Details for: STT3A

Gene ID: 3703

Symbol: STT3A

Ensembl ID: ENSG00000134910

Description: STT3 oligosaccharyltransferase complex catalytic subunit A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.1995
    Cell Significance Index: -23.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.4526
    Cell Significance Index: -23.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 70.8585
    Cell Significance Index: -29.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.9209
    Cell Significance Index: -28.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.1596
    Cell Significance Index: -28.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.8483
    Cell Significance Index: -25.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1685
    Cell Significance Index: -27.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6750
    Cell Significance Index: -26.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4549
    Cell Significance Index: -9.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5573
    Cell Significance Index: 93.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2826
    Cell Significance Index: 208.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1489
    Cell Significance Index: 1037.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8320
    Cell Significance Index: 10.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7848
    Cell Significance Index: 54.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7445
    Cell Significance Index: 19.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6921
    Cell Significance Index: 18.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6337
    Cell Significance Index: 87.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5909
    Cell Significance Index: 27.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5873
    Cell Significance Index: 116.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5732
    Cell Significance Index: 313.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5059
    Cell Significance Index: 10.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5016
    Cell Significance Index: 90.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4541
    Cell Significance Index: 12.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4210
    Cell Significance Index: 21.8700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.4066
    Cell Significance Index: 4.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4052
    Cell Significance Index: 10.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3756
    Cell Significance Index: 75.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3376
    Cell Significance Index: 41.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2985
    Cell Significance Index: 8.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2253
    Cell Significance Index: 4.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2216
    Cell Significance Index: 5.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2116
    Cell Significance Index: 75.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2008
    Cell Significance Index: 19.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1981
    Cell Significance Index: 33.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1891
    Cell Significance Index: 8.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1681
    Cell Significance Index: 4.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1617
    Cell Significance Index: 71.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1545
    Cell Significance Index: 29.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1410
    Cell Significance Index: 4.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1380
    Cell Significance Index: 16.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1374
    Cell Significance Index: 6.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1200
    Cell Significance Index: 15.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1075
    Cell Significance Index: 2.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0942
    Cell Significance Index: 3.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0927
    Cell Significance Index: 5.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0797
    Cell Significance Index: 55.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0606
    Cell Significance Index: 2.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0287
    Cell Significance Index: 3.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0239
    Cell Significance Index: 1.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0213
    Cell Significance Index: 1.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0209
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0195
    Cell Significance Index: 36.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0137
    Cell Significance Index: 1.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0130
    Cell Significance Index: 9.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0039
    Cell Significance Index: 0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0010
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0099
    Cell Significance Index: -13.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0138
    Cell Significance Index: -6.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0246
    Cell Significance Index: -1.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0310
    Cell Significance Index: -17.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0346
    Cell Significance Index: -3.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0409
    Cell Significance Index: -5.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0457
    Cell Significance Index: -0.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0503
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0574
    Cell Significance Index: -12.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0732
    Cell Significance Index: -8.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0745
    Cell Significance Index: -21.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0786
    Cell Significance Index: -9.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0828
    Cell Significance Index: -5.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1447
    Cell Significance Index: -3.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1688
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1819
    Cell Significance Index: -20.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2088
    Cell Significance Index: -2.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2162
    Cell Significance Index: -2.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2273
    Cell Significance Index: -23.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2286
    Cell Significance Index: -2.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2304
    Cell Significance Index: -7.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2746
    Cell Significance Index: -4.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2774
    Cell Significance Index: -18.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2787
    Cell Significance Index: -5.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2917
    Cell Significance Index: -17.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3106
    Cell Significance Index: -2.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3119
    Cell Significance Index: -24.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3407
    Cell Significance Index: -3.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3427
    Cell Significance Index: -15.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3539
    Cell Significance Index: -18.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3652
    Cell Significance Index: -9.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3679
    Cell Significance Index: -3.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4096
    Cell Significance Index: -7.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4123
    Cell Significance Index: -11.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4178
    Cell Significance Index: -15.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4321
    Cell Significance Index: -21.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4841
    Cell Significance Index: -10.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4893
    Cell Significance Index: -4.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STT3A is a gene that encodes the catalytic subunit of the oligosaccharyltransferase complex, which is responsible for the transfer of N-linked glycosyl moieties to proteins. This process involves the attachment of a carbohydrate molecule to the nitrogen atom of an asparagine residue in the target protein. STT3A is highly expressed in various cell types, including immune cells, such as IgG plasmablasts and IgA plasmablasts, which are critical for the production of antibodies. The gene is also expressed in cells involved in the immune response, such as dendritic cells and macrophages. **Pathways and Functions:** STT3A is involved in several key pathways, including: 1. **Asparagine N-linked glycosylation**: STT3A is essential for the transfer of N-linked glycosyl moieties to proteins, which is critical for the proper functioning of glycoproteins. 2. **Co-translational protein modification**: STT3A is involved in the modification of proteins during translation, which is essential for the proper functioning of proteins involved in immune responses. 3. **Disease**: STT3A has been implicated in various diseases, including infectious diseases, such as SARS-CoV-2 infection. 4. **Infectious disease**: STT3A has been shown to play a critical role in the maturation of the SARS-CoV-2 spike protein, which is essential for viral entry into host cells. **Clinical Significance:** Dysregulation of STT3A has been implicated in various diseases, including: 1. **Infectious diseases**: STT3A has been shown to play a critical role in the maturation of the SARS-CoV-2 spike protein, which is essential for viral entry into host cells. 2. **Immunological disorders**: STT3A has been implicated in various immunological disorders, including autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: STT3A has been shown to be overexpressed in certain types of cancer, including lung and breast cancer. In conclusion, STT3A is a critical gene involved in the post-translational modification of proteins, specifically in the process of N-linked glycosylation. Its dysregulation has been implicated in various diseases, including infectious diseases, immunological disorders, and cancer. Further research is needed to fully understand the role of STT3A in human health and disease.

Genular Protein ID: 1528219646

Symbol: STT3A_HUMAN

Name: B5

UniProtKB Accession Codes:

P46977 B4DJ24 E9PNQ1 Q86XU9 Q8TE35 Q8WUB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CORUM 1 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 EMDB 3 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8838310

Title: Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9.

PubMed ID: 8838310

DOI: 10.1006/geno.1996.0051

PubMed ID: 8634329

Title: Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC.

PubMed ID: 8634329

DOI: 10.1016/0167-4781(96)00025-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12887896

Title: Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.

PubMed ID: 12887896

DOI: 10.1016/s1097-2765(03)00243-0

PubMed ID: 19167329

Title: Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.

PubMed ID: 19167329

DOI: 10.1016/j.cell.2008.11.047

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 23606741

Title: OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

PubMed ID: 23606741

DOI: 10.1242/jcs.115410

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

PubMed ID: 23842455

Title: Mutations in STT3A and STT3B cause two congenital disorders of glycosylation.

PubMed ID: 23842455

DOI: 10.1093/hmg/ddt312

PubMed ID: 34653363

Title: Active site variants in STT3A cause a dominant type I congenital disorder of glycosylation with neuromusculoskeletal findings.

PubMed ID: 34653363

DOI: 10.1016/j.ajhg.2021.09.012

Sequence Information:

  • Length: 705
  • Mass: 80530
  • Checksum: 71426CA5598B51C4
  • Sequence:
    • MTKFGFLRLS YEKQDTLLKL LILSMAAVLS FSTRLFAVLR FESVIHEFDP YFNYRTTRFL 
AEEGFYKFHN WFDDRAWYPL GRIIGGTIYP GLMITSAAIY HVLHFFHITI DIRNVCVFLA 
PLFSSFTTIV TYHLTKELKD AGAGLLAAAM IAVVPGYISR SVAGSYDNEG IAIFCMLLTY 
YMWIKAVKTG SICWAAKCAL AYFYMVSSWG GYVFLINLIP LHVLVLMLTG RFSHRIYVAY 
CTVYCLGTIL SMQISFVGFQ PVLSSEHMAA FGVFGLCQIH AFVDYLRSKL NPQQFEVLFR 
SVISLVGFVL LTVGALLMLT GKISPWTGRF YSLLDPSYAK NNIPIIASVS EHQPTTWSSY 
YFDLQLLVFM FPVGLYYCFS NLSDARIFII MYGVTSMYFS AVMVRLMLVL APVMCILSGI 
GVSQVLSTYM KNLDISRPDK KSKKQQDSTY PIKNEVASGM ILVMAFFLIT YTFHSTWVTS 
EAYSSPSIVL SARGGDGSRI IFDDFREAYY WLRHNTPEDA KVMSWWDYGY QITAMANRTI 
LVDNNTWNNT HISRVGQAMA STEEKAYEIM RELDVSYVLV IFGGLTGYSS DDINKFLWMV 
RIGGSTDTGK HIKENDYYTP TGEFRVDREG SPVLLNCLMY KMCYYRFGQV YTEAKRPPGF 
DRVRNAEIGN KDFELDVLEE AYTTEHWLVR IYKVKDLDNR GLSRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.