Details for: IDH1
Gene ID: 3417
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IDH1
Ensembl ID: ENSG00000138413
Description: isocitrate dehydrogenase (NADP(+)) 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 29.68rCSI 31.09%PRS 44.94
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CSI 29.03rCSI 54.8%PRS 58.37
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CSI 17.81rCSI 26.29%PRS 65.46
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CSI 14.45rCSI 15.1%PRS 47.09
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CSI 12.66rCSI 13.45%PRS 62.17
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CSI 11.26rCSI 18.15%PRS 55.69
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CSI 11.13rCSI 10.73%PRS 38.65
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CSI 10.64rCSI 15.41%PRS 64.35
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CSI 10.05rCSI 15.53%PRS 45.66
-
CSI 9.39rCSI 11.03%PRS 51.27
-
CSI 8.86rCSI 18.86%PRS 62.4
-
CSI 8.57rCSI 49.43%PRS 49.28
-
CSI 7.59rCSI 11.6%PRS 63.74
-
CSI 7.36rCSI 12.9%PRS 40.33
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CSI 7.04rCSI 22.6%PRS 55.28
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CSI 6.85rCSI 17.4%PRS 43.49
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CSI 6.55rCSI 11.22%PRS 57.34
-
CSI 6.25rCSI 9.15%PRS 51.22
-
CSI 6.05rCSI 22.87%PRS 32.8
-
CSI 5.92rCSI 10.25%PRS 38.68
-
CSI 5.91rCSI 25.97%PRS 66.27
-
CSI 5.87rCSI 19.03%PRS 50.4
-
CSI 5.76rCSI 8%PRS 47.35
-
CSI 5.33rCSI 8.5%PRS 41.65
-
CSI 5.22rCSI 11.71%PRS 67.48
-
CSI 4.98rCSI 8.06%PRS 46.18
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CSI 4.95rCSI 11.63%PRS 56.06
-
CSI 4.78rCSI 3.54%PRS 41.45
-
CSI 4.71rCSI 9.36%PRS 46.91
-
CSI 4.4rCSI 4.04%PRS 55.67
-
CSI 4.36rCSI 4.2%PRS 48.28
-
CSI 4.28rCSI 10.15%PRS 53.48
-
CSI 4.16rCSI 3.44%PRS 49.16
-
CSI 3.94rCSI 5.67%PRS 61.14
-
CSI 3.94rCSI 29.56%PRS 67.44
-
CSI 3.88rCSI 3.67%PRS 48.68
-
CSI 3.75rCSI 3.46%PRS 48.68
-
CSI 3.64rCSI 3.02%PRS 46.55
-
CSI 3.63rCSI 2.94%PRS 48.7
-
CSI 3.54rCSI 2.88%PRS 48.55
-
CSI 3.48rCSI 4.02%PRS 42.13
-
CSI 3.43rCSI 3.58%PRS 48.41
-
CSI 3.41rCSI 7.53%PRS 35.92
-
CSI 3.23rCSI 2.83%PRS 57.82
-
CSI 3.2rCSI 2.84%PRS 46.76
-
CSI 3.14rCSI 4.03%PRS 43.08
-
CSI 3.11rCSI 3.87%PRS 50.55
-
CSI 3.02rCSI 6.9%PRS 47.36
-
CSI 2.98rCSI 5.98%PRS 37.74
-
CSI 2.96rCSI 8.77%PRS 59.12
-
CSI 2.92rCSI 2.26%PRS 48.58
-
CSI 2.88rCSI 2.28%PRS 35.64
-
CSI 2.87rCSI 3.82%PRS 52.99
-
CSI 2.85rCSI 4.09%PRS 54.42
-
CSI 2.81rCSI 3.48%PRS 43.76
-
CSI 2.74rCSI 4.21%PRS 48.66
-
CSI 2.7rCSI 3.35%PRS 30.28
-
CSI 2.69rCSI 4.74%PRS 46.01
-
CSI 2.66rCSI 1.85%PRS 49.88
-
CSI 2.64rCSI 3.6%PRS 50.4
-
CSI 2.62rCSI 4.9%PRS 37.51
-
CSI 2.61rCSI 2.69%PRS 66.02
-
CSI 2.59rCSI 2.77%PRS 46.09
-
CSI 2.56rCSI 4.89%PRS 70.53
-
CSI 2.53rCSI 6.19%PRS 43.5
-
CSI 2.52rCSI 6.57%PRS 55.56
-
CSI 2.5rCSI 13.12%PRS 61.8
-
CSI 2.49rCSI 5.99%PRS 66.29
-
CSI 2.47rCSI 4.43%PRS 46.49
-
CSI 2.47rCSI 3.62%PRS 46.65
-
CSI 2.44rCSI 4.17%PRS 74.15
-
CSI 2.43rCSI 3.12%PRS 45.9
-
CSI 2.42rCSI 7.15%PRS 51.94
-
CSI 2.41rCSI 1.6%PRS 51.58
-
CSI 2.38rCSI 2.43%PRS 65.71
-
CSI 2.35rCSI 2.47%PRS 51.09
-
CSI 2.35rCSI 3.64%PRS 57.35
-
CSI 2.29rCSI 6.17%PRS 56.66
-
CSI 2.27rCSI 1.99%PRS 36.98
-
CSI 2.25rCSI 3.35%PRS 50.16
-
CSI 2.18rCSI 4.48%PRS 41.53
-
CSI 2.17rCSI 4.81%PRS 45.42
-
CSI 2.12rCSI 2.46%PRS 57.79
-
CSI 2.12rCSI 1.91%PRS 44.59
-
CSI 2.08rCSI 1.83%PRS 53.1
-
CSI 2.08rCSI 11.17%PRS 62.97
-
CSI 2.07rCSI 32%PRS 72.03
-
CSI 2.06rCSI 2.48%PRS 45.95
-
CSI 2.06rCSI 5.1%PRS 45.89
-
CSI 2.01rCSI 3.08%PRS 52.72
-
CSI 2.01rCSI 3.54%PRS 30.91
-
CSI 1.99rCSI 2.84%PRS 50.56
-
CSI 1.98rCSI 2.65%PRS 70.48
-
CSI 1.93rCSI 1.8%PRS 47.63
-
CSI 1.92rCSI 5.39%PRS 62.14
-
CSI 1.9rCSI 4.15%PRS 66.53
-
CSI 1.83rCSI 2.79%PRS 44.53
-
CSI 1.8rCSI 6.49%PRS 30.74
-
CSI 1.8rCSI 1.77%PRS 50.49
-
CSI 1.77rCSI 2.59%PRS 59.41
-
CSI 0.2rCSI 4.4%PRS 40.2%
-
CSI 0.3rCSI 2.7%PRS 71.7%
-
CSI 0.3rCSI 1.1%PRS 63.2%
-
CSI 0.3rCSI 2.8%PRS 73.0%
-
CSI 0.3rCSI 3.1%PRS 67.3%
-
CSI 0.3rCSI 1.4%PRS 46.8%
-
CSI 0.4rCSI 2.1%PRS 58.6%
-
CSI 0.4rCSI 2.9%PRS 63.5%
-
CSI 0.4rCSI 1.9%PRS 72.2%
-
CSI 0.4rCSI 1.5%PRS 60.0%
-
CSI 0.5rCSI 2.6%PRS 69.4%
-
CSI 0.5rCSI 1.5%PRS 33.2%
-
CSI 0.6rCSI 3.4%PRS 81.8%
-
CSI 0.6rCSI 3.9%PRS 69.8%
-
CSI 0.6rCSI 5.7%PRS 64.1%
-
CSI 0.7rCSI 20.6%PRS 71.4%
-
CSI 0.7rCSI 7.9%PRS 78.4%
-
CSI 0.7rCSI 0.6%PRS 52.0%
-
CSI 0.8rCSI 3.6%PRS 69.9%
-
CSI 0.8rCSI 1.3%PRS 38.6%
-
CSI 0.9rCSI 4.0%PRS 64.0%
-
CSI 0.9rCSI 1.8%PRS 66.8%
-
CSI 1.0rCSI 2.8%PRS 65.0%
-
CSI 1.0rCSI 3.7%PRS 40.9%
-
CSI 1.0rCSI 2.4%PRS 59.7%
-
CSI 1.0rCSI 2.0%PRS 50.1%
-
CSI 1.2rCSI 2.6%PRS 62.7%
-
CSI 1.2rCSI 16.5%PRS 40.1%
-
CSI 1.2rCSI 1.9%PRS 40.9%
-
CSI 1.2rCSI 6.2%PRS 80.8%
-
CSI 1.3rCSI 1.3%PRS 42.0%
-
CSI 1.3rCSI 2.0%PRS 34.1%
-
CSI 1.3rCSI 2.0%PRS 58.8%
-
CSI 1.3rCSI 5.2%PRS 68.3%
-
CSI 1.3rCSI 3.4%PRS 47.3%
-
CSI 1.3rCSI 3.2%PRS 49.9%
-
CSI 1.3rCSI 2.0%PRS 50.3%
-
CSI 1.4rCSI 3.5%PRS 70.0%
-
CSI 1.4rCSI 1.4%PRS 53.8%
-
CSI 1.4rCSI 1.9%PRS 41.0%
-
CSI 1.4rCSI 1.6%PRS 38.1%
-
CSI 1.4rCSI 2.1%PRS 39.1%
-
CSI 1.5rCSI 9.1%PRS 40.4%
-
CSI 1.5rCSI 3.5%PRS 63.1%
-
CSI 1.5rCSI 5.7%PRS 56.2%
-
CSI 1.5rCSI 3.2%PRS 51.0%
-
CSI 1.5rCSI 3.3%PRS 54.6%
-
CSI 1.5rCSI 3.3%PRS 57.7%
-
CSI 1.5rCSI 6.7%PRS 41.0%
-
CSI 1.6rCSI 2.0%PRS 61.3%
-
CSI 1.6rCSI 2.1%PRS 43.9%
-
CSI 1.6rCSI 2.4%PRS 57.2%
-
CSI 1.6rCSI 3.5%PRS 52.0%
-
CSI 1.6rCSI 2.9%PRS 41.3%
-
CSI 1.6rCSI 5.3%PRS 49.9%
-
CSI 1.6rCSI 3.8%PRS 64.9%
-
CSI 1.7rCSI 3.7%PRS 32.7%
-
CSI 1.7rCSI 2.7%PRS 53.5%
-
CSI 1.7rCSI 2.7%PRS 38.4%
-
CSI 1.7rCSI 2.2%PRS 52.7%
-
CSI 1.7rCSI 4.5%PRS 47.3%
-
CSI 1.7rCSI 3.1%PRS 41.5%
-
CSI 1.7rCSI 6.5%PRS 39.5%
-
CSI 1.8rCSI 2.1%PRS 55.6%
-
CSI 1.8rCSI 2.2%PRS 61.4%
-
CSI 1.8rCSI 2.6%PRS 59.4%
-
CSI 1.8rCSI 1.8%PRS 50.5%
-
CSI 1.8rCSI 6.5%PRS 30.7%
-
CSI 1.8rCSI 2.8%PRS 44.5%
-
CSI 1.9rCSI 4.2%PRS 66.5%
-
CSI 1.9rCSI 5.4%PRS 62.1%
-
CSI 1.9rCSI 1.8%PRS 47.6%
-
CSI 2.0rCSI 2.7%PRS 70.5%
-
CSI 2.0rCSI 2.8%PRS 50.6%
-
CSI 2.0rCSI 3.5%PRS 30.9%
-
CSI 2.0rCSI 3.1%PRS 52.7%
-
CSI 2.1rCSI 5.1%PRS 45.9%
-
CSI 2.1rCSI 2.5%PRS 46.0%
-
CSI 2.1rCSI 32.0%PRS 72.0%
-
CSI 2.1rCSI 11.2%PRS 63.0%
-
CSI 2.1rCSI 1.8%PRS 53.1%
-
CSI 2.1rCSI 1.9%PRS 44.6%
-
CSI 2.1rCSI 2.5%PRS 57.8%
-
CSI 2.2rCSI 4.8%PRS 45.4%
-
CSI 2.2rCSI 4.5%PRS 41.5%
-
CSI 2.3rCSI 3.4%PRS 50.2%
-
CSI 2.3rCSI 2.0%PRS 37.0%
-
CSI 2.3rCSI 6.2%PRS 56.7%
-
CSI 2.4rCSI 3.6%PRS 57.4%
-
CSI 2.4rCSI 2.5%PRS 51.1%
-
CSI 2.4rCSI 2.4%PRS 65.7%
-
CSI 2.4rCSI 1.6%PRS 51.6%
-
CSI 2.4rCSI 7.2%PRS 51.9%
-
CSI 2.4rCSI 3.1%PRS 45.9%
-
CSI 2.4rCSI 4.2%PRS 74.2%
-
CSI 2.5rCSI 3.6%PRS 46.7%
-
CSI 2.5rCSI 4.4%PRS 46.5%
-
CSI 2.5rCSI 6.0%PRS 66.3%
-
CSI 2.5rCSI 13.1%PRS 61.8%
-
CSI 2.5rCSI 6.6%PRS 55.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1032175092
Symbol: IDHC_HUMAN
Name: Isocitrate dehydrogenase [NADP] cytoplasmic
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9866202
Title: Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.
PubMed ID: 9866202
PubMed ID: 10521434
Title: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase.
PubMed ID: 10521434
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 15173171
Title: Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.
PubMed ID: 15173171
PubMed ID: 19935646
Title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
PubMed ID: 19935646
DOI: 10.1038/nature08617
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 18772396
Title: An integrated genomic analysis of human glioblastoma multiforme.
PubMed ID: 18772396
PubMed ID: 19117336
Title: IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.
PubMed ID: 19117336
DOI: 10.1002/humu.20937
PubMed ID: 26161668
Title: Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.
PubMed ID: 26161668
Sequence Information:
- Length: 414
- Mass: 46659
- Checksum: 60428B0B6E5851DC
- Sequence:
MSKKISGGSV VEMQGDEMTR IIWELIKEKL IFPYVELDLH SYDLGIENRD ATNDQVTKDA AEAIKKHNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GTQKVTYLVH NFEEGGGVAM GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK ELAFFANALE EVSIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKIKLA QAKL