Details for: FOXK2

Gene ID: 3607

Symbol: FOXK2

Ensembl ID: ENSG00000141568

Description: forkhead box K2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.28
    Marker Score: 58176
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.84
    Marker Score: 3440
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.67
    Marker Score: 3589
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.46
    Marker Score: 1437
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.36
    Marker Score: 5188
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.18
    Marker Score: 2469
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.13
    Marker Score: 8920.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2
    Marker Score: 75940
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.96
    Marker Score: 8122
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.94
    Marker Score: 71468
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.87
    Marker Score: 1091
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.87
    Marker Score: 27907
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.82
    Marker Score: 13974
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.81
    Marker Score: 35914
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8
    Marker Score: 110912
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.77
    Marker Score: 39481
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.74
    Marker Score: 16412
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.74
    Marker Score: 7097
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.74
    Marker Score: 2003
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.73
    Marker Score: 6705
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.73
    Marker Score: 1909.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.69
    Marker Score: 14505
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.67
    Marker Score: 35609
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.66
    Marker Score: 15798
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.63
    Marker Score: 16835
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.63
    Marker Score: 514
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.62
    Marker Score: 1439
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.6
    Marker Score: 460
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.59
    Marker Score: 1107
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.58
    Marker Score: 661
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.56
    Marker Score: 455
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.54
    Marker Score: 2957
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.5
    Marker Score: 2318
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.49
    Marker Score: 3722
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.46
    Marker Score: 1261
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.46
    Marker Score: 6737
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3337
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.41
    Marker Score: 2374
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.33
    Marker Score: 45017
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.32
    Marker Score: 787
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.32
    Marker Score: 1640
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.31
    Marker Score: 411
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.29
    Marker Score: 719
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.27
    Marker Score: 8191
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19872
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.27
    Marker Score: 409
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.26
    Marker Score: 343
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.24
    Marker Score: 4398.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.24
    Marker Score: 1178
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.22
    Marker Score: 388
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.2
    Marker Score: 440
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2
    Marker Score: 19305
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.2
    Marker Score: 926
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.19
    Marker Score: 647
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.19
    Marker Score: 5145
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.17
    Marker Score: 960
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.16
    Marker Score: 1246
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.15
    Marker Score: 363
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.15
    Marker Score: 2002
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.13
    Marker Score: 3236
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.13
    Marker Score: 38588
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.12
    Marker Score: 2281
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.12
    Marker Score: 590
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.1
    Marker Score: 1604
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.09
    Marker Score: 5877
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.07
    Marker Score: 519
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.07
    Marker Score: 402
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.06
    Marker Score: 591
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.05
    Marker Score: 2521
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1
    Marker Score: 5262
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71707
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47934
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.99
    Marker Score: 1065
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.98
    Marker Score: 550
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.97
    Marker Score: 248
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 583
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1010
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.96
    Marker Score: 325
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.95
    Marker Score: 1146
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.94
    Marker Score: 1331
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.92
    Marker Score: 1297.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.92
    Marker Score: 186
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.92
    Marker Score: 241
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1474
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2709
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5409
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.88
    Marker Score: 456
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.88
    Marker Score: 329
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.88
    Marker Score: 948
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.88
    Marker Score: 1294
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.87
    Marker Score: 432
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.87
    Marker Score: 571
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.86
    Marker Score: 1059
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4883.5

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Other Information

**Key characteristics** * FOXK2 is a transcription factor with a complex structure consisting of multiple domains. * It is a member of the forkhead box protein family, which are characterized by their ability to bind to DNA and regulate gene expression. * FOXK2 is ubiquitinated in a ubiquitin-dependent manner, which modulates its activity. * It is highly expressed in cells of the CNS, particularly in neurons, glial cells, and endothelial cells. **Pathways and functions** * FOXK2 plays a crucial role in regulating the development and survival of the CNS. * It is involved in the development of the brain and spinal cord. * It is essential for the survival of retinal ganglion cells and the development of the optic nerve. * It is involved in the regulation of eye development and function. * It is involved in the regulation of metabolism, cell cycle, and apoptosis. **Clinical significance** * Mutations in FOXK2 have been linked to several eye disorders, including retinitis pigmentosa, Usher syndrome, and glaucoma. * FOXK2 inhibitors are being investigated as potential treatments for these diseases. * Understanding the role of FOXK2 in eye development and disease could lead to the development of new therapeutic strategies. **Additional information** * FOXK2 is also involved in the regulation of inflammation, metabolism, and apoptosis. * It is a target for cancer therapy. * FOXK2 is a promising target for the treatment of neurodegenerative diseases.

Genular Protein ID: 3223828733

Symbol: FOXK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q01167 A6NEP5 Q13622 Q13623 Q13624

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1909027

Title: Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

PubMed ID: 1909027

DOI: 10.1073/pnas.88.17.7739

PubMed ID: 1339390

Title: Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF.

PubMed ID: 1339390

DOI: 10.1016/0888-7543(92)90139-j

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20097901

Title: FOXK2 transcription factor is a novel G/T-mismatch DNA binding protein.

PubMed ID: 20097901

DOI: 10.1093/jb/mvq004

PubMed ID: 20810654

Title: Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK.cyclin complexes.

PubMed ID: 20810654

DOI: 10.1074/jbc.m110.154005

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22083952

Title: The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

PubMed ID: 22083952

DOI: 10.1128/mcb.05504-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24748658

Title: The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.

PubMed ID: 24748658

DOI: 10.1093/nar/gku274

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 25451922

Title: BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes.

PubMed ID: 25451922

DOI: 10.1074/jbc.m114.609834

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29540677

Title: SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells.

PubMed ID: 29540677

DOI: 10.1038/s41389-018-0038-6

PubMed ID: 12402362

Title: Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a).

PubMed ID: 12402362

DOI: 10.1002/prot.10227

PubMed ID: 16624804

Title: Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.

PubMed ID: 16624804

DOI: 10.1074/jbc.m600478200

Sequence Information:

  • Length: 660
  • Mass: 69062
  • Checksum: E11C0B24370F1260
  • Sequence:
    • MAAAAAALSG AGTPPAGGGA GGGGAGGGGS PPGGWAVARL EGREFEYLMK KRSVTIGRNS 
SQGSVDVSMG HSSFISRRHL EIFTPPGGGG HGGAAPELPP AQPRPDAGGD FYLRCLGKNG 
VFVDGVFQRR GAPPLQLPRV CTFRFPSTNI KITFTALSSE KREKQEASES PVKAVQPHIS 
PLTINIPDTM AHLISPLPSP TGTISAANSC PSSPRGAGSS GYKVGRVMPS DLNLMADNSQ 
PENEKEASGG DSPKDDSKPP YSYAQLIVQA ITMAPDKQLT LNGIYTHITK NYPYYRTADK 
GWQNSIRHNL SLNRYFIKVP RSQEEPGKGS FWRIDPASES KLIEQAFRKR RPRGVPCFRT 
PLGPLSSRSA PASPNHAGVL SAHSSGAQTP ESLSREGSPA PLEPEPGAAQ PKLAVIQEAR 
FAQSAPGSPL SSQPVLITVQ RQLPQAIKPV TYTVATPVTT STSQPPVVQT VHVVHQIPAV 
SVTSVAGLAP ANTYTVSGQA VVTPAAVLAP PKAEAQENGD HREVKVKVEP IPAIGHATLG 
TASRIIQTAQ TTPVQTVTIV QQAPLGQHQL PIKTVTQNGT HVASVPTAVH GQVNNAAASP 
LHMLATHASA SASLPTKRHN GDQPEQPELK RIKTEDGEGI VIALSVDTPP AAVREKGVQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.