
    Cell Significance Index: -1.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1140
    Cell Significance Index: -1.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1145
    Cell Significance Index: -4.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1169
    Cell Significance Index: -5.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1174
    Cell Significance Index: -4.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1212
    Cell Significance Index: -3.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1359
    Cell Significance Index: -5.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1360
    Cell Significance Index: -4.3300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1385
    Cell Significance Index: -1.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1388
    Cell Significance Index: -3.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1417
    Cell Significance Index: -4.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1537
    Cell Significance Index: -2.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1545
    Cell Significance Index: -3.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1564
    Cell Significance Index: -4.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1632
    Cell Significance Index: -4.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1678
    Cell Significance Index: -4.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1707
    Cell Significance Index: -4.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1731
    Cell Significance Index: -4.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Unique expression pattern:** HLA-G is primarily expressed on the surface of placental trophoblast cells, where it helps maintain maternal-fetal tolerance. 2. **Non-classical MHC class I molecule:** HLA-G does not present exogenous antigens to CD8+ T cells, unlike classical MHC class I molecules. 3. **Immunomodulatory functions:** HLA-G has been shown to suppress immune responses, promoting tolerance and reducing inflammation. 4. **Interactions with immune cells:** HLA-G interacts with CD8+ T cells, NK cells, and Tregs, influencing their activity and function. **Pathways and Functions:** 1. **Immune tolerance:** HLA-G promotes immune tolerance by inhibiting the activation of CD8+ T cells, NK cells, and Tregs. 2. **Antigen presentation:** Although HLA-G does not present exogenous antigens, it can interact with peptides derived from self-proteins, influencing immune responses. 3. **Cytokine signaling:** HLA-G modulates cytokine production, including the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory cytokines. 4. **Regulation of immune cell function:** HLA-G regulates the activity of immune cells, including CD8+ T cells, NK cells, and Tregs. **Clinical Significance:** 1. **Pregnancy and fetal tolerance:** HLA-G plays a crucial role in maintaining maternal-fetal tolerance, preventing rejection of the fetus by the mother's immune system. 2. **Cancer immunotherapy:** HLA-G has been explored as a target for cancer immunotherapy, where its expression can be used to modulate the immune response against tumors. 3. **Autoimmune diseases:** HLA-G has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where its expression is often reduced or altered. 4. **Viral infections:** HLA-G has been shown to modulate the immune response to viral infections, such as HIV and SARS-CoV-2, influencing the severity of disease and the efficacy of treatment. In conclusion, HLA-G is a unique MHC class I molecule that plays a crucial role in modulating the immune response, promoting immune tolerance and suppressing inflammation. Its expression and function have significant implications for various diseases, including pregnancy, cancer, autoimmune diseases, and viral infections. Further research is needed to fully understand the mechanisms by which HLA-G regulates the immune response and to explore its potential therapeutic applications.

Genular Protein ID: 3050809269

Symbol: HLAG_HUMAN

Name: HLA class I histocompatibility antigen, alpha chain G

UniProtKB Accession Codes:

P17693

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 35 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2336406

Title: The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression.

PubMed ID: 2336406

DOI: 10.1093/nar/18.8.2189

PubMed ID: 1570318

Title: Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.

PubMed ID: 1570318

DOI: 10.1073/pnas.89.9.3947

PubMed ID: 3480534

Title: A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

PubMed ID: 3480534

DOI: 10.1073/pnas.84.24.9145

PubMed ID: 10727083

Title: A 356-Kb sequence of the subtelomeric part of the MHC class I region.

PubMed ID: 10727083

DOI: 10.3109/10425179909033955

PubMed ID: 7589701

Title: HLA-G mRNA forms in human trophoblasts and peripheral blood lymphocytes: potential use in prenatal diagnosis.

PubMed ID: 7589701

PubMed ID: 7989753

Title: A soluble form of the HLA-G antigen is encoded by a messenger ribonucleic acid containing intron 4.

PubMed ID: 7989753

PubMed ID: 8183892

Title: An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes.

PubMed ID: 8183892

DOI: 10.1073/pnas.91.10.4209

PubMed ID: 7558941

Title: Soluble HLA-G molecule. An alternatively spliced HLA-G mRNA form candidate to encode it in peripheral blood mononuclear cells and human trophoblasts.

PubMed ID: 7558941

DOI: 10.1016/0198-8859(95)00009-s

PubMed ID: 11137219

Title: Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells.

PubMed ID: 11137219

DOI: 10.1016/s0198-8859(00)00197-x

PubMed ID: 7584149

Title: The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association.

PubMed ID: 7584149

DOI: 10.1016/1074-7613(95)90130-2

PubMed ID: 8805247

Title: Nonclassical HLA-G molecules are classical peptide presenters.

PubMed ID: 8805247

DOI: 10.1016/s0960-9822(02)00481-5

PubMed ID: 9640257

Title: Calreticulin associates with non-HLA-A,-B class I proteins in the human choriocarcinoma cell lines JEG-3 and BeWo.

PubMed ID: 9640257

DOI: 10.1046/j.1365-2567.1998.00439.x

PubMed ID: 10190900

Title: A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells.

PubMed ID: 10190900

DOI: 10.1084/jem.189.7.1093

PubMed ID: 11520457

Title: The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments.

PubMed ID: 11520457

DOI: 10.1016/s1074-7613(01)00179-0

PubMed ID: 11290782

Title: HLA-G2, -G3, and -G4 isoforms expressed as nonmature cell surface glycoproteins inhibit NK and antigen-specific CTL cytolysis.

PubMed ID: 11290782

DOI: 10.4049/jimmunol.166.8.5018

PubMed ID: 12454284

Title: Disulfide bond-mediated dimerization of HLA-G on the cell surface.

PubMed ID: 12454284

DOI: 10.1073/pnas.212643199

PubMed ID: 12582157

Title: An essential function of tapasin in quality control of HLA-G molecules.

PubMed ID: 12582157

DOI: 10.1074/jbc.m212882200

PubMed ID: 12874224

Title: Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.

PubMed ID: 12874224

DOI: 10.4049/jimmunol.171.3.1343

PubMed ID: 12853576

Title: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.

PubMed ID: 12853576

DOI: 10.1073/pnas.1431057100

PubMed ID: 16809620

Title: Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells.

PubMed ID: 16809620

DOI: 10.1182/blood-2005-12-019919

PubMed ID: 16210391

Title: Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro.

PubMed ID: 16210391

DOI: 10.1093/humrep/dei305

PubMed ID: 16366734

Title: Activation of NK cells by an endocytosed receptor for soluble HLA-G.

PubMed ID: 16366734

DOI: 10.1371/journal.pbio.0040009

PubMed ID: 19304799

Title: HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.

PubMed ID: 19304799

DOI: 10.1073/pnas.0901173106

PubMed ID: 20448110

Title: Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.

PubMed ID: 20448110

DOI: 10.1182/blood-2009-07-234872

PubMed ID: 20179272

Title: DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells.

PubMed ID: 20179272

DOI: 10.1126/scisignal.2000467

PubMed ID: 23184984

Title: Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling.

PubMed ID: 23184984

DOI: 10.1073/pnas.1208248109

PubMed ID: 23737137

Title: Matrix metalloproteinase-2 (MMP-2) generates soluble HLA-G1 by cell surface proteolytic shedding.

PubMed ID: 23737137

DOI: 10.1007/s11010-013-1708-5

PubMed ID: 24453251

Title: Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses.

PubMed ID: 24453251

DOI: 10.4049/jimmunol.1300438

PubMed ID: 26460007

Title: The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface.

PubMed ID: 26460007

DOI: 10.1073/pnas.1517724112

PubMed ID: 27859042

Title: HLA-G promotes myeloid-derived suppressor cell accumulation and suppressive activity during human pregnancy through engagement of the receptor ILT4.

PubMed ID: 27859042

DOI: 10.1002/eji.201646564

PubMed ID: 29262349

Title: Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

PubMed ID: 29262349

DOI: 10.1016/j.immuni.2017.11.018

PubMed ID: 28348268

Title: Class II-like structural features and strong receptor binding of the nonclassical HLA-G2 isoform homodimer.

PubMed ID: 28348268

DOI: 10.4049/jimmunol.1601296

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 15718280

Title: Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface.

PubMed ID: 15718280

DOI: 10.1073/pnas.0409676102

PubMed ID: 16455647

Title: Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.

PubMed ID: 16455647

DOI: 10.1074/jbc.m512305200

PubMed ID: 17056715

Title: Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).

PubMed ID: 17056715

DOI: 10.1073/pnas.0605228103

PubMed ID: 20122941

Title: The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide.

PubMed ID: 20122941

DOI: 10.1016/j.jmb.2010.01.052

Sequence Information:

  • Length: 338
  • Mass: 38224
  • Checksum: 0678E263BE8962FF
  • Sequence:
    • MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF 
DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEASSHTLQ 
WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANVAEQR 
RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT 
WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ 
SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD

Genular Protein ID: 3163617347

Symbol: Q31611_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q31611

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 15 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 3 ProteomicsDB 2 RefSeq 2 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 1570318

Title: Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.

PubMed ID: 1570318

DOI: 10.1073/pnas.89.9.3947

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 246
  • Mass: 27680
  • Checksum: C9B1F92620203909
  • Sequence:
    • MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF 
DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEANPPKTH 
VTHHPVFDYE ATLRCWALGF YPAEIILTWQ RDGEDQTQDV ELVETRPAGD GTFQKWAAVV 
VPSGEEQRYT CHVQHEGLPE PLMLRWKQSS LPTIPIMGIV AGLVVLAAVV TGAAVAAVLW 
RKKSSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.