Details for: IL12RB2

Gene ID: 3595

Symbol: IL12RB2

Ensembl ID: ENSG00000081985

Description: interleukin 12 receptor subunit beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 51.9463
    Cell Significance Index: -8.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.9079
    Cell Significance Index: -6.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.0027
    Cell Significance Index: -7.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5696
    Cell Significance Index: -8.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8742
    Cell Significance Index: 82.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.6639
    Cell Significance Index: 85.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2465
    Cell Significance Index: -6.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.9567
    Cell Significance Index: 28.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5189
    Cell Significance Index: 37.0600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.4068
    Cell Significance Index: 10.7900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.3536
    Cell Significance Index: 21.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0138
    Cell Significance Index: 26.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6093
    Cell Significance Index: 122.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5697
    Cell Significance Index: 15.9200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5280
    Cell Significance Index: 16.7000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: 0.4881
    Cell Significance Index: 5.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4673
    Cell Significance Index: 88.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4441
    Cell Significance Index: 11.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4324
    Cell Significance Index: 8.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3215
    Cell Significance Index: 19.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2939
    Cell Significance Index: 3.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2848
    Cell Significance Index: 6.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2444
    Cell Significance Index: 48.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2278
    Cell Significance Index: 6.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2050
    Cell Significance Index: 22.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1957
    Cell Significance Index: 19.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1951
    Cell Significance Index: 14.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1600
    Cell Significance Index: 10.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1281
    Cell Significance Index: 3.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1226
    Cell Significance Index: 110.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1197
    Cell Significance Index: 17.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1121
    Cell Significance Index: 18.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0973
    Cell Significance Index: 1.3900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0702
    Cell Significance Index: 0.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0676
    Cell Significance Index: 1.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0643
    Cell Significance Index: 23.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0621
    Cell Significance Index: 4.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0609
    Cell Significance Index: 2.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0389
    Cell Significance Index: 26.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0307
    Cell Significance Index: 1.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0256
    Cell Significance Index: 0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0172
    Cell Significance Index: 26.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0143
    Cell Significance Index: 26.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0125
    Cell Significance Index: 2.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0115
    Cell Significance Index: 1.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0095
    Cell Significance Index: 0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0086
    Cell Significance Index: 15.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0047
    Cell Significance Index: 6.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0015
    Cell Significance Index: 0.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0015
    Cell Significance Index: 0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0014
    Cell Significance Index: -0.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0022
    Cell Significance Index: -0.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0064
    Cell Significance Index: -2.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0091
    Cell Significance Index: -0.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0115
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0141
    Cell Significance Index: -7.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0148
    Cell Significance Index: -6.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0239
    Cell Significance Index: -6.8700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0239
    Cell Significance Index: -0.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0309
    Cell Significance Index: -0.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0316
    Cell Significance Index: -1.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0335
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0400
    Cell Significance Index: -8.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0424
    Cell Significance Index: -5.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0503
    Cell Significance Index: -0.7200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0516
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0534
    Cell Significance Index: -2.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0565
    Cell Significance Index: -7.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0573
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0656
    Cell Significance Index: -7.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0663
    Cell Significance Index: -8.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0704
    Cell Significance Index: -0.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0712
    Cell Significance Index: -3.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0721
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0736
    Cell Significance Index: -8.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0748
    Cell Significance Index: -2.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0750
    Cell Significance Index: -1.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0771
    Cell Significance Index: -9.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0823
    Cell Significance Index: -8.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0852
    Cell Significance Index: -2.2800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0896
    Cell Significance Index: -0.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0957
    Cell Significance Index: -4.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0977
    Cell Significance Index: -5.4800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1056
    Cell Significance Index: -1.3300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1121
    Cell Significance Index: -1.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1157
    Cell Significance Index: -1.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1206
    Cell Significance Index: -8.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1256
    Cell Significance Index: -5.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1309
    Cell Significance Index: -8.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1314
    Cell Significance Index: -2.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1328
    Cell Significance Index: -6.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1345
    Cell Significance Index: -3.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL12RB2 shares structural similarities with the alpha and gamma subunits of the IL-12 receptor, which are encoded by the IL12A and IL12G genes, respectively. The beta 2 subunit is critical for the assembly and activation of the IL-12 receptor complex, which then triggers the downstream signaling cascade. IL12RB2 has been shown to interact with several proteins, including phosphorylase kinase, protein kinase C, and STAT1, which are essential for the regulation of immune responses. **Pathways and Functions** The IL-12 signaling pathway is a complex network of molecular interactions that involves the binding of IL-12 to its receptor, followed by the activation of downstream signaling molecules. IL12RB2 plays a crucial role in this pathway by facilitating the assembly and activation of the IL-12 receptor complex. The signaling cascade triggered by IL-12/IL12RB2 is characterized by the activation of STAT1, which translocates to the nucleus and regulates the expression of target genes involved in immune responses, including the production of interferons and cytokines. The IL-12 signaling pathway is involved in various immune processes, including: 1. **T cell differentiation**: IL-12/IL12RB2 signaling is essential for the differentiation of naive T cells into Th1 cells, which are crucial for fighting off intracellular pathogens. 2. **Immune responses to pathogens**: IL-12/IL12RB2 signaling is involved in the regulation of immune responses to pathogens, including bacteria and viruses. 3. **Autoimmune diseases**: Dysregulation of the IL-12 signaling pathway has been implicated in various autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 4. **Tumor immune evasion**: IL-12/IL12RB2 signaling has been shown to play a role in the immune evasion of tumor cells, highlighting the potential for IL-12/IL12RB2 as a therapeutic target. **Clinical Significance** IL12RB2 has significant implications for the treatment and understanding of various immune-related disorders. Dysregulation of the IL-12 signaling pathway has been implicated in several diseases, including: 1. **Autoimmune diseases**: IL12RB2 has been shown to play a critical role in the regulation of immune responses in autoimmune diseases, making it a potential target for therapy. 2. **Cancer**: IL-12/IL12RB2 signaling has been implicated in the immune evasion of tumor cells, highlighting the potential for IL-12/IL12RB2 as a therapeutic target. 3. **Infectious diseases**: IL12RB2 has been shown to play a role in the regulation of immune responses to pathogens, making it a potential target for the development of novel therapies. In conclusion, IL12RB2 is a critical gene involved in the regulation of the immune system, particularly in the differentiation of T cells into Th1 cells and the regulation of immune responses to pathogens. Its dysregulation has been implicated in various immune-related disorders, highlighting the potential for IL12RB2 as a therapeutic target. Further research is needed to fully elucidate the functions and clinical significance of IL12RB2, but its importance in the immune system is clear.

Genular Protein ID: 2686226690

Symbol: I12R2_HUMAN

Name: Interleukin-12 receptor subunit beta-2

UniProtKB Accession Codes:

Q99665 B1AN98 B7ZKL9 F5H7L6 Q2M3V3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 6 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 11 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8943050

Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

PubMed ID: 8943050

DOI: 10.1073/pnas.93.24.14002

PubMed ID: 10663559

Title: Genomic organization of the human interleukin-12 receptor beta2-chain gene.

PubMed ID: 10663559

DOI: 10.1007/s002510050005

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10415122

Title: Direct interaction of STAT4 with the IL-12 receptor.

PubMed ID: 10415122

DOI: 10.1006/abbi.1999.1302

PubMed ID: 10198225

Title: Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.

PubMed ID: 10198225

DOI: 10.1006/bbrc.1999.0479

PubMed ID: 9890938

Title: Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.

PubMed ID: 9890938

DOI: 10.1074/jbc.274.4.1875

PubMed ID: 9120388

Title: Selective expression of an interleukin-12 receptor component by human T helper 1 cells.

PubMed ID: 9120388

DOI: 10.1084/jem.185.5.825

PubMed ID: 14559241

Title: SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.

PubMed ID: 14559241

DOI: 10.1016/j.bbrc.2003.09.140

PubMed ID: 10600539

Title: Mutations of the IL-12 receptor beta2 chain gene in atopic subjects.

PubMed ID: 10600539

DOI: 10.1006/bbrc.1999.1859

Sequence Information:

  • Length: 862
  • Mass: 97135
  • Checksum: 67C0E0D946B8DD58
  • Sequence:
    • MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF 
HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV 
GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY 
LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS 
RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL 
YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV SEARGKILHY 
QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG 
LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN 
VSALISENIK SYICYEIRVY ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS 
WNSIPVQEQM GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA 
LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKV FVLLAALRPQ 
WCSREIPDPA NSTCAKKYPI AEEKTQLPLD RLLIDWPTPE DPEPLVISEV LHQVTPVFRH 
PPCSNWPQRE KGIQGHQASE KDMMHSASSP PPPRALQAES RQLVDLYKVL ESRGSDPKPE 
NPACPWTVLP AGDLPTHDGY LPSNIDDLPS HEAPLADSLE ELEPQHISLS VFPSSSLHPL 
TFSCGDKLTL DQLKMRCDSL ML

Genular Protein ID: 3120367657

Symbol: B4DGA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGA4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 659
  • Mass: 74533
  • Checksum: AB313EB61265031B
  • Sequence:
    • MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF 
HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV 
GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTPQ LSGPKNLTWQ KQCKDIYCDY 
LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS 
RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHG LLDLKPFTEY EFQISSKLHL 
YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV SEARGKILHY 
QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG 
LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN 
VSALISENIK SYICYEIRVY ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS 
WNSIPVQEQM GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA 
LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKR RHSCPWTGS

Genular Protein ID: 269269005

Symbol: B7ZB60_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZB60

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 659
  • Mass: 74551
  • Checksum: 7C04FF013C149FDD
  • Sequence:
    • MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF 
HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV 
GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY 
LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS 
RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL 
YKGSWSDWNE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFCKNLSV SEARGKILHY 
QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG 
LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN 
VSALISENIK SYICYEIRVY ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS 
WNSIPVQEQM GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA 
LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKR RHSCPWTGS

Genular Protein ID: 4220768684

Symbol: A0A8Q3SIX0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SIX0

Database IDs:

ARBA 2 CDD 1 CTD 1 DisGeNET 1 EMBL 2 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 635
  • Mass: 71659
  • Checksum: FAE8178E8506A593
  • Sequence:
    • MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF 
HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV 
GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY 
LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS 
RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL 
YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV SEARGKILHY 
QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG 
LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN 
VSALISENIK SYICYEIRVY ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS 
WNSIPVQEQM GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA 
LTAAGESSHG NEREFCLQGE DTAALGQAPD RLAHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.