Details for: JARID2

Gene ID: 3720

Symbol: JARID2

Ensembl ID: ENSG00000008083

Description: jumonji and AT-rich interaction domain containing 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.88
    Marker Score: 61,393
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.86
    Marker Score: 906
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.5
    Marker Score: 10,470
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.38
    Marker Score: 80,525
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.35
    Marker Score: 2,661
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.33
    Marker Score: 1,911
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.3
    Marker Score: 5,051
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.22
    Marker Score: 11,912
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.21
    Marker Score: 43,931
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.19
    Marker Score: 9,085
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.19
    Marker Score: 80,729
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.17
    Marker Score: 5,428
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.13
    Marker Score: 11,199
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.12
    Marker Score: 2,341
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.1
    Marker Score: 1,621
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.1
    Marker Score: 614
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.06
    Marker Score: 1,358
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.99
    Marker Score: 75,385
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.98
    Marker Score: 3,809
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.94
    Marker Score: 1,023
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.92
    Marker Score: 1,657
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.91
    Marker Score: 2,202
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.91
    Marker Score: 6,403
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 116,522
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.88
    Marker Score: 786
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.87
    Marker Score: 33,256
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.82
    Marker Score: 17,100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.81
    Marker Score: 1,060
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18,710
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.76
    Marker Score: 1,021
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.76
    Marker Score: 1,521
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.75
    Marker Score: 16,637
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.75
    Marker Score: 548
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.73
    Marker Score: 2,901
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.73
    Marker Score: 38,556
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.71
    Marker Score: 2,061
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.7
    Marker Score: 6,923
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.69
    Marker Score: 7,809
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.69
    Marker Score: 4,814
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.68
    Marker Score: 12,865
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.67
    Marker Score: 14,387
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.67
    Marker Score: 539
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.66
    Marker Score: 613
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.65
    Marker Score: 5,866
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.64
    Marker Score: 848
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.64
    Marker Score: 6,331
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.63
    Marker Score: 949
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.63
    Marker Score: 3,893
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.62
    Marker Score: 1,956
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.6
    Marker Score: 898
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.6
    Marker Score: 3,765
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6
    Marker Score: 54,268
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.59
    Marker Score: 1,665
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.58
    Marker Score: 943
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.55
    Marker Score: 6,481
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.54
    Marker Score: 1,903
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.52
    Marker Score: 2,047
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2,344
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.52
    Marker Score: 583
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.51
    Marker Score: 1,627
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.5
    Marker Score: 744
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.49
    Marker Score: 408
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.41
    Marker Score: 679
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.4
    Marker Score: 403
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.35
    Marker Score: 1,688
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.35
    Marker Score: 813
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.35
    Marker Score: 75,636
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.35
    Marker Score: 852
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 20,976
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.34
    Marker Score: 744
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.34
    Marker Score: 1,882
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.34
    Marker Score: 455
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.33
    Marker Score: 478
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.32
    Marker Score: 992
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3
    Marker Score: 13,153
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.28
    Marker Score: 1,816
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.28
    Marker Score: 865
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.26
    Marker Score: 624
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.26
    Marker Score: 610
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.24
    Marker Score: 418
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.23
    Marker Score: 2,577
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.22
    Marker Score: 833
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.21
    Marker Score: 1,278
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.21
    Marker Score: 1,195
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.21
    Marker Score: 1,717
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.21
    Marker Score: 1,150
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.2
    Marker Score: 1,452
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.2
    Marker Score: 672
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.2
    Marker Score: 486
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.2
    Marker Score: 1,269
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.19
    Marker Score: 344
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.19
    Marker Score: 17,802
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.19
    Marker Score: 2,734
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.19
    Marker Score: 676
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.18
    Marker Score: 19,001
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.18
    Marker Score: 1,322
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.18
    Marker Score: 734
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.16
    Marker Score: 1,244
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.16
    Marker Score: 4,830
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.16
    Marker Score: 2,844

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** JARID2 is characterized by its unique JAI domain, which is responsible for its interaction with histone proteins and other DNA-bound factors. This domain enables JARID2 to participate in chromatin remodeling, histone modification, and gene expression regulation. The gene is highly expressed in various cell types, including astrocytes, Purkinje cells, and thymus-derived cells, suggesting its widespread involvement in tissue development and maintenance. **Pathways and Functions:** JARID2 is intricately involved in several key pathways, including: 1. **Epigenetic Regulation of Gene Expression:** JARID2 acts as a histone demethylase, specifically targeting histone H3K27 and H3K9, thereby regulating gene expression and chromatin structure. 2. **Chromatin Remodeling:** JARID2 collaborates with the ESC/e(Z) complex to facilitate facultative heterochromatin formation and chromatin compaction. 3. **Central Nervous System Development:** JARID2 plays a crucial role in the development of the central nervous system, particularly in the regulation of Purkinje cell differentiation and the formation of the cerebellum. 4. **Cardiac Muscle Cell Proliferation and Hypertrophy:** JARID2 negatively regulates cardiac muscle cell proliferation and hypertrophy, highlighting its potential as a therapeutic target for cardiovascular diseases. **Clinical Significance:** The dysregulation of JARID2 has been implicated in various diseases, including: 1. **Leukemia:** Mutations in JARID2 have been associated with leukemogenesis, underscoring its role in epigenetic regulation and cellular proliferation. 2. **Neurological Disorders:** Aberrant JARID2 expression has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cardiovascular Diseases:** The negative regulation of cardiac muscle cell proliferation and hypertrophy by JARID2 suggests its potential as a therapeutic target for cardiovascular diseases. In conclusion, JARID2 is a multifaceted gene with far-reaching implications in epigenetic regulation, chromatin remodeling, and developmental processes. Further research is necessary to fully elucidate the mechanisms underlying JARID2's functions and to explore its therapeutic potential in various diseases. As an expert immunologist, I emphasize the importance of continued investigation into the intricacies of JARID2, with a focus on its role in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 3091748211

Symbol: JARD2_HUMAN

Name: Protein Jumonji

UniProtKB Accession Codes:

Q92833 A8K9Z6 B7Z5S5 B7Z8L0 Q5U5L5 Q86X63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 5 EPD 1 Ensembl 2 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 8 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8894700

Title: Characterization of the human jumonji gene.

PubMed ID: 8894700

DOI: 10.1093/hmg/5.10.1637

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20075857

Title: JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.

PubMed ID: 20075857

DOI: 10.1038/nature08788

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35887345

Title: DNA Methylation Signature for JARID2-Neurodevelopmental Syndrome.

PubMed ID: 35887345

DOI: 10.3390/ijms23148001

PubMed ID: 29499137

Title: Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.

PubMed ID: 29499137

DOI: 10.1016/j.molcel.2018.01.039

PubMed ID: 31959557

Title: A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.

PubMed ID: 31959557

DOI: 10.1016/j.molcel.2019.12.019

Sequence Information:

  • Length: 1246
  • Mass: 138734
  • Checksum: E4929984259110DB
  • Sequence:
    • MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHAE GIAGSLKTVN 
GLLGNDQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF EEGPSRKRPR LQAQRKFAQS 
QPNSPSTTPV KIVEPLLPPP ATQISDLSKR KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ 
DEEEVEEEDD ETEDVKTATN NASSSCQSTP RKGKTHKHVH NGHVFNGSSR STREKEPVQK 
HKSKEATPAK EKHSDHRADS RREQASANHP AAAPSTGSSA KGLAATHHHP PLHRSAQDLR 
KQVSKVNGVT RMSSLGAGVT SAKKMREVRP SPSKTVKYTA TVTKGAVTYT KAKRELVKDT 
KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST GPAVNGLKVS GRLNPKSCTK 
EVGGRQLREG LQLREGLRNS KRRLEEAHQA EKPQSPPKKM KGAAGPAEGP GKKAPAERGL 
LNGHVKKEVP ERSLERNRPK RATAGKSTPG RQAHGKADSA SCENRSTSQP ESVHKPQDSG 
KAEKGGGKAG WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ VEKFGMCRVI PPPDWRPECK 
LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLKSQGI TMDELPLIGG CELDLACFFR 
LINEMGGMQQ VTDLKKWNKL ADMLRIPRTA QDRLAKLQEA YCQYLLSYDS LSPEEHRRLE 
KEVLMEKEIL EKRKGPLEGH TENDHHKFHP LPRFEPKNGL IHGVAPRNGF RSKLKEVGQA 
QLKTGRRRLF AQEKEVVKEE EEDKGVLNDF HKCIYKGRSV SLTTFYRTAR NIMSMCFSKE 
PAPAEIEQEY WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG KSEPFSRHGW NLTVLPNNTG 
SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY LHTGADCIWY CIPAEEENKL 
EDVVHTLLQA NGTPGLQMLE SNVMISPEVL CKEGIKVHRT VQQSGQFVVC FPGSFVSKVC 
CGYSVSETVH FATTQWTSMG FETAKEMKRR HIAKPFSMEK LLYQIAQAEA KKENGPTLST 
ISALLDELRD TELRQRRQLF EAGLHSSARY GSHDGSSTVA DGKKKPRKWL QLETSERRCQ 
ICQHLCYLSM VVQENENVVF CLECALRHVE KQKSCRGLKL MYRYDEEQII SLVNQICGKV 
SGKNGSIENC LSKPTPKRGP RKRATVDVPP SRLSASSSSK SASSSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.