Details for: IGBP1

Gene ID: 3476

Symbol: IGBP1

Ensembl ID: ENSG00000089289

Description: immunoglobulin binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 273.6825
    Cell Significance Index: -42.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.3481
    Cell Significance Index: -28.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.0196
    Cell Significance Index: -49.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.0394
    Cell Significance Index: -50.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.2018
    Cell Significance Index: -49.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.9332
    Cell Significance Index: -46.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5352
    Cell Significance Index: -33.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3136
    Cell Significance Index: -48.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.7306
    Cell Significance Index: -36.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7911
    Cell Significance Index: -19.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0474
    Cell Significance Index: 132.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8020
    Cell Significance Index: 41.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7202
    Cell Significance Index: 310.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7050
    Cell Significance Index: 46.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6810
    Cell Significance Index: 230.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6493
    Cell Significance Index: 202.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6274
    Cell Significance Index: 84.5400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5856
    Cell Significance Index: 12.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5645
    Cell Significance Index: 854.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5115
    Cell Significance Index: 106.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4452
    Cell Significance Index: 67.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1758
    Cell Significance Index: 138.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1655
    Cell Significance Index: 86.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1631
    Cell Significance Index: 34.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1189
    Cell Significance Index: 23.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0884
    Cell Significance Index: 28.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0689
    Cell Significance Index: 472.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0662
    Cell Significance Index: 13.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0588
    Cell Significance Index: 9.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0244
    Cell Significance Index: 132.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0166
    Cell Significance Index: 47.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8466
    Cell Significance Index: 29.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8124
    Cell Significance Index: 17.6000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8039
    Cell Significance Index: 8.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7700
    Cell Significance Index: 34.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7279
    Cell Significance Index: 146.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7261
    Cell Significance Index: 10.8800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.6757
    Cell Significance Index: 3.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6653
    Cell Significance Index: 85.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6573
    Cell Significance Index: 17.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5410
    Cell Significance Index: 107.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5347
    Cell Significance Index: 5.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4700
    Cell Significance Index: 8.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4641
    Cell Significance Index: 50.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3386
    Cell Significance Index: 9.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2905
    Cell Significance Index: 15.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2869
    Cell Significance Index: 102.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2201
    Cell Significance Index: 37.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2167
    Cell Significance Index: 21.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1961
    Cell Significance Index: 5.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1492
    Cell Significance Index: 4.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0990
    Cell Significance Index: 3.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0672
    Cell Significance Index: 2.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0586
    Cell Significance Index: 52.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0132
    Cell Significance Index: 9.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0104
    Cell Significance Index: 0.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0063
    Cell Significance Index: 11.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0188
    Cell Significance Index: -25.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0249
    Cell Significance Index: -2.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0404
    Cell Significance Index: -25.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0537
    Cell Significance Index: -39.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0677
    Cell Significance Index: -30.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0736
    Cell Significance Index: -41.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0818
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0892
    Cell Significance Index: -55.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0933
    Cell Significance Index: -5.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1008
    Cell Significance Index: -5.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1035
    Cell Significance Index: -16.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1140
    Cell Significance Index: -8.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1375
    Cell Significance Index: -39.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1510
    Cell Significance Index: -2.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1553
    Cell Significance Index: -22.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2206
    Cell Significance Index: -25.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2243
    Cell Significance Index: -26.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2316
    Cell Significance Index: -5.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2417
    Cell Significance Index: -6.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2529
    Cell Significance Index: -53.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3025
    Cell Significance Index: -20.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3468
    Cell Significance Index: -3.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3809
    Cell Significance Index: -30.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4354
    Cell Significance Index: -5.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4362
    Cell Significance Index: -7.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4486
    Cell Significance Index: -46.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4861
    Cell Significance Index: -8.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5029
    Cell Significance Index: -10.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5906
    Cell Significance Index: -15.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6559
    Cell Significance Index: -29.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6736
    Cell Significance Index: -41.3000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.8147
    Cell Significance Index: -5.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8419
    Cell Significance Index: -31.8800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9426
    Cell Significance Index: -16.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9872
    Cell Significance Index: -36.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9890
    Cell Significance Index: -11.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9951
    Cell Significance Index: -29.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0165
    Cell Significance Index: -26.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0300
    Cell Significance Index: -32.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGBP1 is a cytosolic protein that interacts with various immune-related proteins, including immunoglobulins, cytokines, and signaling molecules. Its expression is widespread across different cell types, including immune cells, epithelial cells, and stem cells. IGBP1 exhibits a unique ability to regulate protein degradation, modulate signaling pathways, and interact with multiple partners, making it a key player in various cellular processes. **Pathways and Functions:** IGBP1 is involved in several critical signaling pathways, including: 1. **B cell activation**: IGBP1 interacts with B cell receptors, influencing B cell development, activation, and differentiation. 2. **Negative regulation of cysteine-type endopeptidase activity**: IGBP1 inhibits the activity of caspases, which are crucial for apoptosis and cell death. 3. **Negative regulation of stress-activated MAPK cascade**: IGBP1 modulates the MAPK signaling pathway, which is involved in stress response and cell survival. 4. **Negative regulation of transcription by RNA polymerase II**: IGBP1 regulates gene expression by interacting with RNA polymerase II, a crucial enzyme for transcription. IGBP1's functions can be broadly categorized into: 1. **Protein binding**: IGBP1 interacts with various proteins, including immunoglobulins, cytokines, and signaling molecules. 2. **Protein phosphatase 2a binding**: IGBP1 inhibits the activity of protein phosphatase 2a, a key regulator of cellular signaling pathways. 3. **Regulation of dephosphorylation**: IGBP1 modulates the activity of dephosphorylating enzymes, influencing protein degradation and signaling pathways. 4. **Regulation of microtubule-based movement**: IGBP1 interacts with microtubule-associated proteins, influencing cellular motility and transport. **Clinical Significance:** IGBP1's involvement in various immune-related processes and its ability to regulate cellular signaling pathways make it a potential target for the development of novel therapeutic strategies. Dysregulation of IGBP1 has been implicated in several diseases, including: 1. **Autoimmune disorders**: IGBP1's role in B cell activation and regulation of immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: IGBP1's involvement in cell signaling pathways and regulation of protein degradation makes it a potential target for the development of cancer therapies. 3. **Neurological disorders**: IGBP1's role in modulating cellular signaling pathways and regulating protein degradation makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, IGBP1 is a multifunctional protein that plays a critical role in various cellular processes, including immune response, cell signaling, and regulation of protein degradation. Its dysregulation has been implicated in several diseases, making it a potential target for the development of novel therapeutic strategies. Further research is necessary to fully elucidate the complexities of IGBP1's role in human health and disease.

Genular Protein ID: 2145258964

Symbol: IGBP1_HUMAN

Name: Immunoglobulin-binding protein 1

UniProtKB Accession Codes:

P78318 Q8TAB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9441740

Title: Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway.

PubMed ID: 9441740

DOI: 10.1006/geno.1997.5048

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9647778

Title: Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PubMed ID: 9647778

DOI: 10.1006/bbrc.1998.8792

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 11806752

Title: MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.

PubMed ID: 11806752

DOI: 10.1186/1471-2121-3-1

PubMed ID: 14556245

Title: A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the alpha 4 gene at Xq13.

PubMed ID: 14556245

DOI: 10.1002/ajmg.a.20504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19818709

Title: Alpha4 is an essential regulator of PP2A phosphatase activity.

PubMed ID: 19818709

DOI: 10.1016/j.molcel.2009.09.025

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20092282

Title: Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

PubMed ID: 20092282

DOI: 10.1021/bi901837h

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22613722

Title: Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation.

PubMed ID: 22613722

DOI: 10.1074/jbc.m112.368613

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23591866

Title: Structural basis of protein phosphatase 2A stable latency.

PubMed ID: 23591866

DOI: 10.1038/ncomms2663

Sequence Information:

  • Length: 339
  • Mass: 39222
  • Checksum: BB00A116EB45273A
  • Sequence:
    • MAAEDELQLP RLPELFETGR QLLDEVEVAT EPAGSRIVQE KVFKGLDLLE KAAEMLSQLD 
LFSRNEDLEE IASTDLKYLL VPAFQGALTM KQVNPSKRLD HLQRAREHFI NYLTQCHCYH 
VAEFELPKTM NNSAENHTAN SSMAYPSLVA MASQRQAKIQ RYKQKKELEH RLSAMKSAVE 
SGQADDERVR EYYLLHLQRW IDISLEEIES IDQEIKILRE RDSSREASTS NSSRQERPPV 
KPFILTRNMA QAKVFGAGYP SLPTMTVSDW YEQHRKYGAL PDQGIAKAAP EEFRKAAQQQ 
EEQEEKEEED DEQTLHRARE WDDWKDTHPR GYGNRQNMG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.