Gene EIF3E - ENSG00000104408 | NCBI Gene ID: 3646

Details for: EIF3E

Gene ID: 3646

Symbol: EIF3E

Ensembl ID: ENSG00000104408

Description: eukaryotic translation initiation factor 3 subunit E

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Cap-dependent translation initiation
(R-HSA-72737)
Eukaryotic translation initiation
(R-HSA-72613)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Metabolism of proteins
(R-HSA-392499)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Translation
(R-HSA-72766)
Translation initiation complex formation
(R-HSA-72649)
Cadherin binding
(GO:0045296)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Eukaryotic 43s preinitiation complex
(GO:0016282)
Eukaryotic 48s preinitiation complex
(GO:0033290)
Eukaryotic translation initiation factor 3 complex
(GO:0005852)
Eukaryotic translation initiation factor 3 complex, eif3e
(GO:0071540)
Extracellular exosome
(GO:0070062)
Formation of cytoplasmic translation initiation complex
(GO:0001732)
Membrane
(GO:0016020)
Negative regulation of translational initiation
(GO:0045947)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pml body
(GO:0016605)
Positive regulation of mrna binding
(GO:1902416)
Positive regulation of translation
(GO:0045727)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Regulation of translational initiation
(GO:0006446)
Rna binding
(GO:0003723)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: theca cell (CL0000503)
Fold Change: 4.16
Marker Score: 2983
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.12
Marker Score: 54322
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.91
Marker Score: 9559
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.75
Marker Score: 198265.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.75
Marker Score: 127558
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.69
Marker Score: 2245.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.69
Marker Score: 4804
Cell Name: naive B cell (CL0000788)
Fold Change: 3.64
Marker Score: 3250
Cell Name: supporting cell (CL0000630)
Fold Change: 3.61
Marker Score: 6776
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 3.5
Marker Score: 6011
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.47
Marker Score: 3419
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.42
Marker Score: 5259
Cell Name: mature T cell (CL0002419)
Fold Change: 3.41
Marker Score: 33776
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.35
Marker Score: 3581
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.34
Marker Score: 21748
Cell Name: malignant cell (CL0001064)
Fold Change: 3.3
Marker Score: 44385
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.27
Marker Score: 2788
Cell Name: naive T cell (CL0000898)
Fold Change: 3.26
Marker Score: 2099
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.25
Marker Score: 13930
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.24
Marker Score: 2442
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.23
Marker Score: 3815
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.19
Marker Score: 1438
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.18
Marker Score: 110061
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.14
Marker Score: 2473
Cell Name: secretory cell (CL0000151)
Fold Change: 3.14
Marker Score: 5723
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.12
Marker Score: 1558
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.1
Marker Score: 4387
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.1
Marker Score: 5534
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.1
Marker Score: 740
Cell Name: blood cell (CL0000081)
Fold Change: 3.07
Marker Score: 35654
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.06
Marker Score: 1068
Cell Name: basophil (CL0000767)
Fold Change: 3.06
Marker Score: 1454
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 3.03
Marker Score: 1027
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.01
Marker Score: 15800.5
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3
Marker Score: 2679
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3
Marker Score: 5995
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.99
Marker Score: 6272
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.99
Marker Score: 1879
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.97
Marker Score: 23204
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.97
Marker Score: 978
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.94
Marker Score: 4819.5
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.93
Marker Score: 19127
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.93
Marker Score: 8103
Cell Name: memory B cell (CL0000787)
Fold Change: 2.92
Marker Score: 2212
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.92
Marker Score: 5096
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.92
Marker Score: 1077
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.92
Marker Score: 4939
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.92
Marker Score: 2731
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.91
Marker Score: 6635
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.9
Marker Score: 11173
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.88
Marker Score: 6542
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.87
Marker Score: 1682
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.87
Marker Score: 2412
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.86
Marker Score: 2248
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.86
Marker Score: 9022
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.85
Marker Score: 916
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.82
Marker Score: 31724
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.82
Marker Score: 855
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.81
Marker Score: 11495
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.81
Marker Score: 1692
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.8
Marker Score: 992
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.8
Marker Score: 1166
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.79
Marker Score: 28297
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.78
Marker Score: 3432
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.78
Marker Score: 155217
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.77
Marker Score: 23882
Cell Name: granulocyte (CL0000094)
Fold Change: 2.77
Marker Score: 1241
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.77
Marker Score: 1128
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.75
Marker Score: 664
Cell Name: papillary tips cell (CL1000597)
Fold Change: 2.75
Marker Score: 555
Cell Name: decidual cell (CL2000002)
Fold Change: 2.75
Marker Score: 11854
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.75
Marker Score: 1096
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.74
Marker Score: 5731.5
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.74
Marker Score: 1247
Cell Name: immature B cell (CL0000816)
Fold Change: 2.73
Marker Score: 1810
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.72
Marker Score: 949
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.72
Marker Score: 1432
Cell Name: pro-B cell (CL0000826)
Fold Change: 2.72
Marker Score: 2623
Cell Name: stromal cell (CL0000499)
Fold Change: 2.7
Marker Score: 3169
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 2.69
Marker Score: 874
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.69
Marker Score: 2686
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.68
Marker Score: 2533
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 2.68
Marker Score: 615
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.68
Marker Score: 7022
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.68
Marker Score: 2521
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.66
Marker Score: 2846
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.66
Marker Score: 1559
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.66
Marker Score: 2888
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.65
Marker Score: 3194.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.64
Marker Score: 4205
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.64
Marker Score: 4493
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.64
Marker Score: 1913
Cell Name: erythroblast (CL0000765)
Fold Change: 2.64
Marker Score: 1648
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.64
Marker Score: 6207
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 2.64
Marker Score: 698
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.63
Marker Score: 2471
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.62
Marker Score: 993
Cell Name: basal cell (CL0000646)
Fold Change: 2.62
Marker Score: 3378
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.6
Marker Score: 2713
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.6
Marker Score: 1709

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**Key characteristics:** * The EIF3E gene is located on chromosome 17q21.1. * It is a large gene encoding a protein of 1,363 amino acids. * The protein is a member of the EIF3 family of translation initiation factors. * It is required for the initiation of translation of all eukaryotic mRNAs. **Pathways and functions:** * EIF3E binds to the cap-binding complex and eifs, and subsequently binds to 43s, Cadherin, Cap-dependent translation initiation, and the ternary complex. * It is involved in the formation of a pool of free 40s subunits, the formation of the cytoplasmic translation initiation complex, the formation of the ternary complex, and subsequently, the 43s complex, Gtp hydrolysis and joining of the 60s ribosomal subunit, L13a-mediated translational silencing of ceruloplasmin expression. * It is also involved in metabolism of proteins, nuclear-transcribed mrna catabolic process, nonsense-mediated decay, and protein binding. **Clinical significance:** * Mutations in the EIF3E gene have been linked to several human diseases, including cancer and neurodegenerative disorders. * The gene is a promising target for cancer therapy, as it is frequently mutated in cancer cells. * Targeting EIF3E has been shown to be effective in inhibiting tumor growth in preclinical models.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Viral integration site protein INT-6 homolog

Genular Protein ID: 417274046

Symbol: EIF3E_HUMAN

Name: Viral integration site protein INT-6 homolog

UniProtKB Accession Codes:

P60228 O43902 Q64058 Q64059 Q64252 Q6FG33 Q8WVK4

Database IDs:

Citations:

PubMed ID: 9295280

Title: The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome.

PubMed ID: 9295280

DOI: 10.1074/jbc.272.38.23477

PubMed ID: 9403073

Title: The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas.

PubMed ID: 9403073

DOI: 10.1006/geno.1997.4996

PubMed ID: 8688078

Title: Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein.

PubMed ID: 8688078

DOI: 10.1126/science.273.5277.951

PubMed ID: 12386384

Title: Divergent subcellular locations of HTLV-I Tax and Int-6: a contrast between in vitro protein-protein binding and intracellular protein colocalization.

PubMed ID: 12386384

DOI: 10.1007/bf02253422

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10504338

Title: Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.

PubMed ID: 10504338

DOI: 10.1242/jcs.112.19.3331

PubMed ID: 11457827

Title: Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.

PubMed ID: 11457827

DOI: 10.1074/jbc.m102161200

PubMed ID: 11590142

Title: The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.

PubMed ID: 11590142

DOI: 10.1074/jbc.m104966200

PubMed ID: 12220626

Title: Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.

PubMed ID: 12220626

DOI: 10.1016/s0014-5793(02)03147-2

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 16023166

Title: Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54.

PubMed ID: 16023166

DOI: 10.1016/j.virol.2005.06.011

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 16973618

Title: Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.

PubMed ID: 16973618

DOI: 10.1074/jbc.m605771200

PubMed ID: 17581632

Title: Reconstitution reveals the functional core of mammalian eIF3.

PubMed ID: 17581632

DOI: 10.1038/sj.emboj.7601765

PubMed ID: 17468741

Title: Human INT6/eIF3e is required for nonsense-mediated mRNA decay.

PubMed ID: 17468741

DOI: 10.1038/sj.embor.7400955

PubMed ID: 17324924

Title: Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation.

PubMed ID: 17324924

DOI: 10.1074/jbc.m700423200

PubMed ID: 17761670

Title: Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.

PubMed ID: 17761670

DOI: 10.1074/jbc.m706276200

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 17310990

Title: Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.

PubMed ID: 17310990

DOI: 10.1038/sj.onc.1210314

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21745818

Title: Mechanisms of translational regulation by a human eIF5-mimic protein.

PubMed ID: 21745818

DOI: 10.1093/nar/gkr339

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

Sequence Information:

Length: 445
Mass: 52221
Checksum: A5368651DD0DDD0C
Sequence:

MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN 
LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK 
HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ 
NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP 
QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY 
VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL 
NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM 
NIEKKLNQNS RSEAPNWATQ DSGFY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EIF3E

Associated with

Cells (max top 100)

Other Information

The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome. PubMed ID: 9295280

The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas. PubMed ID: 9403073

Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein. PubMed ID: 8688078

Divergent subcellular locations of HTLV-I Tax and Int-6: a contrast between in vitro protein-protein binding and intracellular protein colocalization. PubMed ID: 12386384

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. PubMed ID: 10504338

Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits. PubMed ID: 11457827

The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. PubMed ID: 11590142

Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. PubMed ID: 12220626

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. PubMed ID: 15703437

Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54. PubMed ID: 16023166

Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. PubMed ID: 16766523

Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. PubMed ID: 16973618

Reconstitution reveals the functional core of mammalian eIF3. PubMed ID: 17581632

Human INT6/eIF3e is required for nonsense-mediated mRNA decay. PubMed ID: 17468741

Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation. PubMed ID: 17324924

Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain. PubMed ID: 17761670

Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. PubMed ID: 17322308

Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle. PubMed ID: 17310990

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. PubMed ID: 18599441

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Mechanisms of translational regulation by a human eIF5-mimic protein. PubMed ID: 21745818

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. PubMed ID: 25849773

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. PubMed ID: 27462815

Structural roles for human translation factor eIF3 in initiation of protein synthesis. PubMed ID: 16322461