Details for: CXCR2

Gene ID: 3579

Symbol: CXCR2

Ensembl ID: ENSG00000180871

Description: C-X-C motif chemokine receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 13.0509
    Cell Significance Index: -2.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 7.9245
    Cell Significance Index: -2.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 4.9463
    Cell Significance Index: 173.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2811
    Cell Significance Index: 139.8500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.2709
    Cell Significance Index: 32.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.6464
    Cell Significance Index: -2.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9739
    Cell Significance Index: 21.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8454
    Cell Significance Index: 38.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6034
    Cell Significance Index: 114.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4265
    Cell Significance Index: 42.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3677
    Cell Significance Index: 331.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2868
    Cell Significance Index: 9.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2198
    Cell Significance Index: 35.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2189
    Cell Significance Index: 11.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1996
    Cell Significance Index: 21.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1672
    Cell Significance Index: 3.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1641
    Cell Significance Index: 3.5000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1523
    Cell Significance Index: 1.7700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1513
    Cell Significance Index: 1.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1111
    Cell Significance Index: 7.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0939
    Cell Significance Index: 5.6400
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.0898
    Cell Significance Index: 0.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0784
    Cell Significance Index: 1.0700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0295
    Cell Significance Index: 0.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0267
    Cell Significance Index: 0.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0252
    Cell Significance Index: 4.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0216
    Cell Significance Index: 2.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0054
    Cell Significance Index: 2.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0012
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0039
    Cell Significance Index: -0.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0048
    Cell Significance Index: -2.1600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0060
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0080
    Cell Significance Index: -1.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0083
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0097
    Cell Significance Index: -1.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0100
    Cell Significance Index: -0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0106
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0111
    Cell Significance Index: -1.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0115
    Cell Significance Index: -0.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0132
    Cell Significance Index: -0.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0134
    Cell Significance Index: -1.9500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0153
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0169
    Cell Significance Index: -1.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0187
    Cell Significance Index: -2.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0188
    Cell Significance Index: -1.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0219
    Cell Significance Index: -1.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0250
    Cell Significance Index: -0.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0262
    Cell Significance Index: -0.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0279
    Cell Significance Index: -0.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0283
    Cell Significance Index: -2.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0306
    Cell Significance Index: -1.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0310
    Cell Significance Index: -0.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0321
    Cell Significance Index: -2.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0332
    Cell Significance Index: -0.4800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0353
    Cell Significance Index: -2.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0372
    Cell Significance Index: -1.9400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0380
    Cell Significance Index: -0.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0398
    Cell Significance Index: -1.8600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0404
    Cell Significance Index: -1.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0417
    Cell Significance Index: -1.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0422
    Cell Significance Index: -1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0432
    Cell Significance Index: -2.0300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0452
    Cell Significance Index: -0.2800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0467
    Cell Significance Index: -0.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0467
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0474
    Cell Significance Index: -1.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0563
    Cell Significance Index: -2.4900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0566
    Cell Significance Index: -0.6200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0574
    Cell Significance Index: -0.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0580
    Cell Significance Index: -1.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0581
    Cell Significance Index: -1.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0596
    Cell Significance Index: -1.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0640
    Cell Significance Index: -1.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0653
    Cell Significance Index: -1.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0665
    Cell Significance Index: -2.5200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0672
    Cell Significance Index: -0.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0675
    Cell Significance Index: -1.3200
  • Cell Name: mature neutrophil (CL0000096)
    Fold Change: -0.0684
    Cell Significance Index: -0.5600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0689
    Cell Significance Index: -1.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0719
    Cell Significance Index: -1.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0744
    Cell Significance Index: -2.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0746
    Cell Significance Index: -2.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0761
    Cell Significance Index: -2.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0764
    Cell Significance Index: -2.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0773
    Cell Significance Index: -2.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0774
    Cell Significance Index: -1.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0802
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCR2 is a member of the CXC chemokine receptor family and exhibits several distinct characteristics. These include: 1. **High-affinity binding**: CXCR2 has a high affinity for its ligands, which allows for efficient signaling and activation of downstream pathways. 2. **Specific ligand binding**: CXCR2 is specific for the binding of CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL8 (IL-8), and CXCL10, which allows for the regulation of immune responses and inflammation. 3. **Chemotaxis**: CXCR2 is involved in the chemotaxis of various immune cells, including neutrophils, dendritic cells, and T cells, which is essential for the regulation of immune responses and inflammation. 4. **Signaling pathways**: CXCR2 activates various signaling pathways, including calcium-mediated signaling, phospholipase C-activating GPCR signaling pathway, and G alpha (i) signaling events, which regulate immune responses and inflammation. **Pathways and Functions** CXCR2 plays a crucial role in various biological processes, including: 1. **Acute inflammatory response**: CXCR2 is involved in the recruitment of neutrophils to sites of inflammation, which is essential for the resolution of acute inflammatory responses. 2. **Cancer progression**: CXCR2 is overexpressed in various types of cancer, including lung, colon, and breast cancer, and is associated with tumor progression and metastasis. 3. **Immune system development**: CXCR2 is involved in the development and maturation of immune cells, including dendritic cells and T cells. 4. **Neuroinflammation**: CXCR2 is involved in the regulation of neuroinflammation, including the recruitment of microglia and the activation of astrocytes. **Clinical Significance** CXCR2 has significant clinical implications, particularly in the context of: 1. **Inflammatory disorders**: CXCR2 is involved in the pathogenesis of various inflammatory disorders, including rheumatoid arthritis, psoriasis, and asthma. 2. **Cancer**: CXCR2 is a potential therapeutic target for the treatment of various types of cancer, including lung, colon, and breast cancer. 3. **Neurodegenerative diseases**: CXCR2 is involved in the regulation of neuroinflammation and may be a potential therapeutic target for the treatment of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Immunotherapy**: CXCR2 is a potential target for immunotherapy, including the development of CXCR2-targeting antibodies and small molecules. In conclusion, CXCR2 is a crucial receptor involved in the regulation of immune responses, inflammation, and cell migration. Its dysregulation has significant clinical implications, particularly in the context of inflammatory disorders, cancer, and neurodegenerative diseases. Further research is needed to fully understand the role of CXCR2 in human disease and to develop effective therapeutic strategies targeting this receptor.

Genular Protein ID: 3970031595

Symbol: CXCR2_HUMAN

Name: C-X-C chemokine receptor type 2

UniProtKB Accession Codes:

P25025 Q8IUZ1 Q9P2T6 Q9P2T7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 9 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1891716

Title: Cloning of complementary DNA encoding a functional human interleukin-8 receptor.

PubMed ID: 1891716

DOI: 10.1126/science.1891716

PubMed ID: 8384312

Title: Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

PubMed ID: 8384312

DOI: 10.1016/0161-5890(93)90065-j

PubMed ID: 7512557

Title: Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.

PubMed ID: 7512557

DOI: 10.1016/s0021-9258(19)78092-2

PubMed ID: 7929358

Title: Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.

PubMed ID: 7929358

DOI: 10.1016/s0021-9258(18)47205-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11196695

Title: Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.

PubMed ID: 11196695

DOI: 10.1038/sj.gene.6363682

PubMed ID: 1379593

Title: Characterization of two high affinity human interleukin-8 receptors.

PubMed ID: 1379593

DOI: 10.1016/s0021-9258(18)41997-7

PubMed ID: 8662698

Title: Physical association of Gi2alpha with interleukin-8 receptors.

PubMed ID: 8662698

DOI: 10.1074/jbc.271.22.12783

PubMed ID: 9079638

Title: Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor.

PubMed ID: 9079638

DOI: 10.1074/jbc.272.13.8207

PubMed ID: 22850671

Title: Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.

PubMed ID: 22850671

DOI: 10.1038/emboj.2012.212

PubMed ID: 24777453

Title: Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits.

PubMed ID: 24777453

DOI: 10.1038/ng.2962

Sequence Information:

  • Length: 360
  • Mass: 40759
  • Checksum: 564F04A8BCC0A197
  • Sequence:
    • MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF VVIIYALVFL 
LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT LPIWAASKVN GWIFGTFLCK 
VVSLLKEVNF YSGILLLACI SVDRYLAIVH ATRTLTQKRY LVKFICLSIW GLSLLLALPV 
LLFRRTVYSS NVSPACYEDM GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK 
AHMGQKHRAM RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE 
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG SSSGHTSTTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.