Details for: ITGA1

Gene ID: 3672

Symbol: ITGA1

Ensembl ID: ENSG00000213949

Description: integrin subunit alpha 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.49
    Marker Score: 79,683
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.66
    Marker Score: 3,488
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.59
    Marker Score: 6,914
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.38
    Marker Score: 4,205
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.05
    Marker Score: 1,696
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.73
    Marker Score: 3,036
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.67
    Marker Score: 1,445
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.66
    Marker Score: 3,845
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.55
    Marker Score: 1,525
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.23
    Marker Score: 7,308
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.15
    Marker Score: 814
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.09
    Marker Score: 4,909
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.08
    Marker Score: 1,482
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.99
    Marker Score: 2,291
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.96
    Marker Score: 4,972
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.75
    Marker Score: 1,267
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.74
    Marker Score: 15,252
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.73
    Marker Score: 541
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.68
    Marker Score: 632
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.64
    Marker Score: 8,797
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.6
    Marker Score: 10,291
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.57
    Marker Score: 6,772
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.55
    Marker Score: 2,915
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.55
    Marker Score: 1,658
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.52
    Marker Score: 553
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.51
    Marker Score: 2,198
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,326
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.46
    Marker Score: 3,444
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.43
    Marker Score: 837
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.35
    Marker Score: 383
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.35
    Marker Score: 1,849
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.34
    Marker Score: 3,707
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.32
    Marker Score: 1,418
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.3
    Marker Score: 856
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.27
    Marker Score: 322
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.26
    Marker Score: 648
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.25
    Marker Score: 463
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.25
    Marker Score: 1,065
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.22
    Marker Score: 24,338
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2,473
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.18
    Marker Score: 305
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.15
    Marker Score: 556
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.13
    Marker Score: 484
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.12
    Marker Score: 285
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.12
    Marker Score: 674
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.09
    Marker Score: 1,174
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.08
    Marker Score: 721
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.08
    Marker Score: 972
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.07
    Marker Score: 1,503
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16,688
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.06
    Marker Score: 591
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1,986
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,724
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.04
    Marker Score: 35,238
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.02
    Marker Score: 962
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.01
    Marker Score: 236
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 688
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1,212
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,748
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1
    Marker Score: 315
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,973
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.99
    Marker Score: 519
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2,154
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.97
    Marker Score: 337
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.97
    Marker Score: 2,539
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.96
    Marker Score: 3,982
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.95
    Marker Score: 371
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.94
    Marker Score: 291
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.92
    Marker Score: 519
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.91
    Marker Score: 1,187
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,719
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.91
    Marker Score: 266
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.9
    Marker Score: 289
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5,288
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.87
    Marker Score: 230
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.86
    Marker Score: 412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,886
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.85
    Marker Score: 332
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.83
    Marker Score: 1,008
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.83
    Marker Score: 524
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.82
    Marker Score: 200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.82
    Marker Score: 8,146
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.82
    Marker Score: 399
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.82
    Marker Score: 306
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.82
    Marker Score: 1,630
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.82
    Marker Score: 737
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.82
    Marker Score: 475
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.81
    Marker Score: 337
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.81
    Marker Score: 401
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 616
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.8
    Marker Score: 227
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.8
    Marker Score: 462
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.79
    Marker Score: 453

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell surface receptor:** ITGA1 is a transmembrane receptor that spans the plasma membrane, interacting with its ligands through its extracellular domain. 2. **Integrin subunit:** ITGA1 is a subunit of the integrin heterodimer, which associates with the integrin subunit beta 1 (ITGB1) to form the alpha 1 beta 1 integrin complex. 3. **Cell-matrix adhesion:** ITGA1 facilitates cell-matrix adhesion by interacting with various ECM components, such as collagen, laminin, and fibronectin. 4. **Cell-cell adhesion:** ITGA1 also participates in cell-cell adhesion by interacting with other integrins, such as alpha 2 beta 1 and alpha 4 beta 1. **Pathways and Functions:** 1. **Integrin-mediated signaling pathway:** ITGA1 activates various signaling pathways upon binding to its ligands, including the MAPK cascade, PI3K/Akt pathway, and NF-κB pathway. 2. **Cell migration and invasion:** ITGA1 plays a crucial role in cell migration and invasion by facilitating the interaction between cells and the ECM. 3. **Cell proliferation and differentiation:** ITGA1 regulates cell proliferation and differentiation by modulating the expression of growth factors and cytokines. 4. **Neurological functions:** ITGA1 is involved in the development and maintenance of the nervous system, including neuron projection morphogenesis and axon guidance. **Clinical Significance:** 1. **Cancer progression:** Abnormal expression of ITGA1 has been observed in various cancers, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Neurological disorders:** ITGA1 is implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it plays a role in neuronal survival and degeneration. 3. **Cardiovascular diseases:** ITGA1 is involved in the development of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy, where it regulates cell-matrix adhesion and signaling pathways. 4. **Wound healing:** ITGA1 is essential for wound healing by facilitating the interaction between cells and the ECM, promoting tissue repair and regeneration. In conclusion, the integrin subunit alpha 1 (ITGA1) is a crucial component of cell-cell and cell-matrix adhesion, playing a vital role in various cellular processes and physiological conditions. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its function and pathology.

Genular Protein ID: 389744936

Symbol: ITA1_HUMAN

Name: Integrin alpha-1

UniProtKB Accession Codes:

P56199 B2RNU0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8428973

Title: Expression of native and truncated forms of the human integrin alpha 1 subunit.

PubMed ID: 8428973

DOI: 10.1016/s0021-9258(18)53871-0

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 15592458

Title: Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.

PubMed ID: 15592458

DOI: 10.1038/ncb1209

PubMed ID: 16754960

Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

PubMed ID: 16754960

DOI: 10.1083/jcb.200509019

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10455165

Title: Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.

PubMed ID: 10455165

DOI: 10.1074/jbc.274.35.24906

PubMed ID: 14660600

Title: Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1.

PubMed ID: 14660600

DOI: 10.1074/jbc.m312912200

Sequence Information:

  • Length: 1179
  • Mass: 130848
  • Checksum: 1A86F30FD916C845
  • Sequence:
    • MAPRPRARPG VAVACCWLLT VVLRCCVSFN VDVKNSMTFS GPVEDMFGYT VQQYENEEGK 
WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCVKLDLPVN TSIPNVTEVK ENMTFGSTLV 
TNPNGGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS 
NSIYPWDSVT AFLNDLLERM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI 
VQRGGRQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE 
NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVKTLGERIF 
ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD WNGTVVMQKA SQIIIPRNTT 
FNVESTKKNE PLASYLGYTV NSATASSGDV LYIAGQPRYN HTGQVIIYRM EDGNIKILQT 
LSGEQIGSYF GSILTTTDID KDSNTDILLV GAPMYMGTEK EEQGKVYVYA LNQTRFEYQM 
SLEPIKQTCC SSRQHNSCTT ENKNEPCGAR FGTAIAAVKD LNLDGFNDIV IGAPLEDDHG 
GAVYIYHGSG KTIRKEYAQR IPSGGDGKTL KFFGQSIHGE MDLNGDGLTD VTIGGLGGAA 
LFWSRDVAVV KVTMNFEPNK VNIQKKNCHM EGKETVCINA TVCFDVKLKS KEDTIYEADL 
QYRVTLDSLR QISRSFFSGT QERKVQRNIT VRKSECTKHS FYMLDKHDFQ DSVRITLDFN 
LTDPENGPVL DDSLPNSVHE YIPFAKDCGN KEKCISDLSL HVATTEKDLL IVRSQNDKFN 
VSLTVKNTKD SAYNTRTIVH YSPNLVFSGI EAIQKDSCES NHNITCKVGY PFLRRGEMVT 
FKILFQFNTS YLMENVTIYL SATSDSEEPP ETLSDNVVNI SIPVKYEVGL QFYSSASEYH 
ISIAANETVP EVINSTEDIG NEINIFYLIR KSGSFPMPEL KLSISFPNMT SNGYPVLYPT 
GLSSSENANC RPHIFEDPFS INSGKKMTTS TDHLKRGTIL DCNTCKFATI TCNLTSSDIS 
QVNVSLILWK PTFIKSYFSS LNLTIRGELR SENASLVLSS SNQKRELAIQ ISKDGLPGRV 
PLWVILLSAF AGLLLLMLLI LALWKIGFFK RPLKKKMEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.