Details for: MR1

Gene ID: 3140

Symbol: MR1

Ensembl ID: ENSG00000153029

Description: major histocompatibility complex, class I-related

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.3841
    Cell Significance Index: -12.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.0847
    Cell Significance Index: -12.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.2918
    Cell Significance Index: -11.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.1450
    Cell Significance Index: -13.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 25.6811
    Cell Significance Index: -13.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.4693
    Cell Significance Index: -11.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1034
    Cell Significance Index: -13.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2325
    Cell Significance Index: -13.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8188
    Cell Significance Index: -10.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5555
    Cell Significance Index: -14.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8049
    Cell Significance Index: 343.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6902
    Cell Significance Index: 23.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1027
    Cell Significance Index: 109.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0900
    Cell Significance Index: 56.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0694
    Cell Significance Index: 22.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0296
    Cell Significance Index: 167.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9089
    Cell Significance Index: 24.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8933
    Cell Significance Index: 806.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8671
    Cell Significance Index: 156.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7561
    Cell Significance Index: 45.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7159
    Cell Significance Index: 77.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6522
    Cell Significance Index: 80.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3734
    Cell Significance Index: 25.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3722
    Cell Significance Index: 6.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3069
    Cell Significance Index: 191.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3006
    Cell Significance Index: 59.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2891
    Cell Significance Index: 7.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2501
    Cell Significance Index: 6.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2386
    Cell Significance Index: 15.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2300
    Cell Significance Index: 26.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2203
    Cell Significance Index: 30.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1901
    Cell Significance Index: 13.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1829
    Cell Significance Index: 3.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1772
    Cell Significance Index: 2.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1697
    Cell Significance Index: 4.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1355
    Cell Significance Index: 6.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1245
    Cell Significance Index: 55.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1092
    Cell Significance Index: 21.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1004
    Cell Significance Index: 0.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0989
    Cell Significance Index: 11.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0846
    Cell Significance Index: 0.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0824
    Cell Significance Index: 2.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0681
    Cell Significance Index: 2.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0669
    Cell Significance Index: 1.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0659
    Cell Significance Index: 35.9700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0507
    Cell Significance Index: 0.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0403
    Cell Significance Index: 5.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0092
    Cell Significance Index: 3.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0054
    Cell Significance Index: 0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0048
    Cell Significance Index: 2.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0001
    Cell Significance Index: 0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0054
    Cell Significance Index: -0.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0060
    Cell Significance Index: -0.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0071
    Cell Significance Index: -4.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0082
    Cell Significance Index: -15.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0093
    Cell Significance Index: -1.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0094
    Cell Significance Index: -14.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0102
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0129
    Cell Significance Index: -17.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0135
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0257
    Cell Significance Index: -2.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0299
    Cell Significance Index: -2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0367
    Cell Significance Index: -10.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0378
    Cell Significance Index: -7.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0473
    Cell Significance Index: -2.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0523
    Cell Significance Index: -7.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0531
    Cell Significance Index: -6.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0633
    Cell Significance Index: -0.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0714
    Cell Significance Index: -4.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0734
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0927
    Cell Significance Index: -10.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0957
    Cell Significance Index: -2.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1009
    Cell Significance Index: -2.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1139
    Cell Significance Index: -8.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1244
    Cell Significance Index: -2.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1259
    Cell Significance Index: -13.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1482
    Cell Significance Index: -9.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1491
    Cell Significance Index: -6.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1511
    Cell Significance Index: -4.8400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.1593
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1607
    Cell Significance Index: -12.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1679
    Cell Significance Index: -1.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1768
    Cell Significance Index: -11.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1809
    Cell Significance Index: -6.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2006
    Cell Significance Index: -5.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2201
    Cell Significance Index: -13.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2347
    Cell Significance Index: -3.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2602
    Cell Significance Index: -14.6000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2857
    Cell Significance Index: -4.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2868
    Cell Significance Index: -15.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3108
    Cell Significance Index: -8.8700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3196
    Cell Significance Index: -4.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3421
    Cell Significance Index: -10.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3438
    Cell Significance Index: -12.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3530
    Cell Significance Index: -12.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** MR1 is expressed in a diverse range of cell types, including choroid plexus epithelial cells, mural cells, alveolar macrophages, and intestinal crypt stem cells. 2. **MHC Class I-Related:** MR1 belongs to the MHC class I family, which is responsible for presenting antigens to CD8+ T cells. 3. **Antigen Presentation:** MR1 is involved in the presentation of exogenous antigens, which are foreign substances that can trigger an immune response. 4. **Beta-2-Microglobulin Binding:** MR1 interacts with beta-2-microglobulin, a protein that is also a component of MHC class I molecules. **Pathways and Functions:** 1. **Antigen Processing and Presentation:** MR1 is involved in the processing and presentation of exogenous antigens to the immune system. 2. **MHC Class I Protein Complex:** MR1 forms a complex with beta-2-microglobulin and other MHC class I molecules to present antigens to CD8+ T cells. 3. **Immune Response:** MR1 plays a crucial role in the regulation of immune responses, particularly in the context of infections and autoimmune diseases. 4. **Innate Immunity:** MR1 is also involved in the innate immune response, which provides the first line of defense against pathogens. **Clinical Significance:** 1. **Infectious Diseases:** MR1 has been implicated in the regulation of immune responses to infectious diseases, such as tuberculosis and malaria. 2. **Autoimmune Diseases:** MR1 has also been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** MR1 has been identified as a potential target for cancer immunotherapy, as it can be used to stimulate CD8+ T cell responses against tumor cells. 4. **Vaccine Development:** MR1 has been recognized as a potential antigen for vaccine development, particularly in the context of infectious diseases. In conclusion, MR1 is a complex gene that plays a crucial role in the immune system. Its multifaceted functions have far-reaching implications for our understanding of immune responses, particularly in the context of infections, autoimmune diseases, and cancer. Further research is needed to fully elucidate the mechanisms by which MR1 regulates immune responses and to explore its potential applications in vaccine development and cancer immunotherapy.

Genular Protein ID: 1178942056

Symbol: HMR1_HUMAN

Name: Major histocompatibility complex class I-related gene protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7624800

Title: A gene outside the human MHC related to classical HLA class I genes.

PubMed ID: 7624800

DOI: 10.1126/science.7624800

PubMed ID: 11019920

Title: A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.

PubMed ID: 11019920

DOI: 10.1034/j.1399-0039.2000.560211.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9780177

Title: Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.

PubMed ID: 9780177

PubMed ID: 9784382

Title: Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog.

PubMed ID: 9784382

DOI: 10.1006/bbrc.1998.9353

PubMed ID: 12794138

Title: Biochemical features of the MHC-related protein 1 consistent with an immunological function.

PubMed ID: 12794138

DOI: 10.4049/jimmunol.170.12.6090

PubMed ID: 18068122

Title: Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells.

PubMed ID: 18068122

DOI: 10.1016/j.bbrc.2007.11.156

PubMed ID: 19760593

Title: The MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa.

PubMed ID: 19760593

DOI: 10.14670/hh-24.1439

PubMed ID: 19416870

Title: MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.

PubMed ID: 19416870

DOI: 10.1073/pnas.0903196106

PubMed ID: 20581831

Title: Antimicrobial activity of mucosal-associated invariant T cells.

PubMed ID: 20581831

DOI: 10.1038/ni.1890

PubMed ID: 23457030

Title: MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells.

PubMed ID: 23457030

DOI: 10.1002/eji.201242461

PubMed ID: 22692454

Title: Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.

PubMed ID: 22692454

DOI: 10.1038/mi.2012.45

PubMed ID: 27527800

Title: Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.

PubMed ID: 27527800

DOI: 10.1038/ncomms12506

PubMed ID: 27043408

Title: The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.

PubMed ID: 27043408

DOI: 10.1038/ni.3416

PubMed ID: 31113973

Title: Diverse MR1-restricted T cells in mice and humans.

PubMed ID: 31113973

DOI: 10.1038/s41467-019-10198-w

PubMed ID: 31959982

Title: Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1.

PubMed ID: 31959982

DOI: 10.1038/s41590-019-0578-8

PubMed ID: 23051753

Title: MR1 presents microbial vitamin B metabolites to MAIT cells.

PubMed ID: 23051753

DOI: 10.1038/nature11605

PubMed ID: 23846752

Title: Recognition of vitamin B metabolites by mucosal-associated invariant T cells.

PubMed ID: 23846752

DOI: 10.1038/ncomms3142

PubMed ID: 24695216

Title: T-cell activation by transitory neo-antigens derived from distinct microbial pathways.

PubMed ID: 24695216

DOI: 10.1038/nature13160

PubMed ID: 26795251

Title: Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.

PubMed ID: 26795251

DOI: 10.1016/j.immuni.2015.12.005

PubMed ID: 28166217

Title: Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

PubMed ID: 28166217

DOI: 10.1038/ni.3679

Sequence Information:

  • Length: 341
  • Mass: 39366
  • Checksum: 2990C1F3F0A1CAD9
  • Sequence:
  • MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS 
    VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC 
    ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE 
    EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG 
    EEIVQEIDYG DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL 
    VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.