Details for: KIF11

Gene ID: 3832

Symbol: KIF11

Ensembl ID: ENSG00000138160

Description: kinesin family member 11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.21
    Marker Score: 4571
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.22
    Marker Score: 3307
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.04
    Marker Score: 1250
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.03
    Marker Score: 965
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2008
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5141
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.87
    Marker Score: 1653
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.87
    Marker Score: 1246
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.84
    Marker Score: 470
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.83
    Marker Score: 608
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.82
    Marker Score: 2444
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12304
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1248
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.76
    Marker Score: 242
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.74
    Marker Score: 981
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.72
    Marker Score: 770
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 652
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.71
    Marker Score: 1208
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.71
    Marker Score: 195
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 223
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.68
    Marker Score: 213
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2809.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.6
    Marker Score: 753.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.56
    Marker Score: 275
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.55
    Marker Score: 1303
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.55
    Marker Score: 413
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.53
    Marker Score: 538
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 216
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.51
    Marker Score: 319
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.48
    Marker Score: 233
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.48
    Marker Score: 138
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 433
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 123
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.46
    Marker Score: 642
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 204
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.41
    Marker Score: 469
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.41
    Marker Score: 121
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 392
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.41
    Marker Score: 847
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.39
    Marker Score: 1069
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.37
    Marker Score: 181
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.37
    Marker Score: 121
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.37
    Marker Score: 288
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.36
    Marker Score: 181
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.36
    Marker Score: 380
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.36
    Marker Score: 240
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.36
    Marker Score: 235
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.36
    Marker Score: 223
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.36
    Marker Score: 88
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.35
    Marker Score: 188
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.34
    Marker Score: 198
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.34
    Marker Score: 356
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.34
    Marker Score: 354.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.33
    Marker Score: 1396.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.33
    Marker Score: 771
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 193
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.31
    Marker Score: 1139
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.3
    Marker Score: 287
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.3
    Marker Score: 329
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3
    Marker Score: 257
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.3
    Marker Score: 84
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.3
    Marker Score: 191
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.29
    Marker Score: 203
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.28
    Marker Score: 437
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.28
    Marker Score: 793
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.28
    Marker Score: 141
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 176
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.28
    Marker Score: 138
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.28
    Marker Score: 202.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.28
    Marker Score: 69
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.27
    Marker Score: 118
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.27
    Marker Score: 173
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.27
    Marker Score: 635
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.26
    Marker Score: 9095
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.26
    Marker Score: 188
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.26
    Marker Score: 119
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.25
    Marker Score: 992
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.25
    Marker Score: 275
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.24
    Marker Score: 3190
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.24
    Marker Score: 2249
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.24
    Marker Score: 223

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Other Information

**Key characteristics:** * KIF11 is a microtubule-associated protein that is expressed in a variety of cell types. * It is a key regulator of the mitotic cell cycle and is involved in the organization of the spindle apparatus. * KIF11 is also involved in the trafficking of vesicles and proteins between the Golgi apparatus and the endoplasmic reticulum. **Pathways and functions:** * KIF11 is involved in the adaptive immune system, where it is expressed in immune cells such as macrophages and dendritic cells. * It is involved in the Atp binding pathway, which is a signaling pathway that is involved in cell cycle regulation and apoptosis. * KIF11 is also involved in the Golgi-to-er retrograde transport pathway, which is a process by which proteins are transported from the Golgi apparatus to the endoplasmic reticulum. * It is involved in the factors involved in megakaryocyte development and platelet production, and is also involved in the regulation of the immune system. **Clinical significance:** * Mutations in KIF11 have been linked to several human diseases, including cancer and autoimmune disorders. * These diseases are characterized by abnormal cell migration, organelle transport, and immune responses. * Targeting KIF11 has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 593690850

Symbol: KIF11_HUMAN

Name: Kinesin-like protein KIF11

UniProtKB Accession Codes:

P52732 A0AV49 B2RMV3 Q15716 Q5VWX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 7 EMDB 14 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 74 PDBsum 61 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8548803

Title: Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.

PubMed ID: 8548803

DOI: 10.1016/0092-8674(95)90142-6

PubMed ID: 9701554

Title: Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle.

PubMed ID: 9701554

DOI: 10.1242/jcs.111.17.2551

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7776974

Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

PubMed ID: 7776974

DOI: 10.1210/mend.9.2.7776974

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19001501

Title: The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.

PubMed ID: 19001501

DOI: 10.1242/jcs.035360

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21303978

Title: Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the alpha-tubulin tyrosination cycle.

PubMed ID: 21303978

DOI: 10.1158/0008-5472.can-10-2294

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23857769

Title: Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface.

PubMed ID: 23857769

DOI: 10.1083/jcb.201303163

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 37728657

Title: UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.

PubMed ID: 37728657

DOI: 10.1083/jcb.202210093

PubMed ID: 11328809

Title: Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.

PubMed ID: 11328809

DOI: 10.1074/jbc.m100395200

PubMed ID: 17707232

Title: A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.

PubMed ID: 17707232

DOI: 10.1016/j.molcel.2007.07.024

PubMed ID: 22284827

Title: Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.

PubMed ID: 22284827

DOI: 10.1016/j.ajhg.2011.12.018

Sequence Information:

  • Length: 1056
  • Mass: 119159
  • Checksum: C7F2606FE68DA8EA
  • Sequence:
    • MASQPNSSAK KKEEKGKNIQ VVVRCRPFNL AERKASAHSI VECDPVRKEV SVRTGGLADK 
SSRKTYTFDM VFGASTKQID VYRSVVCPIL DEVIMGYNCT IFAYGQTGTG KTFTMEGERS 
PNEEYTWEED PLAGIIPRTL HQIFEKLTDN GTEFSVKVSL LEIYNEELFD LLNPSSDVSE 
RLQMFDDPRN KRGVIIKGLE EITVHNKDEV YQILEKGAAK RTTAATLMNA YSSRSHSVFS 
VTIHMKETTI DGEELVKIGK LNLVDLAGSE NIGRSGAVDK RAREAGNINQ SLLTLGRVIT 
ALVERTPHVP YRESKLTRIL QDSLGGRTRT SIIATISPAS LNLEETLSTL EYAHRAKNIL 
NKPEVNQKLT KKALIKEYTE EIERLKRDLA AAREKNGVYI SEENFRVMSG KLTVQEEQIV 
ELIEKIGAVE EELNRVTELF MDNKNELDQC KSDLQNKTQE LETTQKHLQE TKLQLVKEEY 
ITSALESTEE KLHDAASKLL NTVEETTKDV SGLHSKLDRK KAVDQHNAEA QDIFGKNLNS 
LFNNMEELIK DGSSKQKAML EVHKTLFGNL LSSSVSALDT ITTVALGSLT SIPENVSTHV 
SQIFNMILKE QSLAAESKTV LQELINVLKT DLLSSLEMIL SPTVVSILKI NSQLKHIFKT 
SLTVADKIED QKKELDGFLS ILCNNLHELQ ENTICSLVES QKQCGNLTED LKTIKQTHSQ 
ELCKLMNLWT ERFCALEEKC ENIQKPLSSV QENIQQKSKD IVNKMTFHSQ KFCADSDGFS 
QELRNFNQEG TKLVEESVKH SDKLNGNLEK ISQETEQRCE SLNTRTVYFS EQWVSSLNER 
EQELHNLLEV VSQCCEASSS DITEKSDGRK AAHEKQHNIF LDQMTIDEDK LIAQNLELNE 
TIKIGLTKLN CFLEQDLKLD IPTGTTPQRK SYLYPSTLVR TEPREHLLDQ LKRKQPELLM 
MLNCSENNKE ETIPDVDVEE AVLGQYTEEP LSQEPSVDAG VDCSSIGGVP FFQHKKSHGK 
DKENRGINTL ERSKVEETTE HLVTKSRLPL RAQINL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.