Details for: ERAS

Gene ID: 3266

Symbol: ERAS

Ensembl ID: ENSG00000187682

Description: ES cell expressed Ras

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 10.8007
    Cell Significance Index: -1.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.7417
    Cell Significance Index: -1.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3548
    Cell Significance Index: 21.7500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1225
    Cell Significance Index: 1.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0969
    Cell Significance Index: 1.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0850
    Cell Significance Index: 8.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0737
    Cell Significance Index: 1.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0700
    Cell Significance Index: 63.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0349
    Cell Significance Index: 0.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0336
    Cell Significance Index: 3.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0326
    Cell Significance Index: 5.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0318
    Cell Significance Index: 11.4000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0287
    Cell Significance Index: 0.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0261
    Cell Significance Index: 0.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0256
    Cell Significance Index: 4.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0170
    Cell Significance Index: 0.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0144
    Cell Significance Index: 2.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0137
    Cell Significance Index: 0.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0127
    Cell Significance Index: 0.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0091
    Cell Significance Index: 1.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0005
    Cell Significance Index: -0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0023
    Cell Significance Index: -1.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0060
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0071
    Cell Significance Index: -0.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0072
    Cell Significance Index: -1.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0073
    Cell Significance Index: -0.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0080
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0089
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0092
    Cell Significance Index: -1.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0121
    Cell Significance Index: -1.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0123
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0126
    Cell Significance Index: -1.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0127
    Cell Significance Index: -1.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0136
    Cell Significance Index: -0.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0158
    Cell Significance Index: -1.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0161
    Cell Significance Index: -1.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0219
    Cell Significance Index: -0.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0228
    Cell Significance Index: -0.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0234
    Cell Significance Index: -0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0236
    Cell Significance Index: -1.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0237
    Cell Significance Index: -0.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0245
    Cell Significance Index: -0.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0250
    Cell Significance Index: -0.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0251
    Cell Significance Index: -1.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0261
    Cell Significance Index: -0.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0282
    Cell Significance Index: -1.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0299
    Cell Significance Index: -1.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0302
    Cell Significance Index: -1.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0317
    Cell Significance Index: -0.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0317
    Cell Significance Index: -1.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0329
    Cell Significance Index: -0.6500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0359
    Cell Significance Index: -0.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0377
    Cell Significance Index: -1.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0391
    Cell Significance Index: -1.2800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0393
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0396
    Cell Significance Index: -1.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0401
    Cell Significance Index: -1.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0405
    Cell Significance Index: -1.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0420
    Cell Significance Index: -0.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0446
    Cell Significance Index: -1.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0451
    Cell Significance Index: -0.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0466
    Cell Significance Index: -1.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0484
    Cell Significance Index: -1.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0486
    Cell Significance Index: -1.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0487
    Cell Significance Index: -0.9900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0488
    Cell Significance Index: -1.5500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0493
    Cell Significance Index: -0.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0504
    Cell Significance Index: -0.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0508
    Cell Significance Index: -0.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0516
    Cell Significance Index: -1.2900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0524
    Cell Significance Index: -0.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0526
    Cell Significance Index: -1.5500
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0529
    Cell Significance Index: -0.4700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0533
    Cell Significance Index: -0.7100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0543
    Cell Significance Index: -0.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0551
    Cell Significance Index: -0.8000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0564
    Cell Significance Index: -1.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0565
    Cell Significance Index: -1.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0567
    Cell Significance Index: -1.4900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0570
    Cell Significance Index: -0.5900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0577
    Cell Significance Index: -0.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0587
    Cell Significance Index: -1.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0588
    Cell Significance Index: -1.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0605
    Cell Significance Index: -0.8600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0618
    Cell Significance Index: -1.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERAS is a member of the Ras family of GTPases, which are small, GTP-binding proteins that regulate a wide range of cellular processes, including cell growth, differentiation, and survival. ERAS is predominantly expressed in cells of the immune system, including glial cells, endothelial cells, dendritic cells, T cells, and plasma cells, as well as in epithelial cells of the gut, such as enterocytes and goblet cells. Its expression is also observed in hematopoietic stem cells, including granulocyte-monocyte progenitor cells and intestinal crypt stem cells. **Pathways and Functions:** ERAS is involved in several critical signaling pathways, including: 1. **GDP-binding and GTPase activity**: ERAS regulates the exchange of GDP for GTP, which triggers the activation of downstream signaling pathways. 2. **G protein activity**: ERAS interacts with G proteins to modulate the activity of various effectors, including adenylyl cyclase and phospholipase C. 3. **GTP binding**: ERAS binds GTP, which activates the protein and triggers downstream signaling cascades. 4. **Ras protein signal transduction**: ERAS is a key component of the Ras signaling pathway, which regulates cell growth, differentiation, and survival. ERAS's involvement in these pathways suggests that it plays a critical role in regulating cellular responses to various stimuli, including growth factors, cytokines, and stress signals. **Clinical Significance:** ERAS's expression in multiple cell types and its involvement in key signaling pathways have significant implications for our understanding of various diseases, including: 1. **Immunological disorders**: ERAS's role in T cell activation and plasma cell differentiation suggests that dysregulation of ERAS may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Gastrointestinal disorders**: ERAS's expression in enterocytes and goblet cells suggests that it may play a role in the regulation of gut homeostasis and the development of gastrointestinal disorders, such as inflammatory bowel disease. 3. **Cancer**: ERAS's involvement in the Ras signaling pathway suggests that it may be a target for cancer therapy, particularly in tumors with aberrant Ras activity. In conclusion, ERAS is a critical regulator of cellular signaling pathways, with significant implications for our understanding of immunological and gastrointestinal disorders. Further research is needed to fully elucidate the functions and dysregulations of ERAS in human disease.

Genular Protein ID: 563227897

Symbol: RASE_HUMAN

Name: GTPase ERas

UniProtKB Accession Codes:

Q7Z444

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 Rhea 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 12774123

Title: Role of Eras in promoting tumor-like properties in mouse embryonic stem cells.

PubMed ID: 12774123

DOI: 10.1038/nature01646

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 233
  • Mass: 25287
  • Checksum: D5451F95978E7823
  • Sequence:
    • MELPTKPGTF DLGLATWSPS FQGETHRAQA RRRDVGRQLP EYKAVVVGAS GVGKSALTIQ 
LNHQCFVEDH DPTIQDSYWK ELTLDSGDCI LNVLDTAGQA IHRALRDQCL AVCDGVLGVF 
ALDDPSSLIQ LQQIWATWGP HPAQPLVLVG NKCDLVTTAG DAHAAAAALA HSWGAHFVET 
SAKTRQGVEE AFSLLVHEIQ RVQEAMAKEP MARSCREKTR HQKATCHCGC SVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.