Details for: IRF5

Gene ID: 3663

Symbol: IRF5

Ensembl ID: ENSG00000128604

Description: interferon regulatory factor 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.27
    Marker Score: 2479
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.26
    Marker Score: 70648
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.21
    Marker Score: 2451
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.12
    Marker Score: 1145
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.04
    Marker Score: 6328
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.03
    Marker Score: 1789
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.02
    Marker Score: 2545
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5146
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.88
    Marker Score: 10266
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.83
    Marker Score: 955
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.79
    Marker Score: 199
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.78
    Marker Score: 432
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.77
    Marker Score: 728
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.76
    Marker Score: 916
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.74
    Marker Score: 535
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.74
    Marker Score: 18888
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.72
    Marker Score: 232
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2887
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.68
    Marker Score: 977.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.67
    Marker Score: 5661
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.64
    Marker Score: 2622
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.64
    Marker Score: 204.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.62
    Marker Score: 242
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.61
    Marker Score: 395
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.61
    Marker Score: 140
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.6
    Marker Score: 1405
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.56
    Marker Score: 134
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.56
    Marker Score: 279
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.56
    Marker Score: 606
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 356.5
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.56
    Marker Score: 133
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1024
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.51
    Marker Score: 178
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.51
    Marker Score: 1222
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.48
    Marker Score: 1242
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.48
    Marker Score: 198.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.48
    Marker Score: 330
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.47
    Marker Score: 347
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 742
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.46
    Marker Score: 189
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.45
    Marker Score: 263
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.44
    Marker Score: 1837
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.43
    Marker Score: 155
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.42
    Marker Score: 253
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.42
    Marker Score: 417
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.42
    Marker Score: 123
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.41
    Marker Score: 1579
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.41
    Marker Score: 308
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6264
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 106
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 196
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.36
    Marker Score: 474
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 214
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.36
    Marker Score: 123
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.36
    Marker Score: 395
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.35
    Marker Score: 2254
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 236
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.34
    Marker Score: 1004
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.33
    Marker Score: 1144
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 189
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.33
    Marker Score: 291
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.31
    Marker Score: 569
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.31
    Marker Score: 153
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.31
    Marker Score: 648
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.31
    Marker Score: 204
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.31
    Marker Score: 108
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 201
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.3
    Marker Score: 203
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.3
    Marker Score: 102
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.28
    Marker Score: 147
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.28
    Marker Score: 136
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.26
    Marker Score: 2277
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.26
    Marker Score: 172
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.26
    Marker Score: 224
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.26
    Marker Score: 268.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.25
    Marker Score: 216
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.25
    Marker Score: 88
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.25
    Marker Score: 239
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 159
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.25
    Marker Score: 632

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Other Information

**Key characteristics:** * IRF5 is a member of the IRF family of transcription factors. * It is expressed in high levels in cells that are activated in response to infection or inflammation. * IRF5 is a key regulator of type I IFN production, which are important for the innate immune response. * It also plays a role in regulating the production of type II and III IFNs, as well as other cytokines and chemokines. * IRF5 is a well-known target for inflammatory diseases, such as rheumatoid arthritis and tuberculosis. **Pathways and functions:** * IRF5 is activated by a variety of stimuli, including infection, inflammation, and stress. * It binds to DNA sequences in the promoters of type I IFN genes and facilitates their transcription. * IRF5 also binds to DNA sequences in the promoters of other immune genes, such as those involved in inflammation and cell death. * Once activated, IRF5 translocates to the nucleus and activates the transcription of its target genes. * These genes encode proteins that are involved in the production of type I IFNs, as well as other cytokines and chemokines. **Clinical significance:** * IRF5 is a key target for inflammatory diseases. * Mutations in the IRF5 gene have been linked to a number of inflammatory diseases, including rheumatoid arthritis, tuberculosis, and Crohn's disease. * Inhibition of IRF5 has been shown to be effective in alleviating inflammation and disease activity. * Therefore, IRF5 is a promising target for the treatment of inflammatory diseases. **Additional information:** * IRF5 is a highly conserved protein with significant sequence similarity in humans and mice. * It is a member of the interferon regulatory factor (IRF) family of transcription factors. * IRF5 is a key regulator of innate immunity and inflammation. * It is a well-known target for inflammatory diseases.

Genular Protein ID: 2408877754

Symbol: IRF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13568 A4D1J8 A8DUA8 A8DUA9 E7EQ16 E7EW54 Q1A7B4 Q64GA9 Q64GB1 Q64GB2 Q6RCM8 Q9BQF0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 18 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 2 RefSeq 15 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11303025

Title: Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.

PubMed ID: 11303025

DOI: 10.1074/jbc.m101216200

PubMed ID: 15695821

Title: The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.

PubMed ID: 15695821

DOI: 10.1074/jbc.m412584200

PubMed ID: 15805103

Title: Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function.

PubMed ID: 15805103

DOI: 10.1074/jbc.m500543200

PubMed ID: 16642019

Title: A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

PubMed ID: 16642019

DOI: 10.1038/ng1782

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12138184

Title: Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes.

PubMed ID: 12138184

DOI: 10.1128/mcb.22.16.5721-5740.2002

PubMed ID: 15657875

Title: Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

PubMed ID: 15657875

DOI: 10.1086/428480

PubMed ID: 15556946

Title: A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.

PubMed ID: 15556946

DOI: 10.1074/jbc.m408452200

PubMed ID: 17599733

Title: Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.

PubMed ID: 17599733

DOI: 10.1002/art.22704

PubMed ID: 17881657

Title: An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.

PubMed ID: 17881657

DOI: 10.1093/hmg/ddm259

PubMed ID: 18824541

Title: Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.

PubMed ID: 18824541

DOI: 10.1128/mcb.00662-08

PubMed ID: 22412986

Title: Activation of interferon regulatory factor 5 by site specific phosphorylation.

PubMed ID: 22412986

DOI: 10.1371/journal.pone.0033098

PubMed ID: 25326418

Title: Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.

PubMed ID: 25326418

DOI: 10.1073/pnas.1418399111

PubMed ID: 32433612

Title: TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.

PubMed ID: 32433612

DOI: 10.1038/s41586-020-2282-0

PubMed ID: 33440148

Title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.

PubMed ID: 33440148

DOI: 10.1016/j.celrep.2020.108628

PubMed ID: 18836453

Title: Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.

PubMed ID: 18836453

DOI: 10.1038/nsmb.1496

Sequence Information:

  • Length: 498
  • Mass: 56044
  • Checksum: 01B2ED95C28384E8
  • Sequence:
    • MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 
NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 
CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ 
PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI 
SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP 
SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP 
IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP 
VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG 
AGLGVGQGPW PMHPAGMQ

Genular Protein ID: 58802160

Symbol: A0A0G2USB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0G2USB5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 417
  • Mass: 46816
  • Checksum: 85B233DF3782AD4E
  • Sequence:
    • MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 
NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 
CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT DAVQSGPHMT PYSLLKEDVK 
WPPTLQPPTL RPPTLQPPTL QPPVVLGPPA PDPSPLAPPP GNPAGFRELL SEVLEPGPLP 
ASLPPAGEQL LPDLLISPHM LPLTDLEIKF QYRGRPPRAL TISNPHGCRL FYSQLEATQE 
QVELFGPISL EQVRFPSPED IPSDKQRFYT NQLLDVLDRG LILQLQGQDL YAIRLCQCKV 
FWSGPCASAH DSCPNPIQRE VKTKLFSLEH FLNELILFQK GQTNTPPPFE IFFCFGE

Genular Protein ID: 2034621736

Symbol: B7Z1M2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1M2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 3 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 140
  • Mass: 16367
  • Checksum: A94DEF487C1D40DC
  • Sequence:
    • MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 
NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYET 
PSPLRITLLV QERRRKKRKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.