Details for: IL2RB

Gene ID: 3560

Symbol: IL2RB

Ensembl ID: ENSG00000100385

Description: interleukin 2 receptor subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.26
    Marker Score: 11768
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.12
    Marker Score: 3466
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.69
    Marker Score: 7846
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.45
    Marker Score: 807
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.43
    Marker Score: 1049
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.14
    Marker Score: 542
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.98
    Marker Score: 1975
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1155
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.57
    Marker Score: 4961
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.53
    Marker Score: 15179
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.53
    Marker Score: 9788
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.52
    Marker Score: 2240
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.45
    Marker Score: 4058
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.38
    Marker Score: 793
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 857
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.27
    Marker Score: 985
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.22
    Marker Score: 395
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.18
    Marker Score: 709
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 479
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.15
    Marker Score: 2803
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4793
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.09
    Marker Score: 792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48023
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.98
    Marker Score: 305
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.98
    Marker Score: 1275
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.97
    Marker Score: 298
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.96
    Marker Score: 806
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.95
    Marker Score: 843
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.94
    Marker Score: 520
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.93
    Marker Score: 546
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5276
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.92
    Marker Score: 723
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1743
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.91
    Marker Score: 1007
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.91
    Marker Score: 276
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.9
    Marker Score: 463
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.9
    Marker Score: 606
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.89
    Marker Score: 727
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.78
    Marker Score: 335
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.77
    Marker Score: 563
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.76
    Marker Score: 546
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.75
    Marker Score: 263
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.74
    Marker Score: 653
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.73
    Marker Score: 448
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.71
    Marker Score: 353
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.67
    Marker Score: 650
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.67
    Marker Score: 923
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.66
    Marker Score: 557
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.65
    Marker Score: 147
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.64
    Marker Score: 1148
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.64
    Marker Score: 481
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9848
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.6
    Marker Score: 970
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.58
    Marker Score: 30922
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.58
    Marker Score: 201
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.58
    Marker Score: 208
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.56
    Marker Score: 6483
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.55
    Marker Score: 149
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.54
    Marker Score: 251
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.53
    Marker Score: 120
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.52
    Marker Score: 434
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.51
    Marker Score: 727
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 134
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.49
    Marker Score: 246
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.48
    Marker Score: 1001
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.48
    Marker Score: 422
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.48
    Marker Score: 447
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.45
    Marker Score: 775
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 211
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.42
    Marker Score: 273
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.42
    Marker Score: 554
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 130
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.41
    Marker Score: 90
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.41
    Marker Score: 1739
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.4
    Marker Score: 792
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 228
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.39
    Marker Score: 205
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.37
    Marker Score: 282.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.36
    Marker Score: 392

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Other Information

**Key characteristics:** - IL2RB is a type I transmembrane receptor that belongs to the interleukin-2 receptor family. - It is expressed on a variety of immune cells, including dendritic cells, macrophages, and lymphocytes. - IL2RB is a key receptor for interleukin-2 (IL-2), a cytokine that plays a crucial role in the regulation of immune responses. **Pathways and functions:** - IL2RB is a coreceptor for IL-2. - It is involved in the activation of signal transduction pathways that are activated by IL-2. - IL2RB signaling is important for the regulation of T cell responses, as it is required for the development and maintenance of T cell anergy. - It is also involved in the regulation of natural killer (NK) cell activity. **Clinical significance:** - Mutations in the IL2RB gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and cancer. - In rheumatoid arthritis, IL2RB signaling is impaired, which leads to the activation of pro-inflammatory immune responses. - In asthma, IL2RB signaling is also impaired, which leads to the development of airway inflammation. - Targeting IL2RB signaling has been explored as a therapeutic strategy for these diseases.

Genular Protein ID: 3169914925

Symbol: IL2RB_HUMAN

Name: Interleukin-2 receptor subunit beta

UniProtKB Accession Codes:

P14784 B2R765

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 ELM 1 EMBL 7 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2785715

Title: Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.

PubMed ID: 2785715

DOI: 10.1126/science.2785715

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8648694

Title: The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.

PubMed ID: 8648694

DOI: 10.1128/jvi.70.6.3599-3605.1996

PubMed ID: 12200137

Title: IL-2 receptor signaling through the Shb adapter protein in T and NK cells.

PubMed ID: 12200137

DOI: 10.1016/s0006-291x(02)02016-8

PubMed ID: 15123770

Title: Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.

PubMed ID: 15123770

DOI: 10.1189/jlb.0605298

PubMed ID: 7529123

Title: The interleukin-2 and interleukin-4 receptors studied by molecular modelling.

PubMed ID: 7529123

DOI: 10.1016/s0969-2126(94)00085-9

PubMed ID: 16293754

Title: Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

PubMed ID: 16293754

DOI: 10.1126/science.1117893

PubMed ID: 16477002

Title: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.

PubMed ID: 16477002

DOI: 10.1073/pnas.0511161103

PubMed ID: 31040184

Title: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.

PubMed ID: 31040184

DOI: 10.1084/jem.20182015

PubMed ID: 31040185

Title: Human interleukin-2 receptor beta mutations associated with defects in immunity and peripheral tolerance.

PubMed ID: 31040185

DOI: 10.1084/jem.20182304

Sequence Information:

  • Length: 551
  • Mass: 61117
  • Checksum: 1A76FA1936BB7EE6
  • Sequence:
    • MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ 
VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA 
IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE 
APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT 
IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV 
QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT 
NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT 
FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP 
DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ 
ELQGQDPTHL V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.