Details for: IFNAR2

Gene ID: 3455

Symbol: IFNAR2

Ensembl ID: ENSG00000159110

Description: interferon alpha and beta receptor subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.43
    Marker Score: 1716
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.12
    Marker Score: 1268
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.94
    Marker Score: 1180
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.64
    Marker Score: 1983
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56552
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92279
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.49
    Marker Score: 14155
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.46
    Marker Score: 5931
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.44
    Marker Score: 1438
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.43
    Marker Score: 13433
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.43
    Marker Score: 1309
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.35
    Marker Score: 11614
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2087
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.3
    Marker Score: 25906
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.28
    Marker Score: 5302
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.28
    Marker Score: 1088
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.27
    Marker Score: 48335
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.25
    Marker Score: 553
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.2
    Marker Score: 18000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.17
    Marker Score: 1341
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.15
    Marker Score: 330
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.14
    Marker Score: 8765
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.14
    Marker Score: 24332
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.13
    Marker Score: 1119
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.12
    Marker Score: 487
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.11
    Marker Score: 7065
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1
    Marker Score: 2696
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1
    Marker Score: 2323.5
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.09
    Marker Score: 3575
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.09
    Marker Score: 9549
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.07
    Marker Score: 1424
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.04
    Marker Score: 4317
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.03
    Marker Score: 358
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.01
    Marker Score: 3886
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71682
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47906
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.99
    Marker Score: 1398
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.98
    Marker Score: 10088
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.96
    Marker Score: 403
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.96
    Marker Score: 755
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2696
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9
    Marker Score: 1323
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5090
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.89
    Marker Score: 906
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1432
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.88
    Marker Score: 7610
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5274
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.87
    Marker Score: 276
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.87
    Marker Score: 736
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.86
    Marker Score: 743
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.86
    Marker Score: 3960
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.85
    Marker Score: 1704
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.85
    Marker Score: 295
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.83
    Marker Score: 715
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.82
    Marker Score: 885
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.82
    Marker Score: 1970
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.81
    Marker Score: 932
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.81
    Marker Score: 2229
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.8
    Marker Score: 161
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.79
    Marker Score: 598
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.79
    Marker Score: 1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 252
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.78
    Marker Score: 436
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.77
    Marker Score: 426
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.77
    Marker Score: 1912
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.76
    Marker Score: 209
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.76
    Marker Score: 3734
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.74
    Marker Score: 516
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.74
    Marker Score: 2918
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.74
    Marker Score: 3025
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.74
    Marker Score: 254
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.73
    Marker Score: 526
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3031
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 433
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.72
    Marker Score: 419
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.72
    Marker Score: 385
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.71
    Marker Score: 180
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.7
    Marker Score: 250
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.7
    Marker Score: 1813
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.7
    Marker Score: 844
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.7
    Marker Score: 725
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.7
    Marker Score: 435
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.7
    Marker Score: 1666.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.69
    Marker Score: 251
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.68
    Marker Score: 265
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.68
    Marker Score: 148
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.68
    Marker Score: 151
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.68
    Marker Score: 9081
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.67
    Marker Score: 753
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.67
    Marker Score: 160
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.67
    Marker Score: 371
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172

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Other Information

**Key characteristics** * The gene is located on chromosome 15q21.1. * It is a member of the immunoglobulin superfamily. * It is expressed in high levels in various immune cell types, including monocytes, dendritic cells, and neurons. * It is a key regulator of innate immune responses. **Pathways and functions** * The IFNAR2 gene is involved in the regulation of innate immune responses. * It is a key component of the Jak pathway, a signaling pathway that is activated by cytokines. * It also plays a role in the regulation of the type I interferon (IFN) signaling pathway. * It is involved in the regulation of viral infection and inflammation. * It is also involved in the regulation of respiratory syncytial virus (RSV) infection. **Clinical significance** * Mutations in the IFNAR2 gene have been linked to human diseases, including systemic sclerosis, rheumatoid arthritis, and tuberculosis. * Targeting IFNAR2 with antibodies or small molecules is a promising strategy for the treatment of these diseases.

Genular Protein ID: 2119234939

Symbol: INAR2_HUMAN

Name: Interferon alpha/beta receptor 2

UniProtKB Accession Codes:

P48551 A8KAJ4 D3DSE8 D3DSE9 Q15467 Q6FHD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 16 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 38 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 9 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8181059

Title: The human interferon alpha/beta receptor: characterization and molecular cloning.

PubMed ID: 8181059

DOI: 10.1016/0092-8674(94)90154-6

PubMed ID: 7588638

Title: Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

PubMed ID: 7588638

DOI: 10.1002/j.1460-2075.1995.tb00192.x

PubMed ID: 7665574

Title: Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.

PubMed ID: 7665574

DOI: 10.1074/jbc.270.37.21606

PubMed ID: 7759950

Title: Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor.

PubMed ID: 7759950

DOI: 10.1002/jlb.57.5.712

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 8798579

Title: Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor.

PubMed ID: 8798579

DOI: 10.1074/jbc.271.39.23630

PubMed ID: 8969169

Title: The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein.

PubMed ID: 8969169

DOI: 10.1074/jbc.271.52.33165

PubMed ID: 9121453

Title: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.

PubMed ID: 9121453

DOI: 10.1128/mcb.17.4.2048

PubMed ID: 10049744

Title: Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation.

PubMed ID: 10049744

DOI: 10.1006/bbrc.1998.0105

PubMed ID: 10556041

Title: Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2.

PubMed ID: 10556041

DOI: 10.1006/jmbi.1999.3230

PubMed ID: 11682488

Title: Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.

PubMed ID: 11682488

DOI: 10.1074/jbc.m108928200

PubMed ID: 12105218

Title: STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.

PubMed ID: 12105218

DOI: 10.1074/jbc.m204578200

PubMed ID: 17517919

Title: A structural basis for interferon-alpha-receptor interactions.

PubMed ID: 17517919

DOI: 10.1096/fj.07-8585com

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12842042

Title: The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding.

PubMed ID: 12842042

DOI: 10.1016/s0969-2126(03)00120-5

PubMed ID: 16757563

Title: Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

PubMed ID: 16757563

DOI: 10.1073/pnas.0602800103

PubMed ID: 24075985

Title: A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

PubMed ID: 24075985

DOI: 10.1016/j.celrep.2013.08.025

PubMed ID: 17001036

Title: Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex.

PubMed ID: 17001036

DOI: 10.1110/ps.062283006

PubMed ID: 20496919

Title: Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY.

PubMed ID: 20496919

DOI: 10.1021/bi100041f

PubMed ID: 21854986

Title: Structural linkage between ligand discrimination and receptor activation by type I interferons.

PubMed ID: 21854986

DOI: 10.1016/j.cell.2011.06.048

PubMed ID: 21819146

Title: Observation of intermolecular interactions in large protein complexes by 2D-double difference nuclear Overhauser enhancement spectroscopy: application to the 44 kDa interferon-receptor complex.

PubMed ID: 21819146

DOI: 10.1021/ja205480v

PubMed ID: 26424569

Title: Human IFNAR2 deficiency: Lessons for antiviral immunity.

PubMed ID: 26424569

DOI: 10.1126/scitranslmed.aac4227

PubMed ID: 28165510

Title: STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.

PubMed ID: 28165510

DOI: 10.1038/nsmb.3378

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

  • Length: 515
  • Mass: 57759
  • Checksum: 4D7730D93AA739F4
  • Sequence:
    • MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS 
IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF 
SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK 
HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE 
SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD 
MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI 
DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR 
ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT 
FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR

Genular Protein ID: 1994288128

Symbol: Q9BUA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BUA0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 331
  • Mass: 37375
  • Checksum: 6698C961E119BDCB
  • Sequence:
    • MLLSQNAFIV RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS 
IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF 
SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK 
HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE 
SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL RQGLTKGWNA VAIHRCSHNA 
LQSETPELKQ SSCLSFPSSW DYKRASLCPS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.