Details for: ITGA1

Gene ID: 3672

Symbol: ITGA1

Ensembl ID: ENSG00000213949

Description: integrin subunit alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 160.4035
    Cell Significance Index: -24.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.3270
    Cell Significance Index: -24.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.0467
    Cell Significance Index: -25.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.7067
    Cell Significance Index: -23.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.4228
    Cell Significance Index: -24.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.1970
    Cell Significance Index: -24.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.0120
    Cell Significance Index: -23.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2440
    Cell Significance Index: -24.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3498
    Cell Significance Index: -24.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 8.2429
    Cell Significance Index: 220.8700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 7.3064
    Cell Significance Index: 105.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2772
    Cell Significance Index: -24.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.4568
    Cell Significance Index: 75.0800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 4.4258
    Cell Significance Index: 55.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.7818
    Cell Significance Index: 275.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4364
    Cell Significance Index: 126.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1276
    Cell Significance Index: 422.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0667
    Cell Significance Index: 31.9800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.4453
    Cell Significance Index: 7.6100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.3488
    Cell Significance Index: 13.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1836
    Cell Significance Index: 1068.6700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.0331
    Cell Significance Index: 4.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9876
    Cell Significance Index: 160.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9687
    Cell Significance Index: 105.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8092
    Cell Significance Index: 48.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8061
    Cell Significance Index: 17.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6148
    Cell Significance Index: 117.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5916
    Cell Significance Index: 16.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5313
    Cell Significance Index: 13.2800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.5265
    Cell Significance Index: 7.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.4965
    Cell Significance Index: -1.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4508
    Cell Significance Index: 31.1800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.4223
    Cell Significance Index: 2.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3702
    Cell Significance Index: 2.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3228
    Cell Significance Index: 6.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2201
    Cell Significance Index: 1.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1720
    Cell Significance Index: 2.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1571
    Cell Significance Index: 21.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1341
    Cell Significance Index: 1.9800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1265
    Cell Significance Index: 2.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1118
    Cell Significance Index: 3.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0800
    Cell Significance Index: 10.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0773
    Cell Significance Index: 145.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0539
    Cell Significance Index: 82.9500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0498
    Cell Significance Index: 0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0341
    Cell Significance Index: 15.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0286
    Cell Significance Index: 5.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0202
    Cell Significance Index: 7.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0148
    Cell Significance Index: 20.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0146
    Cell Significance Index: 1.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0132
    Cell Significance Index: 9.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0033
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0106
    Cell Significance Index: -6.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0161
    Cell Significance Index: -8.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0215
    Cell Significance Index: -15.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0282
    Cell Significance Index: -21.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0310
    Cell Significance Index: -17.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0354
    Cell Significance Index: -15.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0514
    Cell Significance Index: -14.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0554
    Cell Significance Index: -8.0600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0607
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0630
    Cell Significance Index: -10.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0639
    Cell Significance Index: -11.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0707
    Cell Significance Index: -5.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0709
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0809
    Cell Significance Index: -17.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0811
    Cell Significance Index: -8.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1051
    Cell Significance Index: -10.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1198
    Cell Significance Index: -4.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1309
    Cell Significance Index: -16.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1528
    Cell Significance Index: -2.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1589
    Cell Significance Index: -18.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1610
    Cell Significance Index: -18.4500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.1784
    Cell Significance Index: -0.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1862
    Cell Significance Index: -24.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1976
    Cell Significance Index: -4.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2194
    Cell Significance Index: -3.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2257
    Cell Significance Index: -7.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2267
    Cell Significance Index: -26.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2904
    Cell Significance Index: -13.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3077
    Cell Significance Index: -24.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3214
    Cell Significance Index: -21.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3287
    Cell Significance Index: -24.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3610
    Cell Significance Index: -20.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3646
    Cell Significance Index: -22.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3807
    Cell Significance Index: -16.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3982
    Cell Significance Index: -11.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3997
    Cell Significance Index: -25.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4033
    Cell Significance Index: -5.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4113
    Cell Significance Index: -26.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4135
    Cell Significance Index: -25.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4309
    Cell Significance Index: -20.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4630
    Cell Significance Index: -24.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4701
    Cell Significance Index: -17.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4722
    Cell Significance Index: -24.5300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5018
    Cell Significance Index: -4.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell surface receptor:** ITGA1 is a transmembrane receptor that spans the plasma membrane, interacting with its ligands through its extracellular domain. 2. **Integrin subunit:** ITGA1 is a subunit of the integrin heterodimer, which associates with the integrin subunit beta 1 (ITGB1) to form the alpha 1 beta 1 integrin complex. 3. **Cell-matrix adhesion:** ITGA1 facilitates cell-matrix adhesion by interacting with various ECM components, such as collagen, laminin, and fibronectin. 4. **Cell-cell adhesion:** ITGA1 also participates in cell-cell adhesion by interacting with other integrins, such as alpha 2 beta 1 and alpha 4 beta 1. **Pathways and Functions:** 1. **Integrin-mediated signaling pathway:** ITGA1 activates various signaling pathways upon binding to its ligands, including the MAPK cascade, PI3K/Akt pathway, and NF-κB pathway. 2. **Cell migration and invasion:** ITGA1 plays a crucial role in cell migration and invasion by facilitating the interaction between cells and the ECM. 3. **Cell proliferation and differentiation:** ITGA1 regulates cell proliferation and differentiation by modulating the expression of growth factors and cytokines. 4. **Neurological functions:** ITGA1 is involved in the development and maintenance of the nervous system, including neuron projection morphogenesis and axon guidance. **Clinical Significance:** 1. **Cancer progression:** Abnormal expression of ITGA1 has been observed in various cancers, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Neurological disorders:** ITGA1 is implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it plays a role in neuronal survival and degeneration. 3. **Cardiovascular diseases:** ITGA1 is involved in the development of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy, where it regulates cell-matrix adhesion and signaling pathways. 4. **Wound healing:** ITGA1 is essential for wound healing by facilitating the interaction between cells and the ECM, promoting tissue repair and regeneration. In conclusion, the integrin subunit alpha 1 (ITGA1) is a crucial component of cell-cell and cell-matrix adhesion, playing a vital role in various cellular processes and physiological conditions. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its function and pathology.

Genular Protein ID: 389744936

Symbol: ITA1_HUMAN

Name: Integrin alpha-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8428973

Title: Expression of native and truncated forms of the human integrin alpha 1 subunit.

PubMed ID: 8428973

DOI: 10.1016/s0021-9258(18)53871-0

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 15592458

Title: Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.

PubMed ID: 15592458

DOI: 10.1038/ncb1209

PubMed ID: 16754960

Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

PubMed ID: 16754960

DOI: 10.1083/jcb.200509019

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10455165

Title: Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.

PubMed ID: 10455165

DOI: 10.1074/jbc.274.35.24906

PubMed ID: 14660600

Title: Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1.

PubMed ID: 14660600

DOI: 10.1074/jbc.m312912200

Sequence Information:

  • Length: 1179
  • Mass: 130848
  • Checksum: 1A86F30FD916C845
  • Sequence:
  • MAPRPRARPG VAVACCWLLT VVLRCCVSFN VDVKNSMTFS GPVEDMFGYT VQQYENEEGK 
    WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCVKLDLPVN TSIPNVTEVK ENMTFGSTLV 
    TNPNGGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS 
    NSIYPWDSVT AFLNDLLERM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI 
    VQRGGRQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE 
    NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVKTLGERIF 
    ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD WNGTVVMQKA SQIIIPRNTT 
    FNVESTKKNE PLASYLGYTV NSATASSGDV LYIAGQPRYN HTGQVIIYRM EDGNIKILQT 
    LSGEQIGSYF GSILTTTDID KDSNTDILLV GAPMYMGTEK EEQGKVYVYA LNQTRFEYQM 
    SLEPIKQTCC SSRQHNSCTT ENKNEPCGAR FGTAIAAVKD LNLDGFNDIV IGAPLEDDHG 
    GAVYIYHGSG KTIRKEYAQR IPSGGDGKTL KFFGQSIHGE MDLNGDGLTD VTIGGLGGAA 
    LFWSRDVAVV KVTMNFEPNK VNIQKKNCHM EGKETVCINA TVCFDVKLKS KEDTIYEADL 
    QYRVTLDSLR QISRSFFSGT QERKVQRNIT VRKSECTKHS FYMLDKHDFQ DSVRITLDFN 
    LTDPENGPVL DDSLPNSVHE YIPFAKDCGN KEKCISDLSL HVATTEKDLL IVRSQNDKFN 
    VSLTVKNTKD SAYNTRTIVH YSPNLVFSGI EAIQKDSCES NHNITCKVGY PFLRRGEMVT 
    FKILFQFNTS YLMENVTIYL SATSDSEEPP ETLSDNVVNI SIPVKYEVGL QFYSSASEYH 
    ISIAANETVP EVINSTEDIG NEINIFYLIR KSGSFPMPEL KLSISFPNMT SNGYPVLYPT 
    GLSSSENANC RPHIFEDPFS INSGKKMTTS TDHLKRGTIL DCNTCKFATI TCNLTSSDIS 
    QVNVSLILWK PTFIKSYFSS LNLTIRGELR SENASLVLSS SNQKRELAIQ ISKDGLPGRV 
    PLWVILLSAF AGLLLLMLLI LALWKIGFFK RPLKKKMEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.