JAK3 | ENSG00000105639 | NCBI 3718

Details for: JAK3

Gene ID: 3718

Symbol: JAK3

Ensembl ID: ENSG00000105639

Description: Janus kinase 3

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-2 signaling
(R-HSA-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-7 signaling
(R-HSA-1266695)
Interleukin-9 signaling
(R-HSA-8985947)
Interleukin-15 signaling
(R-HSA-8983432)
Interleukin-20 family signaling
(R-HSA-8854691)
Interleukin-21 signaling
(R-HSA-9020958)
Interleukin receptor shc signaling
(R-HSA-912526)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Potential therapeutics for sars
(R-HSA-9679191)
Raf/map kinase cascade
(R-HSA-5673001)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk
(R-HSA-201556)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
B cell differentiation
(GO:0030183)
Cell differentiation
(GO:0030154)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
Extrinsic component of plasma membrane
(GO:0019897)
Growth hormone receptor binding
(GO:0005131)
Growth hormone receptor signaling pathway via jak-stat
(GO:0060397)
Innate immune response
(GO:0045087)
Interleukin-2-mediated signaling pathway
(GO:0038110)
Interleukin-4-mediated signaling pathway
(GO:0035771)
Interleukin-7-mediated signaling pathway
(GO:0038111)
Interleukin-9-mediated signaling pathway
(GO:0038113)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Intracellular signal transduction
(GO:0035556)
Negative regulation of dendritic cell cytokine production
(GO:0002731)
Negative regulation of fasl production
(GO:0045221)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of t-helper 1 cell differentiation
(GO:0045626)
Negative regulation of t-helper 17 cell lineage commitment
(GO:2000329)
Negative regulation of t cell activation
(GO:0050868)
Negative regulation of thymocyte apoptotic process
(GO:0070244)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of apoptotic process
(GO:0042981)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Regulation of t cell apoptotic process
(GO:0070232)
Response to interleukin-2
(GO:0070669)
Response to interleukin-4
(GO:0070670)
Response to interleukin-9
(GO:0071104)
Response to interleukin-15
(GO:0070672)
T cell homeostasis
(GO:0043029)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 59.7254
Cell Significance Index: -9.2900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 29.4210
Cell Significance Index: -11.9500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 25.3312
Cell Significance Index: -13.0300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 24.4043
Cell Significance Index: -6.1900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.5834
Cell Significance Index: -9.3500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.4125
Cell Significance Index: -9.5200
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.9358
Cell Significance Index: 19.4100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.4058
Cell Significance Index: 45.0300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.3771
Cell Significance Index: 40.4500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8272
Cell Significance Index: 17.9200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.8149
Cell Significance Index: 11.6700
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.5351
Cell Significance Index: 13.6700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4979
Cell Significance Index: 58.7200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4649
Cell Significance Index: 88.4800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4556
Cell Significance Index: 8.4200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.3661
Cell Significance Index: 2.9900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3431
Cell Significance Index: 22.1400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3133
Cell Significance Index: 31.0000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2891
Cell Significance Index: 261.0800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.2715
Cell Significance Index: 78.1200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2296
Cell Significance Index: 2.9400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2275
Cell Significance Index: 6.0900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2205
Cell Significance Index: 44.2300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1584
Cell Significance Index: 3.9500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1519
Cell Significance Index: 24.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1505
Cell Significance Index: 17.5400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0895
Cell Significance Index: 9.7300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0740
Cell Significance Index: 26.5300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0277
Cell Significance Index: 15.1500
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.0270
Cell Significance Index: 0.2800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0222
Cell Significance Index: 4.0100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0135
Cell Significance Index: 25.3700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0105
Cell Significance Index: 7.2500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0055
Cell Significance Index: 0.3800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0034
Cell Significance Index: 6.2500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0010
Cell Significance Index: 0.1400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0003
Cell Significance Index: 0.0100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0003
Cell Significance Index: -0.5100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0021
Cell Significance Index: -0.0600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0024
Cell Significance Index: -0.4800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0043
Cell Significance Index: -5.9100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0099
Cell Significance Index: -1.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0122
Cell Significance Index: -9.2300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0124
Cell Significance Index: -0.3100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0140
Cell Significance Index: -8.9100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0140
Cell Significance Index: -10.3400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0163
Cell Significance Index: -7.2000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0175
Cell Significance Index: -12.8600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0175
Cell Significance Index: -9.9000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0195
Cell Significance Index: -8.8400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0275
Cell Significance Index: -3.3800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0356
Cell Significance Index: -2.1800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0364
Cell Significance Index: -0.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0377
Cell Significance Index: -1.7100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0501
Cell Significance Index: -10.5600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0520
Cell Significance Index: -8.8800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0552
Cell Significance Index: -8.0300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0590
Cell Significance Index: -1.5800
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.0642
Cell Significance Index: -0.3500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0744
Cell Significance Index: -4.4700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0768
Cell Significance Index: -7.8500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0776
Cell Significance Index: -1.6100
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.0789
Cell Significance Index: -0.6900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0850
Cell Significance Index: -10.9800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0864
Cell Significance Index: -9.9000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0867
Cell Significance Index: -9.0300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0955
Cell Significance Index: -2.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0964
Cell Significance Index: -6.4800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0999
Cell Significance Index: -7.6700
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1002
Cell Significance Index: -1.2700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1030
Cell Significance Index: -1.1700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1121
Cell Significance Index: -7.9300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1137
Cell Significance Index: -5.0300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1183
Cell Significance Index: -6.2100
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1247
Cell Significance Index: -2.1500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1263
Cell Significance Index: -6.5600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1278
Cell Significance Index: -2.1900
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1313
Cell Significance Index: -1.4300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1344
Cell Significance Index: -5.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1359
Cell Significance Index: -8.3500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1379
Cell Significance Index: -6.4800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1438
Cell Significance Index: -4.5800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1507
Cell Significance Index: -3.2100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1521
Cell Significance Index: -9.5900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1555
Cell Significance Index: -11.5900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1556
Cell Significance Index: -7.8600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1557
Cell Significance Index: -7.2600
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.1607
Cell Significance Index: -1.5500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1639
Cell Significance Index: -9.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1671
Cell Significance Index: -4.4000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1701
Cell Significance Index: -5.9600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1741
Cell Significance Index: -5.7000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1854
Cell Significance Index: -9.6600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1952
Cell Significance Index: -8.4900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2060
Cell Significance Index: -5.8800
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2107
Cell Significance Index: -1.7700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2230
Cell Significance Index: -5.9600
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2261
Cell Significance Index: -5.6400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2348
Cell Significance Index: -9.6200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2456
Cell Significance Index: -4.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** JAK3 is a non-receptor tyrosine kinase that belongs to the Janus kinase family, which is characterized by its ability to phosphorylate tyrosine residues on target proteins. JAK3 is specifically expressed in hematopoietic cells, including T cells, B cells, and dendritic cells, and is essential for the development and function of these cells. The gene is highly conserved across species, suggesting its critical role in immune function. **Pathways and Functions:** JAK3 is involved in several key signaling pathways that regulate immune responses, including: 1. **Cytokine-mediated signaling pathway:** JAK3 is essential for the signaling of various cytokines, such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which are critical for the development and function of immune cells. 2. **Adaptive immune response:** JAK3 is required for the development and function of T cells, including T helper cells (Th1, Th2, and Th17) and cytotoxic T cells. 3. **Innate immune response:** JAK3 is also involved in the regulation of innate immune responses, including the production of cytokines and the activation of immune cells. 4. **Cell differentiation:** JAK3 is essential for the differentiation of hematopoietic cells, including T cells, B cells, and dendritic cells. **Clinical Significance:** JAK3 is involved in various immune-related disorders, including: 1. **Thrombocytopenia:** Mutations in the JAK3 gene have been associated with severe thrombocytopenia, a condition characterized by low platelet counts. 2. **X-linked severe combined immunodeficiency (X-SCID):** JAK3 mutations have been identified as a cause of X-SCID, a rare and life-threatening disorder characterized by severe immune deficiency. 3. **Autoimmune diseases:** JAK3 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 4. **Cancer:** JAK3 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. In conclusion, JAK3 is a critical component of the immune system, playing a pivotal role in regulating various aspects of immune responses. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of this gene in maintaining immune homeostasis. Further research is needed to fully understand the functions of JAK3 and its role in immune regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Janus kinase 3

Genular Protein ID: 959819075

Symbol: JAK3_HUMAN

Name: Janus kinase 3

UniProtKB Accession Codes:

P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2

Database IDs:

Citations:

PubMed ID: 8022790

Title: Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.

PubMed ID: 8022790

DOI: 10.1073/pnas.91.14.6374

PubMed ID: 7559633

Title: A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells.

PubMed ID: 7559633

DOI: 10.1074/jbc.270.42.25028

PubMed ID: 8921370

Title: Genomic sequence, organization, and chromosomal localization of human JAK3.

PubMed ID: 8921370

DOI: 10.1006/geno.1996.0520

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8662778

Title: Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells.

PubMed ID: 8662778

DOI: 10.1074/jbc.271.24.13976

PubMed ID: 8022485

Title: Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

PubMed ID: 8022485

DOI: 10.1038/370151a0

PubMed ID: 7662955

Title: JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase.

PubMed ID: 7662955

PubMed ID: 7535338

Title: Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.

PubMed ID: 7535338

DOI: 10.1084/jem.181.4.1425

PubMed ID: 10899310

Title: STAM2, a new member of the STAM family, binding to the Janus kinases.

PubMed ID: 10899310

DOI: 10.1016/s0014-5793(00)01760-9

PubMed ID: 12200137

Title: IL-2 receptor signaling through the Shb adapter protein in T and NK cells.

PubMed ID: 12200137

DOI: 10.1016/s0006-291x(02)02016-8

PubMed ID: 11909529

Title: The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

PubMed ID: 11909529

DOI: 10.1016/s0960-9822(02)00697-8

PubMed ID: 12351625

Title: The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.

PubMed ID: 12351625

DOI: 10.1074/jbc.m205156200

PubMed ID: 15121872

Title: Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.

PubMed ID: 15121872

DOI: 10.1128/mcb.24.10.4557-4570.2004

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18250158

Title: Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.

PubMed ID: 18250158

DOI: 10.1128/mcb.01789-07

PubMed ID: 19290934

Title: Janus kinases in immune cell signaling.

PubMed ID: 19290934

DOI: 10.1111/j.1600-065x.2008.00754.x

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20440074

Title: IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis.

PubMed ID: 20440074

DOI: 10.1172/jci41344

PubMed ID: 15831699

Title: Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.

PubMed ID: 15831699

DOI: 10.1182/blood-2005-02-0707

PubMed ID: 7659163

Title: Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID).

PubMed ID: 7659163

DOI: 10.1038/377065a0

PubMed ID: 9354668

Title: Structural and functional basis for JAK3-deficient severe combined immunodeficiency.

PubMed ID: 9354668

PubMed ID: 9753072

Title: Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment.

PubMed ID: 9753072

DOI: 10.1111/j.1365-2141.1998.tb08990.x

PubMed ID: 10982185

Title: Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism.

PubMed ID: 10982185

DOI: 10.1007/s004390051012

PubMed ID: 14615376

Title: Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

PubMed ID: 14615376

DOI: 10.1182/blood-2003-06-2104

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1124
Mass: 125099
Checksum: 895D8563439B2B7C
Sequence:

MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA EDLCVQAAKA 
SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY RIRFYFPNWF GLEKCHRFGL 
RKDLASAILD LPVLEHLFAQ HRSDLVSGRL PVGLSLKEQG ECLSLAVLDL ARMAREQAQR 
PGELLKTVSY KACLPPSLRD LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM 
DLERLDPAGA AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD 
ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR LTTDSQHFFC 
KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV LRRSPQDFDS FLLTVCVQNP 
LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL RELLATCWDG GLHVDGVAVT LTSCCIPRPK 
EKSNLIVVQR GHSPPTSSLV QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR 
HEVVDGEARK TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSTMVQ 
EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA RKVLLAREGA 
DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ TLSLEADKWG FGATVWEVFS 
GVTMPISALD PAKKLQFYED RQQLPAPKWT ELALLIQQCM AYEPVQRPSF RAVIRDLNSL 
ISSDYELLSD PTPGALAPRD GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR 
YDPLGDNTGA LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL 
VMEYLPSGCL RDFLQRHRAR LDASRLLLYS SQICKGMEYL GSRRCVHRDL AARNILVESE 
AHVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS DNIFSRQSDV WSFGVVLYEL 
FTYCDKSCSP SAEFLRMMGC ERDVPALCRL LELLEEGQRL PAPPACPAEV HELMKLCWAP 
SPQDRPSFSA LGPQLDMLWS GSRGCETHAF TAHPEGKHHS LSFS

Database document:

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Details for: JAK3

Associated with

Cells (max top 100)

Other Information

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. PubMed ID: 8022790

A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells. PubMed ID: 7559633

Genomic sequence, organization, and chromosomal localization of human JAK3. PubMed ID: 8921370

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells. PubMed ID: 8662778

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. PubMed ID: 8022485

JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase. PubMed ID: 7662955

Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. PubMed ID: 7535338

STAM2, a new member of the STAM family, binding to the Janus kinases. PubMed ID: 10899310

IL-2 receptor signaling through the Shb adapter protein in T and NK cells. PubMed ID: 12200137

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. PubMed ID: 11909529

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. PubMed ID: 12351625

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. PubMed ID: 15121872

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. PubMed ID: 18250158

Janus kinases in immune cell signaling. PubMed ID: 19290934

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. PubMed ID: 20440074

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. PubMed ID: 15831699

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). PubMed ID: 7659163

Structural and functional basis for JAK3-deficient severe combined immunodeficiency. PubMed ID: 9354668

Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment. PubMed ID: 9753072

Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism. PubMed ID: 10982185

Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. PubMed ID: 14615376

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846