Details for: FOXK2

Gene ID: 3607

Symbol: FOXK2

Ensembl ID: ENSG00000141568

Description: forkhead box K2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 271.9788
    Cell Significance Index: -42.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.8879
    Cell Significance Index: -42.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.5427
    Cell Significance Index: -41.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.9526
    Cell Significance Index: -43.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2714
    Cell Significance Index: -40.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5473
    Cell Significance Index: -41.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9768
    Cell Significance Index: -43.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.8563
    Cell Significance Index: -23.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.0087
    Cell Significance Index: 107.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.7660
    Cell Significance Index: 77.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1148
    Cell Significance Index: 419.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9108
    Cell Significance Index: 383.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6964
    Cell Significance Index: 130.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6286
    Cell Significance Index: 22.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2858
    Cell Significance Index: 72.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2580
    Cell Significance Index: 451.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0739
    Cell Significance Index: 125.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0712
    Cell Significance Index: 47.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0671
    Cell Significance Index: 27.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9562
    Cell Significance Index: 36.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9326
    Cell Significance Index: 842.0700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6962
    Cell Significance Index: 6.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6840
    Cell Significance Index: 473.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6722
    Cell Significance Index: 45.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5603
    Cell Significance Index: 91.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4964
    Cell Significance Index: 29.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4911
    Cell Significance Index: 88.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4707
    Cell Significance Index: 57.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3626
    Cell Significance Index: 17.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3497
    Cell Significance Index: 538.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3298
    Cell Significance Index: 621.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3192
    Cell Significance Index: 433.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2754
    Cell Significance Index: 121.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2690
    Cell Significance Index: 4.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2658
    Cell Significance Index: 490.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2562
    Cell Significance Index: 139.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2511
    Cell Significance Index: 7.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2486
    Cell Significance Index: 157.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2385
    Cell Significance Index: 12.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2361
    Cell Significance Index: 10.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1943
    Cell Significance Index: 88.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1839
    Cell Significance Index: 12.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1771
    Cell Significance Index: 17.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1457
    Cell Significance Index: 20.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1165
    Cell Significance Index: 22.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1116
    Cell Significance Index: 3.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0855
    Cell Significance Index: 2.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0534
    Cell Significance Index: 3.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0484
    Cell Significance Index: 8.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0250
    Cell Significance Index: 0.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0208
    Cell Significance Index: 1.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0171
    Cell Significance Index: -10.6600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0177
    Cell Significance Index: -0.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0183
    Cell Significance Index: -0.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0190
    Cell Significance Index: -0.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0292
    Cell Significance Index: -0.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0394
    Cell Significance Index: -28.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0440
    Cell Significance Index: -33.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0496
    Cell Significance Index: -1.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0611
    Cell Significance Index: -34.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0626
    Cell Significance Index: -2.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0878
    Cell Significance Index: -6.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0887
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1192
    Cell Significance Index: -25.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1249
    Cell Significance Index: -35.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1394
    Cell Significance Index: -8.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1478
    Cell Significance Index: -2.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1751
    Cell Significance Index: -18.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1853
    Cell Significance Index: -23.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2237
    Cell Significance Index: -22.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2278
    Cell Significance Index: -26.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2615
    Cell Significance Index: -33.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2692
    Cell Significance Index: -31.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2698
    Cell Significance Index: -1.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2716
    Cell Significance Index: -3.9000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3090
    Cell Significance Index: -2.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3403
    Cell Significance Index: -25.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3415
    Cell Significance Index: -38.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3857
    Cell Significance Index: -8.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3933
    Cell Significance Index: -8.5200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.4036
    Cell Significance Index: -2.4900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4082
    Cell Significance Index: -5.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4238
    Cell Significance Index: -10.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4417
    Cell Significance Index: -6.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4744
    Cell Significance Index: -37.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5766
    Cell Significance Index: -5.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5889
    Cell Significance Index: -36.1100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5919
    Cell Significance Index: -7.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5956
    Cell Significance Index: -8.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6059
    Cell Significance Index: -12.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6200
    Cell Significance Index: -16.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6234
    Cell Significance Index: -32.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6320
    Cell Significance Index: -33.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6691
    Cell Significance Index: -21.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6811
    Cell Significance Index: -22.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7546
    Cell Significance Index: -16.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7585
    Cell Significance Index: -18.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXK2 is a member of the forkhead box (FOX) family of transcription factors, characterized by its ability to bind to specific DNA sequences and regulate gene expression. The gene is highly expressed in various cell types, including cortical cells of the adrenal gland, lens epithelial cells, and VIP GABAergic cortical interneurons. FOXK2 has been implicated in several cellular processes, including: 1. Glucose homeostasis: FOXK2 regulates the expression of genes involved in glucose metabolism, suggesting its role in maintaining blood glucose levels. 2. Protein metabolism: FOXK2 influences the expression of genes involved in protein synthesis and degradation, highlighting its potential role in regulating protein homeostasis. 3. Transcriptional regulation: FOXK2 interacts with RNA polymerase II and other transcription factors to regulate gene expression, indicating its importance in transcriptional control. **Pathways and Functions:** FOXK2 is involved in several signaling pathways, including: 1. Canonical glycolysis: FOXK2 regulates the expression of genes involved in glycolysis, a key metabolic pathway involved in energy production. 2. Chromatin remodeling: FOXK2 interacts with chromatin remodeling complexes to regulate gene expression and maintain chromatin structure. 3. Deubiquitination: FOXK2 influences the expression of deubiquitinating enzymes, which play a crucial role in protein degradation and homeostasis. 4. DNA-binding transcription activator activity: FOXK2 activates the expression of target genes by interacting with RNA polymerase II and other transcription factors. 5. Negative regulation of autophagy: FOXK2 inhibits autophagy, a cellular process involved in protein degradation and homeostasis. FOXK2's functions can be summarized as follows: 1. Regulates glucose homeostasis by controlling the expression of genes involved in glucose metabolism. 2. Maintains protein homeostasis by regulating protein synthesis and degradation. 3. Regulates transcription by interacting with RNA polymerase II and other transcription factors. 4. Inhibits autophagy, a process involved in protein degradation and homeostasis. **Clinical Significance:** FOXK2's dysregulation has been implicated in various diseases, including: 1. Diabetes: FOXK2's role in glucose homeostasis suggests its potential as a therapeutic target for diabetes treatment. 2. Neurological disorders: FOXK2's involvement in transcriptional regulation and autophagy suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. Cancer: FOXK2's regulation of transcription and protein metabolism suggests its potential as a therapeutic target for cancer treatment. In conclusion, FOXK2 is a transcription factor gene that plays a crucial role in regulating various cellular processes, including glucose homeostasis, protein metabolism, and transcription. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for disease treatment. Further research is needed to fully elucidate FOXK2's functions and its implications in human disease.

Genular Protein ID: 3223828733

Symbol: FOXK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q01167 A6NEP5 Q13622 Q13623 Q13624

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1909027

Title: Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

PubMed ID: 1909027

DOI: 10.1073/pnas.88.17.7739

PubMed ID: 1339390

Title: Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF.

PubMed ID: 1339390

DOI: 10.1016/0888-7543(92)90139-j

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20097901

Title: FOXK2 transcription factor is a novel G/T-mismatch DNA binding protein.

PubMed ID: 20097901

DOI: 10.1093/jb/mvq004

PubMed ID: 20810654

Title: Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK.cyclin complexes.

PubMed ID: 20810654

DOI: 10.1074/jbc.m110.154005

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22083952

Title: The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

PubMed ID: 22083952

DOI: 10.1128/mcb.05504-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24748658

Title: The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.

PubMed ID: 24748658

DOI: 10.1093/nar/gku274

PubMed ID: 24634419

Title: MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain.

PubMed ID: 24634419

DOI: 10.1002/pmic.201400013

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 25451922

Title: BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes.

PubMed ID: 25451922

DOI: 10.1074/jbc.m114.609834

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29540677

Title: SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells.

PubMed ID: 29540677

DOI: 10.1038/s41389-018-0038-6

PubMed ID: 30664650

Title: BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation.

PubMed ID: 30664650

DOI: 10.1038/s41467-018-08255-x

PubMed ID: 12402362

Title: Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a).

PubMed ID: 12402362

DOI: 10.1002/prot.10227

PubMed ID: 16624804

Title: Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.

PubMed ID: 16624804

DOI: 10.1074/jbc.m600478200

Sequence Information:

  • Length: 660
  • Mass: 69062
  • Checksum: E11C0B24370F1260
  • Sequence:
    • MAAAAAALSG AGTPPAGGGA GGGGAGGGGS PPGGWAVARL EGREFEYLMK KRSVTIGRNS 
SQGSVDVSMG HSSFISRRHL EIFTPPGGGG HGGAAPELPP AQPRPDAGGD FYLRCLGKNG 
VFVDGVFQRR GAPPLQLPRV CTFRFPSTNI KITFTALSSE KREKQEASES PVKAVQPHIS 
PLTINIPDTM AHLISPLPSP TGTISAANSC PSSPRGAGSS GYKVGRVMPS DLNLMADNSQ 
PENEKEASGG DSPKDDSKPP YSYAQLIVQA ITMAPDKQLT LNGIYTHITK NYPYYRTADK 
GWQNSIRHNL SLNRYFIKVP RSQEEPGKGS FWRIDPASES KLIEQAFRKR RPRGVPCFRT 
PLGPLSSRSA PASPNHAGVL SAHSSGAQTP ESLSREGSPA PLEPEPGAAQ PKLAVIQEAR 
FAQSAPGSPL SSQPVLITVQ RQLPQAIKPV TYTVATPVTT STSQPPVVQT VHVVHQIPAV 
SVTSVAGLAP ANTYTVSGQA VVTPAAVLAP PKAEAQENGD HREVKVKVEP IPAIGHATLG 
TASRIIQTAQ TTPVQTVTIV QQAPLGQHQL PIKTVTQNGT HVASVPTAVH GQVNNAAASP 
LHMLATHASA SASLPTKRHN GDQPEQPELK RIKTEDGEGI VIALSVDTPP AAVREKGVQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.