Details for: KPNA3

Gene ID: 3839

Symbol: KPNA3

Ensembl ID: ENSG00000102753

Description: karyopherin subunit alpha 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 306.5025
    Cell Significance Index: -47.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.0016
    Cell Significance Index: -51.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.5073
    Cell Significance Index: -55.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 110.5334
    Cell Significance Index: -44.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 101.3832
    Cell Significance Index: -52.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.3803
    Cell Significance Index: -55.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.1960
    Cell Significance Index: -45.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.2554
    Cell Significance Index: -54.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.8401
    Cell Significance Index: -50.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.0774
    Cell Significance Index: -55.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.8631
    Cell Significance Index: -42.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.4327
    Cell Significance Index: -27.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.3044
    Cell Significance Index: 27.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2046
    Cell Significance Index: 442.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.9452
    Cell Significance Index: 50.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7142
    Cell Significance Index: 1547.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5259
    Cell Significance Index: 37.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5215
    Cell Significance Index: 85.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3889
    Cell Significance Index: 18.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3349
    Cell Significance Index: 264.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2046
    Cell Significance Index: 92.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1946
    Cell Significance Index: 75.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1277
    Cell Significance Index: 122.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1165
    Cell Significance Index: 400.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0631
    Cell Significance Index: 172.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9555
    Cell Significance Index: 57.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6774
    Cell Significance Index: 18.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6362
    Cell Significance Index: 439.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5862
    Cell Significance Index: 36.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5236
    Cell Significance Index: 35.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4752
    Cell Significance Index: 85.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4210
    Cell Significance Index: 51.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3803
    Cell Significance Index: 207.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3641
    Cell Significance Index: 160.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3494
    Cell Significance Index: 47.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3060
    Cell Significance Index: 6.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2494
    Cell Significance Index: 339.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2453
    Cell Significance Index: 15.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2207
    Cell Significance Index: 415.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1903
    Cell Significance Index: 5.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1895
    Cell Significance Index: 8.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1501
    Cell Significance Index: 2.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1318
    Cell Significance Index: 83.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1146
    Cell Significance Index: 13.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1129
    Cell Significance Index: 11.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1091
    Cell Significance Index: 4.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0999
    Cell Significance Index: 17.0600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0948
    Cell Significance Index: 1.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0666
    Cell Significance Index: 102.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0573
    Cell Significance Index: 3.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0457
    Cell Significance Index: 1.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0433
    Cell Significance Index: 1.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0394
    Cell Significance Index: 72.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0293
    Cell Significance Index: 13.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0169
    Cell Significance Index: 0.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0154
    Cell Significance Index: 1.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0109
    Cell Significance Index: 2.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0161
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0212
    Cell Significance Index: -0.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0261
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0287
    Cell Significance Index: -21.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0479
    Cell Significance Index: -35.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0515
    Cell Significance Index: -38.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0647
    Cell Significance Index: -8.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0727
    Cell Significance Index: -41.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0830
    Cell Significance Index: -10.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0873
    Cell Significance Index: -4.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0949
    Cell Significance Index: -4.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1076
    Cell Significance Index: -2.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1092
    Cell Significance Index: -5.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1124
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1500
    Cell Significance Index: -31.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1624
    Cell Significance Index: -16.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1648
    Cell Significance Index: -47.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1915
    Cell Significance Index: -27.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2076
    Cell Significance Index: -3.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2256
    Cell Significance Index: -7.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2583
    Cell Significance Index: -13.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2714
    Cell Significance Index: -5.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2757
    Cell Significance Index: -20.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2905
    Cell Significance Index: -33.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2938
    Cell Significance Index: -33.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4096
    Cell Significance Index: -46.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4526
    Cell Significance Index: -47.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4640
    Cell Significance Index: -12.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4797
    Cell Significance Index: -8.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4800
    Cell Significance Index: -2.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5012
    Cell Significance Index: -13.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5093
    Cell Significance Index: -26.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5918
    Cell Significance Index: -46.8700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6125
    Cell Significance Index: -8.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6738
    Cell Significance Index: -13.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6922
    Cell Significance Index: -22.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7103
    Cell Significance Index: -20.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7153
    Cell Significance Index: -43.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8432
    Cell Significance Index: -22.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8690
    Cell Significance Index: -18.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9107
    Cell Significance Index: -15.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9256
    Cell Significance Index: -30.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KPNA3 is a 46-kDa protein that belongs to the importin subunit alpha family. It is composed of three alpha-helical regions and a nuclear localization signal (NLS) that mediates its nuclear localization. KPNA3 is significantly expressed in various cell types, including secondary lens fiber, Purkinje cells, neurons, and pigmented epithelial cells. Its expression is also observed in immune cells, such as L2/3-6 intratelencephalic projecting glutamatergic neurons, dopaminergic neurons, and GABAergic cortical interneurons. **Pathways and Functions:** KPNA3 is involved in various cellular processes, including: 1. **Nuclear Import:** KPNA3 mediates the nuclear import of proteins, including interferon-stimulated genes, which play a crucial role in immune responses. 2. **Antiviral Mechanism:** KPNA3 is involved in the antiviral mechanism of interferon-stimulated genes, which helps to prevent viral infections. 3. **Cytokine Signaling:** KPNA3 regulates cytokine signaling pathways, which are essential for immune responses and inflammation. 4. **Neurological Function:** KPNA3 is involved in the regulation of neuronal function, including the transport of proteins involved in synaptic plasticity and neurotransmission. **Clinical Significance:** KPNA3 has been implicated in various immune-related disorders and neurological diseases, including: 1. **Infectious Diseases:** KPNA3 plays a crucial role in the antiviral mechanism of interferon-stimulated genes, which helps to prevent viral infections. 2. **Neurological Disorders:** KPNA3 is involved in the regulation of neuronal function, which is disrupted in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Autoimmune Diseases:** KPNA3 is involved in cytokine signaling pathways, which are dysregulated in autoimmune diseases such as rheumatoid arthritis and lupus. In conclusion, KPNA3 is a crucial gene that plays a significant role in regulating immune responses and neurological functions. Its dysregulation has been implicated in various immune-related disorders and neurological diseases, highlighting the importance of further research into the mechanisms of KPNA3 and its potential therapeutic applications.

Genular Protein ID: 1090838518

Symbol: IMA4_HUMAN

Name: Importin subunit alpha-4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9154134

Title: Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1.

PubMed ID: 9154134

DOI: 10.1159/000134521

PubMed ID: 9395085

Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

PubMed ID: 9395085

DOI: 10.1016/s0014-5793(97)01265-9

PubMed ID: 9435235

Title: Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor.

PubMed ID: 9435235

DOI: 10.1073/pnas.95.2.582

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12740372

Title: Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.

PubMed ID: 12740372

DOI: 10.1074/jbc.m303571200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20554775

Title: Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication.

PubMed ID: 20554775

DOI: 10.1128/jvi.00508-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26382858

Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

PubMed ID: 26382858

DOI: 10.1038/ncomms9192

PubMed ID: 34564892

Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.

PubMed ID: 34564892

DOI: 10.1002/ana.26228

PubMed ID: 34981581

Title: A Recurrent KPNA3 Missense Variant Causing Infantile Pure Spastic Paraplegia.

PubMed ID: 34981581

DOI: 10.1002/ana.26297

PubMed ID: 34825409

Title: Heterozygous De Novo KPNA3 Mutations Cause Complex Hereditary Spastic Paraplegia.

PubMed ID: 34825409

DOI: 10.1002/ana.26275

Sequence Information:

  • Length: 521
  • Mass: 57811
  • Checksum: C4FF132C3F346B7F
  • Sequence:
  • MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN VPQEESLEDS 
    DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV 
    KCLERDDNPS LQFEAAWALT NIASGTSAQT QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA 
    LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV 
    QEILPALCVL IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV 
    QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL SNITAGNQQQ 
    VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR KDQVEYLVQQ NVIPPFCNLL 
    SVKDSQVVQV VLDGLKNILI MAGDEASTIA EIIEECGGLE KIEVLQQHEN EDIYKLAFEI 
    IDQYFSGDDI DEDPCLIPEA TQGGTYNFDP TANLQTKEFN F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.