Details for: HMGB2

Gene ID: 3148

Symbol: HMGB2

Ensembl ID: ENSG00000164104

Description: high mobility group box 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.5
    Marker Score: 5383
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.88
    Marker Score: 37967
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.83
    Marker Score: 1043
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.82
    Marker Score: 3323
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.79
    Marker Score: 2625
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.66
    Marker Score: 26339
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.51
    Marker Score: 1968
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.48
    Marker Score: 2654
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.44
    Marker Score: 3507
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.39
    Marker Score: 5001
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.38
    Marker Score: 7069
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.38
    Marker Score: 1492
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.36
    Marker Score: 1990
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.34
    Marker Score: 6454
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.31
    Marker Score: 26809
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.3
    Marker Score: 6548
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.29
    Marker Score: 3890
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.28
    Marker Score: 1337
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.26
    Marker Score: 6158
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.25
    Marker Score: 696
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.22
    Marker Score: 123908
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.21
    Marker Score: 728
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.16
    Marker Score: 6063
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.14
    Marker Score: 7926
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.12
    Marker Score: 1322
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.08
    Marker Score: 5658
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.07
    Marker Score: 4865
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.07
    Marker Score: 8454
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.06
    Marker Score: 2075
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.05
    Marker Score: 887
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.04
    Marker Score: 1486
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.04
    Marker Score: 1908
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.03
    Marker Score: 1169
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.99
    Marker Score: 1329
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.97
    Marker Score: 7726
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.96
    Marker Score: 19837
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.93
    Marker Score: 952
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.92
    Marker Score: 1305
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.9
    Marker Score: 664
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.89
    Marker Score: 1136
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.86
    Marker Score: 7736
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.86
    Marker Score: 63351
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.86
    Marker Score: 918
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.84
    Marker Score: 1018
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.84
    Marker Score: 3256
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.81
    Marker Score: 4366
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.81
    Marker Score: 421
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.81
    Marker Score: 1780
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.79
    Marker Score: 2245
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.79
    Marker Score: 11628
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.78
    Marker Score: 631
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.78
    Marker Score: 800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.77
    Marker Score: 1712.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.77
    Marker Score: 11321
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.77
    Marker Score: 510
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.76
    Marker Score: 7608
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.76
    Marker Score: 1071
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.75
    Marker Score: 417
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.74
    Marker Score: 1261
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.74
    Marker Score: 1987
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.72
    Marker Score: 404.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.72
    Marker Score: 594
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.7
    Marker Score: 4964
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.7
    Marker Score: 1280
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.69
    Marker Score: 1030
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.69
    Marker Score: 16996
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.69
    Marker Score: 2388
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.67
    Marker Score: 2916
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.67
    Marker Score: 375
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.65
    Marker Score: 807
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.65
    Marker Score: 1194
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.64
    Marker Score: 1765
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.63
    Marker Score: 433
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.63
    Marker Score: 7006
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.63
    Marker Score: 775
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.63
    Marker Score: 329
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.63
    Marker Score: 1909
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.62
    Marker Score: 860
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.61
    Marker Score: 1755
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.6
    Marker Score: 514
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.6
    Marker Score: 691
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.6
    Marker Score: 13885
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.6
    Marker Score: 1154
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.59
    Marker Score: 6168.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.59
    Marker Score: 418.5
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.58
    Marker Score: 472
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.58
    Marker Score: 847
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.56
    Marker Score: 3705.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.56
    Marker Score: 636
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.56
    Marker Score: 698
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.55
    Marker Score: 1177
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.55
    Marker Score: 890
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.54
    Marker Score: 548
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.54
    Marker Score: 1452
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.54
    Marker Score: 726
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.53
    Marker Score: 874
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.53
    Marker Score: 806
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.53
    Marker Score: 350
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.52
    Marker Score: 417
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.52
    Marker Score: 758

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * High expression in various cell types * Plays a key role in cell death * Involved in DNA repair * Regulates cell migration * Involved in inflammation and tissue repair **Pathways and functions:** HMGB2 is involved in several pathways and functions, including: * Apoptosis * Apoptosis-induced DNA fragmentation * Apoptotic execution phase * Chemoattractant activity * Cis-regulatory region sequence-specific DNA binding * Damaged DNA binding * Dna binding * Double-stranded DNA binding * Four-way junction DNA binding * Non-sequence-specific DNA binding * Bending * Programmed cell death * Protein binding * Protein domain specific binding * Rna binding * Single-stranded DNA binding * Transcription cis-regulatory region binding * Transcription coactivator activity * Transcription factor binding **Clinical significance:** HMGB2 is a promising target for cancer immunotherapy. Inhibition of HMGB2 has been shown to enhance the efficacy of chemotherapy drugs and improve the survival of cancer cells. However, further research is needed to develop effective HMGB2 inhibitors that are safe and effective for clinical use.

Genular Protein ID: 275125773

Symbol: HMGB2_HUMAN

Name: High mobility group protein B2

UniProtKB Accession Codes:

P26583 B2R4K8 D3DP37 Q5U072

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 59 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1754403

Title: Sequence of human HMG2 cDNA.

PubMed ID: 1754403

DOI: 10.1093/nar/19.23.6643

PubMed ID: 1551873

Title: Structure of a gene coding for human HMG2 protein.

PubMed ID: 1551873

DOI: 10.1016/s0021-9258(19)50475-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1475204

Title: A human HMG2 cDNA with a novel 3'-untranslated region.

PubMed ID: 1475204

DOI: 10.1093/nar/20.23.6413

PubMed ID: 7797075

Title: Activation of the TFIID-TFIIA complex with HMG-2.

PubMed ID: 7797075

DOI: 10.1101/gad.9.11.1354

PubMed ID: 11909973

Title: HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

PubMed ID: 11909973

DOI: 10.1128/mcb.22.8.2810-2820.2002

PubMed ID: 12925773

Title: Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes.

PubMed ID: 12925773

DOI: 10.1091/mbc.e02-09-0581

PubMed ID: 18413230

Title: Transient HMGB protein interactions with B-DNA duplexes and complexes.

PubMed ID: 18413230

DOI: 10.1016/j.bbrc.2008.04.024

PubMed ID: 19811285

Title: High mobility group B2 is secreted by myeloid cells and has mitogenic and chemoattractant activities similar to high mobility group B1.

PubMed ID: 19811285

DOI: 10.1080/08916930902831845

PubMed ID: 19522541

Title: Nucleosome binding properties and Co-remodeling activities of native and in vivo acetylated HMGB-1 and HMGB-2 proteins.

PubMed ID: 19522541

DOI: 10.1021/bi9004304

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19965638

Title: High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription.

PubMed ID: 19965638

DOI: 10.1182/blood-2009-06-230094

PubMed ID: 20123072

Title: HMGB proteins: interactions with DNA and chromatin.

PubMed ID: 20123072

DOI: 10.1016/j.bbagrm.2009.09.008

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23877675

Title: Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein.

PubMed ID: 23877675

DOI: 10.1128/aac.00805-13

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24531895

Title: A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

PubMed ID: 24531895

DOI: 10.2119/molmed.2014.00022

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 209
  • Mass: 24034
  • Checksum: 5E65292BC4AD8373
  • Sequence:
    • MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF 
EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL 
SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG 
SKKKNEPEDE EEEEEEEDED EEEEDEDEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.