Details for: EIF3E
Gene ID: 3646
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EIF3E
Ensembl ID: ENSG00000104408
Description: eukaryotic translation initiation factor 3 subunit E
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 146.23rCSI 97.2%PRS 5.6
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CSI 111.84rCSI 93.75%PRS 5.64
-
CSI 110.26rCSI 89.16%PRS 4.61
-
CSI 107.7rCSI 97.25%PRS 4.13
-
CSI 101.47rCSI 89.12%PRS 5.25
-
CSI 96.42rCSI 67.72%PRS 14.02
-
CSI 92.79rCSI 76.92%PRS 4.43
-
CSI 92.03rCSI 96.19%PRS 4.99
-
CSI 91.42rCSI 88.01%PRS 4.85
-
CSI 87.81rCSI 76.03%PRS 5.22
-
CSI 87.19rCSI 51.49%PRS 6.57
-
CSI 82.27rCSI 79.32%PRS 2.52
-
CSI 80.3rCSI 96.39%PRS 4.69
-
CSI 77.61rCSI 88.84%PRS 9.77
-
CSI 75.82rCSI 59.93%PRS 3.24
-
CSI 72.55rCSI 53.9%PRS 7.02
-
CSI 71.66rCSI 73.04%PRS 6.79
-
CSI 71.21rCSI 55.2%PRS 4.46
-
CSI 68.97rCSI 47.95%PRS 5.51
-
CSI 68.09rCSI 52.46%PRS 4.24
-
CSI 67.91rCSI 90.74%PRS 9
-
CSI 66.58rCSI 95.01%PRS 5.34
-
CSI 66.5rCSI 57.81%PRS 5.78
-
CSI 66.33rCSI 83.24%PRS 5.96
-
CSI 64.84rCSI 76.15%PRS 5.69
-
CSI 63.85rCSI 52.88%PRS 4.69
-
CSI 63.53rCSI 66.55%PRS 4.38
-
CSI 62.61rCSI 77.46%PRS 4.11
-
CSI 61.2rCSI 48.15%PRS 5.59
-
CSI 60.75rCSI 80.74%PRS 5.13
-
CSI 60.6rCSI 76.16%PRS 25.05
-
CSI 58.86rCSI 80.21%PRS 4.25
-
CSI 58.3rCSI 43.81%PRS 4.84
-
CSI 57.04rCSI 56.1%PRS 5.13
-
CSI 56.38rCSI 54.22%PRS 10.22
-
CSI 56.3rCSI 81.21%PRS 6.53
-
CSI 56.18rCSI 45%PRS 8.76
-
CSI 55.5rCSI 85.76%PRS 4.4
-
CSI 54.98rCSI 54.29%PRS 20.51
-
CSI 51.94rCSI 38.77%PRS 7.96
-
CSI 50.5rCSI 72.79%PRS 7.61
-
CSI 49.53rCSI 50.95%PRS 7.66
-
CSI 48.87rCSI 40.79%PRS 15.36
-
CSI 48.83rCSI 51.15%PRS 5.02
-
CSI 48.32rCSI 50.06%PRS 5.51
-
CSI 46.69rCSI 37.93%PRS 4.98
-
CSI 45.06rCSI 39.47%PRS 6.33
-
CSI 44.98rCSI 35.71%PRS 8.37
-
CSI 44.87rCSI 54.2%PRS 5.49
-
CSI 44.7rCSI 56.89%PRS 5.48
-
CSI 43.86rCSI 64.31%PRS 6.17
-
CSI 41.77rCSI 57.1%PRS 5.32
-
CSI 41.73rCSI 29.14%PRS 4.95
-
CSI 41.22rCSI 34.68%PRS 7.9
-
CSI 40.8rCSI 34.99%PRS 12.61
-
CSI 40.68rCSI 86.53%PRS 9.02
-
CSI 40.21rCSI 54.94%PRS 5.19
-
CSI 40.02rCSI 51.32%PRS 5.42
-
CSI 38.18rCSI 33.89%PRS 4.7
-
CSI 37.67rCSI 68%PRS 14.22
-
CSI 37.01rCSI 63.41%PRS 6.28
-
CSI 36.2rCSI 31.83%PRS 3.39
-
CSI 36.13rCSI 86.93%PRS 7.39
-
CSI 35.17rCSI 89.31%PRS 4.8
-
CSI 35rCSI 63.58%PRS 7.19
-
CSI 34.31rCSI 29.58%PRS 7.79
-
CSI 34.26rCSI 52.41%PRS 7.68
-
CSI 33.92rCSI 52.13%PRS 6.78
-
CSI 33.2rCSI 78.91%PRS 7.15
-
CSI 31.99rCSI 80.14%PRS 15.68
-
CSI 31.83rCSI 70.47%PRS 4.4
-
CSI 31.69rCSI 87.07%PRS 7.86
-
CSI 30.82rCSI 37.97%PRS 15.84
-
CSI 30.75rCSI 22.77%PRS 4.41
-
CSI 30.47rCSI 28.11%PRS 4.74
-
CSI 30.01rCSI 22.46%PRS 7.72
-
CSI 30.01rCSI 45.84%PRS 4.68
-
CSI 29.24rCSI 55.81%PRS 11.54
-
CSI 28.28rCSI 43.43%PRS 5.45
-
CSI 28.2rCSI 25.89%PRS 5.36
-
CSI 28.16rCSI 81.52%PRS 5.32
-
CSI 28.06rCSI 21.04%PRS 14.25
-
CSI 27.86rCSI 40.36%PRS 6.91
-
CSI 27.85rCSI 57.19%PRS 11.41
-
CSI 27.39rCSI 37.93%PRS 6.76
-
CSI 27.27rCSI 37.15%PRS 11.86
-
CSI 26.58rCSI 36.93%PRS 4.93
-
CSI 26.01rCSI 50.59%PRS 4.79
-
CSI 25.65rCSI 74.2%PRS 10.6
-
CSI 25.35rCSI 60.99%PRS 33.04
-
CSI 25.33rCSI 98.59%PRS 7.8
-
CSI 24.9rCSI 71.09%PRS 8.34
-
CSI 24.76rCSI 90.01%PRS 23.38
-
CSI 24.49rCSI 85.94%PRS 8.54
-
CSI 24.48rCSI 39.47%PRS 7.63
-
CSI 24.37rCSI 43.46%PRS 8.15
-
CSI 24.06rCSI 22.74%PRS 4.9
-
CSI 23.93rCSI 45.24%PRS 10.6
-
CSI 23.86rCSI 24.9%PRS 4.8
-
CSI 23.39rCSI 15.76%PRS 5.7
-
CSI -23.3rCSI -55.3%PRS 6.3%
-
CSI -19.3rCSI -36.2%PRS 3.6%
-
CSI -19.2rCSI -43.0%PRS 3.0%
-
CSI -14.0rCSI -26.7%PRS 7.5%
-
CSI -13.1rCSI -16.9%PRS 5.8%
-
CSI -12.4rCSI -21.7%PRS 3.6%
-
CSI -11.1rCSI -46.0%PRS 13.9%
-
CSI -10.4rCSI -49.6%PRS 2.7%
-
CSI -8.3rCSI -19.1%PRS 4.2%
-
CSI -7.7rCSI -18.7%PRS 2.8%
-
CSI -7.1rCSI -11.4%PRS 3.2%
-
CSI -6.8rCSI -18.1%PRS 5.6%
-
CSI -6.7rCSI -20.8%PRS 3.0%
-
CSI -6.5rCSI -24.7%PRS 3.0%
-
CSI -5.8rCSI -18.3%PRS 3.3%
-
CSI -5.2rCSI -19.4%PRS 9.7%
-
CSI -5.0rCSI -18.0%PRS 2.5%
-
CSI -4.6rCSI -11.9%PRS 8.3%
-
CSI -4.6rCSI -11.0%PRS 2.6%
-
CSI -4.6rCSI -30.6%PRS 7.4%
-
CSI -4.2rCSI -11.9%PRS 6.8%
-
CSI -3.7rCSI -9.8%PRS 4.8%
-
CSI -3.3rCSI -9.5%PRS 6.4%
-
CSI -3.2rCSI -12.9%PRS 20.1%
-
CSI -3.2rCSI -16.0%PRS 7.1%
-
CSI -2.9rCSI -11.3%PRS 7.8%
-
CSI -2.4rCSI -6.3%PRS 5.6%
-
CSI -2.4rCSI -13.7%PRS 7.1%
-
CSI -2.1rCSI -4.2%PRS 13.7%
-
CSI -2.1rCSI -29.8%PRS 3.6%
-
CSI -2.1rCSI -1.6%PRS 6.2%
-
CSI -2.0rCSI -6.4%PRS 3.4%
-
CSI -1.7rCSI -3.9%PRS 11.8%
-
CSI -1.7rCSI -2.9%PRS 3.6%
-
CSI -1.6rCSI -3.6%PRS 4.4%
-
CSI -1.5rCSI -2.3%PRS 4.8%
-
CSI -1.4rCSI -8.9%PRS 3.9%
-
CSI -1.4rCSI -13.5%PRS 48.1%
-
CSI -1.3rCSI -7.4%PRS 24.7%
-
CSI -1.2rCSI -37.1%PRS 66.2%
-
CSI -1.0rCSI -1.7%PRS 9.7%
-
CSI -0.9rCSI -11.7%PRS 39.5%
-
CSI -0.7rCSI -0.8%PRS 5.9%
-
CSI -0.6rCSI -3.1%PRS 11.2%
-
CSI -0.6rCSI -11.7%PRS 68.5%
-
CSI -0.4rCSI -2.1%PRS 33.9%
-
CSI -0.4rCSI -0.9%PRS 16.6%
-
CSI -0.4rCSI -1.1%PRS 9.4%
-
CSI -0.3rCSI -6.5%PRS 38.4%
-
CSI -0.3rCSI -0.8%PRS 6.0%
-
CSI -0.3rCSI -5.5%PRS 5.1%
-
CSI -0.2rCSI -0.4%PRS 5.3%
-
CSI -0.1rCSI -0.2%PRS 4.3%
-
CSI -0.1rCSI -0.6%PRS 7.4%
-
CSI 0.3rCSI 2.2%PRS 32.3%
-
CSI 0.3rCSI 1.6%PRS 3.0%
-
CSI 0.3rCSI 1.6%PRS 9.6%
-
CSI 0.4rCSI 2.2%PRS 8.6%
-
CSI 0.4rCSI 3.6%PRS 0.6%
-
CSI 0.5rCSI 16.2%PRS 54.5%
-
CSI 0.6rCSI 1.9%PRS 4.1%
-
CSI 0.6rCSI 2.3%PRS 7.6%
-
CSI 0.6rCSI 4.6%PRS 26.5%
-
CSI 0.6rCSI 5.1%PRS 42.6%
-
CSI 0.7rCSI 1.4%PRS 6.5%
-
CSI 0.7rCSI 3.3%PRS 6.2%
-
CSI 0.7rCSI 1.5%PRS 9.6%
-
CSI 0.7rCSI 13.7%PRS 17.2%
-
CSI 0.7rCSI 4.5%PRS 17.5%
-
CSI 0.7rCSI 8.3%PRS 16.4%
-
CSI 0.8rCSI 1.9%PRS 3.7%
-
CSI 0.9rCSI 5.0%PRS 11.7%
-
CSI 0.9rCSI 6.7%PRS 2.2%
-
CSI 0.9rCSI 19.0%PRS 4.7%
-
CSI 1.0rCSI 8.6%PRS 40.8%
-
CSI 1.0rCSI 2.1%PRS 1.6%
-
CSI 1.1rCSI 11.5%PRS 56.9%
-
CSI 1.1rCSI 2.3%PRS 7.3%
-
CSI 1.1rCSI 2.8%PRS 8.4%
-
CSI 1.2rCSI 16.5%PRS 61.4%
-
CSI 1.3rCSI 2.3%PRS 4.0%
-
CSI 1.3rCSI 21.3%PRS 31.0%
-
CSI 1.4rCSI 8.2%PRS 9.6%
-
CSI 1.4rCSI 4.6%PRS 7.4%
-
CSI 1.5rCSI 28.1%PRS 38.8%
-
CSI 1.5rCSI 2.1%PRS 3.9%
-
CSI 1.5rCSI 15.4%PRS 42.1%
-
CSI 1.6rCSI 2.7%PRS 2.8%
-
CSI 1.6rCSI 9.7%PRS 23.7%
-
CSI 1.6rCSI 9.1%PRS 25.5%
-
CSI 1.7rCSI 8.6%PRS 22.2%
-
CSI 1.7rCSI 13.8%PRS 21.5%
-
CSI 1.7rCSI 4.5%PRS 4.4%
-
CSI 1.8rCSI 16.1%PRS 18.1%
-
CSI 1.8rCSI 3.1%PRS 2.8%
-
CSI 1.9rCSI 9.2%PRS 7.8%
-
CSI 2.0rCSI 17.4%PRS 28.6%
-
CSI 2.0rCSI 5.4%PRS 5.4%
-
CSI 2.0rCSI 5.1%PRS 6.9%
-
CSI 2.0rCSI 8.2%PRS 5.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 417274046
Symbol: EIF3E_HUMAN
Name: Viral integration site protein INT-6 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9295280
Title: The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome.
PubMed ID: 9295280
PubMed ID: 9403073
Title: The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas.
PubMed ID: 9403073
PubMed ID: 8688078
Title: Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein.
PubMed ID: 8688078
PubMed ID: 12386384
Title: Divergent subcellular locations of HTLV-I Tax and Int-6: a contrast between in vitro protein-protein binding and intracellular protein colocalization.
PubMed ID: 12386384
DOI: 10.1007/bf02253422
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10504338
Title: Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.
PubMed ID: 10504338
PubMed ID: 11457827
Title: Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.
PubMed ID: 11457827
PubMed ID: 11590142
Title: The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.
PubMed ID: 11590142
PubMed ID: 12220626
Title: Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.
PubMed ID: 12220626
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15703437
Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.
PubMed ID: 15703437
DOI: 10.1261/rna.7215305
PubMed ID: 16023166
Title: Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54.
PubMed ID: 16023166
PubMed ID: 16766523
Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.
PubMed ID: 16766523
PubMed ID: 16973618
Title: Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.
PubMed ID: 16973618
PubMed ID: 17581632
Title: Reconstitution reveals the functional core of mammalian eIF3.
PubMed ID: 17581632
PubMed ID: 17468741
Title: Human INT6/eIF3e is required for nonsense-mediated mRNA decay.
PubMed ID: 17468741
PubMed ID: 17324924
Title: Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation.
PubMed ID: 17324924
PubMed ID: 17761670
Title: Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.
PubMed ID: 17761670
PubMed ID: 17322308
Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.
PubMed ID: 17322308
PubMed ID: 17310990
Title: Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.
PubMed ID: 17310990
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18599441
Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.
PubMed ID: 18599441
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21745818
Title: Mechanisms of translational regulation by a human eIF5-mimic protein.
PubMed ID: 21745818
DOI: 10.1093/nar/gkr339
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25849773
Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.
PubMed ID: 25849773
DOI: 10.1038/nature14267
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27462815
Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
PubMed ID: 27462815
DOI: 10.1038/nature18954
PubMed ID: 16322461
Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.
PubMed ID: 16322461
Sequence Information:
- Length: 445
- Mass: 52221
- Checksum: A5368651DD0DDD0C
- Sequence:
MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM NIEKKLNQNS RSEAPNWATQ DSGFY