Details for: IDH1

Gene ID: 3417

Symbol: IDH1

Ensembl ID: ENSG00000138413

Description: isocitrate dehydrogenase (NADP(+)) 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 250.1845
    Cell Significance Index: -38.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.7291
    Cell Significance Index: -35.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 102.4159
    Cell Significance Index: -42.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.5665
    Cell Significance Index: -40.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 80.8232
    Cell Significance Index: -32.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.8661
    Cell Significance Index: -38.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.9667
    Cell Significance Index: -40.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.3077
    Cell Significance Index: -32.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.0612
    Cell Significance Index: -39.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0284
    Cell Significance Index: -37.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1012
    Cell Significance Index: -39.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 8.2417
    Cell Significance Index: 75.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0157
    Cell Significance Index: -24.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.6950
    Cell Significance Index: 243.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.6495
    Cell Significance Index: 124.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.7509
    Cell Significance Index: 676.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.7749
    Cell Significance Index: 166.5900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.6202
    Cell Significance Index: 3.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4552
    Cell Significance Index: 301.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3630
    Cell Significance Index: 468.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0909
    Cell Significance Index: 54.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4690
    Cell Significance Index: 42.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3035
    Cell Significance Index: 28.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2376
    Cell Significance Index: 33.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.0927
    Cell Significance Index: 8.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0486
    Cell Significance Index: 47.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0089
    Cell Significance Index: 47.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8526
    Cell Significance Index: 138.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8201
    Cell Significance Index: 22.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7594
    Cell Significance Index: 53.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7426
    Cell Significance Index: 405.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7424
    Cell Significance Index: 670.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5024
    Cell Significance Index: 28.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5009
    Cell Significance Index: 100.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3598
    Cell Significance Index: 49.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3462
    Cell Significance Index: 34.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3119
    Cell Significance Index: 59.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2291
    Cell Significance Index: 3.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2271
    Cell Significance Index: 17.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2117
    Cell Significance Index: 75.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2080
    Cell Significance Index: 91.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1946
    Cell Significance Index: 10.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1711
    Cell Significance Index: 2.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1694
    Cell Significance Index: 21.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1314
    Cell Significance Index: 22.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1115
    Cell Significance Index: 12.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0953
    Cell Significance Index: 3.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0889
    Cell Significance Index: 6.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0835
    Cell Significance Index: 5.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0717
    Cell Significance Index: 1.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0529
    Cell Significance Index: 40.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0519
    Cell Significance Index: 97.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0456
    Cell Significance Index: 28.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0353
    Cell Significance Index: 1.1300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0050
    Cell Significance Index: 0.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0098
    Cell Significance Index: -0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -21.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0158
    Cell Significance Index: -7.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0197
    Cell Significance Index: -12.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0226
    Cell Significance Index: -30.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0236
    Cell Significance Index: -17.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0433
    Cell Significance Index: -4.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0453
    Cell Significance Index: -25.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0549
    Cell Significance Index: -1.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0589
    Cell Significance Index: -3.6200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0657
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0743
    Cell Significance Index: -15.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0933
    Cell Significance Index: -10.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1012
    Cell Significance Index: -11.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1019
    Cell Significance Index: -29.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1082
    Cell Significance Index: -15.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1120
    Cell Significance Index: -5.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1321
    Cell Significance Index: -2.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1476
    Cell Significance Index: -19.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1488
    Cell Significance Index: -1.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1689
    Cell Significance Index: -5.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1876
    Cell Significance Index: -22.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1979
    Cell Significance Index: -9.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2950
    Cell Significance Index: -8.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3093
    Cell Significance Index: -4.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3104
    Cell Significance Index: -7.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3547
    Cell Significance Index: -36.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3548
    Cell Significance Index: -23.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3973
    Cell Significance Index: -31.4700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4395
    Cell Significance Index: -2.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4429
    Cell Significance Index: -7.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4721
    Cell Significance Index: -7.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4726
    Cell Significance Index: -28.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5541
    Cell Significance Index: -7.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5701
    Cell Significance Index: -15.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5778
    Cell Significance Index: -16.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6118
    Cell Significance Index: -15.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6328
    Cell Significance Index: -18.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6620
    Cell Significance Index: -15.3000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6702
    Cell Significance Index: -4.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7081
    Cell Significance Index: -31.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7299
    Cell Significance Index: -13.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7372
    Cell Significance Index: -18.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IDH1 is a NADP+-dependent enzyme, meaning it requires NADP+ as a cofactor to catalyze the reaction. It is a homodimeric enzyme, consisting of two identical subunits. IDH1 is also a magnesium ion-binding enzyme, which is essential for its catalytic activity. The enzyme is localized to the cytosol and is involved in various cellular processes, including metabolism, immune response, and stress response. **Pathways and Functions** IDH1 is involved in several metabolic pathways, including: 1. **2-Oxoglutarate Metabolic Process**: IDH1 catalyzes the conversion of isocitrate to alpha-ketoglutarate, which is a key step in the TCA cycle. 2. **Abnormal Conversion of 2-Oxoglutarate to 2-Hydroxyglutarate**: IDH1 is also involved in the regulation of the conversion of 2-oxoglutarate to 2-hydroxyglutarate, a process that has been implicated in cancer development. 3. **Glyoxylate Cycle**: IDH1 is involved in the glyoxylate cycle, a metabolic pathway that allows cells to generate energy from the breakdown of fatty acids and amino acids. 4. **Immune Response**: IDH1 is expressed in immune cells, such as macrophages, and is involved in the regulation of immune responses, including neutrophil degranulation. 5. **Stress Response**: IDH1 is also involved in the regulation of cellular responses to stress, including oxidative stress and chemical stress. **Clinical Significance** IDH1 mutations have been identified in various diseases, including: 1. **Leukemia**: IDH1 mutations are commonly found in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). 2. **Brain Tumors**: IDH1 mutations are also found in glioblastoma, a type of brain cancer. 3. **Neurodegenerative Diseases**: IDH1 mutations have been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders**: IDH1 mutations have been associated with metabolic disorders, such as mitochondrial myopathies and lactic acidosis. In summary, IDH1 is an enzyme that plays a crucial role in various cellular processes, including metabolism, immune response, and stress response. Its dysregulation has been implicated in various diseases, highlighting its importance as a therapeutic target.

Genular Protein ID: 1032175092

Symbol: IDHC_HUMAN

Name: Isocitrate dehydrogenase [NADP] cytoplasmic

UniProtKB Accession Codes:

O75874 Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 1 EMBL 10 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 54 PDBsum 54 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9866202

Title: Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.

PubMed ID: 9866202

DOI: 10.1093/oxfordjournals.molbev.a025894

PubMed ID: 10521434

Title: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase.

PubMed ID: 10521434

DOI: 10.1074/jbc.274.43.30527

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15173171

Title: Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.

PubMed ID: 15173171

DOI: 10.1074/jbc.m404298200

PubMed ID: 19935646

Title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

PubMed ID: 19935646

DOI: 10.1038/nature08617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18772396

Title: An integrated genomic analysis of human glioblastoma multiforme.

PubMed ID: 18772396

DOI: 10.1126/science.1164382

PubMed ID: 19117336

Title: IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.

PubMed ID: 19117336

DOI: 10.1002/humu.20937

PubMed ID: 26161668

Title: Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.

PubMed ID: 26161668

DOI: 10.1371/journal.pone.0131998

Sequence Information:

  • Length: 414
  • Mass: 46659
  • Checksum: 60428B0B6E5851DC
  • Sequence:
    • MSKKISGGSV VEMQGDEMTR IIWELIKEKL IFPYVELDLH SYDLGIENRD ATNDQVTKDA 
AEAIKKHNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL 
VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GTQKVTYLVH NFEEGGGVAM 
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE 
AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG 
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK ELAFFANALE 
EVSIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKIKLA QAKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.