Details for: ITGA1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 160.4035
Cell Significance Index: -24.9500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 98.3270
Cell Significance Index: -24.9400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 62.0467
Cell Significance Index: -25.5600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 58.7067
Cell Significance Index: -23.8500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 52.4228
Cell Significance Index: -24.7500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 37.1970
Cell Significance Index: -24.9600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.0120
Cell Significance Index: -23.8800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 20.2440
Cell Significance Index: -24.9600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.3498
Cell Significance Index: -24.8400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 8.2429
Cell Significance Index: 220.8700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 7.3064
Cell Significance Index: 105.0900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.2772
Cell Significance Index: -24.7700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.4568
Cell Significance Index: 75.0800 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 4.4258
Cell Significance Index: 55.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.7818
Cell Significance Index: 275.1900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.4364
Cell Significance Index: 126.9100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1276
Cell Significance Index: 422.2300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.0667
Cell Significance Index: 31.9800 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.4453
Cell Significance Index: 7.6100 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.3488
Cell Significance Index: 13.9700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1836
Cell Significance Index: 1068.6700 - Cell Name: perivascular cell (CL4033054)
Fold Change: 1.0331
Cell Significance Index: 4.7700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9876
Cell Significance Index: 160.6200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9687
Cell Significance Index: 105.3600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8092
Cell Significance Index: 48.5800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.8061
Cell Significance Index: 17.2300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6148
Cell Significance Index: 117.0000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5916
Cell Significance Index: 16.9600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5313
Cell Significance Index: 13.2800 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.5265
Cell Significance Index: 7.2100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.4965
Cell Significance Index: -1.3300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4508
Cell Significance Index: 31.1800 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.4223
Cell Significance Index: 2.0200 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.3702
Cell Significance Index: 2.3000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3228
Cell Significance Index: 6.3000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2201
Cell Significance Index: 1.3300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1720
Cell Significance Index: 2.4700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1571
Cell Significance Index: 21.5700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1341
Cell Significance Index: 1.9800 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.1265
Cell Significance Index: 2.0300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1118
Cell Significance Index: 3.2200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0800
Cell Significance Index: 10.2600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0773
Cell Significance Index: 145.6100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0539
Cell Significance Index: 82.9500 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.0498
Cell Significance Index: 0.8200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0341
Cell Significance Index: 15.4800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0286
Cell Significance Index: 5.7400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0202
Cell Significance Index: 7.2600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0148
Cell Significance Index: 20.0800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0146
Cell Significance Index: 1.6700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0132
Cell Significance Index: 9.1200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0033
Cell Significance Index: 0.1500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0016
Cell Significance Index: -2.9200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0027
Cell Significance Index: -1.7000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0102
Cell Significance Index: -7.5700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0106
Cell Significance Index: -6.5900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0161
Cell Significance Index: -8.8000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0185
Cell Significance Index: -0.4000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0215
Cell Significance Index: -15.7800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0282
Cell Significance Index: -21.3700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0310
Cell Significance Index: -17.4700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0354
Cell Significance Index: -15.6300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0514
Cell Significance Index: -14.8000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0554
Cell Significance Index: -8.0600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0607
Cell Significance Index: -0.5100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0630
Cell Significance Index: -10.7500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0639
Cell Significance Index: -11.5200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0707
Cell Significance Index: -5.4300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0709
Cell Significance Index: -1.5100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0809
Cell Significance Index: -17.0300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0811
Cell Significance Index: -8.4400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1051
Cell Significance Index: -10.7400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1198
Cell Significance Index: -4.2100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1309
Cell Significance Index: -16.1000 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1528
Cell Significance Index: -2.7000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1589
Cell Significance Index: -18.5200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1610
Cell Significance Index: -18.4500 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: -0.1784
Cell Significance Index: -0.6600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1862
Cell Significance Index: -24.0600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1976
Cell Significance Index: -4.1000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2194
Cell Significance Index: -3.6700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2257
Cell Significance Index: -7.2300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2267
Cell Significance Index: -26.7400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2904
Cell Significance Index: -13.6500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3077
Cell Significance Index: -24.3700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3214
Cell Significance Index: -21.6100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3287
Cell Significance Index: -24.5000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3610
Cell Significance Index: -20.2600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3646
Cell Significance Index: -22.4100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3807
Cell Significance Index: -16.8400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3982
Cell Significance Index: -11.7300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3997
Cell Significance Index: -25.1900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4033
Cell Significance Index: -5.7800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4113
Cell Significance Index: -26.5400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4135
Cell Significance Index: -25.3500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4309
Cell Significance Index: -20.0900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4630
Cell Significance Index: -24.3100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4701
Cell Significance Index: -17.8000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4722
Cell Significance Index: -24.5300 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.5018
Cell Significance Index: -4.7700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 389744936
Symbol: ITA1_HUMAN
Name: Integrin alpha-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8428973
Title: Expression of native and truncated forms of the human integrin alpha 1 subunit.
PubMed ID: 8428973
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 15592458
Title: Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.
PubMed ID: 15592458
DOI: 10.1038/ncb1209
PubMed ID: 16754960
Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.
PubMed ID: 16754960
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10455165
Title: Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.
PubMed ID: 10455165
PubMed ID: 14660600
Title: Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1.
PubMed ID: 14660600
Sequence Information:
- Length: 1179
- Mass: 130848
- Checksum: 1A86F30FD916C845
- Sequence:
MAPRPRARPG VAVACCWLLT VVLRCCVSFN VDVKNSMTFS GPVEDMFGYT VQQYENEEGK WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCVKLDLPVN TSIPNVTEVK ENMTFGSTLV TNPNGGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS NSIYPWDSVT AFLNDLLERM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI VQRGGRQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVKTLGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD WNGTVVMQKA SQIIIPRNTT FNVESTKKNE PLASYLGYTV NSATASSGDV LYIAGQPRYN HTGQVIIYRM EDGNIKILQT LSGEQIGSYF GSILTTTDID KDSNTDILLV GAPMYMGTEK EEQGKVYVYA LNQTRFEYQM SLEPIKQTCC SSRQHNSCTT ENKNEPCGAR FGTAIAAVKD LNLDGFNDIV IGAPLEDDHG GAVYIYHGSG KTIRKEYAQR IPSGGDGKTL KFFGQSIHGE MDLNGDGLTD VTIGGLGGAA LFWSRDVAVV KVTMNFEPNK VNIQKKNCHM EGKETVCINA TVCFDVKLKS KEDTIYEADL QYRVTLDSLR QISRSFFSGT QERKVQRNIT VRKSECTKHS FYMLDKHDFQ DSVRITLDFN LTDPENGPVL DDSLPNSVHE YIPFAKDCGN KEKCISDLSL HVATTEKDLL IVRSQNDKFN VSLTVKNTKD SAYNTRTIVH YSPNLVFSGI EAIQKDSCES NHNITCKVGY PFLRRGEMVT FKILFQFNTS YLMENVTIYL SATSDSEEPP ETLSDNVVNI SIPVKYEVGL QFYSSASEYH ISIAANETVP EVINSTEDIG NEINIFYLIR KSGSFPMPEL KLSISFPNMT SNGYPVLYPT GLSSSENANC RPHIFEDPFS INSGKKMTTS TDHLKRGTIL DCNTCKFATI TCNLTSSDIS QVNVSLILWK PTFIKSYFSS LNLTIRGELR SENASLVLSS SNQKRELAIQ ISKDGLPGRV PLWVILLSAF AGLLLLMLLI LALWKIGFFK RPLKKKMEK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.