Gene IL10RA - ENSG00000110324 | NCBI Gene ID: 3587

Details for: IL10RA

Gene ID: 3587

Symbol: IL10RA

Ensembl ID: ENSG00000110324

Description: interleukin 10 receptor subunit alpha

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by interleukins
(R-HSA-449147)
Apical plasma membrane
(GO:0016324)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytosol
(GO:0005829)
Interleukin-10 binding
(GO:0019969)
Interleukin-10 receptor activity
(GO:0004920)
Intestinal epithelial structure maintenance
(GO:0060729)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of inflammatory response
(GO:0050728)
Plasma membrane
(GO:0005886)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein binding
(GO:0005515)
Regulation of synapse organization
(GO:0050807)
Response to lipopolysaccharide
(GO:0032496)
Signaling receptor activity
(GO:0038023)
Ubiquitin-dependent endocytosis
(GO:0070086)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.1
Marker Score: 8996
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.09
Marker Score: 4076
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.09
Marker Score: 116906
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.05
Marker Score: 1984
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.04
Marker Score: 1790
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.03
Marker Score: 4955
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.01
Marker Score: 5650
Cell Name: blood cell (CL0000081)
Fold Change: 2.01
Marker Score: 23339
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 1.95
Marker Score: 680
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.92
Marker Score: 3769
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.92
Marker Score: 1917
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.9
Marker Score: 2800
Cell Name: mature T cell (CL0002419)
Fold Change: 1.9
Marker Score: 18767
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.86
Marker Score: 658
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.83
Marker Score: 2528
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.81
Marker Score: 5727
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.76
Marker Score: 547
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.73
Marker Score: 1044
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.71
Marker Score: 3482
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.71
Marker Score: 1596
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.7
Marker Score: 1046
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.66
Marker Score: 1217
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.64
Marker Score: 706
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.61
Marker Score: 10301
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.61
Marker Score: 1351
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.59
Marker Score: 934
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.57
Marker Score: 517
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.57
Marker Score: 1140
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.53
Marker Score: 80759.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.53
Marker Score: 4214
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.5
Marker Score: 1333
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.5
Marker Score: 1714
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.49
Marker Score: 4363
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.47
Marker Score: 3658
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167834
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.46
Marker Score: 444
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.42
Marker Score: 1534
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 1.42
Marker Score: 783
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.41
Marker Score: 3401
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 1.35
Marker Score: 523
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.34
Marker Score: 772
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.3
Marker Score: 543
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.29
Marker Score: 1395
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.25
Marker Score: 1027
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.22
Marker Score: 735
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.22
Marker Score: 309
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.18
Marker Score: 590
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.16
Marker Score: 375
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.16
Marker Score: 3011
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 1.15
Marker Score: 304
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4765
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.13
Marker Score: 462
Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.12
Marker Score: 1236
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.09
Marker Score: 248
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.09
Marker Score: 600
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.04
Marker Score: 1055
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.02
Marker Score: 1755
Cell Name: Unknown (CL0000548)
Fold Change: 1.02
Marker Score: 745
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.01
Marker Score: 502
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71747
Cell Name: classical monocyte (CL0000860)
Fold Change: 1
Marker Score: 4142
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47972
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.98
Marker Score: 963
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.97
Marker Score: 5877.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.96
Marker Score: 1673
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.96
Marker Score: 694
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.95
Marker Score: 748.5
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.95
Marker Score: 657
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 449
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.95
Marker Score: 1795.5
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.94
Marker Score: 801
Cell Name: macrophage (CL0000235)
Fold Change: 0.94
Marker Score: 1048
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.94
Marker Score: 645
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 366
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.91
Marker Score: 240
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.91
Marker Score: 856
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2725
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.91
Marker Score: 1179
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5185
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.91
Marker Score: 1621
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.9
Marker Score: 23130
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.87
Marker Score: 766
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.87
Marker Score: 446
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5261
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.86
Marker Score: 729
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.85
Marker Score: 563
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.85
Marker Score: 646
Cell Name: memory B cell (CL0000787)
Fold Change: 0.84
Marker Score: 636
Cell Name: centroblast (CL0009112)
Fold Change: 0.84
Marker Score: 414
Cell Name: naive T cell (CL0000898)
Fold Change: 0.84
Marker Score: 540
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.83
Marker Score: 485
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.82
Marker Score: 1721
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.82
Marker Score: 282
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.8
Marker Score: 290
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.79
Marker Score: 1771
Cell Name: memory T cell (CL0000813)
Fold Change: 0.78
Marker Score: 336

Hover over a box to see details here...

**Key characteristics:** * IL10RA is a type I transmembrane receptor that belongs to the TNF receptor superfamily. * It is expressed in both mRNA and protein form. * It is a key regulator of inflammation and immune responses. * It acts as a decoy receptor for IL10, thereby dampening inflammatory responses. **Pathways and functions:** * IL10RA is a key component of the cytokine-mediated signaling pathway, which is involved in regulating immune responses. * It interacts with the IL10 receptor subunit beta (IL10RB), which is expressed on various immune cells. * When IL10RA binds to IL10RB, it recruits the IL10 receptor complex to the cell surface, leading to the activation of downstream signaling pathways. * These pathways include the JAK/STAT pathway, the MAPK pathway, and the PI3K/AKT pathway. * IL10RA signaling modulates inflammation, immune cell differentiation, and cytokine production. **Clinical significance:** * IL10RA gene polymorphisms have been associated with various diseases, including asthma, inflammatory bowel disease, and cancer. * Targeting IL10RA signaling has emerged as a potential therapeutic strategy for these diseases. * Antibody therapies targeting IL10RA have shown promise in preclinical and clinical studies. **Additional notes:** * IL10RA is a pleiotropic protein with additional functions beyond dampening inflammation. * It is involved in cell growth, differentiation, and metabolism. * It is a key regulator of immune responses to various stimuli, including pathogens, cytokines, and growth factors.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-10 receptor subunit alpha

Genular Protein ID: 2376532400

Symbol: I10R1_HUMAN

Name: Interleukin-10 receptor subunit alpha

UniProtKB Accession Codes:

Q13651 A8K6I0 B0YJ27

Database IDs:

Citations:

PubMed ID: 8120391

Title: Expression cloning and characterization of a human IL-10 receptor.

PubMed ID: 8120391

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12133952

Title: Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.

PubMed ID: 12133952

DOI: 10.4049/jimmunol.169.3.1302

PubMed ID: 16982608

Title: Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex.

PubMed ID: 16982608

DOI: 10.1074/jbc.m606791200

PubMed ID: 22087322

Title: Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase.

PubMed ID: 22087322

DOI: 10.1371/journal.pone.0027464

PubMed ID: 26962683

Title: IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.

PubMed ID: 26962683

DOI: 10.1038/cddis.2016.44

PubMed ID: 11485736

Title: Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.

PubMed ID: 11485736

DOI: 10.1016/s1074-7613(01)00169-8

PubMed ID: 12093920

Title: Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.

PubMed ID: 12093920

DOI: 10.1073/pnas.152147499

PubMed ID: 15837194

Title: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.

PubMed ID: 15837194

DOI: 10.1016/j.str.2005.01.016

PubMed ID: 19890111

Title: Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

PubMed ID: 19890111

DOI: 10.1056/nejmoa0907206

PubMed ID: 23839161

Title: Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis.

PubMed ID: 23839161

DOI: 10.1097/meg.0b013e328361a4f9

PubMed ID: 24785691

Title: Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.

PubMed ID: 24785691

DOI: 10.1038/jhg.2014.32

Sequence Information:

Length: 578
Mass: 63003
Checksum: 54B183ABE84808DB
Sequence:

MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA 
LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV 
DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF 
THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF 
AFVLLLSGAL AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA 
FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN REPPVLGDSC 
SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD SGIDLVQNSE GRAGDTQGGS 
ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT RCAEEKATKT GCLEEESPLT DGLGPKFGRC 
LVDEAGLHPP ALAKGYLKQD PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS 
FAHDLAPLGC VAAPGGLLGS FNSDLVTLPL ISSLQSSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL10RA

Associated with

Cells (max top 100)

Other Information

Expression cloning and characterization of a human IL-10 receptor. PubMed ID: 8120391

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. PubMed ID: 12133952

Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. PubMed ID: 16982608

Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase. PubMed ID: 22087322

IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. PubMed ID: 26962683

Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. PubMed ID: 11485736

Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. PubMed ID: 12093920

Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. PubMed ID: 15837194

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. PubMed ID: 19890111

Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis. PubMed ID: 23839161

Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations. PubMed ID: 24785691