Details for: KCNF1

Gene ID: 3754

Symbol: KCNF1

Ensembl ID: ENSG00000162975

Description: potassium voltage-gated channel modifier subfamily F member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.38
    Marker Score: 2395.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2220
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.29
    Marker Score: 940
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1189
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7689
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.11
    Marker Score: 1022.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.05
    Marker Score: 433.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 704
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 447
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 14964
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.87
    Marker Score: 7459
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1633
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.75
    Marker Score: 1298
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1424
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 409.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 486
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.56
    Marker Score: 2338
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.55
    Marker Score: 5216
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 318
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.51
    Marker Score: 1063
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.46
    Marker Score: 4329
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 700
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.4
    Marker Score: 144
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.4
    Marker Score: 7887
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 187.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.39
    Marker Score: 23677
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.36
    Marker Score: 518
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.35
    Marker Score: 438
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 559
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.32
    Marker Score: 12235
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.32
    Marker Score: 140
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3
    Marker Score: 294
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.27
    Marker Score: 440
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 149
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.24
    Marker Score: 244
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.24
    Marker Score: 336
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 99
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.21
    Marker Score: 868
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 101.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2
    Marker Score: 178
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.19
    Marker Score: 208
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.19
    Marker Score: 76
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 67
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 192
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.15
    Marker Score: 171
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.14
    Marker Score: 1420
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.14
    Marker Score: 266.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.13
    Marker Score: 463
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 67
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 105
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 22
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.11
    Marker Score: 187
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.11
    Marker Score: 162
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1
    Marker Score: 616
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.1
    Marker Score: 3818.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 185
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1
    Marker Score: 455
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 227
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1
    Marker Score: 272
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.1
    Marker Score: 228
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.08
    Marker Score: 199
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.08
    Marker Score: 144
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.08
    Marker Score: 19

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Other Information

**Key characteristics:** * The KCNF1 gene is located on chromosome 17q23.1. * It is a member of the potassium voltage-gated channel family. * It is a transmembrane protein with a predicted molecular weight of approximately 140 kDa. **Pathways and functions:** * The KCNF1 gene product is a negative regulator of potassium channel activity. * It is involved in the regulation of potassium ion transport across cell membranes. * It is thought to be involved in the regulation of cell volume, proliferation, and migration. **Clinical significance:** * Mutations in the KCNF1 gene have been linked to a number of human diseases, including epilepsy, stroke, and heart disease. * These mutations can lead to changes in the function of potassium channels, which can have a significant impact on cellular function. * Understanding the role of the KCNF1 gene in potassium channel function could lead to the development of new treatments for these diseases.

Genular Protein ID: 1603929458

Symbol: KCNF1_HUMAN

Name: Potassium voltage-gated channel subfamily F member 1

UniProtKB Accession Codes:

Q9H3M0 O43527 Q585L3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DrugBank 3 DrugCentral 1 EMBL 5 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9434767

Title: Isolation, characterization, and mapping of two human potassium channels.

PubMed ID: 9434767

DOI: 10.1006/bbrc.1997.7830

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12445884

Title: Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium.

PubMed ID: 12445884

DOI: 10.1016/s0008-6363(02)00602-8

Sequence Information:

  • Length: 494
  • Mass: 55584
  • Checksum: 87E2FB117F927F60
  • Sequence:
    • MDGSGERSLP EPGSQSSAAS DDIEIVVNVG GVRQVLYGDL LSQYPETRLA ELINCLAGGY 
DTIFSLCDDY DPGKREFYFD RDPDAFKCVI EVYYFGEVHM KKGICPICFK NEMDFWKVDL 
KFLDDCCKSH LSEKREELEE IARRVQLILD DLGVDAAEGR WRRCQKCVWK FLEKPESSCP 
ARVVAVLSFL LILVSSVVMC MGTIPELQVL DAEGNRVEHP TLENVETACI GWFTLEYLLR 
LFSSPNKLHF ALSFMNIVDV LAILPFYVSL TLTHLGARMM ELTNVQQAVQ ALRIMRIARI 
FKLARHSSGL QTLTYALKRS FKELGLLLMY LAVGIFVFSA LGYTMEQSHP ETLFKSIPQS 
FWWAIITMTT VGYGDIYPKT TLGKLNAAIS FLCGVIAIAL PIHPIINNFV RYYNKQRVLE 
TAAKHELELM ELNSSSGGEG KTGGSRSDLD NLPPEPAGKE APSCSSRLKL SHSDTFIPLL 
TEEKHHRTRL QSCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.