Details for: HOXA6

Gene ID: 3203

Symbol: HOXA6

Ensembl ID: ENSG00000106006

Description: homeobox A6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.54
    Marker Score: 1863.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.47
    Marker Score: 1003
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.31
    Marker Score: 1369
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7620
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1
    Marker Score: 316.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5325
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 379
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.86
    Marker Score: 582.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1836
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.73
    Marker Score: 486.5
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.73
    Marker Score: 261
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.72
    Marker Score: 849
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 474
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.71
    Marker Score: 1490
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 410
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6
    Marker Score: 1027.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.55
    Marker Score: 5577
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.54
    Marker Score: 140
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.53
    Marker Score: 325
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.53
    Marker Score: 124
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.53
    Marker Score: 842
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 958
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 445.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.44
    Marker Score: 4981
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.42
    Marker Score: 420
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.42
    Marker Score: 280
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 131
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.4
    Marker Score: 612
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.38
    Marker Score: 768
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.35
    Marker Score: 374.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.35
    Marker Score: 355
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.33
    Marker Score: 314
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.3
    Marker Score: 90
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.26
    Marker Score: 85
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.26
    Marker Score: 98
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 108
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.24
    Marker Score: 347
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.23
    Marker Score: 58
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.22
    Marker Score: 103
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.22
    Marker Score: 511
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 119
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.21
    Marker Score: 80
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 121
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2
    Marker Score: 146
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.19
    Marker Score: 55
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.18
    Marker Score: 2395
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.18
    Marker Score: 466
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.18
    Marker Score: 352
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.17
    Marker Score: 747
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.17
    Marker Score: 127
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.17
    Marker Score: 122
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.16
    Marker Score: 2557
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.15
    Marker Score: 86
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 882
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.14
    Marker Score: 151
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.14
    Marker Score: 335
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.14
    Marker Score: 265
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.14
    Marker Score: 176
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 71
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.13
    Marker Score: 72
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.11
    Marker Score: 356

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Other Information

**Key characteristics:** - HOXA6 is a homeodomain protein that is expressed in a variety of cell types. - It is involved in the specification of the anterior/posterior (A/P) axis of the embryo. - It is also involved in the development of the kidney, the neural tube, and the cardiovascular system. **Pathways and functions:** - HOXA6 is a key regulator of the anterior/posterior (A/P) axis of the embryo. - It is expressed in a variety of cell types, including mesangial cells, common lymphoid progenitor cells, and renal cells. - HOXA6 is required for the early formation of the heart, brain, and other tissues along the A/P axis. - It is also involved in the specification of the neural tube and the development of the kidney. **Clinical significance:** HOXA6 mutations have been linked to a number of human diseases, including heart defects, kidney dysfunction, and cancer. - Mutations in HOXA6 have been shown to be responsible for the development of Hirschsprung's disease, an inherited disorder that affects the development of the digestive tract. - HOXA6 is a promising target for the treatment of cancer, as it is frequently overexpressed in cancer cells.

Genular Protein ID: 2106708185

Symbol: HXA6_HUMAN

Name: Homeobox protein Hox-A6

UniProtKB Accession Codes:

P31267 A4D192 Q2M3G3 Q9UPM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 233
  • Mass: 26339
  • Checksum: 9D9DFD03FAF25967
  • Sequence:
    • MSSYFVNPTF PGSLPSGQDS FLGQLPLYQA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ 
SNSVLACNRA SYEYGASCFY SDKDLSGASP SGSGKQRGPG DYLHFSPEQQ YKPDSSSGQG 
KALHDEGADR KYTSPVYPWM QRMNSCAGAV YGSHGRRGRQ TYTRYQTLEL EKEFHFNRYL 
TRRRRIEIAN ALCLTERQIK IWFQNRRMKW KKENKLINST QPSGEDSEAK AGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.