Details for: EIF3E
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 741.8743
Cell Significance Index: -115.4000 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 362.7160
Cell Significance Index: -149.4200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 326.1173
Cell Significance Index: -82.7200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 316.4252
Cell Significance Index: -128.5500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 311.3386
Cell Significance Index: -146.9900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 281.9093
Cell Significance Index: -145.0100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 220.1865
Cell Significance Index: -147.7500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 136.3508
Cell Significance Index: -130.1800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 107.6803
Cell Significance Index: -132.7700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 44.6197
Cell Significance Index: -119.5300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 35.7269
Cell Significance Index: -140.9800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 28.5142
Cell Significance Index: -87.5800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.4503
Cell Significance Index: -40.3800 - Cell Name: theca cell (CL0000503)
Fold Change: 14.8297
Cell Significance Index: 87.1300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 7.7672
Cell Significance Index: 162.5800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 7.2300
Cell Significance Index: 78.6000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 6.4165
Cell Significance Index: 222.9700 - Cell Name: kidney cell (CL1000497)
Fold Change: 5.7563
Cell Significance Index: 45.9600 - Cell Name: lactocyte (CL0002325)
Fold Change: 5.4652
Cell Significance Index: 706.0700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.3174
Cell Significance Index: 139.8200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 5.3129
Cell Significance Index: 729.6100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 4.7974
Cell Significance Index: 339.2900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 4.3684
Cell Significance Index: 77.2000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.2996
Cell Significance Index: 202.0800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 4.2034
Cell Significance Index: 2295.5700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.0512
Cell Significance Index: 498.1300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.9974
Cell Significance Index: 257.8900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.6355
Cell Significance Index: 169.5100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.5975
Cell Significance Index: 1590.5300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.5528
Cell Significance Index: 45.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.4501
Cell Significance Index: 621.9400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.3925
Cell Significance Index: 38.5400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.1186
Cell Significance Index: 84.8900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.9568
Cell Significance Index: 220.3700 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.7467
Cell Significance Index: 352.1100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.6509
Cell Significance Index: 75.9900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.5021
Cell Significance Index: 66.8100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.4047
Cell Significance Index: 283.5900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.9677
Cell Significance Index: 335.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8255
Cell Significance Index: 362.2800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.6774
Cell Significance Index: 1514.5800 - Cell Name: peg cell (CL4033014)
Fold Change: 1.6707
Cell Significance Index: 38.6000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5694
Cell Significance Index: 82.4000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.4887
Cell Significance Index: 43.7200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.0452
Cell Significance Index: 9.6300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0310
Cell Significance Index: 206.8200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7690
Cell Significance Index: 531.8500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4983
Cell Significance Index: 49.2900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4151
Cell Significance Index: 79.0000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3919
Cell Significance Index: 140.5900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3460
Cell Significance Index: 17.9800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2755
Cell Significance Index: 7.7000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1649
Cell Significance Index: 2.7600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1469
Cell Significance Index: 111.1600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0938
Cell Significance Index: 4.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0475
Cell Significance Index: 89.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0070
Cell Significance Index: 0.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0051
Cell Significance Index: -3.7600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0431
Cell Significance Index: -79.4400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0433
Cell Significance Index: -19.6400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0579
Cell Significance Index: -89.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0647
Cell Significance Index: -47.9100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0841
Cell Significance Index: -114.3300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0894
Cell Significance Index: -56.7600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0982
Cell Significance Index: -10.0300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1110
Cell Significance Index: -69.3400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1660
Cell Significance Index: -11.4800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1696
Cell Significance Index: -95.6500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2255
Cell Significance Index: -7.9300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3449
Cell Significance Index: -72.6600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4278
Cell Significance Index: -123.0900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5648
Cell Significance Index: -14.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6059
Cell Significance Index: -88.0800 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.6325
Cell Significance Index: -6.7200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7227
Cell Significance Index: -82.8000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8201
Cell Significance Index: -95.5700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.8324
Cell Significance Index: -14.3500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.8335
Cell Significance Index: -51.2300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9298
Cell Significance Index: -71.3500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9721
Cell Significance Index: -61.2700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.9835
Cell Significance Index: -8.0200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.9907
Cell Significance Index: -11.8100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.9984
Cell Significance Index: -67.1300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.0541
Cell Significance Index: -47.7800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.1303
Cell Significance Index: -129.0200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1422
Cell Significance Index: -90.4600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.1900
Cell Significance Index: -7.1900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.2021
Cell Significance Index: -38.5000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.2587
Cell Significance Index: -131.0700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.2904
Cell Significance Index: -23.8500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.3401
Cell Significance Index: -33.5000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.5204
Cell Significance Index: -32.9400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.7199
Cell Significance Index: -76.0800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.7236
Cell Significance Index: -49.6600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.9106
Cell Significance Index: -32.7400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.9418
Cell Significance Index: -119.0500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.1369
Cell Significance Index: -80.9200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.4033
Cell Significance Index: -32.7900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.5107
Cell Significance Index: -37.6200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.5120
Cell Significance Index: -64.5700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 417274046
Symbol: EIF3E_HUMAN
Name: Viral integration site protein INT-6 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9295280
Title: The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome.
PubMed ID: 9295280
PubMed ID: 9403073
Title: The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas.
PubMed ID: 9403073
PubMed ID: 8688078
Title: Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein.
PubMed ID: 8688078
PubMed ID: 12386384
Title: Divergent subcellular locations of HTLV-I Tax and Int-6: a contrast between in vitro protein-protein binding and intracellular protein colocalization.
PubMed ID: 12386384
DOI: 10.1007/bf02253422
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10504338
Title: Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.
PubMed ID: 10504338
PubMed ID: 11457827
Title: Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.
PubMed ID: 11457827
PubMed ID: 11590142
Title: The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.
PubMed ID: 11590142
PubMed ID: 12220626
Title: Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.
PubMed ID: 12220626
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15703437
Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.
PubMed ID: 15703437
DOI: 10.1261/rna.7215305
PubMed ID: 16023166
Title: Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54.
PubMed ID: 16023166
PubMed ID: 16766523
Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.
PubMed ID: 16766523
PubMed ID: 16973618
Title: Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.
PubMed ID: 16973618
PubMed ID: 17581632
Title: Reconstitution reveals the functional core of mammalian eIF3.
PubMed ID: 17581632
PubMed ID: 17468741
Title: Human INT6/eIF3e is required for nonsense-mediated mRNA decay.
PubMed ID: 17468741
PubMed ID: 17324924
Title: Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation.
PubMed ID: 17324924
PubMed ID: 17761670
Title: Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.
PubMed ID: 17761670
PubMed ID: 17322308
Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.
PubMed ID: 17322308
PubMed ID: 17310990
Title: Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.
PubMed ID: 17310990
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18599441
Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.
PubMed ID: 18599441
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21745818
Title: Mechanisms of translational regulation by a human eIF5-mimic protein.
PubMed ID: 21745818
DOI: 10.1093/nar/gkr339
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25849773
Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.
PubMed ID: 25849773
DOI: 10.1038/nature14267
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27462815
Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
PubMed ID: 27462815
DOI: 10.1038/nature18954
PubMed ID: 16322461
Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.
PubMed ID: 16322461
Sequence Information:
- Length: 445
- Mass: 52221
- Checksum: A5368651DD0DDD0C
- Sequence:
MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM NIEKKLNQNS RSEAPNWATQ DSGFY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.