Details for: IFNA4

Gene ID: 3441

Symbol: IFNA4

Ensembl ID: ENSG00000236637

Description: interferon alpha 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1254
    Cell Significance Index: 0.7400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0280
    Cell Significance Index: 0.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0209
    Cell Significance Index: 0.3000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0089
    Cell Significance Index: 0.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0074
    Cell Significance Index: 0.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0067
    Cell Significance Index: 0.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0060
    Cell Significance Index: 0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0033
    Cell Significance Index: -0.0800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0064
    Cell Significance Index: -0.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0078
    Cell Significance Index: -0.2200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0104
    Cell Significance Index: -0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0106
    Cell Significance Index: -0.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0110
    Cell Significance Index: -0.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0118
    Cell Significance Index: -0.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0128
    Cell Significance Index: -0.0900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0133
    Cell Significance Index: -0.1600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0136
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0157
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0174
    Cell Significance Index: -0.2000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0183
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0183
    Cell Significance Index: -0.2200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0191
    Cell Significance Index: -0.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0191
    Cell Significance Index: -0.6300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0191
    Cell Significance Index: -0.2100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0195
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0198
    Cell Significance Index: -0.5000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0204
    Cell Significance Index: -0.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0206
    Cell Significance Index: -0.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0209
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0218
    Cell Significance Index: -0.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0230
    Cell Significance Index: -0.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0232
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0264
    Cell Significance Index: -0.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0270
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0294
    Cell Significance Index: -0.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0320
    Cell Significance Index: -0.5500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0322
    Cell Significance Index: -0.3500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0326
    Cell Significance Index: -0.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0327
    Cell Significance Index: -0.6600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0329
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0333
    Cell Significance Index: -0.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0345
    Cell Significance Index: -0.7200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0363
    Cell Significance Index: -0.6300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0400
    Cell Significance Index: -0.2100
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0417
    Cell Significance Index: -0.4600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0420
    Cell Significance Index: -0.5600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0422
    Cell Significance Index: -0.4000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0433
    Cell Significance Index: -0.5700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0436
    Cell Significance Index: -0.5500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0445
    Cell Significance Index: -0.4900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0452
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0456
    Cell Significance Index: -0.5600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0457
    Cell Significance Index: -0.5700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0467
    Cell Significance Index: -0.5600
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0468
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0469
    Cell Significance Index: -0.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0469
    Cell Significance Index: -0.5800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0470
    Cell Significance Index: -0.5100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0480
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0489
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0543
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0612
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNA4 is a type I interferon, characterized by its ability to bind to the interferon alpha/beta receptor, triggering the activation of downstream signaling pathways. It is primarily expressed in epithelial cells, including those in the gut, and has been implicated in the regulation of immune responses in various tissues. IFNA4 has been shown to have antiviral properties, inhibiting the replication of several viruses, including respiratory syncytial virus (RSV) and SARS-CoV-2. Additionally, IFNA4 has been found to be involved in the regulation of immune cell development and function, including the activation of natural killer cells and T cells. **Pathways and Functions:** IFNA4's primary function is to induce a type I interferon-mediated signaling pathway, which activates immune cells and promotes the production of other type I interferons. This pathway involves the binding of IFNA4 to its receptor, triggering the activation of JAK/STAT proteins, which in turn phosphorylate and activate IRF3, a transcription factor that regulates the expression of interferon-stimulated genes (ISGs). ISGs play a crucial role in the antiviral response, producing proteins that inhibit viral replication and promote the activation of immune cells. IFNA4 has also been implicated in the regulation of immune cell development and function, including the activation of natural killer cells and T cells. For example, IFNA4 has been shown to induce the expression of genes involved in the activation of natural killer cells, including the production of perforin and granzymes. Additionally, IFNA4 has been found to regulate the expression of genes involved in the activation of T cells, including the production of cytokines and chemokines that promote immune cell recruitment and activation. **Clinical Significance:** IFNA4's role in the immune response has significant clinical implications, particularly in the context of viral infections. For example, IFNA4 has been shown to be elevated in patients with RSV infection, suggesting its potential as a biomarker for disease diagnosis and monitoring. Additionally, IFNA4 has been found to be involved in the regulation of immune responses in patients with SARS-CoV-2 infection, suggesting its potential as a therapeutic target for the treatment of COVID-19. Furthermore, IFNA4's role in the regulation of immune cell development and function has implications for the treatment of immune-related disorders, such as autoimmune diseases and cancer. For example, IFNA4 has been shown to regulate the expression of genes involved in the activation of T cells, suggesting its potential as a therapeutic target for the treatment of autoimmune diseases. Additionally, IFNA4's role in the regulation of immune cell development and function has implications for the treatment of cancer, as it may be involved in the regulation of immune cell responses to tumor antigens. In conclusion, IFNA4 is a crucial component of the innate immune response, playing a pivotal role in defending against viral infections and maintaining immune homeostasis. Its clinical significance is evident in its role in the regulation of immune responses in various diseases, including viral infections and immune-related disorders. Further research is needed to fully elucidate the functions and significance of IFNA4, but its potential as a therapeutic target and biomarker for disease diagnosis and monitoring is clear.

Genular Protein ID: 1994306652

Symbol: IFNA4_HUMAN

Name: Interferon alpha-4

UniProtKB Accession Codes:

P05014 P13358 Q14CS4 Q5VV15

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6089830

Title: Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides.

PubMed ID: 6089830

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 9335434

Title: Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population.

PubMed ID: 9335434

DOI: 10.1089/jir.1997.17.559

Sequence Information:

  • Length: 189
  • Mass: 21808
  • Checksum: 828DF9C33ABC337F
  • Sequence:
    • MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF SCLKDRHDFG 
FPEEEFDGHQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE 
ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN 
LQKRLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.