Details for: KPNA3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 306.5025
Cell Significance Index: -47.6800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 203.0016
Cell Significance Index: -51.4900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 118.5073
Cell Significance Index: -55.9500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 110.5334
Cell Significance Index: -44.9100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 101.3832
Cell Significance Index: -52.1500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 83.3803
Cell Significance Index: -55.9500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 47.1960
Cell Significance Index: -45.0600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 44.2554
Cell Significance Index: -54.5700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.8401
Cell Significance Index: -50.4700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.0774
Cell Significance Index: -55.5500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.8631
Cell Significance Index: -42.5800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.4327
Cell Significance Index: -27.2100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.3044
Cell Significance Index: 27.4700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2046
Cell Significance Index: 442.2400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.9452
Cell Significance Index: 50.0000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.7142
Cell Significance Index: 1547.8400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.5259
Cell Significance Index: 37.2300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.5215
Cell Significance Index: 85.3800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3889
Cell Significance Index: 18.9500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3349
Cell Significance Index: 264.9100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2046
Cell Significance Index: 92.4400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.1946
Cell Significance Index: 75.2900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1277
Cell Significance Index: 122.6600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1165
Cell Significance Index: 400.4700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0631
Cell Significance Index: 172.9000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9555
Cell Significance Index: 57.3700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6774
Cell Significance Index: 18.9300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6362
Cell Significance Index: 439.9900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5862
Cell Significance Index: 36.0300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5236
Cell Significance Index: 35.2100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4752
Cell Significance Index: 85.6600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4210
Cell Significance Index: 51.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3803
Cell Significance Index: 207.6900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3641
Cell Significance Index: 160.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3494
Cell Significance Index: 47.9800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3060
Cell Significance Index: 6.7000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2494
Cell Significance Index: 339.1700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2453
Cell Significance Index: 15.8300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2207
Cell Significance Index: 415.5000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.1903
Cell Significance Index: 5.4300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1895
Cell Significance Index: 8.3800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1501
Cell Significance Index: 2.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1318
Cell Significance Index: 83.7200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1146
Cell Significance Index: 13.5100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1129
Cell Significance Index: 11.1700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1091
Cell Significance Index: 4.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0999
Cell Significance Index: 17.0600 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.0948
Cell Significance Index: 1.5300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0666
Cell Significance Index: 102.4600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0573
Cell Significance Index: 3.9600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0457
Cell Significance Index: 1.2200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0433
Cell Significance Index: 1.5200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0394
Cell Significance Index: 72.6800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0293
Cell Significance Index: 13.3000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0169
Cell Significance Index: 0.2900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0154
Cell Significance Index: 1.0900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0109
Cell Significance Index: 2.0700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0161
Cell Significance Index: -0.4700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0203
Cell Significance Index: -12.6600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0212
Cell Significance Index: -0.4600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0261
Cell Significance Index: -1.3600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0287
Cell Significance Index: -21.2900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0479
Cell Significance Index: -35.1100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0515
Cell Significance Index: -38.9800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0647
Cell Significance Index: -8.2900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0727
Cell Significance Index: -41.0200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0830
Cell Significance Index: -10.7300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0873
Cell Significance Index: -4.0700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0949
Cell Significance Index: -4.3000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1076
Cell Significance Index: -2.5800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1092
Cell Significance Index: -5.1300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1124
Cell Significance Index: -3.0000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1500
Cell Significance Index: -31.5900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1624
Cell Significance Index: -16.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1648
Cell Significance Index: -47.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1915
Cell Significance Index: -27.8300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2076
Cell Significance Index: -3.0700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2256
Cell Significance Index: -7.8400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2583
Cell Significance Index: -13.4200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2714
Cell Significance Index: -5.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2757
Cell Significance Index: -20.5500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2905
Cell Significance Index: -33.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2938
Cell Significance Index: -33.6600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4096
Cell Significance Index: -46.7500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4526
Cell Significance Index: -47.1300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4640
Cell Significance Index: -12.6300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4797
Cell Significance Index: -8.0300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4800
Cell Significance Index: -2.9000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5012
Cell Significance Index: -13.1800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5093
Cell Significance Index: -26.7400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5918
Cell Significance Index: -46.8700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.6125
Cell Significance Index: -8.8100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6738
Cell Significance Index: -13.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6922
Cell Significance Index: -22.1700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.7103
Cell Significance Index: -20.8600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7153
Cell Significance Index: -43.8600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8432
Cell Significance Index: -22.5600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.8690
Cell Significance Index: -18.1900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.9107
Cell Significance Index: -15.3400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9256
Cell Significance Index: -30.3100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1090838518
Symbol: IMA4_HUMAN
Name: Importin subunit alpha-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9154134
Title: Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1.
PubMed ID: 9154134
DOI: 10.1159/000134521
PubMed ID: 9395085
Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.
PubMed ID: 9395085
PubMed ID: 9435235
Title: Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor.
PubMed ID: 9435235
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12740372
Title: Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.
PubMed ID: 12740372
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20554775
Title: Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication.
PubMed ID: 20554775
DOI: 10.1128/jvi.00508-10
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26382858
Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.
PubMed ID: 26382858
DOI: 10.1038/ncomms9192
PubMed ID: 34564892
Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.
PubMed ID: 34564892
DOI: 10.1002/ana.26228
PubMed ID: 34981581
Title: A Recurrent KPNA3 Missense Variant Causing Infantile Pure Spastic Paraplegia.
PubMed ID: 34981581
DOI: 10.1002/ana.26297
PubMed ID: 34825409
Title: Heterozygous De Novo KPNA3 Mutations Cause Complex Hereditary Spastic Paraplegia.
PubMed ID: 34825409
DOI: 10.1002/ana.26275
Sequence Information:
- Length: 521
- Mass: 57811
- Checksum: C4FF132C3F346B7F
- Sequence:
MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN VPQEESLEDS DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV KCLERDDNPS LQFEAAWALT NIASGTSAQT QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV QEILPALCVL IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL SNITAGNQQQ VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR KDQVEYLVQQ NVIPPFCNLL SVKDSQVVQV VLDGLKNILI MAGDEASTIA EIIEECGGLE KIEVLQQHEN EDIYKLAFEI IDQYFSGDDI DEDPCLIPEA TQGGTYNFDP TANLQTKEFN F
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.