Gene JAK3 - ENSG00000105639 | NCBI Gene ID: 3718

Details for: JAK3

Gene ID: 3718

Symbol: JAK3

Ensembl ID: ENSG00000105639

Description: Janus kinase 3

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-2 signaling
(R-HSA-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-7 signaling
(R-HSA-1266695)
Interleukin-9 signaling
(R-HSA-8985947)
Interleukin-15 signaling
(R-HSA-8983432)
Interleukin-20 family signaling
(R-HSA-8854691)
Interleukin-21 signaling
(R-HSA-9020958)
Interleukin receptor shc signaling
(R-HSA-912526)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Potential therapeutics for sars
(R-HSA-9679191)
Raf/map kinase cascade
(R-HSA-5673001)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk
(R-HSA-201556)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
B cell differentiation
(GO:0030183)
Cell differentiation
(GO:0030154)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
Extrinsic component of plasma membrane
(GO:0019897)
Growth hormone receptor binding
(GO:0005131)
Growth hormone receptor signaling pathway via jak-stat
(GO:0060397)
Innate immune response
(GO:0045087)
Interleukin-2-mediated signaling pathway
(GO:0038110)
Interleukin-4-mediated signaling pathway
(GO:0035771)
Interleukin-9-mediated signaling pathway
(GO:0038113)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Intracellular signal transduction
(GO:0035556)
Negative regulation of dendritic cell cytokine production
(GO:0002731)
Negative regulation of fasl production
(GO:0045221)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of t-helper 1 cell differentiation
(GO:0045626)
Negative regulation of t cell activation
(GO:0050868)
Negative regulation of thymocyte apoptotic process
(GO:0070244)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of apoptotic process
(GO:0042981)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Regulation of t cell apoptotic process
(GO:0070232)
Response to interleukin-2
(GO:0070669)
Response to interleukin-4
(GO:0070670)
Response to interleukin-9
(GO:0071104)
Response to interleukin-15
(GO:0070672)
T cell homeostasis
(GO:0043029)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.65
Marker Score: 824
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.56
Marker Score: 1136
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.49
Marker Score: 78541
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.36
Marker Score: 414
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.31
Marker Score: 2255
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.16
Marker Score: 2081
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4758
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.12
Marker Score: 7192
Cell Name: blood cell (CL0000081)
Fold Change: 1.07
Marker Score: 12411
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.06
Marker Score: 2961
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.05
Marker Score: 602
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.03
Marker Score: 319
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.02
Marker Score: 951
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.01
Marker Score: 4342
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.01
Marker Score: 1978
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71759
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47984
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 490
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2405
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.95
Marker Score: 742
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 445
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.94
Marker Score: 690
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.94
Marker Score: 1012
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.92
Marker Score: 383
Cell Name: mature T cell (CL0002419)
Fold Change: 0.92
Marker Score: 9130
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2728
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.91
Marker Score: 2865
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5177
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 360
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5258
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.86
Marker Score: 622
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.86
Marker Score: 282
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.84
Marker Score: 7075
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.83
Marker Score: 896
Cell Name: microglial cell (CL0000129)
Fold Change: 0.81
Marker Score: 1477
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.8
Marker Score: 775.5
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.8
Marker Score: 346
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.78
Marker Score: 649
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.77
Marker Score: 558
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.77
Marker Score: 278
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.77
Marker Score: 267
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.76
Marker Score: 820
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.76
Marker Score: 1228
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.76
Marker Score: 42242
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 571.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 382
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.73
Marker Score: 498
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.73
Marker Score: 1782
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.72
Marker Score: 610
Cell Name: brush cell (CL0002204)
Fold Change: 0.72
Marker Score: 655
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.72
Marker Score: 706.5
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.71
Marker Score: 324
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.71
Marker Score: 788
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.7
Marker Score: 1229
Cell Name: centrocyte (CL0009111)
Fold Change: 0.7
Marker Score: 167
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.69
Marker Score: 2053
Cell Name: naive B cell (CL0000788)
Fold Change: 0.69
Marker Score: 615
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.67
Marker Score: 328
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.67
Marker Score: 560
Cell Name: naive T cell (CL0000898)
Fold Change: 0.66
Marker Score: 428
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.66
Marker Score: 663
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.66
Marker Score: 905
Cell Name: memory B cell (CL0000787)
Fold Change: 0.65
Marker Score: 492
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.65
Marker Score: 226.5
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.65
Marker Score: 340
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.64
Marker Score: 913
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.64
Marker Score: 388
Cell Name: Unknown (CL0000548)
Fold Change: 0.64
Marker Score: 465
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.64
Marker Score: 374
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.63
Marker Score: 291
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.62
Marker Score: 551
Cell Name: plasmablast (CL0000980)
Fold Change: 0.6
Marker Score: 795
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.58
Marker Score: 1139
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.57
Marker Score: 616
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.56
Marker Score: 427
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.56
Marker Score: 1552
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.56
Marker Score: 288
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.56
Marker Score: 198
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.56
Marker Score: 377
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.56
Marker Score: 403
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.56
Marker Score: 146
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.55
Marker Score: 338
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.53
Marker Score: 469.5
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.53
Marker Score: 169
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.53
Marker Score: 353
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.53
Marker Score: 294
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.53
Marker Score: 776
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.53
Marker Score: 1104
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.52
Marker Score: 499
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.52
Marker Score: 576
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.51
Marker Score: 420
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.5
Marker Score: 233
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.5
Marker Score: 301
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.5
Marker Score: 467
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.5
Marker Score: 333
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.49
Marker Score: 1113

Hover over a box to see details here...

**Key characteristics:** * Janus kinase 3 is a Janus kinase, meaning it can activate both pro-inflammatory and anti-inflammatory signaling pathways. * It is a key regulator of the immune response to viral infections and other inflammatory stimuli. * It is involved in the regulation of T cell development, differentiation, and activation. * It also plays a role in the regulation of B cell development and function. **Pathways and functions:** * JAK3 is involved in the regulation of the innate immune response to viral infections. * It is a key regulator of the production of type I interferons, which are crucial for the innate immune response. * It also plays a role in the regulation of the adaptive immune response, including the activation of T cells and the production of antibodies. * JAK3 is also involved in the regulation of inflammation and tissue repair. **Clinical significance:** * Mutations in JAK3 have been linked to a number of human diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. * Inhibition of JAK3 has been shown to be effective in reducing inflammation and disease activity in animal models of these diseases. * Therefore, JAK3 is a promising target for the treatment of inflammatory diseases. **Additional notes:** * JAK3 is a highly conserved protein with homologs in other species. * It is a key regulator of the immune system, and its dysfunction can lead to a variety of immune disorders. * JAK3 is a promising target for the development of new therapies for inflammatory diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Janus kinase 3

Genular Protein ID: 959819075

Symbol: JAK3_HUMAN

Name: Janus kinase 3

UniProtKB Accession Codes:

P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2

Database IDs:

Citations:

PubMed ID: 8022790

Title: Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.

PubMed ID: 8022790

DOI: 10.1073/pnas.91.14.6374

PubMed ID: 7559633

Title: A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells.

PubMed ID: 7559633

DOI: 10.1074/jbc.270.42.25028

PubMed ID: 8921370

Title: Genomic sequence, organization, and chromosomal localization of human JAK3.

PubMed ID: 8921370

DOI: 10.1006/geno.1996.0520

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8662778

Title: Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells.

PubMed ID: 8662778

DOI: 10.1074/jbc.271.24.13976

PubMed ID: 8022485

Title: Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

PubMed ID: 8022485

DOI: 10.1038/370151a0

PubMed ID: 7662955

Title: JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase.

PubMed ID: 7662955

PubMed ID: 7535338

Title: Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.

PubMed ID: 7535338

DOI: 10.1084/jem.181.4.1425

PubMed ID: 10899310

Title: STAM2, a new member of the STAM family, binding to the Janus kinases.

PubMed ID: 10899310

DOI: 10.1016/s0014-5793(00)01760-9

PubMed ID: 12200137

Title: IL-2 receptor signaling through the Shb adapter protein in T and NK cells.

PubMed ID: 12200137

DOI: 10.1016/s0006-291x(02)02016-8

PubMed ID: 11909529

Title: The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

PubMed ID: 11909529

DOI: 10.1016/s0960-9822(02)00697-8

PubMed ID: 12351625

Title: The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.

PubMed ID: 12351625

DOI: 10.1074/jbc.m205156200

PubMed ID: 15121872

Title: Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.

PubMed ID: 15121872

DOI: 10.1128/mcb.24.10.4557-4570.2004

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18250158

Title: Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.

PubMed ID: 18250158

DOI: 10.1128/mcb.01789-07

PubMed ID: 19290934

Title: Janus kinases in immune cell signaling.

PubMed ID: 19290934

DOI: 10.1111/j.1600-065x.2008.00754.x

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20440074

Title: IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis.

PubMed ID: 20440074

DOI: 10.1172/jci41344

PubMed ID: 15831699

Title: Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.

PubMed ID: 15831699

DOI: 10.1182/blood-2005-02-0707

PubMed ID: 7659163

Title: Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID).

PubMed ID: 7659163

DOI: 10.1038/377065a0

PubMed ID: 9354668

Title: Structural and functional basis for JAK3-deficient severe combined immunodeficiency.

PubMed ID: 9354668

PubMed ID: 9753072

Title: Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment.

PubMed ID: 9753072

DOI: 10.1111/j.1365-2141.1998.tb08990.x

PubMed ID: 10982185

Title: Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism.

PubMed ID: 10982185

DOI: 10.1007/s004390051012

PubMed ID: 14615376

Title: Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

PubMed ID: 14615376

DOI: 10.1182/blood-2003-06-2104

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1124
Mass: 125099
Checksum: 895D8563439B2B7C
Sequence:

MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA EDLCVQAAKA 
SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY RIRFYFPNWF GLEKCHRFGL 
RKDLASAILD LPVLEHLFAQ HRSDLVSGRL PVGLSLKEQG ECLSLAVLDL ARMAREQAQR 
PGELLKTVSY KACLPPSLRD LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM 
DLERLDPAGA AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD 
ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR LTTDSQHFFC 
KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV LRRSPQDFDS FLLTVCVQNP 
LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL RELLATCWDG GLHVDGVAVT LTSCCIPRPK 
EKSNLIVVQR GHSPPTSSLV QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR 
HEVVDGEARK TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSTMVQ 
EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA RKVLLAREGA 
DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ TLSLEADKWG FGATVWEVFS 
GVTMPISALD PAKKLQFYED RQQLPAPKWT ELALLIQQCM AYEPVQRPSF RAVIRDLNSL 
ISSDYELLSD PTPGALAPRD GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR 
YDPLGDNTGA LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL 
VMEYLPSGCL RDFLQRHRAR LDASRLLLYS SQICKGMEYL GSRRCVHRDL AARNILVESE 
AHVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS DNIFSRQSDV WSFGVVLYEL 
FTYCDKSCSP SAEFLRMMGC ERDVPALCRL LELLEEGQRL PAPPACPAEV HELMKLCWAP 
SPQDRPSFSA LGPQLDMLWS GSRGCETHAF TAHPEGKHHS LSFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: JAK3

Associated with

Cells (max top 100)

Other Information

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. PubMed ID: 8022790

A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells. PubMed ID: 7559633

Genomic sequence, organization, and chromosomal localization of human JAK3. PubMed ID: 8921370

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells. PubMed ID: 8662778

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. PubMed ID: 8022485

JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase. PubMed ID: 7662955

Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. PubMed ID: 7535338

STAM2, a new member of the STAM family, binding to the Janus kinases. PubMed ID: 10899310

IL-2 receptor signaling through the Shb adapter protein in T and NK cells. PubMed ID: 12200137

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. PubMed ID: 11909529

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. PubMed ID: 12351625

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. PubMed ID: 15121872

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. PubMed ID: 18250158

Janus kinases in immune cell signaling. PubMed ID: 19290934

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. PubMed ID: 20440074

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. PubMed ID: 15831699

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). PubMed ID: 7659163

Structural and functional basis for JAK3-deficient severe combined immunodeficiency. PubMed ID: 9354668

Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment. PubMed ID: 9753072

Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism. PubMed ID: 10982185

Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. PubMed ID: 14615376

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846