Details for: HNRNPAB

Gene ID: 3182

Symbol: HNRNPAB

Ensembl ID: ENSG00000197451

Description: heterogeneous nuclear ribonucleoprotein A/B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.92
    Marker Score: 3119
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.71
    Marker Score: 92358
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.49
    Marker Score: 7825
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.31
    Marker Score: 5645
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.29
    Marker Score: 1956
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.25
    Marker Score: 1772
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.22
    Marker Score: 925
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.22
    Marker Score: 25017
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.15
    Marker Score: 3166
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.06
    Marker Score: 10112
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.05
    Marker Score: 2153
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.98
    Marker Score: 2393
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.95
    Marker Score: 1326
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.95
    Marker Score: 1942
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.94
    Marker Score: 7924
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.92
    Marker Score: 66480
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.89
    Marker Score: 19117
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.89
    Marker Score: 12031
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.88
    Marker Score: 13974
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.86
    Marker Score: 916
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.81
    Marker Score: 1700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.79
    Marker Score: 607
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.79
    Marker Score: 446
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.78
    Marker Score: 446
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.76
    Marker Score: 506
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.75
    Marker Score: 1373
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.74
    Marker Score: 1876
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.73
    Marker Score: 1939
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.71
    Marker Score: 1828
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.71
    Marker Score: 1246
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7
    Marker Score: 659
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.69
    Marker Score: 4022
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.69
    Marker Score: 1064
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.68
    Marker Score: 1057
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.65
    Marker Score: 6100
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.65
    Marker Score: 3094
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.65
    Marker Score: 3749
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.64
    Marker Score: 1570
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.64
    Marker Score: 7054
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.64
    Marker Score: 6304.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.61
    Marker Score: 2021
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.61
    Marker Score: 3650
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.59
    Marker Score: 1603
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.58
    Marker Score: 1187
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.58
    Marker Score: 2593
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.58
    Marker Score: 737
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.57
    Marker Score: 12294
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.57
    Marker Score: 806
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.56
    Marker Score: 387
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.56
    Marker Score: 3110
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.56
    Marker Score: 1730
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.55
    Marker Score: 448
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.55
    Marker Score: 1034
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.53
    Marker Score: 4177
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.53
    Marker Score: 4169
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.52
    Marker Score: 7295.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.52
    Marker Score: 1738
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.51
    Marker Score: 38745
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.51
    Marker Score: 864
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.5
    Marker Score: 465
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.49
    Marker Score: 1557
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.49
    Marker Score: 356
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.48
    Marker Score: 12798
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.47
    Marker Score: 509
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.46
    Marker Score: 550
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.46
    Marker Score: 1550
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.46
    Marker Score: 2341
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.45
    Marker Score: 726
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.45
    Marker Score: 7619
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.45
    Marker Score: 2305
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.43
    Marker Score: 675
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.43
    Marker Score: 5617
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.43
    Marker Score: 499
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.42
    Marker Score: 701
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.41
    Marker Score: 2033.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.41
    Marker Score: 1650
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.4
    Marker Score: 371
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.4
    Marker Score: 1265
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4
    Marker Score: 12277.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.4
    Marker Score: 1479.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.4
    Marker Score: 282
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.4
    Marker Score: 448
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.4
    Marker Score: 640
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.39
    Marker Score: 333
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.37
    Marker Score: 451.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.37
    Marker Score: 1143
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.36
    Marker Score: 3212
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.36
    Marker Score: 337
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.36
    Marker Score: 774
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.35
    Marker Score: 1916
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.34
    Marker Score: 563
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.34
    Marker Score: 839
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.33
    Marker Score: 1255
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.33
    Marker Score: 306
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.33
    Marker Score: 648
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.33
    Marker Score: 366
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.33
    Marker Score: 1442
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.33
    Marker Score: 905
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.33
    Marker Score: 881
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.32
    Marker Score: 705

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Other Information

**Key characteristics** * HNRNPAB is a protein with a molecular weight of approximately 120 kDa. * It is a multi-functional protein that can be found in both the cytoplasm and the nucleus. * It is involved in a variety of cellular processes, including cytoplasm, epithelial to mesenchymal transition, mRNA binding, mRNA editing complex, mRNA modification, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nucleoplasm, nucleus, positive regulation of DNA-templated transcription, positive regulation of DNA demethylation, protein binding, regulation of gene expression, and RNA binding. **Pathways and functions** HNRNPAB is involved in a variety of cellular processes, including: * **Cytoplasm:** HNRNPAB is found in the cytoplasm of cells and is involved in the regulation of gene expression. It is a key regulator of the expression of genes involved in cell cycle regulation, proliferation, and differentiation. * **Epithelial to mesenchymal transition:** HNRNPAB is also involved in the epithelial to mesenchymal transition, a process by which epithelial cells lose their epithelial characteristics and acquire mesenchymal characteristics. * **mRNA binding:** HNRNPAB is a key regulator of mRNA binding. It is involved in the regulation of the expression of genes involved in cell cycle regulation, proliferation, and differentiation. * **mRNA editing complex:** HNRNPAB is a component of the mRNA editing complex, which is responsible for the removal of non-coding RNA molecules from mRNA. * **mRNA modification:** HNRNPAB is involved in the modification of mRNA molecules, including the addition of a polyadenylation tail. * **Negative regulation of nuclear-transcribed mRNA catabolic process:** HNRNPAB is a key regulator of the negative regulation of nuclear-transcribed mRNA catabolic process. It is involved in the control of mRNA decay and is a negative regulator of the expression of genes involved in cell cycle regulation and apoptosis. * **Nonsense-mediated decay:** HNRNPAB is also involved in the nonsense-mediated decay of mRNA molecules. * **Nucleoplasm:** HNRNPAB is a component of the nucleoplasm, a complex that is involved in the regulation of gene expression. * **Nucleus:** HNRNPAB is also a component of the nucleus, where it is involved in the regulation of gene expression. * **Positive regulation of DNA-templated transcription:** HNRNPAB is involved in the positive regulation of DNA-templated transcription. * **Positive regulation of DNA demethylation:** HNRNPAB is also involved in the positive regulation of DNA demethylation. * **Protein binding:** HNRNPAB can bind to a variety of proteins, including RNA polymerase II, which is responsible for the transcription of mRNA molecules. **Clinical significance** HNRNPAB is a gene that is involved in a variety of human diseases, including cancer and cardiovascular disease. Mutations in HNRNPAB have been linked to a number of human diseases, including cancer, heart disease, and stroke.

Genular Protein ID: 555557264

Symbol: ROAA_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein A/B

UniProtKB Accession Codes:

Q99729 B3KNN5 D3DWP7 Q04150 Q8N7U3 Q9BQ99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1717314

Title: Cloning and sequence analysis of a human type A/B hnRNP protein.

PubMed ID: 1717314

DOI: 10.1016/0014-5793(91)81249-8

PubMed ID: 8999813

Title: Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing.

PubMed ID: 8999813

DOI: 10.1074/jbc.272.3.1452

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 332
  • Mass: 36225
  • Checksum: F824A7E08D15268A
  • Sequence:
    • MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN QNGAEGDQIN 
ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI KMDPNTGRSR GFGFILFKDA 
ASVEKVLDQK EHRLDGRVID PKKAMAMKKD PVKKIFVGGL NPESPTEEKI REYFGEFGEI 
EAIELPMDPK LNKRRGFVFI TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY 
GSGGRGNRNR GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY 
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.