Details for: MR1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 83.3841
Cell Significance Index: -12.9700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 49.0847
Cell Significance Index: -12.4500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 29.2918
Cell Significance Index: -11.9000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 29.1450
Cell Significance Index: -13.7600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 25.6811
Cell Significance Index: -13.2100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 12.4693
Cell Significance Index: -11.9100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.1034
Cell Significance Index: -13.6900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.2325
Cell Significance Index: -13.0000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.8188
Cell Significance Index: -10.2300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.5555
Cell Significance Index: -14.0300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.8049
Cell Significance Index: 343.4800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.6902
Cell Significance Index: 23.0600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1027
Cell Significance Index: 109.0800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0900
Cell Significance Index: 56.6200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.0694
Cell Significance Index: 22.7800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0296
Cell Significance Index: 167.4600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.9089
Cell Significance Index: 24.3600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8933
Cell Significance Index: 806.6200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8671
Cell Significance Index: 156.3100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7561
Cell Significance Index: 45.3900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7159
Cell Significance Index: 77.8700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6522
Cell Significance Index: 80.2000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3734
Cell Significance Index: 25.8200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.3722
Cell Significance Index: 6.8800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.3069
Cell Significance Index: 191.6300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3006
Cell Significance Index: 59.6500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2891
Cell Significance Index: 7.7200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2501
Cell Significance Index: 6.9900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2386
Cell Significance Index: 15.4000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2300
Cell Significance Index: 26.8000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2203
Cell Significance Index: 30.2600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1901
Cell Significance Index: 13.4500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1829
Cell Significance Index: 3.5700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1772
Cell Significance Index: 2.6700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1697
Cell Significance Index: 4.6200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1355
Cell Significance Index: 6.8500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1245
Cell Significance Index: 55.0400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1092
Cell Significance Index: 21.9100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1004
Cell Significance Index: 0.9300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0989
Cell Significance Index: 11.6600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.0846
Cell Significance Index: 0.6900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0824
Cell Significance Index: 2.0600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0681
Cell Significance Index: 2.0000 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0669
Cell Significance Index: 1.7100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0659
Cell Significance Index: 35.9700 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0507
Cell Significance Index: 0.8100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0403
Cell Significance Index: 5.1700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0092
Cell Significance Index: 3.2900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0054
Cell Significance Index: 0.2800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0048
Cell Significance Index: 2.1700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0011
Cell Significance Index: 2.0400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0001
Cell Significance Index: 0.0500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0017
Cell Significance Index: -0.0600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0022
Cell Significance Index: -1.6500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0037
Cell Significance Index: -2.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0054
Cell Significance Index: -0.5500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0060
Cell Significance Index: -0.2700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0069
Cell Significance Index: -5.0700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0071
Cell Significance Index: -4.0300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0082
Cell Significance Index: -15.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0093
Cell Significance Index: -1.5900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0094
Cell Significance Index: -14.4800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0102
Cell Significance Index: -0.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0129
Cell Significance Index: -17.5900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0135
Cell Significance Index: -0.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0257
Cell Significance Index: -2.9500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0299
Cell Significance Index: -2.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0367
Cell Significance Index: -10.5700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0378
Cell Significance Index: -7.9600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0473
Cell Significance Index: -2.2300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0523
Cell Significance Index: -7.6000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0531
Cell Significance Index: -6.8600 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0633
Cell Significance Index: -0.4200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0714
Cell Significance Index: -4.3800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0734
Cell Significance Index: -3.4200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0927
Cell Significance Index: -10.5800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0957
Cell Significance Index: -2.2100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1009
Cell Significance Index: -2.7000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1139
Cell Significance Index: -8.7400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1244
Cell Significance Index: -2.5800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1259
Cell Significance Index: -13.1100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1482
Cell Significance Index: -9.9700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1491
Cell Significance Index: -6.6000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1511
Cell Significance Index: -4.8400 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.1593
Cell Significance Index: -0.6100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1607
Cell Significance Index: -12.7300 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.1679
Cell Significance Index: -1.4100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1768
Cell Significance Index: -11.1400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1809
Cell Significance Index: -6.8500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2006
Cell Significance Index: -5.7500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2201
Cell Significance Index: -13.5300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2347
Cell Significance Index: -3.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2602
Cell Significance Index: -14.6000 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.2857
Cell Significance Index: -4.0600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2868
Cell Significance Index: -15.0600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3108
Cell Significance Index: -8.8700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.3196
Cell Significance Index: -4.5500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3421
Cell Significance Index: -10.9000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3438
Cell Significance Index: -12.6200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3530
Cell Significance Index: -12.3700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1178942056
Symbol: HMR1_HUMAN
Name: Major histocompatibility complex class I-related gene protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7624800
Title: A gene outside the human MHC related to classical HLA class I genes.
PubMed ID: 7624800
PubMed ID: 11019920
Title: A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.
PubMed ID: 11019920
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9780177
Title: Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.
PubMed ID: 9780177
PubMed ID: 9784382
Title: Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog.
PubMed ID: 9784382
PubMed ID: 12794138
Title: Biochemical features of the MHC-related protein 1 consistent with an immunological function.
PubMed ID: 12794138
PubMed ID: 18068122
Title: Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells.
PubMed ID: 18068122
PubMed ID: 19760593
Title: The MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa.
PubMed ID: 19760593
DOI: 10.14670/hh-24.1439
PubMed ID: 19416870
Title: MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.
PubMed ID: 19416870
PubMed ID: 20581831
Title: Antimicrobial activity of mucosal-associated invariant T cells.
PubMed ID: 20581831
DOI: 10.1038/ni.1890
PubMed ID: 23457030
Title: MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells.
PubMed ID: 23457030
PubMed ID: 22692454
Title: Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.
PubMed ID: 22692454
DOI: 10.1038/mi.2012.45
PubMed ID: 27527800
Title: Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.
PubMed ID: 27527800
DOI: 10.1038/ncomms12506
PubMed ID: 27043408
Title: The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.
PubMed ID: 27043408
DOI: 10.1038/ni.3416
PubMed ID: 31113973
Title: Diverse MR1-restricted T cells in mice and humans.
PubMed ID: 31113973
PubMed ID: 31959982
Title: Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1.
PubMed ID: 31959982
PubMed ID: 23051753
Title: MR1 presents microbial vitamin B metabolites to MAIT cells.
PubMed ID: 23051753
DOI: 10.1038/nature11605
PubMed ID: 23846752
Title: Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
PubMed ID: 23846752
DOI: 10.1038/ncomms3142
PubMed ID: 24695216
Title: T-cell activation by transitory neo-antigens derived from distinct microbial pathways.
PubMed ID: 24695216
DOI: 10.1038/nature13160
PubMed ID: 26795251
Title: Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.
PubMed ID: 26795251
PubMed ID: 28166217
Title: Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.
PubMed ID: 28166217
DOI: 10.1038/ni.3679
Sequence Information:
- Length: 341
- Mass: 39366
- Checksum: 2990C1F3F0A1CAD9
- Sequence:
MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.