Details for: JARID2

Gene ID: 3720

Symbol: JARID2

Ensembl ID: ENSG00000008083

Description: jumonji and AT-rich interaction domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 380.9182
    Cell Significance Index: -59.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 223.5422
    Cell Significance Index: -56.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 138.9734
    Cell Significance Index: -65.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 131.4685
    Cell Significance Index: -53.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 118.3354
    Cell Significance Index: -60.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.4759
    Cell Significance Index: -53.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.9751
    Cell Significance Index: -62.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6944
    Cell Significance Index: -60.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.4470
    Cell Significance Index: -44.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.7761
    Cell Significance Index: -57.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.2289
    Cell Significance Index: -64.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.6138
    Cell Significance Index: 61.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.7302
    Cell Significance Index: 70.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4529
    Cell Significance Index: 68.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4296
    Cell Significance Index: 482.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3518
    Cell Significance Index: 471.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7194
    Cell Significance Index: 105.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7152
    Cell Significance Index: 131.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6558
    Cell Significance Index: 73.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4337
    Cell Significance Index: 54.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4100
    Cell Significance Index: 164.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3725
    Cell Significance Index: 949.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2967
    Cell Significance Index: 465.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2526
    Cell Significance Index: 30.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1384
    Cell Significance Index: 13.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0785
    Cell Significance Index: 28.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0509
    Cell Significance Index: 58.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9132
    Cell Significance Index: 12.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7749
    Cell Significance Index: 50.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7001
    Cell Significance Index: 113.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6712
    Cell Significance Index: 426.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6335
    Cell Significance Index: 68.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5982
    Cell Significance Index: 40.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5829
    Cell Significance Index: 16.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5796
    Cell Significance Index: 12.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5430
    Cell Significance Index: 1022.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4746
    Cell Significance Index: 46.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4624
    Cell Significance Index: 27.7600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3847
    Cell Significance Index: 5.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3334
    Cell Significance Index: 9.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3131
    Cell Significance Index: 170.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2941
    Cell Significance Index: 6.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2695
    Cell Significance Index: 33.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2566
    Cell Significance Index: 16.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2304
    Cell Significance Index: 41.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1845
    Cell Significance Index: 83.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1624
    Cell Significance Index: 7.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1519
    Cell Significance Index: 7.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1419
    Cell Significance Index: 192.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1289
    Cell Significance Index: 56.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1277
    Cell Significance Index: 196.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1192
    Cell Significance Index: 107.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0990
    Cell Significance Index: 182.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0116
    Cell Significance Index: 2.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0378
    Cell Significance Index: -5.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0427
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0456
    Cell Significance Index: -33.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0696
    Cell Significance Index: -51.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0740
    Cell Significance Index: -41.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0842
    Cell Significance Index: -63.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0899
    Cell Significance Index: -3.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1065
    Cell Significance Index: -3.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1090
    Cell Significance Index: -2.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1282
    Cell Significance Index: -2.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1562
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1883
    Cell Significance Index: -32.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1962
    Cell Significance Index: -56.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2056
    Cell Significance Index: -43.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2151
    Cell Significance Index: -4.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2431
    Cell Significance Index: -31.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2501
    Cell Significance Index: -17.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2978
    Cell Significance Index: -38.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3159
    Cell Significance Index: -8.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3333
    Cell Significance Index: -15.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3715
    Cell Significance Index: -37.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3746
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4026
    Cell Significance Index: -46.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4176
    Cell Significance Index: -21.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4308
    Cell Significance Index: -50.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4359
    Cell Significance Index: -6.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4504
    Cell Significance Index: -46.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4770
    Cell Significance Index: -9.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5215
    Cell Significance Index: -59.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5375
    Cell Significance Index: -27.9200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.5928
    Cell Significance Index: -5.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6029
    Cell Significance Index: -42.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6208
    Cell Significance Index: -46.2700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6745
    Cell Significance Index: -5.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7298
    Cell Significance Index: -57.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7317
    Cell Significance Index: -18.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7484
    Cell Significance Index: -15.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7558
    Cell Significance Index: -15.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7793
    Cell Significance Index: -27.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8849
    Cell Significance Index: -14.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8861
    Cell Significance Index: -11.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8889
    Cell Significance Index: -12.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8973
    Cell Significance Index: -28.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9437
    Cell Significance Index: -8.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** JARID2 is characterized by its unique JAI domain, which is responsible for its interaction with histone proteins and other DNA-bound factors. This domain enables JARID2 to participate in chromatin remodeling, histone modification, and gene expression regulation. The gene is highly expressed in various cell types, including astrocytes, Purkinje cells, and thymus-derived cells, suggesting its widespread involvement in tissue development and maintenance. **Pathways and Functions:** JARID2 is intricately involved in several key pathways, including: 1. **Epigenetic Regulation of Gene Expression:** JARID2 acts as a histone demethylase, specifically targeting histone H3K27 and H3K9, thereby regulating gene expression and chromatin structure. 2. **Chromatin Remodeling:** JARID2 collaborates with the ESC/e(Z) complex to facilitate facultative heterochromatin formation and chromatin compaction. 3. **Central Nervous System Development:** JARID2 plays a crucial role in the development of the central nervous system, particularly in the regulation of Purkinje cell differentiation and the formation of the cerebellum. 4. **Cardiac Muscle Cell Proliferation and Hypertrophy:** JARID2 negatively regulates cardiac muscle cell proliferation and hypertrophy, highlighting its potential as a therapeutic target for cardiovascular diseases. **Clinical Significance:** The dysregulation of JARID2 has been implicated in various diseases, including: 1. **Leukemia:** Mutations in JARID2 have been associated with leukemogenesis, underscoring its role in epigenetic regulation and cellular proliferation. 2. **Neurological Disorders:** Aberrant JARID2 expression has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cardiovascular Diseases:** The negative regulation of cardiac muscle cell proliferation and hypertrophy by JARID2 suggests its potential as a therapeutic target for cardiovascular diseases. In conclusion, JARID2 is a multifaceted gene with far-reaching implications in epigenetic regulation, chromatin remodeling, and developmental processes. Further research is necessary to fully elucidate the mechanisms underlying JARID2's functions and to explore its therapeutic potential in various diseases. As an expert immunologist, I emphasize the importance of continued investigation into the intricacies of JARID2, with a focus on its role in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 3091748211

Symbol: JARD2_HUMAN

Name: Protein Jumonji

UniProtKB Accession Codes:

Q92833 A8K9Z6 B7Z5S5 B7Z8L0 Q5U5L5 Q86X63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 7 Ensembl 2 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8894700

Title: Characterization of the human jumonji gene.

PubMed ID: 8894700

DOI: 10.1093/hmg/5.10.1637

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20075857

Title: JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.

PubMed ID: 20075857

DOI: 10.1038/nature08788

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35887345

Title: DNA Methylation Signature for JARID2-Neurodevelopmental Syndrome.

PubMed ID: 35887345

DOI: 10.3390/ijms23148001

PubMed ID: 29499137

Title: Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.

PubMed ID: 29499137

DOI: 10.1016/j.molcel.2018.01.039

PubMed ID: 31959557

Title: A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.

PubMed ID: 31959557

DOI: 10.1016/j.molcel.2019.12.019

Sequence Information:

  • Length: 1246
  • Mass: 138734
  • Checksum: E4929984259110DB
  • Sequence:
    • MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHAE GIAGSLKTVN 
GLLGNDQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF EEGPSRKRPR LQAQRKFAQS 
QPNSPSTTPV KIVEPLLPPP ATQISDLSKR KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ 
DEEEVEEEDD ETEDVKTATN NASSSCQSTP RKGKTHKHVH NGHVFNGSSR STREKEPVQK 
HKSKEATPAK EKHSDHRADS RREQASANHP AAAPSTGSSA KGLAATHHHP PLHRSAQDLR 
KQVSKVNGVT RMSSLGAGVT SAKKMREVRP SPSKTVKYTA TVTKGAVTYT KAKRELVKDT 
KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST GPAVNGLKVS GRLNPKSCTK 
EVGGRQLREG LQLREGLRNS KRRLEEAHQA EKPQSPPKKM KGAAGPAEGP GKKAPAERGL 
LNGHVKKEVP ERSLERNRPK RATAGKSTPG RQAHGKADSA SCENRSTSQP ESVHKPQDSG 
KAEKGGGKAG WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ VEKFGMCRVI PPPDWRPECK 
LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLKSQGI TMDELPLIGG CELDLACFFR 
LINEMGGMQQ VTDLKKWNKL ADMLRIPRTA QDRLAKLQEA YCQYLLSYDS LSPEEHRRLE 
KEVLMEKEIL EKRKGPLEGH TENDHHKFHP LPRFEPKNGL IHGVAPRNGF RSKLKEVGQA 
QLKTGRRRLF AQEKEVVKEE EEDKGVLNDF HKCIYKGRSV SLTTFYRTAR NIMSMCFSKE 
PAPAEIEQEY WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG KSEPFSRHGW NLTVLPNNTG 
SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY LHTGADCIWY CIPAEEENKL 
EDVVHTLLQA NGTPGLQMLE SNVMISPEVL CKEGIKVHRT VQQSGQFVVC FPGSFVSKVC 
CGYSVSETVH FATTQWTSMG FETAKEMKRR HIAKPFSMEK LLYQIAQAEA KKENGPTLST 
ISALLDELRD TELRQRRQLF EAGLHSSARY GSHDGSSTVA DGKKKPRKWL QLETSERRCQ 
ICQHLCYLSM VVQENENVVF CLECALRHVE KQKSCRGLKL MYRYDEEQII SLVNQICGKV 
SGKNGSIENC LSKPTPKRGP RKRATVDVPP SRLSASSSSK SASSSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.