Details for: KARS1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 146.3883
Cell Significance Index: -22.7700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 81.0540
Cell Significance Index: -33.3900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 77.3648
Cell Significance Index: -31.4300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 73.7626
Cell Significance Index: -34.8300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 72.6216
Cell Significance Index: -18.4200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 66.3899
Cell Significance Index: -34.1500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.9806
Cell Significance Index: -30.8000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.3501
Cell Significance Index: -32.9500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.1404
Cell Significance Index: -18.8600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.6064
Cell Significance Index: -12.2700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.1103
Cell Significance Index: 126.6900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.9280
Cell Significance Index: 20.9600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.8427
Cell Significance Index: 200.4300 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.8035
Cell Significance Index: 14.4000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4361
Cell Significance Index: 39.0900 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.3931
Cell Significance Index: 179.9800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1825
Cell Significance Index: 1067.6800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.0381
Cell Significance Index: 21.7300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0083
Cell Significance Index: 52.3800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9684
Cell Significance Index: 33.6500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9579
Cell Significance Index: 66.2500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.9489
Cell Significance Index: 14.3000 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9292
Cell Significance Index: 16.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.8581
Cell Significance Index: 63.9500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7435
Cell Significance Index: 47.9700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7176
Cell Significance Index: 18.8700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7070
Cell Significance Index: 86.9400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5812
Cell Significance Index: 115.3500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5788
Cell Significance Index: 104.3500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5601
Cell Significance Index: 39.6100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5469
Cell Significance Index: 298.6500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.5440
Cell Significance Index: 6.1800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5372
Cell Significance Index: 73.7800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5182
Cell Significance Index: 24.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4972
Cell Significance Index: 14.3300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4599
Cell Significance Index: 203.3500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4580
Cell Significance Index: 58.7100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4297
Cell Significance Index: 50.6800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4214
Cell Significance Index: 26.5600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3242
Cell Significance Index: 9.0600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3040
Cell Significance Index: 15.9600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3032
Cell Significance Index: 14.2500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3025
Cell Significance Index: 60.6800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2924
Cell Significance Index: 47.5600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2688
Cell Significance Index: 51.1600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2392
Cell Significance Index: 23.6600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2257
Cell Significance Index: 6.6300 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1550
Cell Significance Index: 3.5800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1163
Cell Significance Index: 41.7000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0914
Cell Significance Index: 15.6000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0828
Cell Significance Index: 1.5300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0485
Cell Significance Index: 2.4500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0364
Cell Significance Index: 1.6500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0292
Cell Significance Index: 0.7800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0271
Cell Significance Index: 20.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0083
Cell Significance Index: 0.2900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0003
Cell Significance Index: -0.2500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0066
Cell Significance Index: -12.4700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0119
Cell Significance Index: -8.2300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0160
Cell Significance Index: -29.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0206
Cell Significance Index: -31.7500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0249
Cell Significance Index: -33.8400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0251
Cell Significance Index: -0.6400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0259
Cell Significance Index: -2.6500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0263
Cell Significance Index: -0.4400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0282
Cell Significance Index: -17.9100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0347
Cell Significance Index: -25.7200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0392
Cell Significance Index: -2.2000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0453
Cell Significance Index: -20.5600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0545
Cell Significance Index: -30.7600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0556
Cell Significance Index: -1.7800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0568
Cell Significance Index: -35.4700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0605
Cell Significance Index: -6.9300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0832
Cell Significance Index: -23.9300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0981
Cell Significance Index: -14.2600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0994
Cell Significance Index: -0.8300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1676
Cell Significance Index: -12.8600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1712
Cell Significance Index: -36.0500 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.2537
Cell Significance Index: -2.1800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2805
Cell Significance Index: -11.4900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3099
Cell Significance Index: -24.5500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3100
Cell Significance Index: -2.8600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3122
Cell Significance Index: -32.5100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3195
Cell Significance Index: -21.4800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3196
Cell Significance Index: -4.3600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3508
Cell Significance Index: -8.7700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3932
Cell Significance Index: -4.0700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4011
Cell Significance Index: -24.5900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4039
Cell Significance Index: -8.7500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4146
Cell Significance Index: -11.8900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4211
Cell Significance Index: -5.0200 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.4385
Cell Significance Index: -7.5600 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.4551
Cell Significance Index: -4.8400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4786
Cell Significance Index: -10.4800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4980
Cell Significance Index: -12.8000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5372
Cell Significance Index: -27.9800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5471
Cell Significance Index: -24.2000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5559
Cell Significance Index: -8.3300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5818
Cell Significance Index: -9.9700 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.5843
Cell Significance Index: -8.2000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 823821768
Symbol: SYK_HUMAN
Name: Lysine--tRNA ligase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9278442
Title: Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant.
PubMed ID: 9278442
PubMed ID: 10952987
Title: The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript.
PubMed ID: 10952987
PubMed ID: 7584044
Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7584044
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 5338216
Title: Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-tRNA synthetase.
PubMed ID: 5338216
PubMed ID: 9878398
Title: Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.
PubMed ID: 9878398
PubMed ID: 14659874
Title: The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes.
PubMed ID: 14659874
PubMed ID: 14975237
Title: The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells.
PubMed ID: 14975237
PubMed ID: 12756246
Title: The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly.
PubMed ID: 12756246
PubMed ID: 15220430
Title: Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly.
PubMed ID: 15220430
PubMed ID: 15851690
Title: Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response.
PubMed ID: 15851690
PubMed ID: 18029264
Title: Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro.
PubMed ID: 18029264
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19131329
Title: Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.
PubMed ID: 19131329
PubMed ID: 19289464
Title: Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.
PubMed ID: 19289464
PubMed ID: 19524539
Title: LysRS serves as a key signaling molecule in the immune response by regulating gene expression.
PubMed ID: 19524539
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24312579
Title: Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex.
PubMed ID: 24312579
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 18272479
Title: Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation.
PubMed ID: 18272479
PubMed ID: 23159739
Title: Structural switch of lysyl-tRNA synthetase between translation and transcription.
PubMed ID: 23159739
PubMed ID: 26074468
Title: Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
PubMed ID: 26074468
PubMed ID: 20920668
Title: Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy.
PubMed ID: 20920668
PubMed ID: 23768514
Title: Mutations in KARS, encoding lysyl-tRNA synthetase, cause autosomal-recessive nonsyndromic hearing impairment DFNB89.
PubMed ID: 23768514
PubMed ID: 25330800
Title: Congenital Visual Impairment and Progressive Microcephaly Due to Lysyl-Transfer Ribonucleic Acid (RNA) Synthetase (KARS) Mutations: The Expanding Phenotype of Aminoacyl-Transfer RNA Synthetase Mutations in Human Disease.
PubMed ID: 25330800
PubMed ID: 27891585
Title: Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect.
PubMed ID: 27891585
DOI: 10.1111/cge.12931
PubMed ID: 28887846
Title: Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism.
PubMed ID: 28887846
DOI: 10.1002/humu.23335
PubMed ID: 30252186
Title: Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis.
PubMed ID: 30252186
DOI: 10.1002/humu.23657
PubMed ID: 29615062
Title: KARS-related diseases: progressive leukoencephalopathy with brainstem and spinal cord calcifications as new phenotype and a review of literature.
PubMed ID: 29615062
PubMed ID: 30715177
Title: Biallelic KARS pathogenic variants cause an early-onset progressive leukodystrophy.
PubMed ID: 30715177
DOI: 10.1093/brain/awz001
PubMed ID: 31116475
Title: Mutations in KARS cause a severe neurological and neurosensory disease with optic neuropathy.
PubMed ID: 31116475
DOI: 10.1002/humu.23799
PubMed ID: 30737337
Title: Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy.
PubMed ID: 30737337
Sequence Information:
- Length: 597
- Mass: 68048
- Checksum: E7770953332D905D
- Sequence:
MAAVQAAEVK VDGSEPKLSK NELKRRLKAE KKVAEKEAKQ KELSEKQLSQ ATAAATNHTT DNGVGPEEES VDPNQYYKIR SQAIHQLKVN GEDPYPHKFH VDISLTDFIQ KYSHLQPGDH LTDITLKVAG RIHAKRASGG KLIFYDLRGE GVKLQVMANS RNYKSEEEFI HINNKLRRGD IIGVQGNPGK TKKGELSIIP YEITLLSPCL HMLPHLHFGL KDKETRYRQR YLDLILNDFV RQKFIIRSKI ITYIRSFLDE LGFLEIETPM MNIIPGGAVA KPFITYHNEL DMNLYMRIAP ELYHKMLVVG GIDRVYEIGR QFRNEGIDLT HNPEFTTCEF YMAYADYHDL MEITEKMVSG MVKHITGSYK VTYHPDGPEG QAYDVDFTPP FRRINMVEEL EKALGMKLPE TNLFETEETR KILDDICVAK AVECPPPRTT ARLLDKLVGE FLEVTCINPT FICDHPQIMS PLAKWHRSKE GLTERFELFV MKKEICNAYT ELNDPMRQRQ LFEEQAKAKA AGDDEAMFID ENFCTALEYG LPPTAGWGMG IDRVAMFLTD SNNIKEVLLF PAMKPEDKKE NVATTDTLES TTVGTSV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.