Details for: HLX

Gene ID: 3142

Symbol: HLX

Ensembl ID: ENSG00000136630

Description: H2.0 like homeobox

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 57.4110
    Cell Significance Index: -8.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.3182
    Cell Significance Index: -7.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.8510
    Cell Significance Index: -8.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.2265
    Cell Significance Index: -8.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.2656
    Cell Significance Index: -8.9400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.1307
    Cell Significance Index: 5.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0418
    Cell Significance Index: -2.2800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9981
    Cell Significance Index: 6.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8653
    Cell Significance Index: 55.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6688
    Cell Significance Index: 10.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6024
    Cell Significance Index: 5.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5284
    Cell Significance Index: 14.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5068
    Cell Significance Index: 3.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4810
    Cell Significance Index: 8.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4243
    Cell Significance Index: 3.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4101
    Cell Significance Index: 7.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1622
    Cell Significance Index: 0.9800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1307
    Cell Significance Index: 1.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1188
    Cell Significance Index: 1.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1013
    Cell Significance Index: 1.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0588
    Cell Significance Index: 36.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0495
    Cell Significance Index: 44.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0251
    Cell Significance Index: 0.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0167
    Cell Significance Index: 3.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0005
    Cell Significance Index: -0.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0041
    Cell Significance Index: -0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0085
    Cell Significance Index: -13.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0091
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0100
    Cell Significance Index: -2.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0119
    Cell Significance Index: -0.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0151
    Cell Significance Index: -1.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0173
    Cell Significance Index: -9.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0181
    Cell Significance Index: -2.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0201
    Cell Significance Index: -7.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0232
    Cell Significance Index: -3.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0253
    Cell Significance Index: -5.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0258
    Cell Significance Index: -5.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0262
    Cell Significance Index: -7.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0302
    Cell Significance Index: -5.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0342
    Cell Significance Index: -4.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0459
    Cell Significance Index: -6.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0490
    Cell Significance Index: -5.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0535
    Cell Significance Index: -6.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0569
    Cell Significance Index: -2.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0580
    Cell Significance Index: -7.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0658
    Cell Significance Index: -1.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0704
    Cell Significance Index: -7.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0712
    Cell Significance Index: -2.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0718
    Cell Significance Index: -8.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0720
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0743
    Cell Significance Index: -8.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0851
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0865
    Cell Significance Index: -9.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0872
    Cell Significance Index: -3.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0942
    Cell Significance Index: -5.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0980
    Cell Significance Index: -2.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0994
    Cell Significance Index: -7.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1099
    Cell Significance Index: -3.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1102
    Cell Significance Index: -5.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1109
    Cell Significance Index: -8.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1118
    Cell Significance Index: -8.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1129
    Cell Significance Index: -7.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1170
    Cell Significance Index: -2.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1217
    Cell Significance Index: -5.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1338
    Cell Significance Index: -6.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1373
    Cell Significance Index: -9.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1541
    Cell Significance Index: -3.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1554
    Cell Significance Index: -9.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1746
    Cell Significance Index: -2.9900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1849
    Cell Significance Index: -2.1300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1861
    Cell Significance Index: -1.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1862
    Cell Significance Index: -10.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1935
    Cell Significance Index: -10.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1935
    Cell Significance Index: -10.0500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2005
    Cell Significance Index: -2.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2124
    Cell Significance Index: -5.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2130
    Cell Significance Index: -3.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2258
    Cell Significance Index: -7.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2260
    Cell Significance Index: -4.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2291
    Cell Significance Index: -7.9600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.2321
    Cell Significance Index: -1.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2371
    Cell Significance Index: -6.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2376
    Cell Significance Index: -10.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2506
    Cell Significance Index: -4.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2603
    Cell Significance Index: -8.2900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2618
    Cell Significance Index: -2.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2657
    Cell Significance Index: -8.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2662
    Cell Significance Index: -7.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2686
    Cell Significance Index: -4.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2791
    Cell Significance Index: -10.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HLX is a transcription factor gene that belongs to the homeobox gene family, which is characterized by the presence of a homeodomain (Hox) and a paired box (Paired) domain. The homeodomain is responsible for DNA binding, while the paired box domain is involved in transcriptional regulation. HLX is specifically expressed in cells of various tissues and organs, including the embryonic digestive tract, liver, and skeletal muscle tissue. **Pathways and Functions** HLX is involved in several developmental pathways, including: 1. **Embryonic digestive tract morphogenesis**: HLX regulates the expression of genes involved in the development of the embryonic digestive tract, including the formation of the enteric nervous system and epithelial cells. 2. **Enteric nervous system development**: HLX is essential for the development of the enteric nervous system, which controls the function of the gastrointestinal tract. 3. **Liver development**: HLX regulates the expression of genes involved in liver development, including the formation of hepatocytes and bile ducts. 4. **Skeletal muscle tissue development**: HLX is involved in the development of skeletal muscle tissue, including the formation of muscle fibers and neuromuscular junctions. 5. **Cell differentiation**: HLX regulates the expression of genes involved in cell differentiation, including the differentiation of T-helper 1 and T-helper 2 cells. HLX also regulates various cellular functions, including: 1. **Epithelial cell proliferation**: HLX promotes the proliferation of epithelial cells, which are essential for the formation of epithelial tissues. 2. **Organ growth**: HLX regulates the expression of genes involved in organ growth, including the formation of organs such as the liver and skeletal muscle tissue. 3. **Signal transduction**: HLX is involved in signal transduction pathways, including the regulation of gene expression in response to extracellular signals. **Clinical Significance** Dysregulation of HLX has been implicated in various diseases, including: 1. **Cancer**: HLX has been shown to be overexpressed in certain types of cancer, including colorectal cancer and leukemia. 2. **Autoimmune diseases**: HLX has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: HLX has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease. Further research is needed to fully understand the role of HLX in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 3412429413

Symbol: HLX_HUMAN

Name: H2.0-like homeobox protein

UniProtKB Accession Codes:

Q14774 B2R8A8 Q15988 Q59HE7 Q9NZ75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1676597

Title: Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes.

PubMed ID: 1676597

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7806220

Title: Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1.

PubMed ID: 7806220

DOI: 10.1006/geno.1994.1394

PubMed ID: 8095486

Title: Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q.

PubMed ID: 8095486

DOI: 10.1006/geno.1993.1068

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 488
  • Mass: 50789
  • Checksum: FC2EA805DACAA0C1
  • Sequence:
    • MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFPLDPAAVK KPSFCIADIL HAGVGDLGAA 
PEGLAGASAA ALTAHLGSVH PHASFQAAAR SPLRPTPVVA PSEVPAGFPQ RLSPLSAAYH 
HHHPQQQQQQ QQPQQQQPPP PPRAGALQPP ASGTRVVPNP HHSGSAPAPS SKDLKFGIDR 
ILSAEFDPKV KEGNTLRDLT SLLTGGRPAG VHLSGLQPSA GQFFASLDPI NEASAILSPL 
NSNPRNSVQH QFQDTFPGPY AVLTKDTMPQ TYKRKRSWSR AVFSNLQRKG LEKRFEIQKY 
VTKPDRKQLA AMLGLTDAQV KVWFQNRRMK WRHSKEAQAQ KDKDKEAGEK PSGGAPAADG 
EQDERSPSRS EGEAESESSD SESLDMAPSD TERTEGSERS LHQTTVIKAP VTGALITASS 
AGSGGSSGGG GNSFSFSSAS SLSSSSTSAG CASSLGGGGA SELLPATQPT ASSAPKSPEP 
AQGALGCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.