Details for: HSF2

Gene ID: 3298

Symbol: HSF2

Ensembl ID: ENSG00000025156

Description: heat shock transcription factor 2

Associated with

  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Identical protein binding
    (GO:0042802)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii intronic transcription regulatory region sequence-specific dna binding
    (GO:0001162)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spermatogenesis
    (GO:0007283)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 159.8892
    Cell Significance Index: -24.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.5779
    Cell Significance Index: -24.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.0278
    Cell Significance Index: -27.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.6145
    Cell Significance Index: -19.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.2092
    Cell Significance Index: -26.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.8119
    Cell Significance Index: -19.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4103
    Cell Significance Index: -22.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7206
    Cell Significance Index: -26.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0037
    Cell Significance Index: -18.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0967
    Cell Significance Index: 399.0100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.4834
    Cell Significance Index: 36.2000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.3077
    Cell Significance Index: 21.1000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0800
    Cell Significance Index: 8.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0539
    Cell Significance Index: 211.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9530
    Cell Significance Index: 11.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8158
    Cell Significance Index: 11.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7907
    Cell Significance Index: 713.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7139
    Cell Significance Index: 8.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7092
    Cell Significance Index: 39.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6764
    Cell Significance Index: 18.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6590
    Cell Significance Index: 65.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6462
    Cell Significance Index: 105.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6374
    Cell Significance Index: 69.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6134
    Cell Significance Index: 220.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6059
    Cell Significance Index: 38.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5631
    Cell Significance Index: 33.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5454
    Cell Significance Index: 33.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5362
    Cell Significance Index: 41.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5266
    Cell Significance Index: 18.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5144
    Cell Significance Index: 59.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4977
    Cell Significance Index: 98.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3315
    Cell Significance Index: 229.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3310
    Cell Significance Index: 7.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3111
    Cell Significance Index: 7.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3081
    Cell Significance Index: 6.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2800
    Cell Significance Index: 7.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2621
    Cell Significance Index: 115.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2500
    Cell Significance Index: 17.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2392
    Cell Significance Index: 32.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2066
    Cell Significance Index: 5.3100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1995
    Cell Significance Index: 3.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1950
    Cell Significance Index: 8.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1514
    Cell Significance Index: 4.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1496
    Cell Significance Index: 4.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1339
    Cell Significance Index: 24.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1324
    Cell Significance Index: 3.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1316
    Cell Significance Index: 71.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1278
    Cell Significance Index: 16.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0894
    Cell Significance Index: 168.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0719
    Cell Significance Index: 1.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0525
    Cell Significance Index: 6.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0520
    Cell Significance Index: 0.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0498
    Cell Significance Index: 31.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0436
    Cell Significance Index: 2.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0425
    Cell Significance Index: 1.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0420
    Cell Significance Index: 0.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0398
    Cell Significance Index: 61.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0389
    Cell Significance Index: 2.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0359
    Cell Significance Index: 66.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0351
    Cell Significance Index: 1.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0345
    Cell Significance Index: 2.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0313
    Cell Significance Index: 1.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0098
    Cell Significance Index: 4.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0079
    Cell Significance Index: 10.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0058
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0175
    Cell Significance Index: -2.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0188
    Cell Significance Index: -2.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0209
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0223
    Cell Significance Index: -16.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0252
    Cell Significance Index: -1.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0266
    Cell Significance Index: -20.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0271
    Cell Significance Index: -0.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0448
    Cell Significance Index: -27.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0551
    Cell Significance Index: -2.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0617
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0733
    Cell Significance Index: -12.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0734
    Cell Significance Index: -1.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0743
    Cell Significance Index: -21.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0944
    Cell Significance Index: -2.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0968
    Cell Significance Index: -3.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1127
    Cell Significance Index: -7.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1198
    Cell Significance Index: -8.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1209
    Cell Significance Index: -12.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1259
    Cell Significance Index: -26.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1310
    Cell Significance Index: -13.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1420
    Cell Significance Index: -3.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1498
    Cell Significance Index: -7.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1551
    Cell Significance Index: -3.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1596
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1606
    Cell Significance Index: -18.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1876
    Cell Significance Index: -2.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1926
    Cell Significance Index: -5.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2676
    Cell Significance Index: -21.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2747
    Cell Significance Index: -3.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3042
    Cell Significance Index: -8.6800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3125
    Cell Significance Index: -4.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3298
    Cell Significance Index: -20.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3473
    Cell Significance Index: -11.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding transcription activator**: HSF2 is a transcription factor that binds to specific DNA sequences, thereby regulating the expression of target genes. 2. **RNA polymerase II-specific**: HSF2 interacts with RNA polymerase II, a key enzyme responsible for transcribing genes into mRNA. 3. **Heat shock-inducible**: HSF2 is activated in response to heat shock, allowing it to regulate the expression of heat shock proteins. 4. **Cell-type specific**: HSF2 expression is tissue-specific, with significant expression in neural progenitor cells, GABAergic neurons, and male germ cells. **Pathways and Functions:** 1. **Heat shock response**: HSF2 regulates the expression of heat shock proteins, which protect cells against protein misfolding, aggregation, and degradation. 2. **Transcriptional regulation**: HSF2 interacts with RNA polymerase II to regulate the transcription of target genes, including those involved in cellular stress response, development, and differentiation. 3. **Cell survival and differentiation**: HSF2 plays a critical role in maintaining cellular homeostasis, particularly in neural progenitor cells, where it regulates the expression of genes involved in differentiation and survival. 4. **Spermatogenesis**: HSF2 is essential for male germ cell development, regulating the expression of genes involved in spermatogenesis. **Clinical Significance:** Dysregulation of HSF2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: HSF2 dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: HSF2 overexpression has been observed in certain types of cancer, including breast cancer and lung cancer. 3. **Neurodevelopmental disorders**: HSF2 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, HSF2 is a critical transcriptional regulator that plays a pivotal role in maintaining cellular homeostasis, particularly in response to environmental stressors. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of HSF2 function and its role in human disease.

Genular Protein ID: 2433058637

Symbol: HSF2_HUMAN

Name: Heat shock factor protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1871106

Title: Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.

PubMed ID: 1871106

DOI: 10.1073/pnas.88.16.6911

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8339932

Title: Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2.

PubMed ID: 8339932

DOI: 10.1101/gad.7.8.1549

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 536
  • Mass: 60348
  • Checksum: 00DFD05CFD9DF0D3
  • Sequence:
  • MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP KYFKHNNMAS 
    FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ DDLLENIKRK VSSSKPEENK 
    IRQEDLTKII SSAQKVQIKQ ETIESRLSEL KSENESLWKE VSELRAKHAQ QQQVIRKIVQ 
    FIVTLVQNNQ LVSLKRKRPL LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE 
    RISDDIIIYD VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ 
    SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND NINLLGKVEL 
    LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDLFTSSVQM NPTDYINNTK SENKGLETTK 
    NNVVQPVSEE GRKSKSKPDK QLIQYTAFPL LAFLDGNPAS SVEQASTTAS SEVLSSVDKP 
    IEVDELLDSS LDPEPTQSKL VRLEPLTEAE ASEATLFYLC ELAPAPLDSD MPLLDS

Genular Protein ID: 3388633090

Symbol: Q9BS48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 230
  • Mass: 27027
  • Checksum: 01C72FAA9E62D37A
  • Sequence:
  • MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP KYFKHNNMAS 
    FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ DDLLENIKRK VSSSKPEENK 
    IRQEDLTKII SSAQKVQIKQ ETIESRLSEL KSENESLWKE VSELRAKHAQ QQQVIRKIVQ 
    FIVTLVQNNQ LVSLKRKRPL LLNTNGAQKK NLFQHIVKEP TDNHHHKVIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.