Details for: HLX

Gene ID: 3142

Symbol: HLX

Ensembl ID: ENSG00000136630

Description: H2.0 like homeobox

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.43
    Marker Score: 1945
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.83
    Marker Score: 24115
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.48
    Marker Score: 3015
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2524
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1305
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.23
    Marker Score: 2888
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.22
    Marker Score: 1149
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Marker Score: 546
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5300.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.91
    Marker Score: 258
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.85
    Marker Score: 8648
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.85
    Marker Score: 321
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.84
    Marker Score: 264
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 269
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.81
    Marker Score: 1170
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.75
    Marker Score: 859
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11586
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.74
    Marker Score: 397
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 351
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.71
    Marker Score: 289
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.7
    Marker Score: 344
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.67
    Marker Score: 1755
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.66
    Marker Score: 784
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.66
    Marker Score: 1637.5
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.65
    Marker Score: 805
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.65
    Marker Score: 161
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.64
    Marker Score: 646
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.64
    Marker Score: 982.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.59
    Marker Score: 144
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.55
    Marker Score: 31001
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.54
    Marker Score: 125
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.52
    Marker Score: 202
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 486
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 293
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.47
    Marker Score: 474
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.47
    Marker Score: 295.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.46
    Marker Score: 294
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.45
    Marker Score: 408
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.44
    Marker Score: 468
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.43
    Marker Score: 210
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.43
    Marker Score: 727.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.42
    Marker Score: 175
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.42
    Marker Score: 502
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 178
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.4
    Marker Score: 347
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 105
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.39
    Marker Score: 88.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.39
    Marker Score: 785
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 257
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.38
    Marker Score: 259
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.38
    Marker Score: 83
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.38
    Marker Score: 517
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.36
    Marker Score: 91
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.36
    Marker Score: 247
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.35
    Marker Score: 353
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.35
    Marker Score: 902
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.34
    Marker Score: 1421
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.33
    Marker Score: 846
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.32
    Marker Score: 140
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.32
    Marker Score: 1966
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.32
    Marker Score: 112
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.32
    Marker Score: 876.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.32
    Marker Score: 307
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1902
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 507
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.31
    Marker Score: 190
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.31
    Marker Score: 337
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.31
    Marker Score: 312
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3
    Marker Score: 70
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 552
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.3
    Marker Score: 171
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.3
    Marker Score: 88
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.3
    Marker Score: 72
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 131
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 122
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.29
    Marker Score: 84

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Other Information

**Key characteristics:** - HLX is a homeobox gene, which are a family of transcription factors that are involved in a variety of cellular processes, including embryonic development, organ growth, and tissue development. - It is expressed in a variety of cell types, including pulmonary interstitial fibroblast, mesodermal cell, colon goblet cell, immature innate lymphoid cell, cardiac endothelial cell, enterocyte of epithelium of large intestine, enteric smooth muscle cell, type EC enteroendocrine cell, and enterocyte of epithelium of small intestine. - HLX protein is a key regulator of epithelial cell proliferation, organ growth, and tissue development. **Pathways and functions:** - HLX is involved in the regulation of epithelial cell proliferation. - It is a key regulator of organ growth, both during embryonic development and in adult tissues. - It is involved in the regulation of tissue development, including the development of the cardiovascular, digestive, and respiratory systems. **Clinical significance:** - Mutations in the HLX gene have been linked to a number of human diseases, including liver cancer, colon cancer, and heart disease. - Studies of HLX have also been used to develop new treatments for cancer and other diseases. **Additional notes:** - HLX is a highly conserved gene, with a similar gene found in mice and flies. - The HLX protein is a transcription factor, which means that it can bind to DNA and regulate gene expression. - HLX is a key player in the development and maintenance of epithelial tissues.

Genular Protein ID: 3412429413

Symbol: HLX_HUMAN

Name: H2.0-like homeobox protein

UniProtKB Accession Codes:

Q14774 B2R8A8 Q15988 Q59HE7 Q9NZ75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1676597

Title: Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes.

PubMed ID: 1676597

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7806220

Title: Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1.

PubMed ID: 7806220

DOI: 10.1006/geno.1994.1394

PubMed ID: 8095486

Title: Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q.

PubMed ID: 8095486

DOI: 10.1006/geno.1993.1068

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 488
  • Mass: 50789
  • Checksum: FC2EA805DACAA0C1
  • Sequence:
    • MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFPLDPAAVK KPSFCIADIL HAGVGDLGAA 
PEGLAGASAA ALTAHLGSVH PHASFQAAAR SPLRPTPVVA PSEVPAGFPQ RLSPLSAAYH 
HHHPQQQQQQ QQPQQQQPPP PPRAGALQPP ASGTRVVPNP HHSGSAPAPS SKDLKFGIDR 
ILSAEFDPKV KEGNTLRDLT SLLTGGRPAG VHLSGLQPSA GQFFASLDPI NEASAILSPL 
NSNPRNSVQH QFQDTFPGPY AVLTKDTMPQ TYKRKRSWSR AVFSNLQRKG LEKRFEIQKY 
VTKPDRKQLA AMLGLTDAQV KVWFQNRRMK WRHSKEAQAQ KDKDKEAGEK PSGGAPAADG 
EQDERSPSRS EGEAESESSD SESLDMAPSD TERTEGSERS LHQTTVIKAP VTGALITASS 
AGSGGSSGGG GNSFSFSSAS SLSSSSTSAG CASSLGGGGA SELLPATQPT ASSAPKSPEP 
AQGALGCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.