Details for: CXCR2

Gene ID: 3579

Symbol: CXCR2

Ensembl ID: ENSG00000180871

Description: C-X-C motif chemokine receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.45
    Marker Score: 1445.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.31
    Marker Score: 1094
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7566
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.67
    Marker Score: 5196
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 348
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.57
    Marker Score: 4871
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1137
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.53
    Marker Score: 761
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.49
    Marker Score: 1441
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6695
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 749
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 223
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.36
    Marker Score: 537
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.36
    Marker Score: 156
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.32
    Marker Score: 284.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.32
    Marker Score: 414
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.3
    Marker Score: 617.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 180
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.28
    Marker Score: 181
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.28
    Marker Score: 370
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.27
    Marker Score: 699
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.26
    Marker Score: 14592
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 108.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.24
    Marker Score: 596
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.22
    Marker Score: 689
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 122
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.2
    Marker Score: 316
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.19
    Marker Score: 285
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.19
    Marker Score: 81.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 113
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.17
    Marker Score: 326
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.15
    Marker Score: 103
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 116
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 74
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 431
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.13
    Marker Score: 135
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.13
    Marker Score: 121.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.12
    Marker Score: 104
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.12
    Marker Score: 221
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 130
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.12
    Marker Score: 479
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1337
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.11
    Marker Score: 275.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 182
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 244
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.1
    Marker Score: 72
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1
    Marker Score: 126
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.09
    Marker Score: 69
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.09
    Marker Score: 27

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Other Information

**Key characteristics:** - CXCR2 is a transmembrane protein with a single extracellular domain and a cytoplasmic domain. - It is expressed on a variety of cell types, including epithelial cells, immune cells, and stromal cells. - CXCR2 is a ligand for CXCL1, CXCL8, and CXCL13. **Pathways and functions:** - CXCR2 is a key receptor for the chemokine CXCL1, which is expressed in mucosal tissues. - CXCR2 signaling is involved in the regulation of epithelial cell migration and inflammation. - CXCR2 is also expressed on immune cells, where it plays a role in the recruitment of immune cells to mucosal sites. **Clinical significance:** - Mutations in CXCR2 have been linked to several inflammatory diseases, including inflammatory bowel disease (IBD). - CXCR2 is a potential therapeutic target for diseases that are characterized by inflammation, such as IBD. **Additional information:** - CXCR2 is a highly conserved protein, with a similar sequence in mice and humans. - It is expressed in high levels in mucosal tissues, where it is involved in the regulation of inflammation. - CXCR2 is a promising target for the treatment of inflammatory diseases.

Genular Protein ID: 3970031595

Symbol: CXCR2_HUMAN

Name: C-X-C chemokine receptor type 2

UniProtKB Accession Codes:

P25025 Q8IUZ1 Q9P2T6 Q9P2T7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 9 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1891716

Title: Cloning of complementary DNA encoding a functional human interleukin-8 receptor.

PubMed ID: 1891716

DOI: 10.1126/science.1891716

PubMed ID: 8384312

Title: Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

PubMed ID: 8384312

DOI: 10.1016/0161-5890(93)90065-j

PubMed ID: 7512557

Title: Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.

PubMed ID: 7512557

DOI: 10.1016/s0021-9258(19)78092-2

PubMed ID: 7929358

Title: Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.

PubMed ID: 7929358

DOI: 10.1016/s0021-9258(18)47205-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11196695

Title: Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.

PubMed ID: 11196695

DOI: 10.1038/sj.gene.6363682

PubMed ID: 1379593

Title: Characterization of two high affinity human interleukin-8 receptors.

PubMed ID: 1379593

DOI: 10.1016/s0021-9258(18)41997-7

PubMed ID: 8662698

Title: Physical association of Gi2alpha with interleukin-8 receptors.

PubMed ID: 8662698

DOI: 10.1074/jbc.271.22.12783

PubMed ID: 9079638

Title: Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor.

PubMed ID: 9079638

DOI: 10.1074/jbc.272.13.8207

PubMed ID: 22850671

Title: Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.

PubMed ID: 22850671

DOI: 10.1038/emboj.2012.212

PubMed ID: 24777453

Title: Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits.

PubMed ID: 24777453

DOI: 10.1038/ng.2962

Sequence Information:

  • Length: 360
  • Mass: 40759
  • Checksum: 564F04A8BCC0A197
  • Sequence:
    • MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF VVIIYALVFL 
LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT LPIWAASKVN GWIFGTFLCK 
VVSLLKEVNF YSGILLLACI SVDRYLAIVH ATRTLTQKRY LVKFICLSIW GLSLLLALPV 
LLFRRTVYSS NVSPACYEDM GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK 
AHMGQKHRAM RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE 
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG SSSGHTSTTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.