Details for: MR1

Gene ID: 3140

Symbol: MR1

Ensembl ID: ENSG00000153029

Description: major histocompatibility complex, class I-related

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.51
    Marker Score: 1384
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168748
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2314
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.09
    Marker Score: 27958
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.07
    Marker Score: 1780
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71751
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47975
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.95
    Marker Score: 1399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5250
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4935
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 799
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11871
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1220
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.72
    Marker Score: 763
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.72
    Marker Score: 4364
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.71
    Marker Score: 477
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2889
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.65
    Marker Score: 150
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.63
    Marker Score: 128
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.63
    Marker Score: 333
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.62
    Marker Score: 4607
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6
    Marker Score: 33648
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.6
    Marker Score: 1087
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.57
    Marker Score: 1433
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.55
    Marker Score: 728
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 350
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.53
    Marker Score: 213
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.51
    Marker Score: 1003
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.51
    Marker Score: 127
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.51
    Marker Score: 345
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.51
    Marker Score: 183
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.51
    Marker Score: 1987
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.5
    Marker Score: 2643
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.5
    Marker Score: 3247
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.5
    Marker Score: 232
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.49
    Marker Score: 5741
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.49
    Marker Score: 301
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.49
    Marker Score: 541
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.48
    Marker Score: 538
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.48
    Marker Score: 476
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.48
    Marker Score: 480
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.48
    Marker Score: 7648
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.47
    Marker Score: 149
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.47
    Marker Score: 1137
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.47
    Marker Score: 135
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.47
    Marker Score: 6263
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.47
    Marker Score: 543
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.46
    Marker Score: 101
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.46
    Marker Score: 230
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 739
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.46
    Marker Score: 313
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.45
    Marker Score: 1253
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 185
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.45
    Marker Score: 812
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.45
    Marker Score: 4415
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.44
    Marker Score: 188
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.44
    Marker Score: 1496
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.43
    Marker Score: 101
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.43
    Marker Score: 85
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.43
    Marker Score: 231
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.43
    Marker Score: 160
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.43
    Marker Score: 94
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.43
    Marker Score: 491
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.43
    Marker Score: 553
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.43
    Marker Score: 321
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 999
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.42
    Marker Score: 205
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 182
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.42
    Marker Score: 290
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.42
    Marker Score: 170
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.42
    Marker Score: 800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.41
    Marker Score: 909
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.41
    Marker Score: 97
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.41
    Marker Score: 1026
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.41
    Marker Score: 447
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.41
    Marker Score: 226
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.41
    Marker Score: 281
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.41
    Marker Score: 8711
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.41
    Marker Score: 1760
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.41
    Marker Score: 3544
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.41
    Marker Score: 91
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.41
    Marker Score: 627
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.4
    Marker Score: 98
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 107

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - MR1 is a type I transmembrane protein that is expressed in the endoplasmic reticulum. - It is a heterodimeric protein, consisting of two polypeptide chains that are linked by a disulfide bond. - MR1 is a key molecule in the recognition of peptide antigens by T cells. - It is involved in the activation of T cells and the induction of an immune response. **Pathways and functions:** - MR1 is involved in the processing and presentation of exogenous and endogenous antigens. - It binds to peptides derived from glycoproteins expressed on the surface of infected cells, and it then delivers these peptides to the MHC class I complex. - The MHC class I complex then presents the peptides to T cells, which become activated and proliferate. - Activated T cells can then recognize and kill infected cells. **Clinical significance:** - Mutations in the MR1 gene have been linked to a number of human diseases, including cancer and autoimmune disorders. - MR1 is a potential target for cancer immunotherapy, as it is often overexpressed on tumor cells. - Inhibition of MR1 has been shown to inhibit tumor growth and metastasis in animal models of cancer.

Genular Protein ID: 1178942056

Symbol: HMR1_HUMAN

Name: Major histocompatibility complex class I-related gene protein

UniProtKB Accession Codes:

Q95460 A8K2V9 B4E3B1 O97985 O97986 Q53GM1 Q95HB8 Q9MY23 Q9NPL2 Q9TQB3 Q9TQB9 Q9TQK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 16 EPD 1 Ensembl 5 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 73 PDBsum 60 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7624800

Title: A gene outside the human MHC related to classical HLA class I genes.

PubMed ID: 7624800

DOI: 10.1126/science.7624800

PubMed ID: 11019920

Title: A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.

PubMed ID: 11019920

DOI: 10.1034/j.1399-0039.2000.560211.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9780177

Title: Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.

PubMed ID: 9780177

PubMed ID: 9784382

Title: Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog.

PubMed ID: 9784382

DOI: 10.1006/bbrc.1998.9353

PubMed ID: 12794138

Title: Biochemical features of the MHC-related protein 1 consistent with an immunological function.

PubMed ID: 12794138

DOI: 10.4049/jimmunol.170.12.6090

PubMed ID: 18068122

Title: Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells.

PubMed ID: 18068122

DOI: 10.1016/j.bbrc.2007.11.156

PubMed ID: 19760593

Title: The MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa.

PubMed ID: 19760593

DOI: 10.14670/hh-24.1439

PubMed ID: 19416870

Title: MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.

PubMed ID: 19416870

DOI: 10.1073/pnas.0903196106

PubMed ID: 20581831

Title: Antimicrobial activity of mucosal-associated invariant T cells.

PubMed ID: 20581831

DOI: 10.1038/ni.1890

PubMed ID: 23457030

Title: MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells.

PubMed ID: 23457030

DOI: 10.1002/eji.201242461

PubMed ID: 22692454

Title: Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.

PubMed ID: 22692454

DOI: 10.1038/mi.2012.45

PubMed ID: 27527800

Title: Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.

PubMed ID: 27527800

DOI: 10.1038/ncomms12506

PubMed ID: 27043408

Title: The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.

PubMed ID: 27043408

DOI: 10.1038/ni.3416

PubMed ID: 31113973

Title: Diverse MR1-restricted T cells in mice and humans.

PubMed ID: 31113973

DOI: 10.1038/s41467-019-10198-w

PubMed ID: 31959982

Title: Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1.

PubMed ID: 31959982

DOI: 10.1038/s41590-019-0578-8

PubMed ID: 23051753

Title: MR1 presents microbial vitamin B metabolites to MAIT cells.

PubMed ID: 23051753

DOI: 10.1038/nature11605

PubMed ID: 23846752

Title: Recognition of vitamin B metabolites by mucosal-associated invariant T cells.

PubMed ID: 23846752

DOI: 10.1038/ncomms3142

PubMed ID: 24695216

Title: T-cell activation by transitory neo-antigens derived from distinct microbial pathways.

PubMed ID: 24695216

DOI: 10.1038/nature13160

PubMed ID: 26795251

Title: Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.

PubMed ID: 26795251

DOI: 10.1016/j.immuni.2015.12.005

PubMed ID: 28166217

Title: Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

PubMed ID: 28166217

DOI: 10.1038/ni.3679

Sequence Information:

  • Length: 341
  • Mass: 39366
  • Checksum: 2990C1F3F0A1CAD9
  • Sequence:
    • MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS 
VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC 
ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE 
EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG 
EEIVQEIDYG DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL 
VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.