Details for: IRF3

Gene ID: 3661

Symbol: IRF3

Ensembl ID: ENSG00000126456

Description: interferon regulatory factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 199.4275
    Cell Significance Index: -31.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.6097
    Cell Significance Index: -29.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.8633
    Cell Significance Index: -30.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.1756
    Cell Significance Index: -35.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.3231
    Cell Significance Index: -34.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.1741
    Cell Significance Index: -35.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.0455
    Cell Significance Index: -31.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0269
    Cell Significance Index: -32.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7150
    Cell Significance Index: -26.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.8427
    Cell Significance Index: -27.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6416
    Cell Significance Index: -34.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9183
    Cell Significance Index: -17.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6672
    Cell Significance Index: 75.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2098
    Cell Significance Index: 32.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0323
    Cell Significance Index: 66.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0180
    Cell Significance Index: 52.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8558
    Cell Significance Index: 18.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8330
    Cell Significance Index: 43.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7814
    Cell Significance Index: 140.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7333
    Cell Significance Index: 19.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7304
    Cell Significance Index: 89.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7074
    Cell Significance Index: 48.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7039
    Cell Significance Index: 384.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6857
    Cell Significance Index: 94.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5682
    Cell Significance Index: 15.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5663
    Cell Significance Index: 112.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5609
    Cell Significance Index: 26.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5486
    Cell Significance Index: 28.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5192
    Cell Significance Index: 24.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4747
    Cell Significance Index: 209.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4167
    Cell Significance Index: 376.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4062
    Cell Significance Index: 47.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3686
    Cell Significance Index: 10.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3109
    Cell Significance Index: 9.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2863
    Cell Significance Index: 10.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2732
    Cell Significance Index: 35.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2528
    Cell Significance Index: 17.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2023
    Cell Significance Index: 10.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2015
    Cell Significance Index: 19.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1712
    Cell Significance Index: 27.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1623
    Cell Significance Index: 4.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1585
    Cell Significance Index: 31.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1360
    Cell Significance Index: 94.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1294
    Cell Significance Index: 2.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1175
    Cell Significance Index: 8.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0700
    Cell Significance Index: 1.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0612
    Cell Significance Index: 21.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0461
    Cell Significance Index: 8.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0272
    Cell Significance Index: 51.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0229
    Cell Significance Index: 42.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0151
    Cell Significance Index: 1.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0148
    Cell Significance Index: 2.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0103
    Cell Significance Index: 15.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0126
    Cell Significance Index: -9.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0136
    Cell Significance Index: -10.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0169
    Cell Significance Index: -22.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0194
    Cell Significance Index: -0.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0279
    Cell Significance Index: -12.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0295
    Cell Significance Index: -4.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0305
    Cell Significance Index: -1.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0340
    Cell Significance Index: -0.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0419
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0456
    Cell Significance Index: -33.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0463
    Cell Significance Index: -4.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0568
    Cell Significance Index: -32.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0625
    Cell Significance Index: -39.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0631
    Cell Significance Index: -2.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0681
    Cell Significance Index: -19.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1200
    Cell Significance Index: -9.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1231
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1479
    Cell Significance Index: -16.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1674
    Cell Significance Index: -19.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1833
    Cell Significance Index: -38.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2111
    Cell Significance Index: -2.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2568
    Cell Significance Index: -6.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2731
    Cell Significance Index: -9.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2905
    Cell Significance Index: -3.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2925
    Cell Significance Index: -30.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3015
    Cell Significance Index: -6.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3041
    Cell Significance Index: -2.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3111
    Cell Significance Index: -8.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3819
    Cell Significance Index: -30.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3838
    Cell Significance Index: -3.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3996
    Cell Significance Index: -24.5600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4322
    Cell Significance Index: -7.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4344
    Cell Significance Index: -26.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4642
    Cell Significance Index: -26.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4909
    Cell Significance Index: -33.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5146
    Cell Significance Index: -14.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5281
    Cell Significance Index: -9.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5553
    Cell Significance Index: -11.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5687
    Cell Significance Index: -16.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6410
    Cell Significance Index: -12.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7117
    Cell Significance Index: -31.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7732
    Cell Significance Index: -16.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7794
    Cell Significance Index: -28.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7878
    Cell Significance Index: -32.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8522
    Cell Significance Index: -32.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8735
    Cell Significance Index: -30.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IRF3 is a transcription factor that belongs to the interferon regulatory factor family. It is a dimeric protein that binds to specific DNA sequences, allowing it to regulate gene expression. IRF3 is activated by the phosphorylation of its C-terminal domain, which occurs in response to viral infections. Once activated, IRF3 translocates to the nucleus and induces the expression of IFN-α/β and other antiviral genes. IRF3 also interacts with other transcription factors, including STAT1 and IRF7, to regulate the expression of immune-related genes. **Pathways and Functions** IRF3 is involved in several key pathways, including: 1. **Antiviral mechanism by IFN-stimulated genes**: IRF3 induces the expression of IFN-α/β, which in turn activates the JAK/STAT signaling pathway, leading to the expression of antiviral genes. 2. **Apoptotic process**: IRF3 regulates the expression of pro-apoptotic genes, leading to the induction of programmed necrotic cell death in infected cells. 3. **Cellular response to exogenous dsRNA**: IRF3 is activated by dsRNA, which is a hallmark of viral infections. 4. **Cytokine signaling in the immune system**: IRF3 regulates the expression of cytokines, including IFN-α/β, which are essential for the coordination of the immune response. **Clinical Significance** IRF3 plays a critical role in the innate immune response against viral infections, and its dysregulation has been implicated in various diseases, including: 1. **Viral infections**: IRF3 is essential for the induction of IFN-α/β in response to viral infections, such as influenza, HIV, and herpes simplex virus. 2. **Autoimmune diseases**: IRF3 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and lupus, where it regulates the expression of immune-related genes. 3. **Cancer**: IRF3 has been shown to regulate the expression of anti-tumor genes, making it a potential target for cancer therapy. 4. **Neurological disorders**: IRF3 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of immune-related genes. In conclusion, IRF3 is a critical transcription factor that plays a central role in the innate immune response against viral infections. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation.

Genular Protein ID: 3706650549

Symbol: IRF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14653 A8K7L2 B2RAZ3 Q5FBY1 Q5FBY2 Q5FBY4 Q7Z5G6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 11 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 48 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 16 RefSeq 12 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8524823

Title: Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

PubMed ID: 8524823

DOI: 10.1073/pnas.92.25.11657

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9803267

Title: Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.

PubMed ID: 9803267

DOI: 10.1046/j.1469-1809.1998.6230231.x

PubMed ID: 9566918

Title: Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.

PubMed ID: 9566918

DOI: 10.1128/mcb.18.5.2986

PubMed ID: 10920266

Title: Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300.

PubMed ID: 10920266

DOI: 10.1093/oxfordjournals.jbchem.a022753

PubMed ID: 10805757

Title: Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1.

PubMed ID: 10805757

DOI: 10.1128/mcb.20.11.4159-4168.2000

PubMed ID: 11035028

Title: Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3.

PubMed ID: 11035028

DOI: 10.1074/jbc.m007790200

PubMed ID: 11124948

Title: IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.

PubMed ID: 11124948

DOI: 10.1074/jbc.m008717200

PubMed ID: 11314014

Title: HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.

PubMed ID: 11314014

DOI: 10.1038/sj.onc.1204163

PubMed ID: 11846977

Title: Control of IRF-3 activation by phosphorylation.

PubMed ID: 11846977

DOI: 10.1089/107999002753452674

PubMed ID: 12471095

Title: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

PubMed ID: 12471095

DOI: 10.4049/jimmunol.169.12.6668

PubMed ID: 12186937

Title: Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1.

PubMed ID: 12186937

DOI: 10.1128/jvi.76.18.9545-9550.2002

PubMed ID: 14517278

Title: LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

PubMed ID: 14517278

DOI: 10.1084/jem.20031023

PubMed ID: 12702806

Title: Triggering the interferon antiviral response through an IKK-related pathway.

PubMed ID: 12702806

DOI: 10.1126/science.1081315

PubMed ID: 14739303

Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

PubMed ID: 14739303

DOI: 10.1074/jbc.m311629200

PubMed ID: 16281057

Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

PubMed ID: 16281057

DOI: 10.1038/sj.emboj.7600863

PubMed ID: 16153868

Title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.

PubMed ID: 16153868

DOI: 10.1016/j.molcel.2005.08.014

PubMed ID: 16846591

Title: Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.

PubMed ID: 16846591

DOI: 10.1016/j.bcp.2006.06.002

PubMed ID: 16979567

Title: Type I interferon gene induction by the interferon regulatory factor family of transcription factors.

PubMed ID: 16979567

DOI: 10.1016/j.immuni.2006.08.009

PubMed ID: 18711448

Title: Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.

PubMed ID: 18711448

DOI: 10.1038/cr.2008.277

PubMed ID: 18641315

Title: The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.

PubMed ID: 18641315

DOI: 10.4049/jimmunol.181.3.1780

PubMed ID: 19153231

Title: Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.

PubMed ID: 19153231

DOI: 10.1128/jvi.01875-08

PubMed ID: 19557502

Title: RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway.

PubMed ID: 19557502

DOI: 10.1007/s11010-009-0180-8

PubMed ID: 21167755

Title: The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.

PubMed ID: 21167755

DOI: 10.1016/j.immuni.2010.11.027

PubMed ID: 20049431

Title: Regulation of immunity and oncogenesis by the IRF transcription factor family.

PubMed ID: 20049431

DOI: 10.1007/s00262-009-0804-6

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 20308324

Title: Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.

PubMed ID: 20308324

DOI: 10.1128/mcb.01466-09

PubMed ID: 22394562

Title: STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

PubMed ID: 22394562

DOI: 10.1126/scisignal.2002521

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24049179

Title: Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production.

PubMed ID: 24049179

DOI: 10.1128/jvi.02355-13

PubMed ID: 23478265

Title: Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation.

PubMed ID: 23478265

DOI: 10.1128/mcb.01603-12

PubMed ID: 23746807

Title: Structural insights into the functions of TBK1 in innate antimicrobial immunity.

PubMed ID: 23746807

DOI: 10.1016/j.str.2013.04.025

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 27980081

Title: DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.

PubMed ID: 27980081

DOI: 10.1042/bcj20160956

PubMed ID: 28331227

Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.

PubMed ID: 28331227

DOI: 10.1038/leu.2017.94

PubMed ID: 29802199

Title: C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.

PubMed ID: 29802199

DOI: 10.1074/jbc.ra117.001491

PubMed ID: 29427864

Title: Seneca Valley Virus 3Cpro abrogates the IRF3- and IRF7-mediated innate immune response by degrading IRF3 and IRF7.

PubMed ID: 29427864

DOI: 10.1016/j.virol.2018.01.028

PubMed ID: 26216125

Title: Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

PubMed ID: 26216125

DOI: 10.1084/jem.20142274

PubMed ID: 25636800

Title: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

PubMed ID: 25636800

DOI: 10.1126/science.aaa2630

PubMed ID: 31413131

Title: LYAR suppresses interferon-beta induction by targeting phosphorylated IRF3.

PubMed ID: 31413131

DOI: 10.1128/jvi.00769-19

PubMed ID: 30863402

Title: Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-beta Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.

PubMed ID: 30863402

DOI: 10.3389/fimmu.2019.00290

PubMed ID: 30867312

Title: Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kappaB-Mediated Transcription.

PubMed ID: 30867312

DOI: 10.1128/jvi.00181-19

PubMed ID: 30878284

Title: Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3.

PubMed ID: 30878284

DOI: 10.1016/j.molcel.2019.02.013

PubMed ID: 31340999

Title: DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.

PubMed ID: 31340999

DOI: 10.1242/jcs.230409

PubMed ID: 32726803

Title: Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.

PubMed ID: 32726803

DOI: 10.1038/s41586-020-2601-5

PubMed ID: 33440148

Title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.

PubMed ID: 33440148

DOI: 10.1016/j.celrep.2020.108628

PubMed ID: 35914352

Title: NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.

PubMed ID: 35914352

DOI: 10.1016/j.bbrc.2022.07.043

PubMed ID: 35922005

Title: Coronaviruses exploit a host cysteine-aspartic protease for replication.

PubMed ID: 35922005

DOI: 10.1038/s41586-022-05148-4

PubMed ID: 36603579

Title: Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.

PubMed ID: 36603579

DOI: 10.1016/j.molcel.2022.12.007

PubMed ID: 14555995

Title: X-ray crystal structure of IRF-3 and its functional implications.

PubMed ID: 14555995

DOI: 10.1038/nsb1001

PubMed ID: 14555996

Title: Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation.

PubMed ID: 14555996

DOI: 10.1038/nsb1002

PubMed ID: 15510218

Title: Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.

PubMed ID: 15510218

DOI: 10.1038/sj.emboj.7600453

PubMed ID: 16154084

Title: Crystal structure of IRF-3 in complex with CBP.

PubMed ID: 16154084

DOI: 10.1016/j.str.2005.06.011

PubMed ID: 27302953

Title: Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.

PubMed ID: 27302953

DOI: 10.1073/pnas.1603269113

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

  • Length: 427
  • Mass: 47219
  • Checksum: F536676FA78B0110
  • Sequence:
    • MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA 
TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NSGVGDFSQP 
DTSPDTNGGG STSDTQEDIL DELLGNMVLA PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT 
PFPNLGPSEN PLKRLLVPGE EWEFEVTAFY RGRQVFQQTI SCPEGLRLVG SEVGDRTLPG 
WPVTLPDPGM SLTDRGVMSY VRHVLSCLGG GLALWRAGQW LWAQRLGHCH TYWAVSEELL 
PNSGHGPDGE VPKDKEGGVF DLGPFIVDLI TFTEGSGRSP RYALWFCVGE SWPQDQPWTK 
RLVMVKVVPT CLRALVEMAR VGGASSLENT VDLHISNSHP LSLTSDQYKA YLQDLVEGMD 
FQGPGES

Genular Protein ID: 2094882281

Symbol: E2GIM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 392
  • Mass: 42970
  • Checksum: 9A942E0AE51F388C
  • Sequence:
    • MVGRKQGWSC RLTGIKPGKP AWAEATGAYV PGRDKPDLPT WKRNFRSALN RKEGLRLAED 
RSKDPHDPHK IYEFVNSGVG DFSQPDTSPD TNGGGSTSDT QEDILDELLG NMVLAPLPDP 
GPPSLAVAPE PCPQPLRSPS LDNPTPFPNL GPSENPLKRL LVPGEEWEFE VTAFYRGRQV 
FQQTISCPEG LRLVGSEVGD RTLPGWPVTL PDPGMSLTDR GVMSYVRHVP SCLGGGLALW 
RAGQWLWAQR LGHCHTYWAV SEELLPNSGH GPDGEVPKDK EGGVFDLGPF IVDLITFTEG 
SGRSPRYALW FCVGESWPQD QPWTKRLVMV KVVPTCLRAL VEMARVGGAS SLENTVDLHI 
SNSHPLSLTS DQYKAYLQDL VEGMDFQGPG ET

Genular Protein ID: 1149259666

Symbol: E2GIM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 300
  • Mass: 33184
  • Checksum: 1585BFBBA65C2DCE
  • Sequence:
    • MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA 
TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NSGVGDFSQP 
DTSPDTNGGG STSDTQEDIL DELLGNMVLA PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT 
PFPNLGPSEN PLKRLLVPGE DLITFTEGSG RSPRYALWFC VGESWPQDQP WTKRLVMVKV 
VPTCLRALVE MARVGGASSL ENTVDLHISN SHPLSLTSDQ YKAYLQDLVE GMDFQGPGET

Genular Protein ID: 1455427007

Symbol: E2GIM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 281
  • Mass: 30793
  • Checksum: B90CD8A841ACF200
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEEWEFEV 
TAFYRGRQVF QQTISCPEGL RLVGSEVGDR TLPGWPVTLP DPGMSLTDRG VMSYVRHVLS 
CLGGGLALWR AGQWLWAQRL GHCHTYWAVS EELLPNSGHG PDGEVPKDKE GGVFDLGPFI 
VDLITFTEGS GRSPRYALWF CVGESWPQDQ PWTKRLVMVK VVPTCLRALV EMARVGGASS 
LENTVDLHIS NSHPLSLTSD QYKAYLQDLV EGMDFQGPGE T

Genular Protein ID: 3555019004

Symbol: E2GIM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 154
  • Mass: 16718
  • Checksum: 7E227E0B7A874231
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEDLITFT 
EGSGRSPRYA LWFCVGESWP QDQPWTKRLV MVKVVPTCLR ALVEMARVGG ASSLENTVDL 
HISNSHPLSL TSDQHKAYLQ DLVEGMDFQG PGET

Genular Protein ID: 1447409907

Symbol: E2GIM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 154
  • Mass: 16744
  • Checksum: 7E227E1716F74231
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEDLITFT 
EGSGRSPRYA LWFCVGESWP QDQPWTKRLV MVKVVPTCLR ALVEMARVGG ASSLENTVDL 
HISNSHPLSL TSDQYKAYLQ DLVEGMDFQG PGET

Genular Protein ID: 3369835348

Symbol: M0QYT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0QYT9

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 5 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 281
  • Mass: 30779
  • Checksum: BD1CD8A841ACF200
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEEWEFEV 
TAFYRGRQVF QQTISCPEGL RLVGSEVGDR TLPGWPVTLP DPGMSLTDRG VMSYVRHVLS 
CLGGGLALWR AGQWLWAQRL GHCHTYWAVS EELLPNSGHG PDGEVPKDKE GGVFDLGPFI 
VDLITFTEGS GRSPRYALWF CVGESWPQDQ PWTKRLVMVK VVPTCLRALV EMARVGGASS 
LENTVDLHIS NSHPLSLTSD QYKAYLQDLV EGMDFQGPGE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.