Details for: IL2RB

Gene ID: 3560

Symbol: IL2RB

Ensembl ID: ENSG00000100385

Description: interleukin 2 receptor subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.4579
    Cell Significance Index: -12.7800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 25.3613
    Cell Significance Index: 67.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.9903
    Cell Significance Index: -9.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 11.3361
    Cell Significance Index: 398.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 7.7984
    Cell Significance Index: 161.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.0296
    Cell Significance Index: 125.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.7473
    Cell Significance Index: 136.7800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.4793
    Cell Significance Index: 53.8300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.2961
    Cell Significance Index: 24.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.2628
    Cell Significance Index: 66.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0349
    Cell Significance Index: -6.2500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.9924
    Cell Significance Index: 12.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7887
    Cell Significance Index: 81.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6448
    Cell Significance Index: 35.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2636
    Cell Significance Index: 240.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0819
    Cell Significance Index: 107.0200
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.9101
    Cell Significance Index: 2.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8312
    Cell Significance Index: 750.5100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.7397
    Cell Significance Index: 7.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6656
    Cell Significance Index: 17.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5634
    Cell Significance Index: 8.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4945
    Cell Significance Index: 80.4300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3989
    Cell Significance Index: 4.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3832
    Cell Significance Index: 41.6800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2778
    Cell Significance Index: 2.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2011
    Cell Significance Index: 13.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0071
    Cell Significance Index: 3.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0023
    Cell Significance Index: 0.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0008
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0072
    Cell Significance Index: -11.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0077
    Cell Significance Index: -0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0127
    Cell Significance Index: -0.7600
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: -0.0141
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0151
    Cell Significance Index: -9.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0163
    Cell Significance Index: -9.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0176
    Cell Significance Index: -2.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0177
    Cell Significance Index: -9.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0211
    Cell Significance Index: -13.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0216
    Cell Significance Index: -7.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0278
    Cell Significance Index: -12.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0335
    Cell Significance Index: -9.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0347
    Cell Significance Index: -6.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0376
    Cell Significance Index: -0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0390
    Cell Significance Index: -7.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0448
    Cell Significance Index: -9.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0515
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0558
    Cell Significance Index: -9.5300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0559
    Cell Significance Index: -0.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0559
    Cell Significance Index: -7.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0571
    Cell Significance Index: -2.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0597
    Cell Significance Index: -10.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0637
    Cell Significance Index: -2.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0666
    Cell Significance Index: -2.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0744
    Cell Significance Index: -10.8100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0765
    Cell Significance Index: -1.3000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0789
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0804
    Cell Significance Index: -9.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0857
    Cell Significance Index: -9.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0890
    Cell Significance Index: -9.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0892
    Cell Significance Index: -10.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1031
    Cell Significance Index: -2.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1050
    Cell Significance Index: -13.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1150
    Cell Significance Index: -11.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1287
    Cell Significance Index: -6.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1388
    Cell Significance Index: -9.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1420
    Cell Significance Index: -10.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1595
    Cell Significance Index: -4.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1642
    Cell Significance Index: -4.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1755
    Cell Significance Index: -13.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1775
    Cell Significance Index: -3.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1864
    Cell Significance Index: -2.6700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1865
    Cell Significance Index: -1.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2005
    Cell Significance Index: -11.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2089
    Cell Significance Index: -12.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2105
    Cell Significance Index: -13.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2149
    Cell Significance Index: -10.0200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2189
    Cell Significance Index: -2.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2235
    Cell Significance Index: -11.6100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.2248
    Cell Significance Index: -2.3300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2272
    Cell Significance Index: -1.6400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2357
    Cell Significance Index: -2.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2400
    Cell Significance Index: -12.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2595
    Cell Significance Index: -11.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2658
    Cell Significance Index: -9.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2801
    Cell Significance Index: -9.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2859
    Cell Significance Index: -9.1100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2869
    Cell Significance Index: -2.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2928
    Cell Significance Index: -10.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3029
    Cell Significance Index: -11.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3120
    Cell Significance Index: -6.5300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3163
    Cell Significance Index: -3.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3308
    Cell Significance Index: -9.4400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3346
    Cell Significance Index: -2.8500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3360
    Cell Significance Index: -4.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3471
    Cell Significance Index: -9.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The IL2RB gene is located on chromosome 4q11.23 and is significantly expressed in various immune cells, including decidual natural killer cells, intraepithelial lymphocytes, and alpha-beta cytokine secreting effector T cells. 2. **Protein Structure:** The IL2RB protein is a subunit of the interleukin-2 receptor complex, consisting of three subunits: alpha, beta, and gamma. The beta subunit is responsible for the binding of interleukin-2 (IL-2) and other cytokines. 3. **Function:** The IL2RB protein plays a crucial role in the regulation of immune response by mediating the signaling pathways that regulate the proliferation, differentiation, and survival of T cells and natural killer cells. **Pathways and Functions:** 1. **Cytokine-Mediated Signaling Pathway:** The IL2RB protein is involved in the cytokine-mediated signaling pathway, which regulates the immune response by activating various signaling cascades. 2. **Interleukin-2 Signaling Pathway:** The IL2RB protein is essential for the IL-2 signaling pathway, which regulates the proliferation, differentiation, and survival of T cells and natural killer cells. 3. **Coreceptor Activity:** The IL2RB protein acts as a coreceptor for IL-2, enhancing the binding of IL-2 to the alpha subunit of the receptor complex. 4. **Regulation of Apoptosis:** The IL2RB protein is involved in the regulation of apoptosis, preventing the excessive death of immune cells. **Clinical Significance:** The IL2RB gene has significant clinical implications, particularly in the context of immune-related disorders. Mutations or variations in the IL2RB gene have been associated with various immune-related diseases, including: 1. **Immunodeficiency Disorders:** Mutations in the IL2RB gene have been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID) and hyper IgM syndrome. 2. **Autoimmune Diseases:** The IL2RB protein has been implicated in the regulation of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** The IL2RB protein is involved in the regulation of immune response in cancer, and its dysregulation has been associated with various types of cancer. In conclusion, the IL2RB gene plays a crucial role in the regulation of immune response, and its dysregulation has significant clinical implications. Further research is needed to fully understand the mechanisms by which the IL2RB gene regulates immune response and to develop novel therapeutic strategies for immune-related disorders.

Genular Protein ID: 3169914925

Symbol: IL2RB_HUMAN

Name: Interleukin-2 receptor subunit beta

UniProtKB Accession Codes:

P14784 B2R765

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 ELM 1 EMBL 7 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2785715

Title: Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.

PubMed ID: 2785715

DOI: 10.1126/science.2785715

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8648694

Title: The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.

PubMed ID: 8648694

DOI: 10.1128/jvi.70.6.3599-3605.1996

PubMed ID: 12200137

Title: IL-2 receptor signaling through the Shb adapter protein in T and NK cells.

PubMed ID: 12200137

DOI: 10.1016/s0006-291x(02)02016-8

PubMed ID: 15123770

Title: Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.

PubMed ID: 15123770

DOI: 10.1189/jlb.0605298

PubMed ID: 7529123

Title: The interleukin-2 and interleukin-4 receptors studied by molecular modelling.

PubMed ID: 7529123

DOI: 10.1016/s0969-2126(94)00085-9

PubMed ID: 16293754

Title: Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

PubMed ID: 16293754

DOI: 10.1126/science.1117893

PubMed ID: 16477002

Title: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.

PubMed ID: 16477002

DOI: 10.1073/pnas.0511161103

PubMed ID: 31040184

Title: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.

PubMed ID: 31040184

DOI: 10.1084/jem.20182015

PubMed ID: 31040185

Title: Human interleukin-2 receptor beta mutations associated with defects in immunity and peripheral tolerance.

PubMed ID: 31040185

DOI: 10.1084/jem.20182304

Sequence Information:

  • Length: 551
  • Mass: 61117
  • Checksum: 1A76FA1936BB7EE6
  • Sequence:
    • MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ 
VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA 
IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE 
APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT 
IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV 
QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT 
NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT 
FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP 
DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ 
ELQGQDPTHL V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.