Details for: KRT19

Gene ID: 3880

Symbol: KRT19

Ensembl ID: ENSG00000171345

Description: keratin 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 142.4938
    Cell Significance Index: -58.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.5824
    Cell Significance Index: -65.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.4657
    Cell Significance Index: -45.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 97.3887
    Cell Significance Index: -65.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.3531
    Cell Significance Index: -45.2100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 34.9861
    Cell Significance Index: 265.3000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 25.9703
    Cell Significance Index: 18.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 23.7651
    Cell Significance Index: 146.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.3901
    Cell Significance Index: -59.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.9161
    Cell Significance Index: -58.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 11.9702
    Cell Significance Index: 110.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 10.7781
    Cell Significance Index: 293.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.3093
    Cell Significance Index: 238.1800
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 9.4591
    Cell Significance Index: 52.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.7971
    Cell Significance Index: 1585.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.5023
    Cell Significance Index: 1045.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.2616
    Cell Significance Index: 615.7300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 7.5408
    Cell Significance Index: 36.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 7.1800
    Cell Significance Index: 372.9800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 6.1008
    Cell Significance Index: 37.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.0071
    Cell Significance Index: 776.0800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 5.8727
    Cell Significance Index: 36.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.8297
    Cell Significance Index: 3183.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.6160
    Cell Significance Index: 84.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.2800
    Cell Significance Index: 248.1600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 4.7602
    Cell Significance Index: 29.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.8867
    Cell Significance Index: 176.1700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.1800
    Cell Significance Index: 36.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.9590
    Cell Significance Index: 79.0100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.7652
    Cell Significance Index: 16.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.6147
    Cell Significance Index: 2360.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2983
    Cell Significance Index: 18.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0879
    Cell Significance Index: 58.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0786
    Cell Significance Index: 226.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4312
    Cell Significance Index: 196.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9261
    Cell Significance Index: 183.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7773
    Cell Significance Index: 36.2400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5840
    Cell Significance Index: 4.8300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.5456
    Cell Significance Index: 4.5100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4983
    Cell Significance Index: 5.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4885
    Cell Significance Index: 215.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4580
    Cell Significance Index: 16.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4521
    Cell Significance Index: 13.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4330
    Cell Significance Index: 42.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4061
    Cell Significance Index: 307.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3405
    Cell Significance Index: 10.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2338
    Cell Significance Index: 3.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2305
    Cell Significance Index: 43.8700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1638
    Cell Significance Index: 2.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0780
    Cell Significance Index: 5.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0583
    Cell Significance Index: 9.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0210
    Cell Significance Index: 32.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0338
    Cell Significance Index: -63.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0463
    Cell Significance Index: -34.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0476
    Cell Significance Index: -29.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0601
    Cell Significance Index: -44.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0607
    Cell Significance Index: -82.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0871
    Cell Significance Index: -55.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0940
    Cell Significance Index: -53.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1075
    Cell Significance Index: -2.3300
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1195
    Cell Significance Index: -0.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1438
    Cell Significance Index: -65.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1479
    Cell Significance Index: -16.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1640
    Cell Significance Index: -8.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1813
    Cell Significance Index: -65.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1864
    Cell Significance Index: -23.9000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2105
    Cell Significance Index: -4.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2178
    Cell Significance Index: -45.8700
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.2251
    Cell Significance Index: -1.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2291
    Cell Significance Index: -65.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2446
    Cell Significance Index: -28.5000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2466
    Cell Significance Index: -1.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3163
    Cell Significance Index: -10.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3276
    Cell Significance Index: -8.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3594
    Cell Significance Index: -72.0900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.3669
    Cell Significance Index: -0.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3790
    Cell Significance Index: -55.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3794
    Cell Significance Index: -38.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4037
    Cell Significance Index: -16.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4093
    Cell Significance Index: -46.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4254
    Cell Significance Index: -21.5000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.4307
    Cell Significance Index: -3.1300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.4994
    Cell Significance Index: -7.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5651
    Cell Significance Index: -66.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5740
    Cell Significance Index: -6.0600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.5762
    Cell Significance Index: -5.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5994
    Cell Significance Index: -36.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6605
    Cell Significance Index: -16.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6725
    Cell Significance Index: -70.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6892
    Cell Significance Index: -7.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7016
    Cell Significance Index: -55.5700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.7139
    Cell Significance Index: -5.6800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.7603
    Cell Significance Index: -7.6700
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.7939
    Cell Significance Index: -6.8300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.8044
    Cell Significance Index: -7.1400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.8478
    Cell Significance Index: -5.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.9758
    Cell Significance Index: -69.0100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -1.0000
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0005
    Cell Significance Index: -67.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Keratin 19 is a type I keratin, which is primarily expressed in epithelial tissues, including those of the skin, respiratory, and gastrointestinal tracts. Its unique structural properties, such as a short cytoplasmic tail and a long tail domain, enable it to form heterodimers with other keratins, thereby contributing to the stability and elasticity of the cytoskeleton. Furthermore, KRT19 has been shown to interact with various cellular proteins, including Notch receptors, estrogen receptors, and cytoskeletal proteins, thereby modulating its cellular functions. **Pathways and Functions:** KRT19 is involved in multiple signaling pathways, including Notch signaling, which plays a crucial role in cell differentiation, proliferation, and survival. Additionally, KRT19 has been implicated in the response to estrogen, influencing cell growth, differentiation, and maintenance of epithelial homeostasis. The protein's association with cytoskeletal proteins, such as vimentin and desmin, underscores its role in maintaining cellular structure and organization. Furthermore, KRT19 has been shown to regulate the formation of the cornified envelope, a critical component of the skin's barrier function. **Clinical Significance:** KRT19's involvement in various diseases highlights its importance in human health and disease. Mutations in the KRT19 gene have been associated with several conditions, including epidermolysis bullosa simplex, a genetic disorder characterized by skin blistering and fragility. Additionally, KRT19 has been implicated in the pathogenesis of various cancers, including breast, lung, and colon cancer, where its dysregulation can contribute to tumorigenesis. In the context of respiratory diseases, KRT19 has been shown to play a role in the development of pulmonary fibrosis, a condition characterized by scarring and inflammation of lung tissue. In conclusion, Keratin 19 is a multifaceted protein that plays a critical role in maintaining cellular integrity, differentiation, and function. Its involvement in various signaling pathways, including Notch signaling and estrogen response, underscores its importance in regulating cellular behavior. As a significantly expressed protein in epithelial tissues, KRT19's dysregulation can contribute to various diseases, including cancer and respiratory disorders. Further research into the immunological significance of KRT19 is warranted, with potential applications in the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2777561689

Symbol: K1C19_HUMAN

Name: Keratin, type I cytoskeletal 19

UniProtKB Accession Codes:

P08727 B2R874 Q5XG83 Q6NW33 Q7L5M9 Q96A53 Q96FV1 Q9BYF9 Q9P1Y4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2447559

Title: Sequence of cDNA coding for human keratin 19.

PubMed ID: 2447559

DOI: 10.1093/nar/15.23.10058

PubMed ID: 2468493

Title: Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene.

PubMed ID: 2468493

PubMed ID: 2448790

Title: Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin.

PubMed ID: 2448790

DOI: 10.1073/pnas.85.4.1114

PubMed ID: 2469734

Title: Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins.

PubMed ID: 2469734

DOI: 10.1111/1523-1747.ep12721500

PubMed ID: 10623642

Title: Genomic organization and amplification of the human keratin 15 and 19 genes.

PubMed ID: 10623642

DOI: 10.1006/bbrc.1999.1966

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11682035

Title: Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line.

PubMed ID: 11682035

DOI: 10.1016/s0168-8278(01)00167-2

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 10212274

Title: Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization.

PubMed ID: 10212274

DOI: 10.1074/jbc.274.18.12861

PubMed ID: 10809736

Title: Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.

PubMed ID: 10809736

DOI: 10.1074/jbc.275.20.14910

PubMed ID: 15846844

Title: Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.

PubMed ID: 15846844

DOI: 10.1002/pmic.200401093

PubMed ID: 16000376

Title: Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

PubMed ID: 16000376

DOI: 10.1091/mbc.e05-02-0112

PubMed ID: 21049038

Title: Characterization of in vivo keratin 19 phosphorylation on tyrosine-391.

PubMed ID: 21049038

DOI: 10.1371/journal.pone.0013538

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 400
  • Mass: 44106
  • Checksum: C559BBBACCE32DCB
  • Sequence:
    • MTSYSYRQSS ATSSFGGLGG GSVRFGPGVA FRAPSIHGGS GGRGVSVSSA RFVSSSSSGA 
YGGGYGGVLT ASDGLLAGNE KLTMQNLNDR LASYLDKVRA LEAANGELEV KIRDWYQKQG 
PGPSRDYSHY YTTIQDLRDK ILGATIENSR IVLQIDNARL AADDFRTKFE TEQALRMSVE 
ADINGLRRVL DELTLARTDL EMQIEGLKEE LAYLKKNHEE EISTLRGQVG GQVSVEVDSA 
PGTDLAKILS DMRSQYEVMA EQNRKDAEAW FTSRTEELNR EVAGHTEQLQ MSRSEVTDLR 
RTLQGLEIEL QSQLSMKAAL EDTLAETEAR FGAQLAHIQA LISGIEAQLG DVRADSERQN 
QEYQRLMDIK SRLEQEIATY RSLLEGQEDH YNNLSASKVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.