Details for: KPNA3

Gene ID: 3839

Symbol: KPNA3

Ensembl ID: ENSG00000102753

Description: karyopherin subunit alpha 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.23
    Marker Score: 1304
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.93
    Marker Score: 65048
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.79
    Marker Score: 7279
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.74
    Marker Score: 107162.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.72
    Marker Score: 17807
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.67
    Marker Score: 14308
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.65
    Marker Score: 62745.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.63
    Marker Score: 24423.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.63
    Marker Score: 6809.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.62
    Marker Score: 59741
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.61
    Marker Score: 15267
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.6
    Marker Score: 5694
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.58
    Marker Score: 28062
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.57
    Marker Score: 31184
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.56
    Marker Score: 14658
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.55
    Marker Score: 11862
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.54
    Marker Score: 3859
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.53
    Marker Score: 32688.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.53
    Marker Score: 5925
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.53
    Marker Score: 5911
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5
    Marker Score: 439
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.49
    Marker Score: 6171
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.47
    Marker Score: 32876.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2243
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.43
    Marker Score: 6594
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.42
    Marker Score: 1564.5
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.38
    Marker Score: 411
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.35
    Marker Score: 1939
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.34
    Marker Score: 4595
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.32
    Marker Score: 995
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.3
    Marker Score: 546
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.29
    Marker Score: 20748
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.29
    Marker Score: 11221
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.27
    Marker Score: 3040
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.27
    Marker Score: 1528
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.26
    Marker Score: 751
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.25
    Marker Score: 619
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.24
    Marker Score: 5176
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.24
    Marker Score: 1304
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.23
    Marker Score: 2699
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.23
    Marker Score: 2333
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.23
    Marker Score: 1063
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.23
    Marker Score: 1536
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.21
    Marker Score: 3281.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.19
    Marker Score: 1201
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.19
    Marker Score: 805
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.18
    Marker Score: 1362
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.17
    Marker Score: 4895.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.17
    Marker Score: 876
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.17
    Marker Score: 2868.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18131
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.15
    Marker Score: 715
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.14
    Marker Score: 542
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.14
    Marker Score: 421
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.12
    Marker Score: 544
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.11
    Marker Score: 5842
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.11
    Marker Score: 647
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.11
    Marker Score: 1017
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1188.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.1
    Marker Score: 301
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1
    Marker Score: 1242
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.1
    Marker Score: 1414
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.09
    Marker Score: 745
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.09
    Marker Score: 1316
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.09
    Marker Score: 3101
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.09
    Marker Score: 3098
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.07
    Marker Score: 2066.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.07
    Marker Score: 778
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.06
    Marker Score: 1143
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.06
    Marker Score: 383
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.05
    Marker Score: 910
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.04
    Marker Score: 1464
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.04
    Marker Score: 1282
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.02
    Marker Score: 260
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.02
    Marker Score: 5483
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.02
    Marker Score: 243
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.02
    Marker Score: 380
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.01
    Marker Score: 1018
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.01
    Marker Score: 2016
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.01
    Marker Score: 522
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1
    Marker Score: 407
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Marker Score: 1692
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71597.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.99
    Marker Score: 403
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.99
    Marker Score: 1052
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47823
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.99
    Marker Score: 1667.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.99
    Marker Score: 1196
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Marker Score: 824
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.98
    Marker Score: 514
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30372
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.98
    Marker Score: 1382
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.98
    Marker Score: 1381
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.97
    Marker Score: 615
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.97
    Marker Score: 280
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.97
    Marker Score: 2020
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.96
    Marker Score: 1022
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.96
    Marker Score: 361
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.95
    Marker Score: 1017
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.95
    Marker Score: 1375

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Other Information

**Key characteristics:** - Gene name: KPNA3 - Ensembl ID: ENSG00000102753 - Pathway/Ontology: Antiviral mechanism by ifn-stimulated genes, Cytokine signaling in immune system, Disease, Immune system, Infectious disease, Influenza infection, Interferon signaling, Isg15 antiviral mechanism, Nls-bearing protein import into nucleus, Ns1 mediated effects on host pathways, Nuclear import signal receptor activity, Nuclear localization sequence binding, Nuclear pore, Nucleus, Protein-containing complex assembly, Protein binding, Protein import into nucleus, Symbiont entry into host cell, Viral infection pathways, Viral penetration into host nucleus **Pathways and functions:** The KPNA3 gene is significantly expressed in cells of the central nervous system, including the secondary lens fiber, Purkinje cell, neuron, L2/3-6 intratelencephalic projecting glutamatergic neuron, dopaminergic neuron, L6b glutamatergic cortical neuron, vip GABAergic cortical interneuron, lamp5 GABAergic cortical interneuron, and pigmented epithelial cell. **Clinical significance:** Mutations in the KPNA3 gene have been linked to several human diseases, including retinitis pigmentosa, which is an eye disorder characterized by the degeneration of retinal pigment cells. The KPNA3 gene is also involved in the regulation of inflammation and immune responses.

Genular Protein ID: 1090838518

Symbol: IMA4_HUMAN

Name: Importin subunit alpha-4

UniProtKB Accession Codes:

O00505 O00191 O43195 Q5JVM9 Q8IYQ9 Q96AA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9154134

Title: Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1.

PubMed ID: 9154134

DOI: 10.1159/000134521

PubMed ID: 9395085

Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

PubMed ID: 9395085

DOI: 10.1016/s0014-5793(97)01265-9

PubMed ID: 9435235

Title: Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor.

PubMed ID: 9435235

DOI: 10.1073/pnas.95.2.582

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12740372

Title: Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.

PubMed ID: 12740372

DOI: 10.1074/jbc.m303571200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20554775

Title: Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication.

PubMed ID: 20554775

DOI: 10.1128/jvi.00508-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26382858

Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

PubMed ID: 26382858

DOI: 10.1038/ncomms9192

PubMed ID: 34564892

Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.

PubMed ID: 34564892

DOI: 10.1002/ana.26228

PubMed ID: 34981581

Title: A Recurrent KPNA3 Missense Variant Causing Infantile Pure Spastic Paraplegia.

PubMed ID: 34981581

DOI: 10.1002/ana.26297

PubMed ID: 34825409

Title: Heterozygous De Novo KPNA3 Mutations Cause Complex Hereditary Spastic Paraplegia.

PubMed ID: 34825409

DOI: 10.1002/ana.26275

Sequence Information:

  • Length: 521
  • Mass: 57811
  • Checksum: C4FF132C3F346B7F
  • Sequence:
    • MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN VPQEESLEDS 
DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV 
KCLERDDNPS LQFEAAWALT NIASGTSAQT QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA 
LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV 
QEILPALCVL IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV 
QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL SNITAGNQQQ 
VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR KDQVEYLVQQ NVIPPFCNLL 
SVKDSQVVQV VLDGLKNILI MAGDEASTIA EIIEECGGLE KIEVLQQHEN EDIYKLAFEI 
IDQYFSGDDI DEDPCLIPEA TQGGTYNFDP TANLQTKEFN F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.