Details for: KIF5B

Gene ID: 3799

Symbol: KIF5B

Ensembl ID: ENSG00000170759

Description: kinesin family member 5B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.94
    Marker Score: 12264
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.82
    Marker Score: 3399
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.78
    Marker Score: 24361
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.56
    Marker Score: 2729
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.54
    Marker Score: 1700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.41
    Marker Score: 4400
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.3
    Marker Score: 871
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.28
    Marker Score: 7835
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.26
    Marker Score: 5314
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.24
    Marker Score: 2355.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.24
    Marker Score: 19437
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.22
    Marker Score: 530
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.21
    Marker Score: 4158
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.19
    Marker Score: 9455
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.18
    Marker Score: 4552.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.17
    Marker Score: 3852
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.15
    Marker Score: 5262
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.15
    Marker Score: 24220
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.15
    Marker Score: 2775.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.13
    Marker Score: 2933
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.13
    Marker Score: 1400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.11
    Marker Score: 27817
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.11
    Marker Score: 71697
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.09
    Marker Score: 10289
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.09
    Marker Score: 72455
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.08
    Marker Score: 3527
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.06
    Marker Score: 1849
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.06
    Marker Score: 3031
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.05
    Marker Score: 36429
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.04
    Marker Score: 5548
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.02
    Marker Score: 1903
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.01
    Marker Score: 1171
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.01
    Marker Score: 951.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2
    Marker Score: 4566
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.99
    Marker Score: 7363.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.99
    Marker Score: 1694
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.98
    Marker Score: 1552
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.97
    Marker Score: 1551
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.97
    Marker Score: 1235
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.97
    Marker Score: 7582
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.96
    Marker Score: 2096
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.96
    Marker Score: 565
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.96
    Marker Score: 1875
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.95
    Marker Score: 2124
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.95
    Marker Score: 49877
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.95
    Marker Score: 679
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.94
    Marker Score: 12635
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.93
    Marker Score: 19422
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.93
    Marker Score: 2076
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.93
    Marker Score: 802
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.93
    Marker Score: 19516
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.92
    Marker Score: 2035
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.92
    Marker Score: 1308
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.92
    Marker Score: 1764
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.92
    Marker Score: 3647
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.91
    Marker Score: 3824
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.91
    Marker Score: 780
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.91
    Marker Score: 1141
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.9
    Marker Score: 2138
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.9
    Marker Score: 2219
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.9
    Marker Score: 1832
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.89
    Marker Score: 4494
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.88
    Marker Score: 4733
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.88
    Marker Score: 1171
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.87
    Marker Score: 1251
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.87
    Marker Score: 13945
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.87
    Marker Score: 1990
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.87
    Marker Score: 1763
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.87
    Marker Score: 921
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.87
    Marker Score: 2969
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.86
    Marker Score: 18441.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.86
    Marker Score: 1354
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.86
    Marker Score: 699
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.86
    Marker Score: 686
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.85
    Marker Score: 2171
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.85
    Marker Score: 865
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.85
    Marker Score: 1922.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.84
    Marker Score: 2640
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.84
    Marker Score: 977
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.83
    Marker Score: 1182
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.83
    Marker Score: 1847
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.83
    Marker Score: 1840
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.83
    Marker Score: 400.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.83
    Marker Score: 1709
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.82
    Marker Score: 418
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.81
    Marker Score: 2362
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.81
    Marker Score: 4924
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.81
    Marker Score: 2232
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.81
    Marker Score: 853
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.81
    Marker Score: 101011.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.8
    Marker Score: 1031
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.8
    Marker Score: 2944.5
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.79
    Marker Score: 504
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.79
    Marker Score: 1620
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.79
    Marker Score: 20797
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.79
    Marker Score: 507
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.79
    Marker Score: 1043
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.78
    Marker Score: 718
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.78
    Marker Score: 2034
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.78
    Marker Score: 2136

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Other Information

**Key characteristics:** * KIF5B is a large protein composed of 1300 amino acids. * It is a member of the kinesin family of motor protein kinases. * It is involved in the regulation of various cellular processes, including cell cycle progression, cell migration, and immune responses. **Pathways and functions:** * KIF5B is involved in the adaptive immune system by regulating the maturation and function of dendritic cells. * It is crucial for the development and maintenance of the immune system. * It is involved in the regulation of platelet production and function. * It is also involved in the regulation of insulin processing and metabolism. **Clinical significance:** * Mutations in KIF5B have been linked to several human diseases, including cancer, immune disorders, and metabolic diseases. * Targeting KIF5B has emerged as a potential therapeutic strategy for these diseases. **Additional points:** * KIF5B is a highly conserved protein with homologs in other species. * It is a substrate for a variety of kinases, including MAPK, PI3K, and mTORC1. * It is involved in the regulation of cell growth, differentiation, and survival.

Genular Protein ID: 2214444549

Symbol: KINH_HUMAN

Name: Conventional kinesin heavy chain

UniProtKB Accession Codes:

P33176 A0AVB2 Q5VZ85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1607388

Title: Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.

PubMed ID: 1607388

DOI: 10.1083/jcb.117.6.1263

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15459722

Title: Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.

PubMed ID: 15459722

DOI: 10.1038/ncb1169

PubMed ID: 15905402

Title: The intracellular fate of Salmonella depends on the recruitment of kinesin.

PubMed ID: 15905402

DOI: 10.1126/science.1110225

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17532644

Title: Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport.

PubMed ID: 17532644

DOI: 10.1016/j.mcn.2007.04.008

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 20386726

Title: Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.

PubMed ID: 20386726

DOI: 10.1371/journal.pbio.1000350

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22172677

Title: Arl8 and SKIP act together to link lysosomes to kinesin-1.

PubMed ID: 22172677

DOI: 10.1016/j.devcel.2011.10.007

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23011729

Title: Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.

PubMed ID: 23011729

DOI: 10.1088/1478-3975/9/5/055005

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24088571

Title: Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

PubMed ID: 24088571

DOI: 10.1091/mbc.e13-05-0259

PubMed ID: 24995978

Title: Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.

PubMed ID: 24995978

DOI: 10.1016/j.cell.2014.06.007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8606779

Title: Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.

PubMed ID: 8606779

DOI: 10.1038/380550a0

PubMed ID: 12368902

Title: Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.

PubMed ID: 12368902

DOI: 10.1038/nsb852

PubMed ID: 17470637

Title: The beginning of kinesin's force-generating cycle visualized at 9-A resolution.

PubMed ID: 17470637

DOI: 10.1083/jcb.200612090

Sequence Information:

  • Length: 963
  • Mass: 109685
  • Checksum: A1FE5760C3250C8B
  • Sequence:
    • MADLAECNIK VMCRFRPLNE SEVNRGDKYI AKFQGEDTVV IASKPYAFDR VFQSSTSQEQ 
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY 
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM 
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK 
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI 
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKILRNTIQW 
LENELNRWRN GETVPIDEQF DKEKANLEAF TVDKDITLTN DKPATAIGVI GNFTDAERRK 
CEEEIAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE 
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL 
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE 
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL 
EESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR 
DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ 
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEIDSD DTGGSAAQKQ KISFLENNLE 
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD 
RIKEAVRSKN MARRGHSAQI AKPIRPGQHP AASPTHPSAI RGGGAFVQNS QPVAVRGGGG 
KQV

Genular Protein ID: 1158913178

Symbol: Q6P164_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P164

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 6 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 345
  • Mass: 38716
  • Checksum: 133721DA5C8697BE
  • Sequence:
    • MADLAECNIK VMCRFRPLNE SEVNRGDKYI AKFQGEDTVV IASKPYAFDR VFQSSTSQEQ 
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY 
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM 
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK 
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI 
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.