Details for: KCNS3

Gene ID: 3790

Symbol: KCNS3

Ensembl ID: ENSG00000170745

Description: potassium voltage-gated channel modifier subfamily S member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.7
    Marker Score: 3543
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.98
    Marker Score: 16720
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.76
    Marker Score: 64841
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.61
    Marker Score: 3051
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.5
    Marker Score: 3046
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3471
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168894
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.47
    Marker Score: 4206
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 852
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.3
    Marker Score: 5403
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19314
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.22
    Marker Score: 12633
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.14
    Marker Score: 1422
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.14
    Marker Score: 683
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.06
    Marker Score: 6364
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.01
    Marker Score: 561
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48007
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.88
    Marker Score: 1059
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.85
    Marker Score: 267
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.83
    Marker Score: 6400
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.83
    Marker Score: 397.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 262
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.77
    Marker Score: 1345
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1245
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3200
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.74
    Marker Score: 2861
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.74
    Marker Score: 326
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 667
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.71
    Marker Score: 797
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.71
    Marker Score: 413
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.7
    Marker Score: 1598
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.68
    Marker Score: 376
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.68
    Marker Score: 318
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.67
    Marker Score: 616.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.67
    Marker Score: 446
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.65
    Marker Score: 779
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.63
    Marker Score: 662
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.61
    Marker Score: 362
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.61
    Marker Score: 631
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.61
    Marker Score: 523
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 693
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.59
    Marker Score: 2478
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.57
    Marker Score: 236
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.57
    Marker Score: 2972
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.56
    Marker Score: 8945
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.54
    Marker Score: 4055.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.53
    Marker Score: 310
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.52
    Marker Score: 150
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.52
    Marker Score: 1357
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.51
    Marker Score: 10231
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.51
    Marker Score: 630
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.51
    Marker Score: 685
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.51
    Marker Score: 695
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5
    Marker Score: 540
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.48
    Marker Score: 323
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.46
    Marker Score: 3011
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.45
    Marker Score: 137
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.44
    Marker Score: 625
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.44
    Marker Score: 509
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.43
    Marker Score: 530
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.41
    Marker Score: 239
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.41
    Marker Score: 146
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.41
    Marker Score: 82
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.4
    Marker Score: 388
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4
    Marker Score: 263
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.39
    Marker Score: 607
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.39
    Marker Score: 564
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.39
    Marker Score: 1197
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.39
    Marker Score: 622
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.39
    Marker Score: 705
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.38
    Marker Score: 134
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.38
    Marker Score: 212
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.38
    Marker Score: 421
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.38
    Marker Score: 488
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.37
    Marker Score: 2006
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.37
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.37
    Marker Score: 234
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 241
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.36
    Marker Score: 102
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.36
    Marker Score: 635.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.36
    Marker Score: 858
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.35
    Marker Score: 123

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Other Information

**Key characteristics:** * It is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including retinal horizontal cells, retinal bipolar neurons, pvalb GABAergic cortical interneurons, cardiac endothelial cells, immature innate lymphoid cells, kidney proximal straight tubule epithelial cells, mural cells, retinal cone cells, granulocyte monocyte progenitor cells, and chandelier pvalb GABAergic cortical interneurons. * It is known to be a negative regulator of potassium channel activity. **Pathways and functions:** * **Cytosol:** KCNS3 modulates the activity of the delayed rectifier potassium channel, which is a key regulator of potassium homeostasis in the cytosol. * **Glucagon-like peptide-1 (glp1):** GLP1 regulates insulin secretion by binding to receptors on pancreatic beta-cells and stimulating the opening of ion channels that allow ions to flow into the cell. KCNS3 has been shown to interact with GLP1 and modulate its effects on insulin secretion. * **Golgi apparatus:** KCNS3 is involved in the regulation of the Golgi apparatus, a complex network of protein complexes involved in the processing, sorting, and packaging of proteins. * **Energy metabolism:** KCNS3 is involved in the regulation of energy metabolism by interacting with the pyruvate kinase pathway. * **Neuronal system:** KCNS3 is expressed in neurons and is involved in regulating potassium channel activity in neurons. * **Plasma membrane:** KCNS3 is a key regulator of potassium channel activity in the plasma membrane, where it modulates the opening and closing of potassium channels. * **Potassium channel regulator activity:** KCNS3 is a negative regulator of potassium channel activity, which means that it opens potassium channels when they are normally closed. **Clinical significance:** Mutations in the KCNS3 gene have been linked to several human diseases, including type 2 diabetes, obesity, and cardiovascular disease. These diseases are characterized by abnormalities in insulin secretion and metabolism, which are partly controlled by the potassium channel activity. Therefore, targeting the KCNS3 gene has emerged as a potential therapeutic strategy for these diseases.

Genular Protein ID: 426519243

Symbol: KCNS3_HUMAN

Name: Potassium voltage-gated channel subfamily S member 3

UniProtKB Accession Codes:

Q9BQ31 D6W520 O43651 Q4ZFY1 Q96B56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10484328

Title: Electrically silent potassium channel subunits from human lens epithelium.

PubMed ID: 10484328

DOI: 10.1152/ajpcell.1999.277.3.c412

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22943705

Title: Expression of an electrically silent voltage-gated potassium channel in the human placenta.

PubMed ID: 22943705

DOI: 10.3109/01443615.2012.709288

Sequence Information:

  • Length: 491
  • Mass: 56001
  • Checksum: FFE02CA3DCA50185
  • Sequence:
    • MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY 
SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSNR 
YQERKEENHE KDWDQKSHDV STDSSFEESS LFEKELEKFD TLRFGQLRKK IWIRMENPAY 
CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR 
LAAAPCQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH TSSLTSIPIC 
WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL PITIIFNKFS KYYQKQKDID 
VDQCSEDAPE KCHELPYFNI RDIYAQRMHT FITSLSSVGI VVSDPDSTDA SSIEDNEDIC 
NTTSLENCTA K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.