Details for: KCNF1

Gene ID: 3754

Symbol: KCNF1

Ensembl ID: ENSG00000162975

Description: potassium voltage-gated channel modifier subfamily F member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5310
    Cell Significance Index: 49.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0020
    Cell Significance Index: 15.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7531
    Cell Significance Index: 39.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3538
    Cell Significance Index: 10.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2386
    Cell Significance Index: 38.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1776
    Cell Significance Index: 35.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1467
    Cell Significance Index: 8.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1260
    Cell Significance Index: 8.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1199
    Cell Significance Index: 2.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0648
    Cell Significance Index: 6.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0569
    Cell Significance Index: 7.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0490
    Cell Significance Index: 3.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0227
    Cell Significance Index: 15.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0078
    Cell Significance Index: 2.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0041
    Cell Significance Index: 1.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0027
    Cell Significance Index: 1.4900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0039
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0063
    Cell Significance Index: -1.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0097
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0140
    Cell Significance Index: -7.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0151
    Cell Significance Index: -9.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0167
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0225
    Cell Significance Index: -10.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0300
    Cell Significance Index: -5.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0396
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0498
    Cell Significance Index: -10.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0517
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0547
    Cell Significance Index: -9.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0553
    Cell Significance Index: -6.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0562
    Cell Significance Index: -0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0664
    Cell Significance Index: -9.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0672
    Cell Significance Index: -9.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0719
    Cell Significance Index: -8.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0732
    Cell Significance Index: -1.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0786
    Cell Significance Index: -10.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0810
    Cell Significance Index: -8.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0816
    Cell Significance Index: -2.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0825
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0897
    Cell Significance Index: -10.2800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1020
    Cell Significance Index: -1.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1039
    Cell Significance Index: -2.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1085
    Cell Significance Index: -4.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1177
    Cell Significance Index: -9.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1219
    Cell Significance Index: -3.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1230
    Cell Significance Index: -1.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1274
    Cell Significance Index: -3.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1360
    Cell Significance Index: -2.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1375
    Cell Significance Index: -4.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1418
    Cell Significance Index: -5.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1430
    Cell Significance Index: -10.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1434
    Cell Significance Index: -1.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1450
    Cell Significance Index: -9.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1461
    Cell Significance Index: -3.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1472
    Cell Significance Index: -3.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1659
    Cell Significance Index: -9.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1775
    Cell Significance Index: -9.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1866
    Cell Significance Index: -3.6900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2030
    Cell Significance Index: -2.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2036
    Cell Significance Index: -1.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2140
    Cell Significance Index: -10.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2149
    Cell Significance Index: -7.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2203
    Cell Significance Index: -10.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2317
    Cell Significance Index: -8.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2333
    Cell Significance Index: -5.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2441
    Cell Significance Index: -3.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2706
    Cell Significance Index: -5.7900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2717
    Cell Significance Index: -3.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2883
    Cell Significance Index: -4.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2917
    Cell Significance Index: -7.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2986
    Cell Significance Index: -10.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3048
    Cell Significance Index: -6.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3100
    Cell Significance Index: -9.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3138
    Cell Significance Index: -3.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3182
    Cell Significance Index: -11.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3227
    Cell Significance Index: -7.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3244
    Cell Significance Index: -8.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3321
    Cell Significance Index: -7.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3409
    Cell Significance Index: -4.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3538
    Cell Significance Index: -9.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3571
    Cell Significance Index: -9.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3589
    Cell Significance Index: -8.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3706
    Cell Significance Index: -9.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3768
    Cell Significance Index: -7.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3914
    Cell Significance Index: -11.2200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4074
    Cell Significance Index: -8.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4090
    Cell Significance Index: -10.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4206
    Cell Significance Index: -10.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4207
    Cell Significance Index: -7.0400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4341
    Cell Significance Index: -5.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4343
    Cell Significance Index: -8.6600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.4356
    Cell Significance Index: -4.7800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4380
    Cell Significance Index: -8.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4529
    Cell Significance Index: -11.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4552
    Cell Significance Index: -7.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4601
    Cell Significance Index: -9.6300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4735
    Cell Significance Index: -6.1800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5035
    Cell Significance Index: -9.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.5081
    Cell Significance Index: -5.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Potassium Channel Modulation:** KCNF1 is a potassium voltage-gated channel modifier subfamily F member, which implies its involvement in regulating potassium channels. These channels are essential for maintaining the resting membrane potential, repolarizing action potentials, and modulating neurotransmitter release. 2. **Cell Type-Specific Expression:** KCNF1 is expressed in various cell types, including blood vessel endothelial cells, plasma cells, colon goblet cells, B cells, and neurons. This cell-type specificity suggests that KCNF1 plays distinct roles in different tissues and organs. 3. **Voltage-Gated Potassium Channel Activity:** KCNF1 is associated with voltage-gated potassium channels, which are critical for generating and regulating the electrical activity of neurons. **Pathways and Functions:** 1. **Neuronal Function:** KCNF1 is involved in regulating neuronal excitability and neurotransmitter release. By modulating potassium channels, KCNF1 helps to maintain the resting membrane potential and repolarize action potentials. 2. **Immune Response:** KCNF1 is expressed in immune cells, such as plasma cells and B cells, where it may play a role in regulating immune responses, including antibody production and cytokine secretion. 3. **Ciliary Function:** KCNF1 is also involved in the assembly and maintenance of non-motile cilia, which are essential for maintaining cellular homeostasis and preventing disease. 4. **Protein Interaction:** KCNF1 interacts with various proteins, including voltage-gated potassium channels, to modulate their activity and regulate cellular function. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in KCNF1 expression or function may contribute to neurological disorders, such as epilepsy, anxiety, and depression, which are characterized by disrupted potassium channel function. 2. **Immune-Mediated Diseases:** Dysregulation of KCNF1 in immune cells may lead to autoimmune diseases, such as rheumatoid arthritis and lupus, where immune responses are impaired. 3. **Ciliary Dysfunction:** Abnormalities in KCNF1 expression or function may contribute to ciliary dysfunction, which is associated with various diseases, including polycystic kidney disease and primary ciliary dyskinesia. 4. **Cancer:** KCNF1 may play a role in cancer development and progression, particularly in cancers with impaired potassium channel function, such as glioblastoma. In conclusion, the KCNF1 gene plays a critical role in regulating potassium channels and maintaining cellular homeostasis in various cell types. Its dysregulation has been implicated in multiple diseases, highlighting the importance of KCNF1 in human health and disease. Further research is necessary to fully understand the mechanisms underlying KCNF1 function and its implications for human disease.

Genular Protein ID: 1603929458

Symbol: KCNF1_HUMAN

Name: Potassium voltage-gated channel subfamily F member 1

UniProtKB Accession Codes:

Q9H3M0 O43527 Q585L3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 5 Ensembl 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9434767

Title: Isolation, characterization, and mapping of two human potassium channels.

PubMed ID: 9434767

DOI: 10.1006/bbrc.1997.7830

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 494
  • Mass: 55584
  • Checksum: 87E2FB117F927F60
  • Sequence:
    • MDGSGERSLP EPGSQSSAAS DDIEIVVNVG GVRQVLYGDL LSQYPETRLA ELINCLAGGY 
DTIFSLCDDY DPGKREFYFD RDPDAFKCVI EVYYFGEVHM KKGICPICFK NEMDFWKVDL 
KFLDDCCKSH LSEKREELEE IARRVQLILD DLGVDAAEGR WRRCQKCVWK FLEKPESSCP 
ARVVAVLSFL LILVSSVVMC MGTIPELQVL DAEGNRVEHP TLENVETACI GWFTLEYLLR 
LFSSPNKLHF ALSFMNIVDV LAILPFYVSL TLTHLGARMM ELTNVQQAVQ ALRIMRIARI 
FKLARHSSGL QTLTYALKRS FKELGLLLMY LAVGIFVFSA LGYTMEQSHP ETLFKSIPQS 
FWWAIITMTT VGYGDIYPKT TLGKLNAAIS FLCGVIAIAL PIHPIINNFV RYYNKQRVLE 
TAAKHELELM ELNSSSGGEG KTGGSRSDLD NLPPEPAGKE APSCSSRLKL SHSDTFIPLL 
TEEKHHRTRL QSCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.