Details for: KCNS3

Gene ID: 3790

Symbol: KCNS3

Ensembl ID: ENSG00000170745

Description: potassium voltage-gated channel modifier subfamily S member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.4175
    Cell Significance Index: -17.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.1270
    Cell Significance Index: -15.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.9717
    Cell Significance Index: -13.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3309
    Cell Significance Index: -17.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9066
    Cell Significance Index: -8.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6287
    Cell Significance Index: 10.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4693
    Cell Significance Index: 24.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4672
    Cell Significance Index: 12.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4652
    Cell Significance Index: 54.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4629
    Cell Significance Index: 166.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4423
    Cell Significance Index: 12.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3793
    Cell Significance Index: 22.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2650
    Cell Significance Index: 3.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2451
    Cell Significance Index: 26.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2392
    Cell Significance Index: 14.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2114
    Cell Significance Index: 5.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2056
    Cell Significance Index: 185.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2003
    Cell Significance Index: 9.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1992
    Cell Significance Index: 19.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1778
    Cell Significance Index: 28.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1612
    Cell Significance Index: 71.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0861
    Cell Significance Index: 5.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0755
    Cell Significance Index: 116.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0605
    Cell Significance Index: 10.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0476
    Cell Significance Index: 9.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0444
    Cell Significance Index: 5.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0381
    Cell Significance Index: 51.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0325
    Cell Significance Index: 1.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0300
    Cell Significance Index: 55.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0249
    Cell Significance Index: 3.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0158
    Cell Significance Index: 10.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0080
    Cell Significance Index: 0.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0031
    Cell Significance Index: 0.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0029
    Cell Significance Index: 0.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0013
    Cell Significance Index: 0.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0052
    Cell Significance Index: -0.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0126
    Cell Significance Index: -6.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0142
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0179
    Cell Significance Index: -8.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0192
    Cell Significance Index: -14.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0205
    Cell Significance Index: -13.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0221
    Cell Significance Index: -1.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0263
    Cell Significance Index: -5.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0281
    Cell Significance Index: -17.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0303
    Cell Significance Index: -17.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0345
    Cell Significance Index: -0.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0346
    Cell Significance Index: -9.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0351
    Cell Significance Index: -6.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0454
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0518
    Cell Significance Index: -6.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0532
    Cell Significance Index: -7.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0573
    Cell Significance Index: -2.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0603
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0603
    Cell Significance Index: -10.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0786
    Cell Significance Index: -1.3200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0839
    Cell Significance Index: -0.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0856
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0889
    Cell Significance Index: -18.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0934
    Cell Significance Index: -1.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0957
    Cell Significance Index: -1.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0977
    Cell Significance Index: -0.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1124
    Cell Significance Index: -11.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1160
    Cell Significance Index: -15.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1268
    Cell Significance Index: -2.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1376
    Cell Significance Index: -16.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1635
    Cell Significance Index: -17.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1692
    Cell Significance Index: -3.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1786
    Cell Significance Index: -1.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1819
    Cell Significance Index: -13.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1914
    Cell Significance Index: -15.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1945
    Cell Significance Index: -13.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2394
    Cell Significance Index: -5.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2401
    Cell Significance Index: -15.4900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2440
    Cell Significance Index: -2.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2468
    Cell Significance Index: -12.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2470
    Cell Significance Index: -7.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2604
    Cell Significance Index: -14.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2780
    Cell Significance Index: -14.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2795
    Cell Significance Index: -12.1500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2801
    Cell Significance Index: -4.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2941
    Cell Significance Index: -15.4400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.3208
    Cell Significance Index: -2.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3262
    Cell Significance Index: -14.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3392
    Cell Significance Index: -7.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3429
    Cell Significance Index: -11.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3596
    Cell Significance Index: -5.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3646
    Cell Significance Index: -9.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3716
    Cell Significance Index: -5.6000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3845
    Cell Significance Index: -4.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3901
    Cell Significance Index: -11.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3937
    Cell Significance Index: -14.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4104
    Cell Significance Index: -6.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The KCNS3 protein is a subunit of voltage-gated potassium channels, which are tetrameric complexes composed of four subunits (C, A, B, and S). The KCNS3 subunit is characterized by its unique structure, which includes a large extracellular loop and a small intracellular loop. This subunit is distinct from other KCN subunits, which are involved in voltage-gated potassium channel activity. The KCNS3 subunit is also unique in its ability to modulate the activity of voltage-gated potassium channels, particularly the KCNQ1 and KCNQ2 channels. **Pathways and Functions** The KCNS3 protein is involved in several cellular processes, including: 1. **Regulation of Insulin Secretion**: KCNS3 interacts with the KCNQ1 channel to modulate insulin secretion in pancreatic beta cells. This interaction is essential for maintaining glucose homeostasis and preventing hyperinsulinemia. 2. **Voltage-Gated Potassium Channel Activity**: KCNS3 regulates the activity of voltage-gated potassium channels, which are essential for maintaining the resting membrane potential and controlling the excitability of neurons and other cells. 3. **Neuronal System**: KCNS3 is expressed in retinal bipolar neurons and is involved in regulating their excitability and synaptic transmission. 4. **Metabolism**: KCNS3 is involved in regulating energy metabolism in various tissues, including the heart and kidneys. **Clinical Significance** Dysregulation of KCNS3 has been implicated in several diseases, including: 1. **Diabetes**: KCNS3 mutations have been associated with diabetes, particularly type 2 diabetes, and impaired insulin secretion. 2. **Neurological Disorders**: KCNS3 mutations have been associated with neurological disorders, such as epilepsy and migraines, due to its role in regulating neuronal excitability. 3. **Cardiovascular Disease**: KCNS3 mutations have been associated with cardiovascular disease, particularly arrhythmias and cardiac failure, due to its role in regulating cardiac function. In conclusion, the KCNS3 gene plays a crucial role in regulating voltage-gated potassium channel activity, insulin secretion, and energy metabolism. Its dysregulation has been implicated in several diseases, highlighting the importance of KCNS3 in maintaining physiological homeostasis. Further research is needed to fully understand the mechanisms by which KCNS3 regulates cellular processes and to develop therapeutic strategies for diseases associated with KCNS3 dysfunction.

Genular Protein ID: 426519243

Symbol: KCNS3_HUMAN

Name: Potassium voltage-gated channel subfamily S member 3

UniProtKB Accession Codes:

Q9BQ31 D6W520 O43651 Q4ZFY1 Q96B56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10484328

Title: Electrically silent potassium channel subunits from human lens epithelium.

PubMed ID: 10484328

DOI: 10.1152/ajpcell.1999.277.3.c412

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22943705

Title: Expression of an electrically silent voltage-gated potassium channel in the human placenta.

PubMed ID: 22943705

DOI: 10.3109/01443615.2012.709288

Sequence Information:

  • Length: 491
  • Mass: 56001
  • Checksum: FFE02CA3DCA50185
  • Sequence:
    • MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY 
SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSNR 
YQERKEENHE KDWDQKSHDV STDSSFEESS LFEKELEKFD TLRFGQLRKK IWIRMENPAY 
CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR 
LAAAPCQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH TSSLTSIPIC 
WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL PITIIFNKFS KYYQKQKDID 
VDQCSEDAPE KCHELPYFNI RDIYAQRMHT FITSLSSVGI VVSDPDSTDA SSIEDNEDIC 
NTTSLENCTA K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.