Details for: IGBP1

Gene ID: 3476

Symbol: IGBP1

Ensembl ID: ENSG00000089289

Description: immunoglobulin binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.8
    Marker Score: 8029
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2
    Marker Score: 5020
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.11
    Marker Score: 27822
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.08
    Marker Score: 72191
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.96
    Marker Score: 19844
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.91
    Marker Score: 8216
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.89
    Marker Score: 3294
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.87
    Marker Score: 932
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.86
    Marker Score: 2733
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.85
    Marker Score: 12028
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.84
    Marker Score: 3260
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.83
    Marker Score: 1323
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.81
    Marker Score: 7420
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.81
    Marker Score: 1824
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.81
    Marker Score: 8678
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.8
    Marker Score: 3765
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.8
    Marker Score: 1093
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.8
    Marker Score: 4264
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.79
    Marker Score: 1194
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.76
    Marker Score: 4802
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.74
    Marker Score: 4345.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.74
    Marker Score: 2678
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.73
    Marker Score: 20087
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.72
    Marker Score: 6742
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.7
    Marker Score: 839
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.7
    Marker Score: 893
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.68
    Marker Score: 3953
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.68
    Marker Score: 2376
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.68
    Marker Score: 1783
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.67
    Marker Score: 6453
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.67
    Marker Score: 4548.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.66
    Marker Score: 2968
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.66
    Marker Score: 532
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.66
    Marker Score: 400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.66
    Marker Score: 1752
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.65
    Marker Score: 22116
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.64
    Marker Score: 1537
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.64
    Marker Score: 86757
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.63
    Marker Score: 549
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.63
    Marker Score: 10390
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.62
    Marker Score: 2654
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.6
    Marker Score: 1893
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.6
    Marker Score: 1708
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6
    Marker Score: 4740
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.57
    Marker Score: 17698
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.57
    Marker Score: 374
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.56
    Marker Score: 5787
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.56
    Marker Score: 2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.55
    Marker Score: 86885
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.55
    Marker Score: 2905
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.54
    Marker Score: 3489
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.53
    Marker Score: 1442
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.52
    Marker Score: 15086
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.52
    Marker Score: 13106
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.52
    Marker Score: 1108
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.52
    Marker Score: 1620
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.51
    Marker Score: 834
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.51
    Marker Score: 530
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.51
    Marker Score: 909
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.5
    Marker Score: 6441
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.5
    Marker Score: 352
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.5
    Marker Score: 2919
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.48
    Marker Score: 876
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.46
    Marker Score: 917
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.46
    Marker Score: 1046
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.46
    Marker Score: 421
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.46
    Marker Score: 1102
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.45
    Marker Score: 10825
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.45
    Marker Score: 712
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.45
    Marker Score: 501
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.45
    Marker Score: 513
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.45
    Marker Score: 49205
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.44
    Marker Score: 1392
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.44
    Marker Score: 36896
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165242
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.44
    Marker Score: 907.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.43
    Marker Score: 598
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.43
    Marker Score: 11152
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.42
    Marker Score: 1271
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.42
    Marker Score: 4474
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.41
    Marker Score: 1773
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.41
    Marker Score: 521
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4
    Marker Score: 14063
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.4
    Marker Score: 525
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.39
    Marker Score: 741
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.39
    Marker Score: 1511
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.39
    Marker Score: 1158
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.37
    Marker Score: 1313
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.37
    Marker Score: 1285
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.37
    Marker Score: 1345
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.36
    Marker Score: 2767.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.36
    Marker Score: 641
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.36
    Marker Score: 924
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.36
    Marker Score: 312
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.35
    Marker Score: 409
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.35
    Marker Score: 1202
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.35
    Marker Score: 1201
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.34
    Marker Score: 1057
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.34
    Marker Score: 546
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.34
    Marker Score: 306

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Other Information

**Key characteristics:** * IGBP1 is a protein of the immunoglobulin superfamily. * It is expressed in a variety of cell types, including pancreatic acinar cells, acinar cells of the salivary gland, mesodermal cells, and immune cells. * IGBP1 is a key regulator of the B cell activation pathway. * It binds to the protein phosphatase 2a (PP2A) and inhibits its activity. * This prevents the degradation of a protein called MAPK14, which is a key regulator of apoptosis. **Pathways and functions:** * IGBP1 works by binding to the protein phosphatase 2a (PP2A) and inhibiting its activity. * This prevents the degradation of a protein called MAPK14, which is a key regulator of apoptosis. * MAPK14 is involved in a variety of cellular processes, including cell cycle regulation, growth, and differentiation. * IGBP1 is also involved in the regulation of the stress-activated mapk cascade, which is a pathway that is activated in response to stress. * IGBP1 also regulates the transcription of a variety of genes, including those involved in cell cycle regulation and apoptosis. **Clinical significance:** * IGBP1 is a promising target for cancer immunotherapy. * Inhibition of IGBP1 has been shown to be effective in promoting the survival of cancer cells and inhibiting their growth. * IGBP1 is a novel target for the treatment of cancer. **Conclusion:** IGBP1 is a key regulator of apoptosis, stress response, and cell migration. It is a promising target for cancer immunotherapy.

Genular Protein ID: 2145258964

Symbol: IGBP1_HUMAN

Name: Immunoglobulin-binding protein 1

UniProtKB Accession Codes:

P78318 Q8TAB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9441740

Title: Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway.

PubMed ID: 9441740

DOI: 10.1006/geno.1997.5048

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9647778

Title: Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PubMed ID: 9647778

DOI: 10.1006/bbrc.1998.8792

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 11806752

Title: MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.

PubMed ID: 11806752

DOI: 10.1186/1471-2121-3-1

PubMed ID: 14556245

Title: A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the alpha 4 gene at Xq13.

PubMed ID: 14556245

DOI: 10.1002/ajmg.a.20504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19818709

Title: Alpha4 is an essential regulator of PP2A phosphatase activity.

PubMed ID: 19818709

DOI: 10.1016/j.molcel.2009.09.025

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20092282

Title: Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

PubMed ID: 20092282

DOI: 10.1021/bi901837h

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22613722

Title: Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation.

PubMed ID: 22613722

DOI: 10.1074/jbc.m112.368613

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23591866

Title: Structural basis of protein phosphatase 2A stable latency.

PubMed ID: 23591866

DOI: 10.1038/ncomms2663

Sequence Information:

  • Length: 339
  • Mass: 39222
  • Checksum: BB00A116EB45273A
  • Sequence:
    • MAAEDELQLP RLPELFETGR QLLDEVEVAT EPAGSRIVQE KVFKGLDLLE KAAEMLSQLD 
LFSRNEDLEE IASTDLKYLL VPAFQGALTM KQVNPSKRLD HLQRAREHFI NYLTQCHCYH 
VAEFELPKTM NNSAENHTAN SSMAYPSLVA MASQRQAKIQ RYKQKKELEH RLSAMKSAVE 
SGQADDERVR EYYLLHLQRW IDISLEEIES IDQEIKILRE RDSSREASTS NSSRQERPPV 
KPFILTRNMA QAKVFGAGYP SLPTMTVSDW YEQHRKYGAL PDQGIAKAAP EEFRKAAQQQ 
EEQEEKEEED DEQTLHRARE WDDWKDTHPR GYGNRQNMG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.