Details for: IDH1

Gene ID: 3417

Symbol: IDH1

Ensembl ID: ENSG00000138413

Description: isocitrate dehydrogenase (NADP(+)) 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.12
    Marker Score: 1076
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.93
    Marker Score: 51953
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.24
    Marker Score: 3305
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.21
    Marker Score: 8676
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.17
    Marker Score: 8408
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.01
    Marker Score: 9635
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.9
    Marker Score: 5966
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.9
    Marker Score: 11527
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.89
    Marker Score: 1039
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.88
    Marker Score: 16219
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.83
    Marker Score: 2091
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.83
    Marker Score: 11659
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.8
    Marker Score: 4275
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.71
    Marker Score: 997
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.64
    Marker Score: 3714
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.62
    Marker Score: 1086
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.58
    Marker Score: 2535
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.57
    Marker Score: 452
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.56
    Marker Score: 1681
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167381
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.41
    Marker Score: 36070
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.4
    Marker Score: 1165.5
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.38
    Marker Score: 4528
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.35
    Marker Score: 10571
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.34
    Marker Score: 1154
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.31
    Marker Score: 8411
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.27
    Marker Score: 712.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.27
    Marker Score: 2322
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.26
    Marker Score: 8208
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.25
    Marker Score: 5403
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.25
    Marker Score: 1252
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.24
    Marker Score: 1189
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.23
    Marker Score: 1894
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.23
    Marker Score: 393
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.22
    Marker Score: 4316
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.21
    Marker Score: 451
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.21
    Marker Score: 7161
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2
    Marker Score: 7789
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.2
    Marker Score: 2818
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.19
    Marker Score: 6420
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.19
    Marker Score: 41085
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.18
    Marker Score: 572
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.18
    Marker Score: 1321
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.16
    Marker Score: 540
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.15
    Marker Score: 569
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.15
    Marker Score: 11887
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.15
    Marker Score: 2339
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.14
    Marker Score: 1210
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.14
    Marker Score: 430
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.14
    Marker Score: 277
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.14
    Marker Score: 8450
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1744
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1
    Marker Score: 11110
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1
    Marker Score: 1095.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.08
    Marker Score: 539
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16925
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.08
    Marker Score: 5658
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.07
    Marker Score: 591
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.07
    Marker Score: 427
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.07
    Marker Score: 954
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.06
    Marker Score: 443
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.05
    Marker Score: 1120
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.05
    Marker Score: 353
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.05
    Marker Score: 1224
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22316
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.03
    Marker Score: 2356
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71688
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47913
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.99
    Marker Score: 320
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.98
    Marker Score: 442
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30387
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.98
    Marker Score: 243
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.96
    Marker Score: 2739.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.95
    Marker Score: 186
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.95
    Marker Score: 633
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.94
    Marker Score: 1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.93
    Marker Score: 1942
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3775
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.92
    Marker Score: 867
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5247
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.91
    Marker Score: 616
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.9
    Marker Score: 263
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.89
    Marker Score: 1076
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.89
    Marker Score: 605
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.89
    Marker Score: 419
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.88
    Marker Score: 2404
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.87
    Marker Score: 1388
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.87
    Marker Score: 450
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.86
    Marker Score: 1821
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.86
    Marker Score: 1239
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.86
    Marker Score: 808
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.86
    Marker Score: 585.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.85
    Marker Score: 269
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.85
    Marker Score: 171

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Other Information

## Summary IDH1 is an enzyme that catalyzes the reversible conversion of 2-oxoglutarate to 2-hydroxyglutarate. This enzyme is expressed in various cell types, including those of the immune system, and is involved in a number of important cellular processes, including energy production, detoxification, and immune responses. ## Key characteristics * IDH1 is a protein of the cytochrome family. * It is a multi-subunit protein, with a molecular weight of approximately 150 kDa. * It is found in the cytoplasm of cells. * It is highly expressed in cells of the immune system, particularly in macrophages and dendritic cells. ## Pathways and functions IDH1 is involved in a number of cellular pathways and functions, including: * **Energy production:** IDH1 is a key enzyme in the citric acid cycle, which is the central pathway for energy production in the mitochondria of cells. * **Detoxification:** IDH1 is involved in the detoxification of reactive oxygen species (ROS) produced by the mitochondria. * **Immune responses:** IDH1 is a key enzyme in the activation of the immune system. It is expressed in cells of the immune system, where it is involved in the production of cytokines and other inflammatory mediators. * **Regulation of inflammation:** IDH1 is a key regulator of inflammation. It is expressed in cells of the immune system, where it helps to control the production of inflammatory cytokines and other mediators. * **Regulation of metabolism:** IDH1 is involved in the metabolism of a variety of cofactors and vitamins, including NADPH. ## Clinical significance IDH1 is a key enzyme in a number of diseases. Mutations in IDH1 genes have been linked to a number of human diseases, including cancer, diabetes, and cardiovascular disease. These diseases are characterized by a number of changes in the metabolism of glucose and other nutrients. IDH1 mutations can lead to the accumulation of 2-oxoglutarate, a metabolite that can damage cells. This can lead to a number of diseases, including cancer, diabetes, and cardiovascular disease. IDH1 is a promising target for the treatment of a variety of diseases. By blocking IDH1, it is possible to prevent the accumulation of 2-oxoglutarate and to treat the diseases that are caused by IDH1 mutations.

Genular Protein ID: 1032175092

Symbol: IDHC_HUMAN

Name: Isocitrate dehydrogenase [NADP] cytoplasmic

UniProtKB Accession Codes:

O75874 Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 1 EMBL 10 EMDB 2 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 77 PDBsum 48 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9866202

Title: Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.

PubMed ID: 9866202

DOI: 10.1093/oxfordjournals.molbev.a025894

PubMed ID: 10521434

Title: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase.

PubMed ID: 10521434

DOI: 10.1074/jbc.274.43.30527

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15173171

Title: Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.

PubMed ID: 15173171

DOI: 10.1074/jbc.m404298200

PubMed ID: 19935646

Title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

PubMed ID: 19935646

DOI: 10.1038/nature08617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18772396

Title: An integrated genomic analysis of human glioblastoma multiforme.

PubMed ID: 18772396

DOI: 10.1126/science.1164382

PubMed ID: 19117336

Title: IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.

PubMed ID: 19117336

DOI: 10.1002/humu.20937

PubMed ID: 26161668

Title: Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.

PubMed ID: 26161668

DOI: 10.1371/journal.pone.0131998

Sequence Information:

  • Length: 414
  • Mass: 46659
  • Checksum: 60428B0B6E5851DC
  • Sequence:
    • MSKKISGGSV VEMQGDEMTR IIWELIKEKL IFPYVELDLH SYDLGIENRD ATNDQVTKDA 
AEAIKKHNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL 
VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GTQKVTYLVH NFEEGGGVAM 
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE 
AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG 
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK ELAFFANALE 
EVSIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKIKLA QAKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.