Details for: IRF3

Gene ID: 3661

Symbol: IRF3

Ensembl ID: ENSG00000126456

Description: interferon regulatory factor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.7
    Marker Score: 2054.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.47
    Marker Score: 2164
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.44
    Marker Score: 5651.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.27
    Marker Score: 12908.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.26
    Marker Score: 12494.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.25
    Marker Score: 14588
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.23
    Marker Score: 382
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.2
    Marker Score: 3378
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.2
    Marker Score: 1122
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.18
    Marker Score: 40714
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.17
    Marker Score: 4326
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.16
    Marker Score: 580
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.15
    Marker Score: 566
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.11
    Marker Score: 389
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1
    Marker Score: 262
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.09
    Marker Score: 2127
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.08
    Marker Score: 2202
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.08
    Marker Score: 2455
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.07
    Marker Score: 9265
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.06
    Marker Score: 1370
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.05
    Marker Score: 1163
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.05
    Marker Score: 9185
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.05
    Marker Score: 2889
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.04
    Marker Score: 1388
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.04
    Marker Score: 2200.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.04
    Marker Score: 391
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.04
    Marker Score: 423
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.03
    Marker Score: 1086
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.03
    Marker Score: 444
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.03
    Marker Score: 1066
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.02
    Marker Score: 2499.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.02
    Marker Score: 855
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.01
    Marker Score: 863
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.01
    Marker Score: 1008
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.01
    Marker Score: 1097
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.01
    Marker Score: 4837
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.01
    Marker Score: 421
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.01
    Marker Score: 4121
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71576
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.99
    Marker Score: 6346
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47800
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.99
    Marker Score: 322
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.98
    Marker Score: 226
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30368
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.98
    Marker Score: 1742
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.97
    Marker Score: 942
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.97
    Marker Score: 979
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.97
    Marker Score: 4168
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.97
    Marker Score: 735
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.97
    Marker Score: 662
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.97
    Marker Score: 205.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.97
    Marker Score: 603
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.96
    Marker Score: 859.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.96
    Marker Score: 580
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.96
    Marker Score: 6152.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.96
    Marker Score: 456
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.96
    Marker Score: 563
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.96
    Marker Score: 552
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.96
    Marker Score: 334
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.96
    Marker Score: 330
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.95
    Marker Score: 640
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.95
    Marker Score: 687
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.95
    Marker Score: 208
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.95
    Marker Score: 277
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.94
    Marker Score: 12692
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.94
    Marker Score: 266
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.94
    Marker Score: 715
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.94
    Marker Score: 639
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.94
    Marker Score: 440
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.94
    Marker Score: 537
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.94
    Marker Score: 354.5
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.94
    Marker Score: 233
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.94
    Marker Score: 308
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.93
    Marker Score: 336
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.93
    Marker Score: 2373
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.93
    Marker Score: 1005
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.93
    Marker Score: 228
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.93
    Marker Score: 429
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.93
    Marker Score: 243.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.92
    Marker Score: 2514
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.92
    Marker Score: 344
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.92
    Marker Score: 200
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.92
    Marker Score: 208
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.92
    Marker Score: 261
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.92
    Marker Score: 447.5
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.92
    Marker Score: 220
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.91
    Marker Score: 636
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.91
    Marker Score: 915
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.91
    Marker Score: 480
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.91
    Marker Score: 977
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.91
    Marker Score: 275
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.9
    Marker Score: 267.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.9
    Marker Score: 872
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.9
    Marker Score: 274
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.9
    Marker Score: 222
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.9
    Marker Score: 1568
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.9
    Marker Score: 235
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.9
    Marker Score: 845

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Other Information

**Key characteristics:** - IRF3 is a member of the interferon regulatory factor family of proteins. - It is a key regulator of innate immune responses. - It plays a role in the regulation of inflammation, cell death, and tissue repair. **Pathways and functions:** - IRF3 is activated by type I interferons (IFNs). - It is involved in the regulation of innate immune responses to cytosolic DNA. - It plays a role in the induction of type I IFNs. - It is involved in the regulation of inflammation, cell death, and tissue repair. - It is involved in the regulation of the immune response to viral infection. **Clinical significance:** - Mutations in IRF3 have been linked to a number of human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - IRF3 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** - IRF3 is a highly conserved protein that is found in mammals. - It is a key regulator of the immune response to viral infection. - It is a potential target for the treatment of inflammatory and autoimmune diseases.

Genular Protein ID: 3706650549

Symbol: IRF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14653 A8K7L2 B2RAZ3 Q5FBY1 Q5FBY2 Q5FBY4 Q7Z5G6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 11 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 18 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 15 RefSeq 12 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8524823

Title: Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

PubMed ID: 8524823

DOI: 10.1073/pnas.92.25.11657

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9803267

Title: Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.

PubMed ID: 9803267

DOI: 10.1046/j.1469-1809.1998.6230231.x

PubMed ID: 9566918

Title: Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.

PubMed ID: 9566918

DOI: 10.1128/mcb.18.5.2986

PubMed ID: 10920266

Title: Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300.

PubMed ID: 10920266

DOI: 10.1093/oxfordjournals.jbchem.a022753

PubMed ID: 10805757

Title: Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1.

PubMed ID: 10805757

DOI: 10.1128/mcb.20.11.4159-4168.2000

PubMed ID: 11035028

Title: Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3.

PubMed ID: 11035028

DOI: 10.1074/jbc.m007790200

PubMed ID: 11124948

Title: IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.

PubMed ID: 11124948

DOI: 10.1074/jbc.m008717200

PubMed ID: 11314014

Title: HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.

PubMed ID: 11314014

DOI: 10.1038/sj.onc.1204163

PubMed ID: 11846977

Title: Control of IRF-3 activation by phosphorylation.

PubMed ID: 11846977

DOI: 10.1089/107999002753452674

PubMed ID: 12471095

Title: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

PubMed ID: 12471095

DOI: 10.4049/jimmunol.169.12.6668

PubMed ID: 12186937

Title: Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1.

PubMed ID: 12186937

DOI: 10.1128/jvi.76.18.9545-9550.2002

PubMed ID: 14517278

Title: LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

PubMed ID: 14517278

DOI: 10.1084/jem.20031023

PubMed ID: 12702806

Title: Triggering the interferon antiviral response through an IKK-related pathway.

PubMed ID: 12702806

DOI: 10.1126/science.1081315

PubMed ID: 14739303

Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

PubMed ID: 14739303

DOI: 10.1074/jbc.m311629200

PubMed ID: 16281057

Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

PubMed ID: 16281057

DOI: 10.1038/sj.emboj.7600863

PubMed ID: 16153868

Title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.

PubMed ID: 16153868

DOI: 10.1016/j.molcel.2005.08.014

PubMed ID: 16846591

Title: Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.

PubMed ID: 16846591

DOI: 10.1016/j.bcp.2006.06.002

PubMed ID: 16979567

Title: Type I interferon gene induction by the interferon regulatory factor family of transcription factors.

PubMed ID: 16979567

DOI: 10.1016/j.immuni.2006.08.009

PubMed ID: 18711448

Title: Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.

PubMed ID: 18711448

DOI: 10.1038/cr.2008.277

PubMed ID: 18641315

Title: The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.

PubMed ID: 18641315

DOI: 10.4049/jimmunol.181.3.1780

PubMed ID: 19153231

Title: Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.

PubMed ID: 19153231

DOI: 10.1128/jvi.01875-08

PubMed ID: 19557502

Title: RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway.

PubMed ID: 19557502

DOI: 10.1007/s11010-009-0180-8

PubMed ID: 21167755

Title: The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.

PubMed ID: 21167755

DOI: 10.1016/j.immuni.2010.11.027

PubMed ID: 20049431

Title: Regulation of immunity and oncogenesis by the IRF transcription factor family.

PubMed ID: 20049431

DOI: 10.1007/s00262-009-0804-6

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 20308324

Title: Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.

PubMed ID: 20308324

DOI: 10.1128/mcb.01466-09

PubMed ID: 22394562

Title: STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

PubMed ID: 22394562

DOI: 10.1126/scisignal.2002521

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24049179

Title: Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production.

PubMed ID: 24049179

DOI: 10.1128/jvi.02355-13

PubMed ID: 23478265

Title: Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation.

PubMed ID: 23478265

DOI: 10.1128/mcb.01603-12

PubMed ID: 23746807

Title: Structural insights into the functions of TBK1 in innate antimicrobial immunity.

PubMed ID: 23746807

DOI: 10.1016/j.str.2013.04.025

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 27980081

Title: DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.

PubMed ID: 27980081

DOI: 10.1042/bcj20160956

PubMed ID: 28331227

Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.

PubMed ID: 28331227

DOI: 10.1038/leu.2017.94

PubMed ID: 29802199

Title: C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.

PubMed ID: 29802199

DOI: 10.1074/jbc.ra117.001491

PubMed ID: 29427864

Title: Seneca Valley Virus 3Cpro abrogates the IRF3- and IRF7-mediated innate immune response by degrading IRF3 and IRF7.

PubMed ID: 29427864

DOI: 10.1016/j.virol.2018.01.028

PubMed ID: 26216125

Title: Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

PubMed ID: 26216125

DOI: 10.1084/jem.20142274

PubMed ID: 25636800

Title: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

PubMed ID: 25636800

DOI: 10.1126/science.aaa2630

PubMed ID: 31413131

Title: LYAR suppresses interferon-beta induction by targeting phosphorylated IRF3.

PubMed ID: 31413131

DOI: 10.1128/jvi.00769-19

PubMed ID: 30863402

Title: Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-beta Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.

PubMed ID: 30863402

DOI: 10.3389/fimmu.2019.00290

PubMed ID: 30867312

Title: Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kappaB-Mediated Transcription.

PubMed ID: 30867312

DOI: 10.1128/jvi.00181-19

PubMed ID: 30878284

Title: Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3.

PubMed ID: 30878284

DOI: 10.1016/j.molcel.2019.02.013

PubMed ID: 31340999

Title: DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.

PubMed ID: 31340999

DOI: 10.1242/jcs.230409

PubMed ID: 32726803

Title: Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.

PubMed ID: 32726803

DOI: 10.1038/s41586-020-2601-5

PubMed ID: 33440148

Title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.

PubMed ID: 33440148

DOI: 10.1016/j.celrep.2020.108628

PubMed ID: 35914352

Title: NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.

PubMed ID: 35914352

DOI: 10.1016/j.bbrc.2022.07.043

PubMed ID: 35922005

Title: Coronaviruses exploit a host cysteine-aspartic protease for replication.

PubMed ID: 35922005

DOI: 10.1038/s41586-022-05148-4

PubMed ID: 36603579

Title: Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.

PubMed ID: 36603579

DOI: 10.1016/j.molcel.2022.12.007

PubMed ID: 14555995

Title: X-ray crystal structure of IRF-3 and its functional implications.

PubMed ID: 14555995

DOI: 10.1038/nsb1001

PubMed ID: 14555996

Title: Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation.

PubMed ID: 14555996

DOI: 10.1038/nsb1002

PubMed ID: 15510218

Title: Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.

PubMed ID: 15510218

DOI: 10.1038/sj.emboj.7600453

PubMed ID: 16154084

Title: Crystal structure of IRF-3 in complex with CBP.

PubMed ID: 16154084

DOI: 10.1016/j.str.2005.06.011

PubMed ID: 27302953

Title: Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.

PubMed ID: 27302953

DOI: 10.1073/pnas.1603269113

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

  • Length: 427
  • Mass: 47219
  • Checksum: F536676FA78B0110
  • Sequence:
    • MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA 
TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NSGVGDFSQP 
DTSPDTNGGG STSDTQEDIL DELLGNMVLA PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT 
PFPNLGPSEN PLKRLLVPGE EWEFEVTAFY RGRQVFQQTI SCPEGLRLVG SEVGDRTLPG 
WPVTLPDPGM SLTDRGVMSY VRHVLSCLGG GLALWRAGQW LWAQRLGHCH TYWAVSEELL 
PNSGHGPDGE VPKDKEGGVF DLGPFIVDLI TFTEGSGRSP RYALWFCVGE SWPQDQPWTK 
RLVMVKVVPT CLRALVEMAR VGGASSLENT VDLHISNSHP LSLTSDQYKA YLQDLVEGMD 
FQGPGES

Genular Protein ID: 3555019004

Symbol: E2GIM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 154
  • Mass: 16718
  • Checksum: 7E227E0B7A874231
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEDLITFT 
EGSGRSPRYA LWFCVGESWP QDQPWTKRLV MVKVVPTCLR ALVEMARVGG ASSLENTVDL 
HISNSHPLSL TSDQHKAYLQ DLVEGMDFQG PGET

Genular Protein ID: 2094882281

Symbol: E2GIM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 392
  • Mass: 42970
  • Checksum: 9A942E0AE51F388C
  • Sequence:
    • MVGRKQGWSC RLTGIKPGKP AWAEATGAYV PGRDKPDLPT WKRNFRSALN RKEGLRLAED 
RSKDPHDPHK IYEFVNSGVG DFSQPDTSPD TNGGGSTSDT QEDILDELLG NMVLAPLPDP 
GPPSLAVAPE PCPQPLRSPS LDNPTPFPNL GPSENPLKRL LVPGEEWEFE VTAFYRGRQV 
FQQTISCPEG LRLVGSEVGD RTLPGWPVTL PDPGMSLTDR GVMSYVRHVP SCLGGGLALW 
RAGQWLWAQR LGHCHTYWAV SEELLPNSGH GPDGEVPKDK EGGVFDLGPF IVDLITFTEG 
SGRSPRYALW FCVGESWPQD QPWTKRLVMV KVVPTCLRAL VEMARVGGAS SLENTVDLHI 
SNSHPLSLTS DQYKAYLQDL VEGMDFQGPG ET

Genular Protein ID: 1455427007

Symbol: E2GIM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 281
  • Mass: 30793
  • Checksum: B90CD8A841ACF200
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEEWEFEV 
TAFYRGRQVF QQTISCPEGL RLVGSEVGDR TLPGWPVTLP DPGMSLTDRG VMSYVRHVLS 
CLGGGLALWR AGQWLWAQRL GHCHTYWAVS EELLPNSGHG PDGEVPKDKE GGVFDLGPFI 
VDLITFTEGS GRSPRYALWF CVGESWPQDQ PWTKRLVMVK VVPTCLRALV EMARVGGASS 
LENTVDLHIS NSHPLSLTSD QYKAYLQDLV EGMDFQGPGE T

Genular Protein ID: 3369835348

Symbol: M0QYT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0QYT9

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 5 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 RefSeq 2 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 281
  • Mass: 30779
  • Checksum: BD1CD8A841ACF200
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEEWEFEV 
TAFYRGRQVF QQTISCPEGL RLVGSEVGDR TLPGWPVTLP DPGMSLTDRG VMSYVRHVLS 
CLGGGLALWR AGQWLWAQRL GHCHTYWAVS EELLPNSGHG PDGEVPKDKE GGVFDLGPFI 
VDLITFTEGS GRSPRYALWF CVGESWPQDQ PWTKRLVMVK VVPTCLRALV EMARVGGASS 
LENTVDLHIS NSHPLSLTSD QYKAYLQDLV EGMDFQGPGE S

Genular Protein ID: 1447409907

Symbol: E2GIM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 154
  • Mass: 16744
  • Checksum: 7E227E1716F74231
  • Sequence:
    • MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL VPGEDLITFT 
EGSGRSPRYA LWFCVGESWP QDQPWTKRLV MVKVVPTCLR ALVEMARVGG ASSLENTVDL 
HISNSHPLSL TSDQYKAYLQ DLVEGMDFQG PGET

Genular Protein ID: 1149259666

Symbol: E2GIM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2GIM9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 21281747

Title: Identification of novel alternative splicing variants of interferon regulatory factor 3.

PubMed ID: 21281747

DOI: 10.1016/j.bbagrm.2011.01.006

Sequence Information:

  • Length: 300
  • Mass: 33184
  • Checksum: 1585BFBBA65C2DCE
  • Sequence:
    • MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA 
TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NSGVGDFSQP 
DTSPDTNGGG STSDTQEDIL DELLGNMVLA PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT 
PFPNLGPSEN PLKRLLVPGE DLITFTEGSG RSPRYALWFC VGESWPQDQP WTKRLVMVKV 
VPTCLRALVE MARVGGASSL ENTVDLHISN SHPLSLTSDQ YKAYLQDLVE GMDFQGPGET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.