Details for: EIF3E

Gene ID: 3646

Symbol: EIF3E

Ensembl ID: ENSG00000104408

Description: eukaryotic translation initiation factor 3 subunit E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 741.8743
    Cell Significance Index: -115.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 362.7160
    Cell Significance Index: -149.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 326.1173
    Cell Significance Index: -82.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 316.4252
    Cell Significance Index: -128.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 311.3386
    Cell Significance Index: -146.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 281.9093
    Cell Significance Index: -145.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 220.1865
    Cell Significance Index: -147.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 136.3508
    Cell Significance Index: -130.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 107.6803
    Cell Significance Index: -132.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 44.6197
    Cell Significance Index: -119.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 35.7269
    Cell Significance Index: -140.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.5142
    Cell Significance Index: -87.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.4503
    Cell Significance Index: -40.3800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 14.8297
    Cell Significance Index: 87.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.7672
    Cell Significance Index: 162.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.2300
    Cell Significance Index: 78.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.4165
    Cell Significance Index: 222.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.7563
    Cell Significance Index: 45.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.4652
    Cell Significance Index: 706.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.3174
    Cell Significance Index: 139.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.3129
    Cell Significance Index: 729.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.7974
    Cell Significance Index: 339.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.3684
    Cell Significance Index: 77.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2996
    Cell Significance Index: 202.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.2034
    Cell Significance Index: 2295.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.0512
    Cell Significance Index: 498.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.9974
    Cell Significance Index: 257.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.6355
    Cell Significance Index: 169.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.5975
    Cell Significance Index: 1590.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.5528
    Cell Significance Index: 45.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4501
    Cell Significance Index: 621.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.3925
    Cell Significance Index: 38.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1186
    Cell Significance Index: 84.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9568
    Cell Significance Index: 220.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.7467
    Cell Significance Index: 352.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6509
    Cell Significance Index: 75.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.5021
    Cell Significance Index: 66.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4047
    Cell Significance Index: 283.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.9677
    Cell Significance Index: 335.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8255
    Cell Significance Index: 362.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6774
    Cell Significance Index: 1514.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6707
    Cell Significance Index: 38.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5694
    Cell Significance Index: 82.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4887
    Cell Significance Index: 43.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0452
    Cell Significance Index: 9.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0310
    Cell Significance Index: 206.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7690
    Cell Significance Index: 531.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4983
    Cell Significance Index: 49.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4151
    Cell Significance Index: 79.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3919
    Cell Significance Index: 140.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3460
    Cell Significance Index: 17.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2755
    Cell Significance Index: 7.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1649
    Cell Significance Index: 2.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1469
    Cell Significance Index: 111.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0938
    Cell Significance Index: 4.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0475
    Cell Significance Index: 89.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0070
    Cell Significance Index: 0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0431
    Cell Significance Index: -79.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0433
    Cell Significance Index: -19.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0579
    Cell Significance Index: -89.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0647
    Cell Significance Index: -47.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0841
    Cell Significance Index: -114.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0894
    Cell Significance Index: -56.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0982
    Cell Significance Index: -10.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1110
    Cell Significance Index: -69.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1660
    Cell Significance Index: -11.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1696
    Cell Significance Index: -95.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2255
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3449
    Cell Significance Index: -72.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4278
    Cell Significance Index: -123.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5648
    Cell Significance Index: -14.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6059
    Cell Significance Index: -88.0800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6325
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7227
    Cell Significance Index: -82.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8201
    Cell Significance Index: -95.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8324
    Cell Significance Index: -14.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8335
    Cell Significance Index: -51.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9298
    Cell Significance Index: -71.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9721
    Cell Significance Index: -61.2700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.9835
    Cell Significance Index: -8.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9907
    Cell Significance Index: -11.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9984
    Cell Significance Index: -67.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0541
    Cell Significance Index: -47.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1303
    Cell Significance Index: -129.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1422
    Cell Significance Index: -90.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1900
    Cell Significance Index: -7.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2021
    Cell Significance Index: -38.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2587
    Cell Significance Index: -131.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2904
    Cell Significance Index: -23.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3401
    Cell Significance Index: -33.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5204
    Cell Significance Index: -32.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7199
    Cell Significance Index: -76.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.7236
    Cell Significance Index: -49.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.9106
    Cell Significance Index: -32.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9418
    Cell Significance Index: -119.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.1369
    Cell Significance Index: -80.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.4033
    Cell Significance Index: -32.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.5107
    Cell Significance Index: -37.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.5120
    Cell Significance Index: -64.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EIF3E is a highly conserved protein that belongs to the eukaryotic translation initiation factor 3 (eIF3) complex. The eIF3 complex is responsible for recruiting the small ribosomal subunit (40S) to the mRNA and facilitating the binding of the large ribosomal subunit (60S) to the mRNA-ribosome complex. EIF3E has been shown to interact with other proteins, including eIF4E, eIF4G, and eIF1, to regulate translation initiation. The protein has a high degree of sequence similarity across species, suggesting its conserved role in eukaryotic translation initiation. **Pathways and Functions** EIF3E is involved in various cellular processes, including: 1. **Translation Initiation**: EIF3E plays a crucial role in the recruitment of the small ribosomal subunit to the mRNA, facilitating the initiation of protein synthesis. 2. **mRNA Binding**: EIF3E has been shown to interact with mRNA-binding proteins, such as eIF4E and eIF4G, to regulate mRNA binding and translation initiation. 3. **Cytoplasmic Organization**: EIF3E has been implicated in the organization of the cytoplasmic translation initiation complex, including the formation of the 40S preinitiation complex. 4. **Regulation of Translation**: EIF3E has been shown to regulate translation initiation by interacting with other proteins, such as eIF1 and eIF1A, to modulate the translation initiation process. **Clinical Significance** EIF3E has been implicated in various diseases, including: 1. **Ceruloplasmin-Related Disorders**: EIF3E has been shown to interact with ceruloplasmin, a protein involved in copper metabolism. Mutations in EIF3E have been linked to ceruloplasmin-related disorders, including Menkes disease and Kufor-Rakeb disease. 2. **Immune System Disorders**: EIF3E has been shown to play a role in the regulation of immune cell function, including the activation of T cells and B cells. 3. **Cancer**: EIF3E has been implicated in the regulation of protein synthesis in cancer cells, including the promotion of tumor growth and metastasis. In conclusion, EIF3E is a critical component of the eukaryotic translation initiation complex, playing a pivotal role in the regulation of protein synthesis and cellular organization. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of EIF3E.

Genular Protein ID: 417274046

Symbol: EIF3E_HUMAN

Name: Viral integration site protein INT-6 homolog

UniProtKB Accession Codes:

P60228 O43902 Q64058 Q64059 Q64252 Q6FG33 Q8WVK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 EMDB 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9295280

Title: The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome.

PubMed ID: 9295280

DOI: 10.1074/jbc.272.38.23477

PubMed ID: 9403073

Title: The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas.

PubMed ID: 9403073

DOI: 10.1006/geno.1997.4996

PubMed ID: 8688078

Title: Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein.

PubMed ID: 8688078

DOI: 10.1126/science.273.5277.951

PubMed ID: 12386384

Title: Divergent subcellular locations of HTLV-I Tax and Int-6: a contrast between in vitro protein-protein binding and intracellular protein colocalization.

PubMed ID: 12386384

DOI: 10.1007/bf02253422

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10504338

Title: Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.

PubMed ID: 10504338

DOI: 10.1242/jcs.112.19.3331

PubMed ID: 11457827

Title: Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.

PubMed ID: 11457827

DOI: 10.1074/jbc.m102161200

PubMed ID: 11590142

Title: The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.

PubMed ID: 11590142

DOI: 10.1074/jbc.m104966200

PubMed ID: 12220626

Title: Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.

PubMed ID: 12220626

DOI: 10.1016/s0014-5793(02)03147-2

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 16023166

Title: Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54.

PubMed ID: 16023166

DOI: 10.1016/j.virol.2005.06.011

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 16973618

Title: Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.

PubMed ID: 16973618

DOI: 10.1074/jbc.m605771200

PubMed ID: 17581632

Title: Reconstitution reveals the functional core of mammalian eIF3.

PubMed ID: 17581632

DOI: 10.1038/sj.emboj.7601765

PubMed ID: 17468741

Title: Human INT6/eIF3e is required for nonsense-mediated mRNA decay.

PubMed ID: 17468741

DOI: 10.1038/sj.embor.7400955

PubMed ID: 17324924

Title: Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation.

PubMed ID: 17324924

DOI: 10.1074/jbc.m700423200

PubMed ID: 17761670

Title: Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.

PubMed ID: 17761670

DOI: 10.1074/jbc.m706276200

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 17310990

Title: Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.

PubMed ID: 17310990

DOI: 10.1038/sj.onc.1210314

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21745818

Title: Mechanisms of translational regulation by a human eIF5-mimic protein.

PubMed ID: 21745818

DOI: 10.1093/nar/gkr339

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

Sequence Information:

  • Length: 445
  • Mass: 52221
  • Checksum: A5368651DD0DDD0C
  • Sequence:
    • MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN 
LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK 
HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ 
NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP 
QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY 
VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL 
NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM 
NIEKKLNQNS RSEAPNWATQ DSGFY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.