Details for: STT3A

Gene ID: 3703

Symbol: STT3A

Ensembl ID: ENSG00000134910

Description: STT3 oligosaccharyltransferase complex catalytic subunit A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.81
    Marker Score: 499
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.49
    Marker Score: 3399
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.45
    Marker Score: 585
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.41
    Marker Score: 370
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.33
    Marker Score: 378
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.28
    Marker Score: 8324
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.27
    Marker Score: 1695
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.25
    Marker Score: 3407
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.2
    Marker Score: 1102
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.16
    Marker Score: 5000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.15
    Marker Score: 2015
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.14
    Marker Score: 1206
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.09
    Marker Score: 624
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.08
    Marker Score: 596
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.08
    Marker Score: 4247
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.06
    Marker Score: 11983
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.06
    Marker Score: 510
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.05
    Marker Score: 2215
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.01
    Marker Score: 687
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71677
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.98
    Marker Score: 490
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.98
    Marker Score: 34006
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30387
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.97
    Marker Score: 1045
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.96
    Marker Score: 1548
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14808
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.95
    Marker Score: 442
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.94
    Marker Score: 327
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.93
    Marker Score: 1375
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.93
    Marker Score: 623
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.91
    Marker Score: 1908
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.91
    Marker Score: 5793
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5177
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2697
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.89
    Marker Score: 221
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.89
    Marker Score: 258
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.89
    Marker Score: 923
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.88
    Marker Score: 511
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.85
    Marker Score: 569
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.85
    Marker Score: 8530
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.84
    Marker Score: 9792
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.84
    Marker Score: 1287
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.82
    Marker Score: 1456
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.82
    Marker Score: 6109
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.82
    Marker Score: 1009
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.82
    Marker Score: 1854
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.82
    Marker Score: 342
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.82
    Marker Score: 518
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 261
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1298
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.79
    Marker Score: 1341
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 184
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.78
    Marker Score: 571
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.78
    Marker Score: 3833
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.78
    Marker Score: 2088
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.78
    Marker Score: 384
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.78
    Marker Score: 2032
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.77
    Marker Score: 416
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.77
    Marker Score: 779
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.77
    Marker Score: 580
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.77
    Marker Score: 248
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.77
    Marker Score: 728
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.77
    Marker Score: 512
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.77
    Marker Score: 269
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 517
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.75
    Marker Score: 373
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.75
    Marker Score: 883
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.75
    Marker Score: 25368
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.74
    Marker Score: 4735
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.74
    Marker Score: 1754
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.73
    Marker Score: 745
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.73
    Marker Score: 1729
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.73
    Marker Score: 1849
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.73
    Marker Score: 508
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.73
    Marker Score: 384
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.72
    Marker Score: 510
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.72
    Marker Score: 9523
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.72
    Marker Score: 4695
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.72
    Marker Score: 687
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.71
    Marker Score: 1936.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.71
    Marker Score: 634
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.71
    Marker Score: 603
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.7
    Marker Score: 509
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2945
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.7
    Marker Score: 170
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 421
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.7
    Marker Score: 222
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.7
    Marker Score: 224
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.7
    Marker Score: 178
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7
    Marker Score: 384

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Other Information

**Key characteristics:** * The STT3A gene is located on chromosome 15q21.1. * It is a large gene with a molecular weight of approximately 320 kDa. * The protein encoded by STT3A is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of protein-protein interactions and is involved in both innate and adaptive immune responses. **Pathways and functions:** * STT3A is involved in the asparagine n-linked glycosylation pathway, which is a major regulator of protein-protein interactions. * It is also involved in the co-translational protein modification pathway, which is responsible for the addition of a glycosyl group to specific amino acids in proteins. * STT3A is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the STT3A gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and inflammatory diseases. * These mutations can lead to the loss of function of the STT3A protein, which can result in the accumulation of abnormal proteins and the development of disease. * Targeting STT3A has been explored as a therapeutic strategy for a variety of diseases. **Additional information:** * The STT3A gene is also known as CD1327. * It is a member of the STT3 family of glycosyltransferases. * The STT3A protein is a highly conserved protein that is found in organisms from yeast to humans.

Genular Protein ID: 1528219646

Symbol: STT3A_HUMAN

Name: B5

UniProtKB Accession Codes:

P46977 B4DJ24 E9PNQ1 Q86XU9 Q8TE35 Q8WUB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CORUM 1 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 EMDB 2 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8838310

Title: Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9.

PubMed ID: 8838310

DOI: 10.1006/geno.1996.0051

PubMed ID: 8634329

Title: Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC.

PubMed ID: 8634329

DOI: 10.1016/0167-4781(96)00025-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12887896

Title: Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.

PubMed ID: 12887896

DOI: 10.1016/s1097-2765(03)00243-0

PubMed ID: 19167329

Title: Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.

PubMed ID: 19167329

DOI: 10.1016/j.cell.2008.11.047

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 23606741

Title: OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

PubMed ID: 23606741

DOI: 10.1242/jcs.115410

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

PubMed ID: 23842455

Title: Mutations in STT3A and STT3B cause two congenital disorders of glycosylation.

PubMed ID: 23842455

DOI: 10.1093/hmg/ddt312

PubMed ID: 34653363

Title: Active site variants in STT3A cause a dominant type I congenital disorder of glycosylation with neuromusculoskeletal findings.

PubMed ID: 34653363

DOI: 10.1016/j.ajhg.2021.09.012

Sequence Information:

  • Length: 705
  • Mass: 80530
  • Checksum: 71426CA5598B51C4
  • Sequence:
    • MTKFGFLRLS YEKQDTLLKL LILSMAAVLS FSTRLFAVLR FESVIHEFDP YFNYRTTRFL 
AEEGFYKFHN WFDDRAWYPL GRIIGGTIYP GLMITSAAIY HVLHFFHITI DIRNVCVFLA 
PLFSSFTTIV TYHLTKELKD AGAGLLAAAM IAVVPGYISR SVAGSYDNEG IAIFCMLLTY 
YMWIKAVKTG SICWAAKCAL AYFYMVSSWG GYVFLINLIP LHVLVLMLTG RFSHRIYVAY 
CTVYCLGTIL SMQISFVGFQ PVLSSEHMAA FGVFGLCQIH AFVDYLRSKL NPQQFEVLFR 
SVISLVGFVL LTVGALLMLT GKISPWTGRF YSLLDPSYAK NNIPIIASVS EHQPTTWSSY 
YFDLQLLVFM FPVGLYYCFS NLSDARIFII MYGVTSMYFS AVMVRLMLVL APVMCILSGI 
GVSQVLSTYM KNLDISRPDK KSKKQQDSTY PIKNEVASGM ILVMAFFLIT YTFHSTWVTS 
EAYSSPSIVL SARGGDGSRI IFDDFREAYY WLRHNTPEDA KVMSWWDYGY QITAMANRTI 
LVDNNTWNNT HISRVGQAMA STEEKAYEIM RELDVSYVLV IFGGLTGYSS DDINKFLWMV 
RIGGSTDTGK HIKENDYYTP TGEFRVDREG SPVLLNCLMY KMCYYRFGQV YTEAKRPPGF 
DRVRNAEIGN KDFELDVLEE AYTTEHWLVR IYKVKDLDNR GLSRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.