Details for: IFNAR2

Gene ID: 3455

Symbol: IFNAR2

Ensembl ID: ENSG00000159110

Description: interferon alpha and beta receptor subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.7758
    Cell Significance Index: -27.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.0941
    Cell Significance Index: -24.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.3743
    Cell Significance Index: -25.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.1750
    Cell Significance Index: -28.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.6198
    Cell Significance Index: -28.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.6878
    Cell Significance Index: -25.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.7827
    Cell Significance Index: -28.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2023
    Cell Significance Index: -20.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.7304
    Cell Significance Index: -26.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3651
    Cell Significance Index: -19.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1768
    Cell Significance Index: -28.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7928
    Cell Significance Index: 25.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2785
    Cell Significance Index: 256.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0171
    Cell Significance Index: 52.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0084
    Cell Significance Index: 191.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9934
    Cell Significance Index: 285.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7355
    Cell Significance Index: 21.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7343
    Cell Significance Index: 32.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7120
    Cell Significance Index: 26.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6330
    Cell Significance Index: 77.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6103
    Cell Significance Index: 110.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5879
    Cell Significance Index: 30.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5312
    Cell Significance Index: 190.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3605
    Cell Significance Index: 325.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3538
    Cell Significance Index: 21.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3368
    Cell Significance Index: 33.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3066
    Cell Significance Index: 14.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3001
    Cell Significance Index: 16.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2869
    Cell Significance Index: 39.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2759
    Cell Significance Index: 7.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2503
    Cell Significance Index: 27.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1990
    Cell Significance Index: 32.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1804
    Cell Significance Index: 4.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1712
    Cell Significance Index: 93.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1315
    Cell Significance Index: 6.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1256
    Cell Significance Index: 16.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0803
    Cell Significance Index: 6.1700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0773
    Cell Significance Index: 0.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0646
    Cell Significance Index: 4.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0590
    Cell Significance Index: 26.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0480
    Cell Significance Index: 1.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0255
    Cell Significance Index: 2.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0230
    Cell Significance Index: 0.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0047
    Cell Significance Index: 0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0149
    Cell Significance Index: -27.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0175
    Cell Significance Index: -32.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0288
    Cell Significance Index: -21.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0346
    Cell Significance Index: -25.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0380
    Cell Significance Index: -0.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0410
    Cell Significance Index: -4.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0417
    Cell Significance Index: -23.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0429
    Cell Significance Index: -27.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0487
    Cell Significance Index: -30.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0565
    Cell Significance Index: -9.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0621
    Cell Significance Index: -28.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0664
    Cell Significance Index: -8.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0784
    Cell Significance Index: -1.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0920
    Cell Significance Index: -4.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0938
    Cell Significance Index: -6.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0957
    Cell Significance Index: -11.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1026
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1225
    Cell Significance Index: -0.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1358
    Cell Significance Index: -7.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1397
    Cell Significance Index: -29.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1827
    Cell Significance Index: -21.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1852
    Cell Significance Index: -4.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1874
    Cell Significance Index: -5.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1906
    Cell Significance Index: -27.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1936
    Cell Significance Index: -4.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1957
    Cell Significance Index: -2.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2637
    Cell Significance Index: -7.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2691
    Cell Significance Index: -19.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2739
    Cell Significance Index: -28.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2749
    Cell Significance Index: -7.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2866
    Cell Significance Index: -9.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3306
    Cell Significance Index: -20.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3403
    Cell Significance Index: -21.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3446
    Cell Significance Index: -27.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3651
    Cell Significance Index: -3.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3670
    Cell Significance Index: -12.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3753
    Cell Significance Index: -5.1200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3753
    Cell Significance Index: -5.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3993
    Cell Significance Index: -6.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4065
    Cell Significance Index: -9.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4283
    Cell Significance Index: -13.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4653
    Cell Significance Index: -10.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4975
    Cell Significance Index: -10.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5086
    Cell Significance Index: -16.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5224
    Cell Significance Index: -6.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5444
    Cell Significance Index: -19.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5481
    Cell Significance Index: -8.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5486
    Cell Significance Index: -9.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5491
    Cell Significance Index: -19.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5574
    Cell Significance Index: -6.9500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5801
    Cell Significance Index: -10.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5868
    Cell Significance Index: -11.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6203
    Cell Significance Index: -18.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6296
    Cell Significance Index: -12.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** IFNAR2 shares structural homology with the alpha/beta interferon receptor subunit 1 (IFNAR1), forming a heterodimeric complex that binds to interferon alpha and beta. 2. **Receptor Signaling:** Upon binding to interferon alpha or beta, IFNAR2 undergoes dimerization and autophosphorylation, triggering the recruitment of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins. 3. **Cellular Expression:** IFNAR2 is expressed in a wide range of cell types, including immune cells (e.g., monocytes, dendritic cells), neurons, and endothelial cells. 4. **Signaling Pathways:** IFNAR2 is involved in various signaling pathways, including the JAK-STAT pathway, the PI3K/AKT pathway, and the MAPK/ERK pathway. **Pathways and Functions:** 1. **Interferon Signaling:** IFNAR2 plays a crucial role in the regulation of type I interferon signaling, which is essential for the induction of antiviral proteins, such as protein kinase R (PKR) and 2',5'-oligoadenylate synthetase (2',5'-OAS). 2. **Immune Cell Regulation:** IFNAR2 modulates the function of immune cells, including monocytes, dendritic cells, and T cells, influencing their proliferation, differentiation, and cytokine production. 3. **Neuroinflammation:** IFNAR2 has been implicated in the regulation of neuroinflammation, with evidence suggesting its involvement in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. 4. **Antiviral Defense:** IFNAR2 contributes to the antiviral defense mechanism by inducing the expression of antiviral genes and proteins, such as interferon-stimulated genes (ISGs) and type I interferons. **Clinical Significance:** 1. **Viral Infections:** IFNAR2 plays a critical role in the regulation of immune responses against viral infections, such as respiratory syncytial virus (RSV), influenza, and SARS-CoV-2. 2. **Neurological Disorders:** IFNAR2 has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease, highlighting its potential as a therapeutic target. 3. **Cancer:** IFNAR2 has been shown to regulate immune responses in cancer, with evidence suggesting its involvement in the development and progression of certain types of cancer, such as melanoma and breast cancer. 4. **Potential Therapeutics:** IFNAR2 has been identified as a potential therapeutic target for the treatment of viral infections and neurological disorders, with several small molecule inhibitors and monoclonal antibodies targeting IFNAR2 currently in preclinical and clinical development. In conclusion, IFNAR2 is a crucial component of the interferon alpha/beta receptor complex, playing a pivotal role in the regulation of immune responses against viral infections and other pathogens. Its involvement in various signaling pathways, including the JAK-STAT pathway, highlights its importance in the context of immune system regulation and viral defense. As a potential therapeutic target, IFNAR2 holds promise for the development of novel treatments for viral infections, neurological disorders, and cancer.

Genular Protein ID: 2119234939

Symbol: INAR2_HUMAN

Name: Interferon alpha/beta receptor 2

UniProtKB Accession Codes:

P48551 A8KAJ4 D3DSE8 D3DSE9 Q15467 Q6FHD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 16 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 38 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 5 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8181059

Title: The human interferon alpha/beta receptor: characterization and molecular cloning.

PubMed ID: 8181059

DOI: 10.1016/0092-8674(94)90154-6

PubMed ID: 7588638

Title: Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

PubMed ID: 7588638

DOI: 10.1002/j.1460-2075.1995.tb00192.x

PubMed ID: 7665574

Title: Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.

PubMed ID: 7665574

DOI: 10.1074/jbc.270.37.21606

PubMed ID: 7759950

Title: Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor.

PubMed ID: 7759950

DOI: 10.1002/jlb.57.5.712

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 8798579

Title: Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor.

PubMed ID: 8798579

DOI: 10.1074/jbc.271.39.23630

PubMed ID: 8969169

Title: The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein.

PubMed ID: 8969169

DOI: 10.1074/jbc.271.52.33165

PubMed ID: 9121453

Title: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.

PubMed ID: 9121453

DOI: 10.1128/mcb.17.4.2048

PubMed ID: 10049744

Title: Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation.

PubMed ID: 10049744

DOI: 10.1006/bbrc.1998.0105

PubMed ID: 10556041

Title: Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2.

PubMed ID: 10556041

DOI: 10.1006/jmbi.1999.3230

PubMed ID: 11682488

Title: Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.

PubMed ID: 11682488

DOI: 10.1074/jbc.m108928200

PubMed ID: 12105218

Title: STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.

PubMed ID: 12105218

DOI: 10.1074/jbc.m204578200

PubMed ID: 17517919

Title: A structural basis for interferon-alpha-receptor interactions.

PubMed ID: 17517919

DOI: 10.1096/fj.07-8585com

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12842042

Title: The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding.

PubMed ID: 12842042

DOI: 10.1016/s0969-2126(03)00120-5

PubMed ID: 16757563

Title: Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

PubMed ID: 16757563

DOI: 10.1073/pnas.0602800103

PubMed ID: 24075985

Title: A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

PubMed ID: 24075985

DOI: 10.1016/j.celrep.2013.08.025

PubMed ID: 17001036

Title: Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex.

PubMed ID: 17001036

DOI: 10.1110/ps.062283006

PubMed ID: 20496919

Title: Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY.

PubMed ID: 20496919

DOI: 10.1021/bi100041f

PubMed ID: 21854986

Title: Structural linkage between ligand discrimination and receptor activation by type I interferons.

PubMed ID: 21854986

DOI: 10.1016/j.cell.2011.06.048

PubMed ID: 21819146

Title: Observation of intermolecular interactions in large protein complexes by 2D-double difference nuclear Overhauser enhancement spectroscopy: application to the 44 kDa interferon-receptor complex.

PubMed ID: 21819146

DOI: 10.1021/ja205480v

PubMed ID: 26424569

Title: Human IFNAR2 deficiency: Lessons for antiviral immunity.

PubMed ID: 26424569

DOI: 10.1126/scitranslmed.aac4227

PubMed ID: 28165510

Title: STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.

PubMed ID: 28165510

DOI: 10.1038/nsmb.3378

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

  • Length: 515
  • Mass: 57759
  • Checksum: 4D7730D93AA739F4
  • Sequence:
    • MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS 
IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF 
SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK 
HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE 
SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD 
MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI 
DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR 
ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT 
FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR

Genular Protein ID: 1994288128

Symbol: Q9BUA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BUA0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 331
  • Mass: 37375
  • Checksum: 6698C961E119BDCB
  • Sequence:
    • MLLSQNAFIV RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS 
IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF 
SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK 
HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE 
SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL RQGLTKGWNA VAIHRCSHNA 
LQSETPELKQ SSCLSFPSSW DYKRASLCPS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.