Details for: IRF5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 37.1596
Cell Significance Index: -5.7800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 14.7690
Cell Significance Index: -6.0000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 12.6170
Cell Significance Index: -6.4900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 10.0929
Cell Significance Index: -2.5600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 6.3054
Cell Significance Index: -6.0200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 4.6920
Cell Significance Index: -5.7900 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.9302
Cell Significance Index: 12.8100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.6829
Cell Significance Index: 31.1100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.4977
Cell Significance Index: -5.9100 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.2469
Cell Significance Index: 7.9600 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.0408
Cell Significance Index: 26.5900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.9915
Cell Significance Index: -2.1700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6521
Cell Significance Index: 124.1000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.5540
Cell Significance Index: 14.8200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4168
Cell Significance Index: 41.2400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3733
Cell Significance Index: 7.9500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3414
Cell Significance Index: 308.2700 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.3381
Cell Significance Index: 3.9300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3062
Cell Significance Index: 2.8200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2319
Cell Significance Index: 6.8100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2274
Cell Significance Index: 24.7300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2191
Cell Significance Index: 35.6400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2080
Cell Significance Index: 24.5300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2001
Cell Significance Index: 12.0100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1708
Cell Significance Index: 8.8700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1473
Cell Significance Index: 2.0100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1353
Cell Significance Index: 24.3900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1198
Cell Significance Index: 8.2900 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.1167
Cell Significance Index: 0.9500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1088
Cell Significance Index: 7.0200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0886
Cell Significance Index: 1.9400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0738
Cell Significance Index: 9.0800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0592
Cell Significance Index: 32.3200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0361
Cell Significance Index: 1.0400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0346
Cell Significance Index: 0.7500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0146
Cell Significance Index: 0.6800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0096
Cell Significance Index: 1.9200 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0070
Cell Significance Index: 0.7200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0040
Cell Significance Index: 1.7700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0034
Cell Significance Index: 0.1200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0020
Cell Significance Index: 0.0300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0020
Cell Significance Index: 0.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0018
Cell Significance Index: -3.3600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0022
Cell Significance Index: -0.1000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0035
Cell Significance Index: -6.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0041
Cell Significance Index: -6.2900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0046
Cell Significance Index: -1.6600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0048
Cell Significance Index: -6.5700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0050
Cell Significance Index: -0.7200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0061
Cell Significance Index: -1.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0063
Cell Significance Index: -4.0300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0071
Cell Significance Index: -5.4000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0073
Cell Significance Index: -1.2500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0078
Cell Significance Index: -5.7300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0078
Cell Significance Index: -5.7800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0098
Cell Significance Index: -6.1400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0102
Cell Significance Index: -5.7600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0129
Cell Significance Index: -0.3600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0131
Cell Significance Index: -5.9500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0150
Cell Significance Index: -4.3300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0213
Cell Significance Index: -1.0800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0238
Cell Significance Index: -2.7700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0244
Cell Significance Index: -2.8000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0253
Cell Significance Index: -3.2400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0297
Cell Significance Index: -6.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0365
Cell Significance Index: -5.0100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0373
Cell Significance Index: -4.8200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0387
Cell Significance Index: -2.3700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0439
Cell Significance Index: -0.9100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0471
Cell Significance Index: -1.9300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0529
Cell Significance Index: -3.7400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0626
Cell Significance Index: -2.9400 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0708
Cell Significance Index: -0.4700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0710
Cell Significance Index: -5.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0720
Cell Significance Index: -5.5200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0783
Cell Significance Index: -6.2000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0850
Cell Significance Index: -5.3600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0879
Cell Significance Index: -5.9100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0892
Cell Significance Index: -1.2700 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0906
Cell Significance Index: -1.3300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0926
Cell Significance Index: -2.5200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0954
Cell Significance Index: -4.1500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0998
Cell Significance Index: -5.2000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1017
Cell Significance Index: -6.2500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1049
Cell Significance Index: -3.3600 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1054
Cell Significance Index: -1.4000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1080
Cell Significance Index: -6.0600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1108
Cell Significance Index: -5.8200 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1128
Cell Significance Index: -0.9200 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1254
Cell Significance Index: -1.7400 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1261
Cell Significance Index: -2.4700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1273
Cell Significance Index: -3.7500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1320
Cell Significance Index: -1.8900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1354
Cell Significance Index: -4.9700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1364
Cell Significance Index: -4.7800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1366
Cell Significance Index: -6.0400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1532
Cell Significance Index: -4.8800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1592
Cell Significance Index: -6.0300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1595
Cell Significance Index: -5.2200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1597
Cell Significance Index: -4.2800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2408877754
Symbol: IRF5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11303025
Title: Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.
PubMed ID: 11303025
PubMed ID: 15695821
Title: The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
PubMed ID: 15695821
PubMed ID: 15805103
Title: Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function.
PubMed ID: 15805103
PubMed ID: 16642019
Title: A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.
PubMed ID: 16642019
DOI: 10.1038/ng1782
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12138184
Title: Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes.
PubMed ID: 12138184
PubMed ID: 15657875
Title: Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
PubMed ID: 15657875
DOI: 10.1086/428480
PubMed ID: 15556946
Title: A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.
PubMed ID: 15556946
PubMed ID: 17599733
Title: Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
PubMed ID: 17599733
DOI: 10.1002/art.22704
PubMed ID: 17881657
Title: An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
PubMed ID: 17881657
DOI: 10.1093/hmg/ddm259
PubMed ID: 18824541
Title: Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.
PubMed ID: 18824541
DOI: 10.1128/mcb.00662-08
PubMed ID: 22412986
Title: Activation of interferon regulatory factor 5 by site specific phosphorylation.
PubMed ID: 22412986
PubMed ID: 25326418
Title: Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
PubMed ID: 25326418
PubMed ID: 32433612
Title: TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
PubMed ID: 32433612
PubMed ID: 33440148
Title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
PubMed ID: 33440148
PubMed ID: 18836453
Title: Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
PubMed ID: 18836453
DOI: 10.1038/nsmb.1496
Sequence Information:
- Length: 498
- Mass: 56044
- Checksum: 01B2ED95C28384E8
- Sequence:
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ
Genular Protein ID: 58802160
Symbol: A0A0G2USB5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 417
- Mass: 46816
- Checksum: 85B233DF3782AD4E
- Sequence:
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT DAVQSGPHMT PYSLLKEDVK WPPTLQPPTL RPPTLQPPTL QPPVVLGPPA PDPSPLAPPP GNPAGFRELL SEVLEPGPLP ASLPPAGEQL LPDLLISPHM LPLTDLEIKF QYRGRPPRAL TISNPHGCRL FYSQLEATQE QVELFGPISL EQVRFPSPED IPSDKQRFYT NQLLDVLDRG LILQLQGQDL YAIRLCQCKV FWSGPCASAH DSCPNPIQRE VKTKLFSLEH FLNELILFQK GQTNTPPPFE IFFCFGE
Genular Protein ID: 2034621736
Symbol: B7Z1M2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 140
- Mass: 16367
- Checksum: A94DEF487C1D40DC
- Sequence:
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYET PSPLRITLLV QERRRKKRKR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.