Details for: IDH3B

Gene ID: 3420

Symbol: IDH3B

Ensembl ID: ENSG00000101365

Description: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.91
    Marker Score: 1989
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.85
    Marker Score: 7256
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.82
    Marker Score: 3803
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.66
    Marker Score: 1108
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.63
    Marker Score: 6657
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.62
    Marker Score: 1716
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.6
    Marker Score: 3250
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.59
    Marker Score: 7627
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.59
    Marker Score: 2694
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.55
    Marker Score: 13390
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.49
    Marker Score: 19709
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.48
    Marker Score: 3504
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.45
    Marker Score: 1465
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.43
    Marker Score: 712
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.43
    Marker Score: 1527
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.41
    Marker Score: 1581
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.38
    Marker Score: 5120
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.37
    Marker Score: 5915
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3112
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.36
    Marker Score: 749
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.34
    Marker Score: 1970
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.34
    Marker Score: 1421
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.33
    Marker Score: 905
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.33
    Marker Score: 1254
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.32
    Marker Score: 827
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.3
    Marker Score: 305
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.29
    Marker Score: 3516
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.28
    Marker Score: 1545.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.27
    Marker Score: 2988
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.27
    Marker Score: 14712
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.26
    Marker Score: 3433
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.26
    Marker Score: 1184.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.24
    Marker Score: 3892
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.23
    Marker Score: 647
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.22
    Marker Score: 1478
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.21
    Marker Score: 1302
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.21
    Marker Score: 2265
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.2
    Marker Score: 394
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.2
    Marker Score: 872
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.2
    Marker Score: 2980
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.19
    Marker Score: 1125
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.19
    Marker Score: 1839
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.18
    Marker Score: 1571
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 979.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.17
    Marker Score: 1858
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.16
    Marker Score: 4471
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.16
    Marker Score: 11661.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.15
    Marker Score: 387
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.15
    Marker Score: 64328
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.15
    Marker Score: 232
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.15
    Marker Score: 1883.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.15
    Marker Score: 432
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.14
    Marker Score: 677
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.14
    Marker Score: 7269
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.14
    Marker Score: 290
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.14
    Marker Score: 3139
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.14
    Marker Score: 3368
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.13
    Marker Score: 8858
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.13
    Marker Score: 535
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.13
    Marker Score: 600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.12
    Marker Score: 709
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.12
    Marker Score: 7291
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.12
    Marker Score: 839
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.12
    Marker Score: 267
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.11
    Marker Score: 1577
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.1
    Marker Score: 540
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.1
    Marker Score: 1948
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1
    Marker Score: 38064
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.1
    Marker Score: 603
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.09
    Marker Score: 11070
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.09
    Marker Score: 8111
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.09
    Marker Score: 1805
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.08
    Marker Score: 263
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.08
    Marker Score: 1302
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.07
    Marker Score: 463
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.07
    Marker Score: 956
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.07
    Marker Score: 343
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.07
    Marker Score: 308
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.07
    Marker Score: 1109
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.06
    Marker Score: 2120
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 673
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.05
    Marker Score: 2053
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.05
    Marker Score: 1360
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.04
    Marker Score: 11755
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.04
    Marker Score: 1816
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.04
    Marker Score: 1497
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 257
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.04
    Marker Score: 1227
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.04
    Marker Score: 626
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.04
    Marker Score: 358
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.03
    Marker Score: 1030
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.03
    Marker Score: 271
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.03
    Marker Score: 993
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.02
    Marker Score: 1092
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.02
    Marker Score: 2724.5
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.02
    Marker Score: 269
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.01
    Marker Score: 1813
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.01
    Marker Score: 1717
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.01
    Marker Score: 349
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.01
    Marker Score: 498

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Other Information

**Key characteristics:** - IDH3B is a protein of the mitochondrial matrix. - It is a subunit of the mitochondrial isocitrate dehydrogenase complex (NAD+). - It is involved in the regulation of the citric acid cycle and respiratory electron transport. **Pathways and functions:** - IDH3B is involved in the citric acid cycle and respiratory electron transport pathways. - In the citric acid cycle, IDH3B is responsible for the reduction of isocitrate to oxaloacetate. - In the respiratory electron transport chain, IDH3B is involved in the transfer of electrons to oxygen, which is produced by the mitochondria. **Clinical significance:** IDH3B gene mutations have been linked to several human diseases, including mitochondrial disorders and cancer. These mutations can disrupt the regulation of the citric acid cycle and respiratory electron transport pathways, leading to the accumulation of isocitrate and other metabolites. This can result in cellular damage and cancer development.

Genular Protein ID: 2239960930

Symbol: IDH3B_HUMAN

Name: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

UniProtKB Accession Codes:

O43837 B2RDR1 D3DVX2 D3DVX3 O95106 Q5JXS8 Q9NQ06 Q9NQ07 Q9NUZ0 Q9UEX0 Q9UG99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10601238

Title: Identification and functional characterization of a novel, tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform.

PubMed ID: 10601238

DOI: 10.1074/jbc.274.52.36866

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28098230

Title: Molecular mechanism of the allosteric regulation of the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase.

PubMed ID: 28098230

DOI: 10.1038/srep40921

PubMed ID: 28139779

Title: The beta and gamma subunits play distinct functional roles in the alpha2betagamma heterotetramer of human NAD-dependent isocitrate dehydrogenase.

PubMed ID: 28139779

DOI: 10.1038/srep41882

PubMed ID: 18806796

Title: Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle.

PubMed ID: 18806796

DOI: 10.1038/ng.223

Sequence Information:

  • Length: 385
  • Mass: 42184
  • Checksum: 7324E6CC30A68EE2
  • Sequence:
    • MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG 
PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME 
YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR 
GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY 
PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY 
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT 
RDMGGYSTTT DFIKSVIGHL QTKGS

Genular Protein ID: 3583626468

Symbol: A0A087WZN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZN1

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 387
  • Mass: 42411
  • Checksum: B7853324E6CC30A6
  • Sequence:
    • MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG 
PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME 
YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR 
GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY 
PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY 
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT 
RDMGGYSTTT DFIKSVIGHL QTKGSNL

Genular Protein ID: 2861885978

Symbol: A0A087X2E5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X2E5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 376
  • Mass: 41220
  • Checksum: F604FCC1D38F9568
  • Sequence:
    • MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG 
PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME 
YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR 
GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY 
PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY 
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKIPS 
AVPSFLLHPL PFSWAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.