Details for: OR6C75

Gene ID: 390323

Symbol: OR6C75

Ensembl ID: ENSG00000187857

Description: olfactory receptor family 6 subfamily C member 75

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.3357
    Cell Significance Index: 3.2000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2198
    Cell Significance Index: 2.8400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1379
    Cell Significance Index: 1.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1030
    Cell Significance Index: 1.7600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0824
    Cell Significance Index: 0.9700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0642
    Cell Significance Index: 0.3500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0621
    Cell Significance Index: 0.5900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0618
    Cell Significance Index: 0.9800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0537
    Cell Significance Index: 0.5500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0516
    Cell Significance Index: 0.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0343
    Cell Significance Index: 1.7800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0328
    Cell Significance Index: 0.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0279
    Cell Significance Index: 1.3000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0227
    Cell Significance Index: 0.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0186
    Cell Significance Index: 0.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0165
    Cell Significance Index: 0.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0138
    Cell Significance Index: 0.2000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0129
    Cell Significance Index: 0.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0099
    Cell Significance Index: 0.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0065
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0052
    Cell Significance Index: 0.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0051
    Cell Significance Index: 0.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0050
    Cell Significance Index: 0.2300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0028
    Cell Significance Index: 0.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0028
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0002
    Cell Significance Index: 0.0200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -1.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0022
    Cell Significance Index: -0.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0025
    Cell Significance Index: -0.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0028
    Cell Significance Index: -1.2800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0048
    Cell Significance Index: -0.1300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0050
    Cell Significance Index: -0.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0067
    Cell Significance Index: -1.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0079
    Cell Significance Index: -1.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0082
    Cell Significance Index: -0.2000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0097
    Cell Significance Index: -1.2000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0110
    Cell Significance Index: -0.1500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0113
    Cell Significance Index: -0.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0121
    Cell Significance Index: -0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0127
    Cell Significance Index: -0.5500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0136
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0151
    Cell Significance Index: -0.2800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0153
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0154
    Cell Significance Index: -0.1900
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0155
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0159
    Cell Significance Index: -0.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0171
    Cell Significance Index: -1.1000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0180
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0183
    Cell Significance Index: -0.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0189
    Cell Significance Index: -0.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0190
    Cell Significance Index: -0.6100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0207
    Cell Significance Index: -1.1600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0209
    Cell Significance Index: -0.1500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0214
    Cell Significance Index: -0.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0238
    Cell Significance Index: -1.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0244
    Cell Significance Index: -0.5100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0250
    Cell Significance Index: -0.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0251
    Cell Significance Index: -1.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0255
    Cell Significance Index: -0.5900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0257
    Cell Significance Index: -0.2800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0259
    Cell Significance Index: -0.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0260
    Cell Significance Index: -0.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0261
    Cell Significance Index: -0.6700
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0269
    Cell Significance Index: -0.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0290
    Cell Significance Index: -1.1000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0297
    Cell Significance Index: -0.3400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0304
    Cell Significance Index: -0.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0310
    Cell Significance Index: -0.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0314
    Cell Significance Index: -0.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0316
    Cell Significance Index: -1.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0316
    Cell Significance Index: -0.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0321
    Cell Significance Index: -0.8000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0345
    Cell Significance Index: -0.7200
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0352
    Cell Significance Index: -0.2100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0356
    Cell Significance Index: -0.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0362
    Cell Significance Index: -0.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0384
    Cell Significance Index: -0.8300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0390
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Family**: OR6C75 belongs to the olfactory receptor family 6 subfamily C, which comprises a group of G protein-coupled receptors responsible for detecting odorant molecules. 2. **Significant Expression**: OR6C75 is expressed in various cell types, including B cells, enterocytes, goblet cells, and intestinal crypt stem cells, indicating its widespread role in sensory perception and immune regulation. 3. **G Protein-Coupled Receptor Activity**: OR6C75 is a G protein-coupled receptor, which allows it to respond to ligand binding and trigger downstream signaling pathways. 4. **Olfactory Signaling Pathway**: OR6C75 mediates olfactory signaling pathways, influencing our ability to perceive odors and detect chemical stimuli. **Pathways and Functions:** 1. **Detection of Chemical Stimuli**: OR6C75 detects odorant molecules, which bind to the receptor and trigger a signaling cascade that ultimately leads to the perception of smell. 2. **Expression and Translocation of Olfactory Receptors**: OR6C75 plays a crucial role in the expression and translocation of olfactory receptors to the plasma membrane, allowing for efficient detection of odorant molecules. 3. **G Protein-Coupled Receptor Signaling Pathway**: OR6C75 activates the G protein-coupled receptor signaling pathway, which involves the activation of G proteins, adenylate cyclase, and the production of secondary messengers. 4. **Olfactory Signaling Pathway**: OR6C75 mediates the olfactory signaling pathway, which involves the activation of olfactory receptors, the production of secondary messengers, and the subsequent perception of smell. **Clinical Significance:** 1. **Olfactory Disorders**: OR6C75 mutations or alterations in expression have been implicated in olfactory disorders, such as anosmia and hyposmia, which affect our ability to perceive odors. 2. **Immune Regulation**: OR6C75 expression in immune cells suggests a potential link between olfaction and immune regulation, with implications for the development of novel therapeutic strategies for immune-related disorders. 3. **Gastrointestinal Disease**: OR6C75 expression in enterocytes and goblet cells suggests a potential role in gastrointestinal disease, such as inflammatory bowel disease, where olfactory perception may be impaired. 4. **Cancer Research**: OR6C75 expression in intestinal crypt stem cells and transit amplifying cells suggests a potential role in cancer research, particularly in the development of novel diagnostic and therapeutic strategies for gastrointestinal cancer. In conclusion, OR6C75 is a critical gene involved in the detection of chemical stimuli involved in sensory perception of smell and immune regulation. Its expression in various cell types and its role in olfactory signaling pathways make it an important target for research into olfactory disorders, immune regulation, and gastrointestinal disease.

Genular Protein ID: 2224744379

Symbol: O6C75_HUMAN

Name: Olfactory receptor 6C75

UniProtKB Accession Codes:

A6NL08

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 312
  • Mass: 35372
  • Checksum: 1A35D8585787F56B
  • Sequence:
    • MRNSTAVTDF ILLGLTSDPQ WQVVLFIFLL VTYMLSVTGN LIIITLTLSD PHLQTPMYFF 
LRNFSFLEIS FTSVCIPRFL VTVVTGNRTI SYNGCVAQLF FFIFLGVTEF YLLAAMSYDR 
CMAICKPLHY TIIMSTRVCT LLVFSSWLAG FLIIFPPVML LLQLDFCASN VIDHFICDSS 
PMLQLSCTNT HFLELMAFFL AVVTLMVTLT LVILSYTNII RTILKIPSMS QRKKAFSTCS 
SHMIVVSISY SSCIFMYIKT SARERVTLSK GVAVLNTSVA PLLNPFIYTL RNKQVKQAFK 
SMVQKMIFSL NK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.