Details for: IL10RA

Gene ID: 3587

Symbol: IL10RA

Ensembl ID: ENSG00000110324

Description: interleukin 10 receptor subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.9920
    Cell Significance Index: -14.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.7439
    Cell Significance Index: -14.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.2228
    Cell Significance Index: -20.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7604
    Cell Significance Index: -14.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6589
    Cell Significance Index: -12.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7762
    Cell Significance Index: -14.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8089
    Cell Significance Index: -15.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6097
    Cell Significance Index: -9.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.5823
    Cell Significance Index: 66.2100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 2.8417
    Cell Significance Index: 35.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3082
    Cell Significance Index: 67.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0866
    Cell Significance Index: 23.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9086
    Cell Significance Index: 172.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6898
    Cell Significance Index: 68.2400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.6677
    Cell Significance Index: 2.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6080
    Cell Significance Index: 548.9800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.5181
    Cell Significance Index: 8.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4736
    Cell Significance Index: 12.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3288
    Cell Significance Index: 38.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2691
    Cell Significance Index: 43.7700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2092
    Cell Significance Index: 2.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1873
    Cell Significance Index: 20.3800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1400
    Cell Significance Index: 0.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1123
    Cell Significance Index: 7.9400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0735
    Cell Significance Index: 0.6000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0559
    Cell Significance Index: 0.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0343
    Cell Significance Index: 2.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0202
    Cell Significance Index: 13.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0120
    Cell Significance Index: 0.4200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0115
    Cell Significance Index: 0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0105
    Cell Significance Index: 4.6600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0019
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0059
    Cell Significance Index: -0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0068
    Cell Significance Index: -2.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0075
    Cell Significance Index: -14.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0119
    Cell Significance Index: -18.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0146
    Cell Significance Index: -19.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0175
    Cell Significance Index: -13.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0203
    Cell Significance Index: -15.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0234
    Cell Significance Index: -1.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0243
    Cell Significance Index: -4.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0245
    Cell Significance Index: -13.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0291
    Cell Significance Index: -21.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0295
    Cell Significance Index: -16.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0320
    Cell Significance Index: -20.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0377
    Cell Significance Index: -17.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0402
    Cell Significance Index: -7.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0512
    Cell Significance Index: -14.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0582
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0837
    Cell Significance Index: -17.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0897
    Cell Significance Index: -16.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0976
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1008
    Cell Significance Index: -17.2200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1009
    Cell Significance Index: -0.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1041
    Cell Significance Index: -2.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1042
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1047
    Cell Significance Index: -14.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1062
    Cell Significance Index: -6.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1146
    Cell Significance Index: -13.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1178
    Cell Significance Index: -2.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1183
    Cell Significance Index: -2.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1331
    Cell Significance Index: -19.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1384
    Cell Significance Index: -17.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1394
    Cell Significance Index: -17.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1418
    Cell Significance Index: -17.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1532
    Cell Significance Index: -17.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1577
    Cell Significance Index: -7.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1600
    Cell Significance Index: -7.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1666
    Cell Significance Index: -12.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1744
    Cell Significance Index: -10.4700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1898
    Cell Significance Index: -0.7900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1997
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2258
    Cell Significance Index: -15.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2373
    Cell Significance Index: -7.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2429
    Cell Significance Index: -14.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2443
    Cell Significance Index: -18.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2568
    Cell Significance Index: -13.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2740
    Cell Significance Index: -12.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2989
    Cell Significance Index: -16.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3017
    Cell Significance Index: -15.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3161
    Cell Significance Index: -11.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3194
    Cell Significance Index: -14.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3254
    Cell Significance Index: -8.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3464
    Cell Significance Index: -2.8200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3524
    Cell Significance Index: -6.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3676
    Cell Significance Index: -5.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3708
    Cell Significance Index: -12.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3954
    Cell Significance Index: -11.0500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4011
    Cell Significance Index: -5.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4267
    Cell Significance Index: -13.5900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4353
    Cell Significance Index: -6.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4520
    Cell Significance Index: -14.8000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.4673
    Cell Significance Index: -3.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4677
    Cell Significance Index: -17.1700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4920
    Cell Significance Index: -6.9100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4985
    Cell Significance Index: -5.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5022
    Cell Significance Index: -14.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL10RA is a single-pass transmembrane protein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain of IL10RA is responsible for binding to IL-10, which is a potent anti-inflammatory cytokine. The intracellular domain of IL10RA interacts with Janus kinase (JAK) and signal transducers and activators of transcription (STAT) proteins, leading to the activation of downstream signaling pathways. IL10RA is highly expressed on various immune cells, including T-helper 22 cells, monocytes, and regulatory T cells, which are involved in maintaining immune tolerance and preventing excessive inflammation. **Pathways and Functions:** IL10RA is a key component of the IL-10 signaling pathway, which is involved in the regulation of immune responses and inflammation. The IL-10 receptor complex consists of two subunits: IL10RA and IL10RB. Upon binding to IL-10, IL10RA recruits JAK and STAT proteins, leading to the activation of STAT proteins and the transcription of anti-inflammatory genes. IL10RA also regulates the expression of anti-inflammatory cytokines, such as IL-10 and IL-22, and the production of anti-inflammatory chemokines. Furthermore, IL10RA modulates the activity of immune cells, including T cells, macrophages, and dendritic cells, which are involved in the regulation of immune responses and inflammation. IL10RA has also been implicated in the regulation of other cellular processes, including autophagy, apoptosis, and cell proliferation. For example, IL10RA has been shown to regulate the expression of autophagy-related genes and to inhibit the activation of autophagy in immune cells. Additionally, IL10RA has been shown to promote apoptosis in cancer cells by regulating the expression of pro-apoptotic genes. **Clinical Significance:** IL10RA has significant clinical implications in the context of immune-mediated diseases, such as autoimmune disorders, inflammatory bowel disease, and cancer. Dysregulation of IL10RA signaling has been implicated in various diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Therapeutic strategies targeting IL10RA, such as monoclonal antibodies and small molecule inhibitors, have been explored as potential treatments for these diseases. In cancer, IL10RA has been shown to promote tumor growth and immune evasion by regulating the expression of anti-inflammatory genes and the activation of immune suppressive cells. Therefore, targeting IL10RA has emerged as a promising strategy for cancer immunotherapy. In conclusion, IL10RA is a critical regulator of immune responses and inflammation, and its dysregulation has significant clinical implications in various diseases. Further research on IL10RA and its signaling pathways is necessary to fully understand its role in immune homeostasis and to develop effective therapeutic strategies for immune-mediated diseases and cancer. **References:** * [Insert relevant references] **Note:** This article is a summary of the gene IL10RA and its functions, and is intended for general information purposes only. It is not intended to be a comprehensive review of the literature on IL10RA, and readers are encouraged to consult primary sources for further information.

Genular Protein ID: 2376532400

Symbol: I10R1_HUMAN

Name: Interleukin-10 receptor subunit alpha

UniProtKB Accession Codes:

Q13651 A8K6I0 B0YJ27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8120391

Title: Expression cloning and characterization of a human IL-10 receptor.

PubMed ID: 8120391

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12133952

Title: Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.

PubMed ID: 12133952

DOI: 10.4049/jimmunol.169.3.1302

PubMed ID: 16982608

Title: Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex.

PubMed ID: 16982608

DOI: 10.1074/jbc.m606791200

PubMed ID: 22087322

Title: Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase.

PubMed ID: 22087322

DOI: 10.1371/journal.pone.0027464

PubMed ID: 26962683

Title: IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.

PubMed ID: 26962683

DOI: 10.1038/cddis.2016.44

PubMed ID: 11485736

Title: Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.

PubMed ID: 11485736

DOI: 10.1016/s1074-7613(01)00169-8

PubMed ID: 12093920

Title: Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.

PubMed ID: 12093920

DOI: 10.1073/pnas.152147499

PubMed ID: 15837194

Title: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.

PubMed ID: 15837194

DOI: 10.1016/j.str.2005.01.016

PubMed ID: 19890111

Title: Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

PubMed ID: 19890111

DOI: 10.1056/nejmoa0907206

PubMed ID: 23839161

Title: Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis.

PubMed ID: 23839161

DOI: 10.1097/meg.0b013e328361a4f9

PubMed ID: 24785691

Title: Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.

PubMed ID: 24785691

DOI: 10.1038/jhg.2014.32

Sequence Information:

  • Length: 578
  • Mass: 63003
  • Checksum: 54B183ABE84808DB
  • Sequence:
    • MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA 
LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV 
DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF 
THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF 
AFVLLLSGAL AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA 
FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN REPPVLGDSC 
SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD SGIDLVQNSE GRAGDTQGGS 
ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT RCAEEKATKT GCLEEESPLT DGLGPKFGRC 
LVDEAGLHPP ALAKGYLKQD PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS 
FAHDLAPLGC VAAPGGLLGS FNSDLVTLPL ISSLQSSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.