Details for: HSF2

Gene ID: 3298

Symbol: HSF2

Ensembl ID: ENSG00000025156

Description: heat shock transcription factor 2

Associated with

  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Identical protein binding
    (GO:0042802)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii intronic transcription regulatory region sequence-specific dna binding
    (GO:0001162)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spermatogenesis
    (GO:0007283)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.68
    Marker Score: 14232
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.64
    Marker Score: 11018
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.12
    Marker Score: 3042
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.66
    Marker Score: 479
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.46
    Marker Score: 1172
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.35
    Marker Score: 11579
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.29
    Marker Score: 12254
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.23
    Marker Score: 75562
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.21
    Marker Score: 1863
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.2
    Marker Score: 4274
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.15
    Marker Score: 285
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.14
    Marker Score: 11783
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.12
    Marker Score: 4333
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.11
    Marker Score: 350
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.09
    Marker Score: 40343
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.09
    Marker Score: 4561
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10031
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16257
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.04
    Marker Score: 1145
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71739
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47962
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.98
    Marker Score: 1041
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.98
    Marker Score: 37120
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.97
    Marker Score: 1048
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.97
    Marker Score: 1213.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.96
    Marker Score: 2005
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3805
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.9
    Marker Score: 17996
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9
    Marker Score: 1532
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.9
    Marker Score: 13470
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.87
    Marker Score: 6694
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4958.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305.5
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.85
    Marker Score: 2119.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.81
    Marker Score: 3349
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.79
    Marker Score: 954
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 380
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.79
    Marker Score: 230
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.77
    Marker Score: 6708
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.77
    Marker Score: 1029
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.74
    Marker Score: 832
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.74
    Marker Score: 366
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.73
    Marker Score: 16258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.72
    Marker Score: 241
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.71
    Marker Score: 1560.5
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.71
    Marker Score: 322
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.7
    Marker Score: 663
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7
    Marker Score: 4561
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2938.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.7
    Marker Score: 745
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 418
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.69
    Marker Score: 1409
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.68
    Marker Score: 203
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1827
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.67
    Marker Score: 6745
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.67
    Marker Score: 389
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.66
    Marker Score: 278
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.66
    Marker Score: 438
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.65
    Marker Score: 378
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.64
    Marker Score: 182
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.64
    Marker Score: 222
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.63
    Marker Score: 3794
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.63
    Marker Score: 1273.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.63
    Marker Score: 1191
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.62
    Marker Score: 421
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.61
    Marker Score: 3638
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.61
    Marker Score: 648
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.61
    Marker Score: 1652
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.6
    Marker Score: 7954
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.6
    Marker Score: 242
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.6
    Marker Score: 298
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.59
    Marker Score: 2743
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.59
    Marker Score: 10470
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.58
    Marker Score: 586
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.58
    Marker Score: 1999
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.57
    Marker Score: 361
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 180
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.57
    Marker Score: 12217
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.57
    Marker Score: 312
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.56
    Marker Score: 1324
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.56
    Marker Score: 1187
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.56
    Marker Score: 190
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.56
    Marker Score: 586
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.55
    Marker Score: 327
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.55
    Marker Score: 2024
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.55
    Marker Score: 258
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.55
    Marker Score: 501

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Other Information

## Summary HSF2 is a stress-responsive gene that plays a crucial role in regulating gene expression under conditions of heat stress, oxidative stress, and DNA damage. It is a key regulator of heat shock proteins (HSPs), which are proteins that protect cellular proteins from denaturation and aggregation under stress conditions. HSF2 is also involved in DNA repair and maintenance. ## Key characteristics * HSF2 is a highly conserved gene with over 90% sequence homology between humans and mice. * It is one of the most highly expressed genes in the human body. * It is located on chromosome 17q25. * It is a member of the HSP family of transcription factors. * It is a key regulator of heat shock protein expression. * It is also involved in DNA repair and maintenance. ## Pathways and functions HSF2 has a number of important functions in the body, including: * Regulating the expression of HSPs. * Protecting cellular proteins from denaturation and aggregation under stress conditions. * Promoting the folding and activity of HSPs. * Repairing DNA damage. * Maintaining genomic stability. HSF2 is also involved in a number of diseases, including heat stress, neurodegenerative diseases, and cancer. ## Clinical significance HSF2 is a promising target for the treatment of a variety of diseases. By understanding the role of HSF2 in stress response and DNA repair, it is possible to develop new therapies for these diseases. Here are some specific clinical implications of HSF2: * HSF2 mutations are associated with an increased risk of heat-related diseases, such as heat exhaustion, heat stroke, and cardiac arrest. * HSF2 inhibitors are being investigated as a treatment for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * HSF2 is also a promising target for the treatment of cancer. HSF2 is a complex and multifaceted gene with important roles in human health. By understanding the role of HSF2 in stress response and DNA repair, it is possible to develop new therapies for a variety of diseases.

Genular Protein ID: 2433058637

Symbol: HSF2_HUMAN

Name: Heat shock factor protein 2

UniProtKB Accession Codes:

Q03933 B4DGJ4 Q0VAH9 Q2M1K4 Q9H445

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1871106

Title: Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.

PubMed ID: 1871106

DOI: 10.1073/pnas.88.16.6911

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8339932

Title: Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2.

PubMed ID: 8339932

DOI: 10.1101/gad.7.8.1549

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 536
  • Mass: 60348
  • Checksum: 00DFD05CFD9DF0D3
  • Sequence:
    • MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP KYFKHNNMAS 
FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ DDLLENIKRK VSSSKPEENK 
IRQEDLTKII SSAQKVQIKQ ETIESRLSEL KSENESLWKE VSELRAKHAQ QQQVIRKIVQ 
FIVTLVQNNQ LVSLKRKRPL LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE 
RISDDIIIYD VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ 
SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND NINLLGKVEL 
LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDLFTSSVQM NPTDYINNTK SENKGLETTK 
NNVVQPVSEE GRKSKSKPDK QLIQYTAFPL LAFLDGNPAS SVEQASTTAS SEVLSSVDKP 
IEVDELLDSS LDPEPTQSKL VRLEPLTEAE ASEATLFYLC ELAPAPLDSD MPLLDS

Genular Protein ID: 3388633090

Symbol: Q9BS48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BS48

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 230
  • Mass: 27027
  • Checksum: 01C72FAA9E62D37A
  • Sequence:
    • MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP KYFKHNNMAS 
FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ DDLLENIKRK VSSSKPEENK 
IRQEDLTKII SSAQKVQIKQ ETIESRLSEL KSENESLWKE VSELRAKHAQ QQQVIRKIVQ 
FIVTLVQNNQ LVSLKRKRPL LLNTNGAQKK NLFQHIVKEP TDNHHHKVIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.