Details for: HOXA6

Gene ID: 3203

Symbol: HOXA6

Ensembl ID: ENSG00000106006

Description: homeobox A6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.1099
    Cell Significance Index: -6.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.4117
    Cell Significance Index: -4.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3124
    Cell Significance Index: -6.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6852
    Cell Significance Index: -6.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0576
    Cell Significance Index: 54.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0401
    Cell Significance Index: 47.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7054
    Cell Significance Index: 10.5700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6738
    Cell Significance Index: 10.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6270
    Cell Significance Index: 40.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6190
    Cell Significance Index: 21.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5956
    Cell Significance Index: 58.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5463
    Cell Significance Index: 11.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5392
    Cell Significance Index: 4.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4680
    Cell Significance Index: 422.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4473
    Cell Significance Index: 10.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3837
    Cell Significance Index: 11.3000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.3668
    Cell Significance Index: 2.0900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3229
    Cell Significance Index: 3.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3182
    Cell Significance Index: 51.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3136
    Cell Significance Index: 34.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2728
    Cell Significance Index: 7.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2537
    Cell Significance Index: 15.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2531
    Cell Significance Index: 45.6200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.2288
    Cell Significance Index: 2.0000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1920
    Cell Significance Index: 1.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1697
    Cell Significance Index: 3.5200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1681
    Cell Significance Index: 2.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1624
    Cell Significance Index: 11.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1268
    Cell Significance Index: 6.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1040
    Cell Significance Index: 2.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0975
    Cell Significance Index: 2.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0941
    Cell Significance Index: 17.9000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0923
    Cell Significance Index: 1.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0296
    Cell Significance Index: 1.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0077
    Cell Significance Index: 5.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0066
    Cell Significance Index: 0.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0060
    Cell Significance Index: 0.1000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0051
    Cell Significance Index: -0.7000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0053
    Cell Significance Index: -0.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0065
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0087
    Cell Significance Index: -3.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0106
    Cell Significance Index: -5.8100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0118
    Cell Significance Index: -0.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0239
    Cell Significance Index: -0.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0252
    Cell Significance Index: -0.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0285
    Cell Significance Index: -1.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0307
    Cell Significance Index: -3.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0324
    Cell Significance Index: -0.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0327
    Cell Significance Index: -6.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0421
    Cell Significance Index: -3.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0423
    Cell Significance Index: -4.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0438
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0499
    Cell Significance Index: -5.7200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0508
    Cell Significance Index: -0.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0539
    Cell Significance Index: -6.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0542
    Cell Significance Index: -3.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0570
    Cell Significance Index: -0.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0591
    Cell Significance Index: -3.6300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0602
    Cell Significance Index: -0.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0628
    Cell Significance Index: -1.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0671
    Cell Significance Index: -2.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0677
    Cell Significance Index: -5.0500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0703
    Cell Significance Index: -0.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1021
    Cell Significance Index: -0.9400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1032
    Cell Significance Index: -1.3500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1084
    Cell Significance Index: -1.3700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1281
    Cell Significance Index: -0.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1361
    Cell Significance Index: -3.6400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1439
    Cell Significance Index: -2.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1513
    Cell Significance Index: -3.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1522
    Cell Significance Index: -2.1800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1547
    Cell Significance Index: -1.5700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1576
    Cell Significance Index: -1.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1610
    Cell Significance Index: -5.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1627
    Cell Significance Index: -4.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1700
    Cell Significance Index: -7.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1734
    Cell Significance Index: -1.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1781
    Cell Significance Index: -2.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1891
    Cell Significance Index: -2.3000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2107
    Cell Significance Index: -3.0200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2112
    Cell Significance Index: -5.3800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2116
    Cell Significance Index: -2.1900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2117
    Cell Significance Index: -1.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2125
    Cell Significance Index: -4.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2196
    Cell Significance Index: -3.2000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2228
    Cell Significance Index: -3.0300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2232
    Cell Significance Index: -2.2800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2232
    Cell Significance Index: -2.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2261
    Cell Significance Index: -4.9500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.2394
    Cell Significance Index: -2.7800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2438
    Cell Significance Index: -2.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2453
    Cell Significance Index: -6.4500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2482
    Cell Significance Index: -3.1400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2549
    Cell Significance Index: -3.4900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2566
    Cell Significance Index: -3.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2572
    Cell Significance Index: -10.5400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2614
    Cell Significance Index: -2.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Homeobox gene family:** HOXA6 belongs to the homeobox gene family, which encodes transcription factors that regulate embryonic development and tissue patterning. 2. **Widespread expression:** HOXA6 is expressed in various cell types, including mesangial cells, common lymphoid progenitors, thymocytes, and goblet cells, highlighting its role in immune system development and function. 3. **RNA polymerase II regulation:** HOXA6 regulates transcription by RNA polymerase II, a key enzyme involved in gene expression. 4. **Chromatin remodeling:** HOXA6 is involved in chromatin remodeling, a process that regulates gene expression by altering chromatin structure. **Pathways and Functions:** 1. **Anterior/posterior pattern specification:** HOXA6 plays a crucial role in anterior/posterior pattern specification during embryonic development, regulating the formation of the nephric duct and kidney development. 2. **Developmental biology:** HOXA6 is involved in various developmental processes, including the development of the embryonic skeletal system and the formation of the nephric duct. 3. **RNA polymerase II-specific transcription:** HOXA6 regulates transcription by RNA polymerase II, a key enzyme involved in gene expression. 4. **Chromatin regulation:** HOXA6 is involved in chromatin remodeling, a process that regulates gene expression by altering chromatin structure. **Clinical Significance:** 1. **Immune system disorders:** Dysregulation of HOXA6 has been linked to various immune-related disorders, including autoimmune diseases and lymphoid malignancies. 2. **Cancer:** HOXA6 has been implicated in the development and progression of certain cancers, including lymphoma and leukemia. 3. **Kidney disease:** HOXA6 plays a role in kidney development and function, and its dysregulation may contribute to kidney disease. 4. **Neurological disorders:** HOXA6 has been implicated in the development of neurological disorders, including schizophrenia and autism. In conclusion, HOXA6 is a critical gene that plays a pivotal role in the development and function of the immune system. Its dysregulation has been linked to various immune-related disorders, highlighting the importance of this gene in maintaining immune homeostasis. Further research is necessary to fully understand the role of HOXA6 in immune system development and function, and to explore its potential as a therapeutic target for immune-related disorders.

Genular Protein ID: 2106708185

Symbol: HXA6_HUMAN

Name: Homeobox protein Hox-A6

UniProtKB Accession Codes:

P31267 A4D192 Q2M3G3 Q9UPM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 233
  • Mass: 26339
  • Checksum: 9D9DFD03FAF25967
  • Sequence:
    • MSSYFVNPTF PGSLPSGQDS FLGQLPLYQA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ 
SNSVLACNRA SYEYGASCFY SDKDLSGASP SGSGKQRGPG DYLHFSPEQQ YKPDSSSGQG 
KALHDEGADR KYTSPVYPWM QRMNSCAGAV YGSHGRRGRQ TYTRYQTLEL EKEFHFNRYL 
TRRRRIEIAN ALCLTERQIK IWFQNRRMKW KKENKLINST QPSGEDSEAK AGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.