Details for: HNRNPAB

Gene ID: 3182

Symbol: HNRNPAB

Ensembl ID: ENSG00000197451

Description: heterogeneous nuclear ribonucleoprotein A/B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.4726
    Cell Significance Index: -36.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 187.6059
    Cell Significance Index: -47.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 141.8384
    Cell Significance Index: -58.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.9871
    Cell Significance Index: -58.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 121.4256
    Cell Significance Index: -49.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 111.8034
    Cell Significance Index: -57.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.8749
    Cell Significance Index: -58.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.7681
    Cell Significance Index: -50.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.8678
    Cell Significance Index: -55.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.6572
    Cell Significance Index: -49.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.9491
    Cell Significance Index: -58.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3594
    Cell Significance Index: -34.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0469
    Cell Significance Index: -19.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.0483
    Cell Significance Index: 108.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.9670
    Cell Significance Index: 179.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6698
    Cell Significance Index: 99.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8020
    Cell Significance Index: 80.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.6576
    Cell Significance Index: 76.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6526
    Cell Significance Index: 124.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.5516
    Cell Significance Index: 180.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.4998
    Cell Significance Index: 271.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4129
    Cell Significance Index: 296.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2718
    Cell Significance Index: 20.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1832
    Cell Significance Index: 393.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9263
    Cell Significance Index: 124.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8816
    Cell Significance Index: 831.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6623
    Cell Significance Index: 86.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5620
    Cell Significance Index: 54.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5501
    Cell Significance Index: 846.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5246
    Cell Significance Index: 33.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3513
    Cell Significance Index: 14.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3217
    Cell Significance Index: 30.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1963
    Cell Significance Index: 13.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0931
    Cell Significance Index: 56.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0648
    Cell Significance Index: 146.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0631
    Cell Significance Index: 79.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0612
    Cell Significance Index: 137.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9724
    Cell Significance Index: 114.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9049
    Cell Significance Index: 42.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7394
    Cell Significance Index: 120.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7312
    Cell Significance Index: 72.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6981
    Cell Significance Index: 18.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6216
    Cell Significance Index: 16.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5571
    Cell Significance Index: 11.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5258
    Cell Significance Index: 474.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4842
    Cell Significance Index: 96.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4455
    Cell Significance Index: 15.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4211
    Cell Significance Index: 6.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3093
    Cell Significance Index: 58.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2876
    Cell Significance Index: 1.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2687
    Cell Significance Index: 34.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1627
    Cell Significance Index: 27.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0370
    Cell Significance Index: 28.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0166
    Cell Significance Index: 3.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0028
    Cell Significance Index: 0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0132
    Cell Significance Index: -8.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0172
    Cell Significance Index: -6.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0209
    Cell Significance Index: -39.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0240
    Cell Significance Index: -36.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0273
    Cell Significance Index: -37.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0278
    Cell Significance Index: -20.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0283
    Cell Significance Index: -52.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0463
    Cell Significance Index: -0.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0471
    Cell Significance Index: -2.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0487
    Cell Significance Index: -4.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0658
    Cell Significance Index: -41.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0746
    Cell Significance Index: -42.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1046
    Cell Significance Index: -47.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1230
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1311
    Cell Significance Index: -27.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1593
    Cell Significance Index: -45.8400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1605
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1679
    Cell Significance Index: -19.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2058
    Cell Significance Index: -23.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2072
    Cell Significance Index: -5.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2317
    Cell Significance Index: -5.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2680
    Cell Significance Index: -31.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2975
    Cell Significance Index: -18.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2991
    Cell Significance Index: -5.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3112
    Cell Significance Index: -45.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3140
    Cell Significance Index: -7.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3254
    Cell Significance Index: -4.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4747
    Cell Significance Index: -13.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4780
    Cell Significance Index: -29.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5434
    Cell Significance Index: -43.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5463
    Cell Significance Index: -41.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5642
    Cell Significance Index: -58.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6800
    Cell Significance Index: -35.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7452
    Cell Significance Index: -50.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7779
    Cell Significance Index: -47.6900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.8229
    Cell Significance Index: -5.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8996
    Cell Significance Index: -24.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9295
    Cell Significance Index: -17.1800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.9346
    Cell Significance Index: -6.2000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.0736
    Cell Significance Index: -10.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0752
    Cell Significance Index: -11.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0928
    Cell Significance Index: -28.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2422
    Cell Significance Index: -45.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2433
    Cell Significance Index: -50.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA-binding properties:** HNRNPAB is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which is known for its ability to bind to RNA molecules, including mRNAs, snRNAs, and other non-coding RNAs. 2. **Dual localization:** HNRNPAB exhibits dual localization in both the nucleus and cytoplasm, allowing it to regulate gene expression and mRNA processing in different compartments. 3. **Regulation of transcription:** HNRNPAB is a key component of the RNA polymerase II transcription regulator complex, which regulates the transcription of protein-coding genes. 4. **Stabilization of mRNAs:** HNRNPAB has been shown to stabilize specific mRNAs by preventing their degradation, thereby modulating gene expression. **Pathways and Functions:** 1. **Positive regulation of DNA-templated transcription:** HNRNPAB regulates the transcription of protein-coding genes by binding to the pre-mRNA and facilitating its processing and translation. 2. **Regulation of gene expression:** HNRNPAB modulates gene expression by regulating the stability and translation of mRNAs, as well as influencing the activity of RNA-binding proteins. 3. **Negative regulation of nuclear-transcribed mRNA catabolic process:** HNRNPAB prevents the degradation of mRNAs by binding to the 5' untranslated region (UTR) of mRNAs, thereby stabilizing them. 4. **Regulation of nonsense-mediated decay:** HNRNPAB has been shown to inhibit nonsense-mediated decay, a process that degrades mRNAs containing premature stop codons. **Clinical Significance:** 1. **Cancer:** Alterations in HNRNPAB expression have been observed in various types of cancer, including breast, lung, and colon cancer. Its dysregulation may contribute to tumorigenesis and cancer progression. 2. **Neurodegenerative diseases:** HNRNPAB has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation may contribute to disease pathogenesis. 3. **Regenerative medicine:** HNRNPAB plays a critical role in the regulation of gene expression and cellular processes in stem cells, making it a potential target for regenerative therapies. 4. **Skeletal muscle diseases:** HNRNPAB has been shown to play a role in the regulation of gene expression in skeletal muscle cells, making it a potential target for the treatment of muscle-related disorders. In conclusion, HNRNPAB is a critical regulator of gene expression and cellular processes, with implications for various diseases and disorders. Further research is needed to fully understand its role in human biology and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 555557264

Symbol: ROAA_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein A/B

UniProtKB Accession Codes:

Q99729 B3KNN5 D3DWP7 Q04150 Q8N7U3 Q9BQ99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1717314

Title: Cloning and sequence analysis of a human type A/B hnRNP protein.

PubMed ID: 1717314

DOI: 10.1016/0014-5793(91)81249-8

PubMed ID: 8999813

Title: Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing.

PubMed ID: 8999813

DOI: 10.1074/jbc.272.3.1452

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 332
  • Mass: 36225
  • Checksum: F824A7E08D15268A
  • Sequence:
    • MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN QNGAEGDQIN 
ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI KMDPNTGRSR GFGFILFKDA 
ASVEKVLDQK EHRLDGRVID PKKAMAMKKD PVKKIFVGGL NPESPTEEKI REYFGEFGEI 
EAIELPMDPK LNKRRGFVFI TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY 
GSGGRGNRNR GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY 
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.