Details for: IFNA4

Gene ID: 3441

Symbol: IFNA4

Ensembl ID: ENSG00000236637

Description: interferon alpha 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10806
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7571
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3652
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32696
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.39
    Marker Score: 228
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 629
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 471
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 133
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3141
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 802
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 335.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.04
    Marker Score: 74
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.03
    Marker Score: 47
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.02
    Marker Score: 47
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 42
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.01
    Marker Score: 45.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 47
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 37
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 47
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 47
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 44

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Other Information

**Key characteristics:** - IFNA4 is a type I interferon, which are proteins that are produced by cells in response to infection or injury. - It is expressed in high levels in the blood and other body fluids during inflammation and infection. - It is a key regulator of the immune response, and its expression is often increased in diseases such as cancer and viral infections. **Pathways and functions:** - IFNA4 is involved in the regulation of the immune response by binding to receptors on immune cells and triggering a signaling cascade. - This signaling cascade leads to the production of other cytokines and chemokines, which can attract immune cells to the site of infection. - IFNA4 also plays a role in the regulation of inflammation and cell growth. **Clinical significance:** - Mutations in the IFNA4 gene have been linked to an increased risk of certain types of cancer, such as lung cancer and melanoma. - IFNA4 is also a potential therapeutic target for cancer treatment. - Studies have shown that blocking IFNA4 can inhibit cancer growth in animal models. **Additional information:** - The gene encoding IFNA4 is located on chromosome 19p13.2. - It is a highly conserved protein, with a similar sequence in humans, mice, and rats. - It is a secreted protein, which means that it is not bound to a protein carrier molecule.

Genular Protein ID: 1994306652

Symbol: IFNA4_HUMAN

Name: Interferon alpha-4

UniProtKB Accession Codes:

P05014 P13358 Q14CS4 Q5VV15

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6089830

Title: Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides.

PubMed ID: 6089830

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 9335434

Title: Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population.

PubMed ID: 9335434

DOI: 10.1089/jir.1997.17.559

Sequence Information:

  • Length: 189
  • Mass: 21808
  • Checksum: 828DF9C33ABC337F
  • Sequence:
    • MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF SCLKDRHDFG 
FPEEEFDGHQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE 
ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN 
LQKRLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.