Details for: KRT19

Gene ID: 3880

Symbol: KRT19

Ensembl ID: ENSG00000171345

Description: keratin 19

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.94
    Marker Score: 66324.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.64
    Marker Score: 5592
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.56
    Marker Score: 29090
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.3
    Marker Score: 31996
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.07
    Marker Score: 7422
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.95
    Marker Score: 12396
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.92
    Marker Score: 9896
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.81
    Marker Score: 1222
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.74
    Marker Score: 3234
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.68
    Marker Score: 2460
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.67
    Marker Score: 17610
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.66
    Marker Score: 2540
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.47
    Marker Score: 3330.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.42
    Marker Score: 2698
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.38
    Marker Score: 2301
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.34
    Marker Score: 1150
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.32
    Marker Score: 115049
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.3
    Marker Score: 7486
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.21
    Marker Score: 5270
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2
    Marker Score: 12331
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.19
    Marker Score: 3362
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.18
    Marker Score: 16734
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.15
    Marker Score: 1554
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 3.03
    Marker Score: 960
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.01
    Marker Score: 26113
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.97
    Marker Score: 7260
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.92
    Marker Score: 4132
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.82
    Marker Score: 4994
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.81
    Marker Score: 4463
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.8
    Marker Score: 3271
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.79
    Marker Score: 7584
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.72
    Marker Score: 4012
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.71
    Marker Score: 4183
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.67
    Marker Score: 995
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.63
    Marker Score: 934
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.59
    Marker Score: 625
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.56
    Marker Score: 741
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.51
    Marker Score: 16375
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.51
    Marker Score: 10469.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.46
    Marker Score: 710
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.44
    Marker Score: 493
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.39
    Marker Score: 1230
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.39
    Marker Score: 2116
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.38
    Marker Score: 8810
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.37
    Marker Score: 5638
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.37
    Marker Score: 682
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.34
    Marker Score: 1093
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.33
    Marker Score: 1283
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.31
    Marker Score: 19905
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.27
    Marker Score: 7793
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.25
    Marker Score: 3621
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8844
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.19
    Marker Score: 35189
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.19
    Marker Score: 600
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.18
    Marker Score: 979
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.18
    Marker Score: 4144
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.09
    Marker Score: 2124
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.07
    Marker Score: 778.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.02
    Marker Score: 502
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.02
    Marker Score: 2010
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.96
    Marker Score: 385
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.88
    Marker Score: 2420.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.86
    Marker Score: 1241
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.84
    Marker Score: 1915
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.74
    Marker Score: 1553.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.7
    Marker Score: 712
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.66
    Marker Score: 389
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.66
    Marker Score: 964
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.64
    Marker Score: 659
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.61
    Marker Score: 409
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.59
    Marker Score: 753
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.55
    Marker Score: 17436
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.53
    Marker Score: 936
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.5
    Marker Score: 778
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.48
    Marker Score: 3084
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.46
    Marker Score: 354
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.43
    Marker Score: 11174.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.39
    Marker Score: 1181
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3129
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.37
    Marker Score: 955
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.37
    Marker Score: 612
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.35
    Marker Score: 1531
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 849
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 1.33
    Marker Score: 346
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.32
    Marker Score: 725
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.31
    Marker Score: 691
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.3
    Marker Score: 354
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.27
    Marker Score: 366
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.27
    Marker Score: 894
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.26
    Marker Score: 275
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.25
    Marker Score: 309
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.21
    Marker Score: 2335
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.21
    Marker Score: 929
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.18
    Marker Score: 430
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.18
    Marker Score: 1277
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.16
    Marker Score: 306
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.11
    Marker Score: 3935.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.08
    Marker Score: 1786
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.07
    Marker Score: 1140
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.07
    Marker Score: 673

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Other Information

**Key characteristics:** * KRT19 is a keratin protein, which are a family of cytoskeletal proteins that are involved in the structural integrity and organization of cell membranes. * It is a transmembrane protein, meaning it spans the cell membrane. * It is a highly conserved protein, with a similar sequence in humans, mice, and rats. * It is expressed in a variety of cell types, including skin cells, epithelial cells, and immune cells. **Pathways and functions:** * KRT19 is involved in a variety of cellular processes, including cell differentiation, migration, and adhesion. * It is a key component of the skin barrier, helping to protect the body from environmental damage. * It is also involved in the formation of the cornified envelope, a protective layer that surrounds the skin. * It is also involved in the regulation of cell migration and adhesion, and in the maintenance of tissue integrity. **Clinical significance:** * Mutations in KRT19 have been linked to a number of skin disorders, including psoriasis and skin cancer. * These disorders are characterized by abnormal skin growth and differentiation. * Targeting KRT19 has been investigated as a potential therapeutic strategy for these diseases. **Other important facts:** * KRT19 is a highly abundant protein in the skin, with an estimated density of 15-20% of the total protein content. * It is a single-pass protein, meaning it has one extracellular domain that is responsible for its interaction with other proteins. * It is a key regulator of cell differentiation and migration. * It is a target for a variety of skin disorders.

Genular Protein ID: 2777561689

Symbol: K1C19_HUMAN

Name: Keratin, type I cytoskeletal 19

UniProtKB Accession Codes:

P08727 B2R874 Q5XG83 Q6NW33 Q7L5M9 Q96A53 Q96FV1 Q9BYF9 Q9P1Y4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2447559

Title: Sequence of cDNA coding for human keratin 19.

PubMed ID: 2447559

DOI: 10.1093/nar/15.23.10058

PubMed ID: 2468493

Title: Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene.

PubMed ID: 2468493

PubMed ID: 2448790

Title: Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin.

PubMed ID: 2448790

DOI: 10.1073/pnas.85.4.1114

PubMed ID: 2469734

Title: Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins.

PubMed ID: 2469734

DOI: 10.1111/1523-1747.ep12721500

PubMed ID: 10623642

Title: Genomic organization and amplification of the human keratin 15 and 19 genes.

PubMed ID: 10623642

DOI: 10.1006/bbrc.1999.1966

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11682035

Title: Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line.

PubMed ID: 11682035

DOI: 10.1016/s0168-8278(01)00167-2

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 10212274

Title: Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization.

PubMed ID: 10212274

DOI: 10.1074/jbc.274.18.12861

PubMed ID: 10809736

Title: Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.

PubMed ID: 10809736

DOI: 10.1074/jbc.275.20.14910

PubMed ID: 15846844

Title: Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.

PubMed ID: 15846844

DOI: 10.1002/pmic.200401093

PubMed ID: 16000376

Title: Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

PubMed ID: 16000376

DOI: 10.1091/mbc.e05-02-0112

PubMed ID: 21049038

Title: Characterization of in vivo keratin 19 phosphorylation on tyrosine-391.

PubMed ID: 21049038

DOI: 10.1371/journal.pone.0013538

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 400
  • Mass: 44106
  • Checksum: C559BBBACCE32DCB
  • Sequence:
    • MTSYSYRQSS ATSSFGGLGG GSVRFGPGVA FRAPSIHGGS GGRGVSVSSA RFVSSSSSGA 
YGGGYGGVLT ASDGLLAGNE KLTMQNLNDR LASYLDKVRA LEAANGELEV KIRDWYQKQG 
PGPSRDYSHY YTTIQDLRDK ILGATIENSR IVLQIDNARL AADDFRTKFE TEQALRMSVE 
ADINGLRRVL DELTLARTDL EMQIEGLKEE LAYLKKNHEE EISTLRGQVG GQVSVEVDSA 
PGTDLAKILS DMRSQYEVMA EQNRKDAEAW FTSRTEELNR EVAGHTEQLQ MSRSEVTDLR 
RTLQGLEIEL QSQLSMKAAL EDTLAETEAR FGAQLAHIQA LISGIEAQLG DVRADSERQN 
QEYQRLMDIK SRLEQEIATY RSLLEGQEDH YNNLSASKVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.