Details for: IDH3B
Gene ID: 3420
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IDH3B
Ensembl ID: ENSG00000101365
Description: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 17.44rCSI 13.52%PRS 58.81
-
CSI 11.62rCSI 15.44%PRS 63.47
-
CSI 9.76rCSI 21.57%PRS 43.85
-
CSI 8.88rCSI 17.84%PRS 46.61
-
CSI 7.26rCSI 5.81%PRS 78.13
-
CSI 6.43rCSI 9.82%PRS 61.82
-
CSI 6.03rCSI 5.8%PRS 57.52
-
CSI 5.81rCSI 8.99%PRS 55.31
-
CSI 5.67rCSI 5.93%PRS 55.61
-
CSI 5.59rCSI 3.88%PRS 67.99
-
CSI 5.47rCSI 8.86%PRS 54.41
-
CSI 4.81rCSI 5.81%PRS 65.94
-
CSI 4.74rCSI 5.55%PRS 73.84
-
CSI 4.59rCSI 3.47%PRS 70.96
-
CSI 4.53rCSI 6.05%PRS 79.11
-
CSI 4.21rCSI 3.2%PRS 70.07
-
CSI 4.18rCSI 5.19%PRS 59.31
-
CSI 4.14rCSI 7.31%PRS 65.83
-
CSI 4.13rCSI 23.68%PRS 67.18
-
CSI 4.03rCSI 7.12%PRS 38.66
-
CSI 3.81rCSI 2.96%PRS 75.31
-
CSI 3.76rCSI 4.42%PRS 59.93
-
CSI 3.69rCSI 16.22%PRS 73.16
-
CSI 3.62rCSI 2.71%PRS 72.3
-
CSI 3.61rCSI 4.94%PRS 63.04
-
CSI 3.59rCSI 6.92%PRS 83.97
-
CSI 3.56rCSI 2.64%PRS 70.97
-
CSI 3.48rCSI 4.31%PRS 53.5
-
CSI 3.38rCSI 3.26%PRS 47.81
-
CSI 3.27rCSI 9.65%PRS 60.58
-
CSI 3.26rCSI 5%PRS 54.69
-
CSI 3.12rCSI 4.64%PRS 59.08
-
CSI 3.05rCSI 2.03%PRS 78.33
-
CSI 3.04rCSI 1.79%PRS 74.37
-
CSI 3.03rCSI 2.28%PRS 62.29
-
CSI 2.99rCSI 2.08%PRS 72.18
-
CSI 2.98rCSI 7.18%PRS 75.34
-
CSI 2.96rCSI 8.5%PRS 76.77
-
CSI 2.93rCSI 2.46%PRS 74.8
-
CSI 2.88rCSI 3.3%PRS 77.21
-
CSI 2.88rCSI 2.5%PRS 67.81
-
CSI 2.87rCSI 3%PRS 57.53
-
CSI 2.73rCSI 3.96%PRS 73.3
-
CSI 2.73rCSI 5.21%PRS 72.74
-
CSI 2.72rCSI 2.77%PRS 70.67
-
CSI 2.68rCSI 9.19%PRS 81.78
-
CSI 2.61rCSI 2.43%PRS 57.4
-
CSI 2.51rCSI 5.55%PRS 55.29
-
CSI 2.46rCSI 4.65%PRS 67.93
-
CSI 2.46rCSI 7.98%PRS 58.31
-
CSI 2.45rCSI 3.58%PRS 61.42
-
CSI 2.37rCSI 2.24%PRS 57.1
-
CSI 2.35rCSI 1.56%PRS 60.58
-
CSI 2.34rCSI 2.15%PRS 65.89
-
CSI 2.34rCSI 4.2%PRS 50.43
-
CSI 2.3rCSI 1.71%PRS 74.62
-
CSI 2.28rCSI 1.53%PRS 70.11
-
CSI 2.26rCSI 3.02%PRS 66.33
-
CSI 2.24rCSI 2.3%PRS 72.98
-
CSI 2.19rCSI 1.89%PRS 63.44
-
CSI 2.18rCSI 2.78%PRS 63.61
-
CSI 2.17rCSI 6.79%PRS 41.13
-
CSI 2.17rCSI 1.96%PRS 54.01
-
CSI 2.16rCSI 2.13%PRS 73.2
-
CSI 2.16rCSI 1.71%PRS 44.29
-
CSI 2.16rCSI 3.69%PRS 81.46
-
CSI 2.11rCSI 4.72%PRS 64.86
-
CSI 2.11rCSI 2.31%PRS 61.24
-
CSI 2.1rCSI 10.53%PRS 69.76
-
CSI 2.08rCSI 1.72%PRS 59.08
-
CSI 2.08rCSI 1.85%PRS 55.44
-
CSI 2.08rCSI 1.82%PRS 67.39
-
CSI 2.08rCSI 1.64%PRS 64.04
-
CSI 2.07rCSI 2.87%PRS 59.14
-
CSI 2.06rCSI 2.12%PRS 74.35
-
CSI 2.06rCSI 2.82%PRS 65.16
-
CSI 2.05rCSI 1.63%PRS 78.96
-
CSI 2.04rCSI 2.04%PRS 50.76
-
CSI 2.01rCSI 3.08%PRS 71.51
-
CSI 2rCSI 2.15%PRS 56.26
-
CSI 1.99rCSI 3.11%PRS 82.02
-
CSI 1.99rCSI 1.84%PRS 77.02
-
CSI 1.98rCSI 21.73%PRS 70.65
-
CSI 1.98rCSI 2.85%PRS 68.7
-
CSI 1.96rCSI 2.08%PRS 68.64
-
CSI 1.95rCSI 3.08%PRS 59.15
-
CSI 1.92rCSI 2.16%PRS 73.78
-
CSI 1.87rCSI 2.28%PRS 64.98
-
CSI 1.86rCSI 2.75%PRS 73.72
-
CSI 1.83rCSI 2.36%PRS 40.79
-
CSI 1.83rCSI 1.53%PRS 70.36
-
CSI 1.81rCSI 1.47%PRS 57.81
-
CSI 1.79rCSI 1.25%PRS 60.06
-
CSI 1.78rCSI 2.72%PRS 66.52
-
CSI 1.74rCSI 2.65%PRS 53.63
-
CSI 1.69rCSI 1.4%PRS 56.24
-
CSI 1.65rCSI 1.45%PRS 62.59
-
CSI 1.62rCSI 2.48%PRS 57.84
-
CSI 1.6rCSI 2.34%PRS 54.06
-
CSI 1.59rCSI 1.47%PRS 58.32
-
CSI 0.1rCSI 1.5%PRS 85.1%
-
CSI 0.2rCSI 4.6%PRS 77.9%
-
CSI 0.2rCSI 3.5%PRS 75.6%
-
CSI 0.4rCSI 2.6%PRS 84.5%
-
CSI 0.4rCSI 3.5%PRS 85.4%
-
CSI 0.5rCSI 2.3%PRS 79.3%
-
CSI 0.5rCSI 0.7%PRS 63.4%
-
CSI 0.5rCSI 2.8%PRS 66.9%
-
CSI 0.5rCSI 7.2%PRS 73.8%
-
CSI 0.5rCSI 3.0%PRS 65.3%
-
CSI 0.6rCSI 8.6%PRS 76.5%
-
CSI 0.6rCSI 1.7%PRS 58.9%
-
CSI 0.7rCSI 3.3%PRS 76.9%
-
CSI 0.7rCSI 1.2%PRS 47.1%
-
CSI 0.7rCSI 2.9%PRS 74.6%
-
CSI 0.7rCSI 4.8%PRS 76.1%
-
CSI 0.8rCSI 2.3%PRS 69.7%
-
CSI 0.8rCSI 1.4%PRS 66.4%
-
CSI 0.9rCSI 2.4%PRS 69.9%
-
CSI 0.9rCSI 6.5%PRS 74.6%
-
CSI 0.9rCSI 2.9%PRS 63.0%
-
CSI 0.9rCSI 1.4%PRS 65.9%
-
CSI 0.9rCSI 7.4%PRS 70.3%
-
CSI 0.9rCSI 2.2%PRS 67.3%
-
CSI 0.9rCSI 2.5%PRS 55.5%
-
CSI 1.0rCSI 1.0%PRS 62.8%
-
CSI 1.0rCSI 3.1%PRS 55.9%
-
CSI 1.0rCSI 2.7%PRS 66.1%
-
CSI 1.1rCSI 1.6%PRS 60.8%
-
CSI 1.1rCSI 2.9%PRS 65.3%
-
CSI 1.1rCSI 1.3%PRS 55.3%
-
CSI 1.1rCSI 2.4%PRS 70.7%
-
CSI 1.1rCSI 1.3%PRS 47.4%
-
CSI 1.1rCSI 1.4%PRS 69.7%
-
CSI 1.2rCSI 1.9%PRS 62.8%
-
CSI 1.2rCSI 1.0%PRS 62.1%
-
CSI 1.2rCSI 2.2%PRS 49.7%
-
CSI 1.2rCSI 2.4%PRS 60.0%
-
CSI 1.2rCSI 1.1%PRS 62.1%
-
CSI 1.2rCSI 3.1%PRS 51.8%
-
CSI 1.2rCSI 2.5%PRS 76.3%
-
CSI 1.2rCSI 6.5%PRS 68.3%
-
CSI 1.2rCSI 2.0%PRS 62.0%
-
CSI 1.3rCSI 2.7%PRS 69.5%
-
CSI 1.3rCSI 1.8%PRS 68.9%
-
CSI 1.3rCSI 2.0%PRS 50.2%
-
CSI 1.3rCSI 1.5%PRS 77.2%
-
CSI 1.3rCSI 1.0%PRS 57.3%
-
CSI 1.3rCSI 1.8%PRS 82.3%
-
CSI 1.3rCSI 1.8%PRS 77.2%
-
CSI 1.4rCSI 1.9%PRS 56.3%
-
CSI 1.4rCSI 3.3%PRS 51.3%
-
CSI 1.4rCSI 5.1%PRS 76.9%
-
CSI 1.4rCSI 1.6%PRS 65.6%
-
CSI 1.4rCSI 1.8%PRS 67.7%
-
CSI 1.4rCSI 7.6%PRS 70.5%
-
CSI 1.4rCSI 3.0%PRS 57.4%
-
CSI 1.4rCSI 1.5%PRS 53.9%
-
CSI 1.4rCSI 2.0%PRS 59.8%
-
CSI 1.5rCSI 2.0%PRS 57.9%
-
CSI 1.5rCSI 2.2%PRS 47.4%
-
CSI 1.5rCSI 3.1%PRS 37.3%
-
CSI 1.5rCSI 3.0%PRS 75.3%
-
CSI 1.5rCSI 2.4%PRS 61.3%
-
CSI 1.5rCSI 1.3%PRS 45.4%
-
CSI 1.5rCSI 1.1%PRS 71.6%
-
CSI 1.5rCSI 3.4%PRS 61.4%
-
CSI 1.5rCSI 2.2%PRS 62.0%
-
CSI 1.6rCSI 2.5%PRS 68.6%
-
CSI 1.6rCSI 2.1%PRS 59.2%
-
CSI 1.6rCSI 2.0%PRS 54.8%
-
CSI 1.6rCSI 2.1%PRS 49.5%
-
CSI 1.6rCSI 6.9%PRS 56.6%
-
CSI 1.6rCSI 3.6%PRS 61.8%
-
CSI 1.6rCSI 1.3%PRS 58.6%
-
CSI 1.6rCSI 1.8%PRS 50.8%
-
CSI 1.6rCSI 2.3%PRS 66.9%
-
CSI 1.6rCSI 1.5%PRS 58.3%
-
CSI 1.6rCSI 2.3%PRS 54.1%
-
CSI 1.6rCSI 2.5%PRS 57.8%
-
CSI 1.7rCSI 1.5%PRS 62.6%
-
CSI 1.7rCSI 1.4%PRS 56.2%
-
CSI 1.7rCSI 2.7%PRS 53.6%
-
CSI 1.8rCSI 2.7%PRS 66.5%
-
CSI 1.8rCSI 1.3%PRS 60.1%
-
CSI 1.8rCSI 1.5%PRS 57.8%
-
CSI 1.8rCSI 1.5%PRS 70.4%
-
CSI 1.8rCSI 2.4%PRS 40.8%
-
CSI 1.9rCSI 2.8%PRS 73.7%
-
CSI 1.9rCSI 2.3%PRS 65.0%
-
CSI 1.9rCSI 2.2%PRS 73.8%
-
CSI 2.0rCSI 3.1%PRS 59.2%
-
CSI 2.0rCSI 2.1%PRS 68.6%
-
CSI 2.0rCSI 2.9%PRS 68.7%
-
CSI 2.0rCSI 21.7%PRS 70.7%
-
CSI 2.0rCSI 1.8%PRS 77.0%
-
CSI 2.0rCSI 3.1%PRS 82.0%
-
CSI 2.0rCSI 2.2%PRS 56.3%
-
CSI 2.0rCSI 3.1%PRS 71.5%
-
CSI 2.0rCSI 2.0%PRS 50.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2239960930
Symbol: IDH3B_HUMAN
Name: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10601238
Title: Identification and functional characterization of a novel, tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform.
PubMed ID: 10601238
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28098230
Title: Molecular mechanism of the allosteric regulation of the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
PubMed ID: 28098230
DOI: 10.1038/srep40921
PubMed ID: 28139779
Title: The beta and gamma subunits play distinct functional roles in the alpha2betagamma heterotetramer of human NAD-dependent isocitrate dehydrogenase.
PubMed ID: 28139779
DOI: 10.1038/srep41882
PubMed ID: 18806796
Title: Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle.
PubMed ID: 18806796
DOI: 10.1038/ng.223
Sequence Information:
- Length: 385
- Mass: 42184
- Checksum: 7324E6CC30A68EE2
- Sequence:
MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT RDMGGYSTTT DFIKSVIGHL QTKGS
Genular Protein ID: 2861885978
Symbol: A0A087X2E5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 376
- Mass: 41220
- Checksum: F604FCC1D38F9568
- Sequence:
MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKIPS AVPSFLLHPL PFSWAI
Genular Protein ID: 3583626468
Symbol: A0A087WZN1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 387
- Mass: 42411
- Checksum: B7853324E6CC30A6
- Sequence:
MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT RDMGGYSTTT DFIKSVIGHL QTKGSNL