Details for: ERAS

Gene ID: 3266

Symbol: ERAS

Ensembl ID: ENSG00000187682

Description: ES cell expressed Ras

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 2.73
    Marker Score: 3000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.28
    Marker Score: 2294.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.21
    Marker Score: 1521
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2004
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.97
    Marker Score: 2197
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.73
    Marker Score: 2980
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1178
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7686
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.11
    Marker Score: 461
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.06
    Marker Score: 1011
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.91
    Marker Score: 7721
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 688
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1175
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 516
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.56
    Marker Score: 296
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 449
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 115
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 210
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 358
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.34
    Marker Score: 599
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3
    Marker Score: 167.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 568.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.27
    Marker Score: 394
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.25
    Marker Score: 308
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 113.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.21
    Marker Score: 424
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 43.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.15
    Marker Score: 60
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 126
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.13
    Marker Score: 126
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1
    Marker Score: 126
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 121
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.09
    Marker Score: 332
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 343
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.08
    Marker Score: 98
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.08
    Marker Score: 1125
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.07
    Marker Score: 671
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 137
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 158
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.07
    Marker Score: 2527
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.06
    Marker Score: 498
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.06
    Marker Score: 161
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.05
    Marker Score: 1943
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.05
    Marker Score: 231
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.05
    Marker Score: 73
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.04
    Marker Score: 887
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.04
    Marker Score: 79
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.04
    Marker Score: 168
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 91
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.04
    Marker Score: 800

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Other Information

**Key characteristics:** - ERAS is a cell surface protein that is expressed in a variety of cell types. - It is a GTPase that is involved in the regulation of the Ras signaling pathway. - ERAS is a key regulator of cell growth, differentiation, and migration. **Pathways and functions:** - ERAS binds to GTP and activates it, which leads to the activation of the Ras signaling pathway. - The Ras signaling pathway is involved in a variety of cellular processes, including cell growth, differentiation, and migration. - ERAS is a key regulator of these processes, and its expression is often altered in cancer. **Clinical significance:** - Mutations in the ERAS gene have been linked to a number of human diseases, including cancer and developmental disorders. - ERAS inhibitors are being investigated as a treatment for cancer and other diseases that are characterized by abnormal cell growth.

Genular Protein ID: 563227897

Symbol: RASE_HUMAN

Name: GTPase ERas

UniProtKB Accession Codes:

Q7Z444

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 Rhea 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 12774123

Title: Role of Eras in promoting tumor-like properties in mouse embryonic stem cells.

PubMed ID: 12774123

DOI: 10.1038/nature01646

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 233
  • Mass: 25287
  • Checksum: D5451F95978E7823
  • Sequence:
    • MELPTKPGTF DLGLATWSPS FQGETHRAQA RRRDVGRQLP EYKAVVVGAS GVGKSALTIQ 
LNHQCFVEDH DPTIQDSYWK ELTLDSGDCI LNVLDTAGQA IHRALRDQCL AVCDGVLGVF 
ALDDPSSLIQ LQQIWATWGP HPAQPLVLVG NKCDLVTTAG DAHAAAAALA HSWGAHFVET 
SAKTRQGVEE AFSLLVHEIQ RVQEAMAKEP MARSCREKTR HQKATCHCGC SVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.