Details for: LAMB2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 190.0412
Cell Significance Index: -29.5600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 114.6294
Cell Significance Index: -29.0800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 59.2007
Cell Significance Index: -27.9500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 58.4851
Cell Significance Index: -23.7600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 24.7763
Cell Significance Index: -23.6600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.9911
Cell Significance Index: -29.5800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.9321
Cell Significance Index: -17.3600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.4784
Cell Significance Index: -29.5100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.4977
Cell Significance Index: 130.1000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.2245
Cell Significance Index: 30.3500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.7806
Cell Significance Index: 338.8600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.7158
Cell Significance Index: 45.9800 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.2348
Cell Significance Index: 19.5900 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.0894
Cell Significance Index: 139.6500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.9947
Cell Significance Index: 11.3000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9851
Cell Significance Index: 889.4500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.9264
Cell Significance Index: 18.0800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8781
Cell Significance Index: 25.1700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7498
Cell Significance Index: 409.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6712
Cell Significance Index: 92.1700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5442
Cell Significance Index: 14.3100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4858
Cell Significance Index: 36.2100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4563
Cell Significance Index: 49.6400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4549
Cell Significance Index: 20.6200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4463
Cell Significance Index: 72.5900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4136
Cell Significance Index: 8.9600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3997
Cell Significance Index: 49.1500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3894
Cell Significance Index: 10.6000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3447
Cell Significance Index: 68.4000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3142
Cell Significance Index: 14.6500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3101
Cell Significance Index: 8.9400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3051
Cell Significance Index: 23.4100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2913
Cell Significance Index: 8.1400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2819
Cell Significance Index: 3.6100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2394
Cell Significance Index: 43.1600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2393
Cell Significance Index: 14.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2142
Cell Significance Index: 21.1900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1439
Cell Significance Index: 6.7700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1357
Cell Significance Index: 0.8200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1333
Cell Significance Index: 58.9400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1242
Cell Significance Index: 6.2800 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0947
Cell Significance Index: 12.2400 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.0364
Cell Significance Index: 0.2300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0200
Cell Significance Index: 0.3400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0144
Cell Significance Index: 0.3600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0095
Cell Significance Index: 0.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0087
Cell Significance Index: 16.4700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0003
Cell Significance Index: 0.6500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0006
Cell Significance Index: -0.0200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0027
Cell Significance Index: -4.1100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0074
Cell Significance Index: -4.6800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0108
Cell Significance Index: -7.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0113
Cell Significance Index: -8.5800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0150
Cell Significance Index: -20.4400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0196
Cell Significance Index: -8.8900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0287
Cell Significance Index: -2.9300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0408
Cell Significance Index: -30.2300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0507
Cell Significance Index: -28.6000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0667
Cell Significance Index: -11.3900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0749
Cell Significance Index: -26.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0905
Cell Significance Index: -26.0400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0982
Cell Significance Index: -1.4500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0999
Cell Significance Index: -2.1400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1088
Cell Significance Index: -15.8200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1179
Cell Significance Index: -13.5100 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1195
Cell Significance Index: -2.7600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1239
Cell Significance Index: -14.4400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1309
Cell Significance Index: -9.2600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1368
Cell Significance Index: -27.4400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1480
Cell Significance Index: -2.6200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1499
Cell Significance Index: -31.5800 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.1609
Cell Significance Index: -1.6800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2279
Cell Significance Index: -12.7900 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2310
Cell Significance Index: -3.2400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2323
Cell Significance Index: -5.9700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2421
Cell Significance Index: -28.5500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2544
Cell Significance Index: -26.4900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2662
Cell Significance Index: -5.6700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2907
Cell Significance Index: -15.1000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3061
Cell Significance Index: -6.3500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3168
Cell Significance Index: -25.0900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.3195
Cell Significance Index: -2.1700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3474
Cell Significance Index: -21.3000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3594
Cell Significance Index: -11.5100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3860
Cell Significance Index: -15.8100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3993
Cell Significance Index: -10.6600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4249
Cell Significance Index: -27.4100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4278
Cell Significance Index: -26.9600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4337
Cell Significance Index: -29.1600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4484
Cell Significance Index: -27.5600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4581
Cell Significance Index: -15.9200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.4675
Cell Significance Index: -4.8400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.4923
Cell Significance Index: -3.0300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5872
Cell Significance Index: -30.8300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5872
Cell Significance Index: -12.2900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6202
Cell Significance Index: -27.4400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.6390
Cell Significance Index: -9.6300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.6648
Cell Significance Index: -16.2200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6773
Cell Significance Index: -19.9500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6833
Cell Significance Index: -25.0900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 172199374
Symbol: LAMB2_HUMAN
Name: Laminin subunit beta-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7698745
Title: Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas.
PubMed ID: 7698745
PubMed ID: 7795887
Title: The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene.
PubMed ID: 7795887
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 15367484
Title: Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.
PubMed ID: 15367484
DOI: 10.1093/hmg/ddh284
PubMed ID: 16912710
Title: Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders.
PubMed ID: 16912710
PubMed ID: 20798252
Title: Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome.
PubMed ID: 20798252
DOI: 10.2215/cjn.01190210
PubMed ID: 21236492
Title: A novel mutation of LAMB2 in a multigenerational mennonite family reveals a new phenotypic variant of Pierson syndrome.
PubMed ID: 21236492
PubMed ID: 23595123
Title: A molecular genetic analysis of childhood nephrotic syndrome in a cohort of Saudi Arabian families.
PubMed ID: 23595123
DOI: 10.1038/jhg.2013.27
Sequence Information:
- Length: 1798
- Mass: 195981
- Checksum: FFB3531AD13E1486
- Sequence:
MELTSRERGR GQPLPWELRL GLLLSVLAAT LAQAPAPDVP GCSRGSCYPA TGDLLVGRAD RLTASSTCGL NGPQPYCIVS HLQDEKKCFL CDSRRPFSAR DNPHSHRIQN VVTSFAPQRR AAWWQSENGI PAVTIQLDLE AEFHFTHLIM TFKTFRPAAM LVERSADFGR TWHVYRYFSY DCGADFPGVP LAPPRHWDDV VCESRYSEIE PSTEGEVIYR VLDPAIPIPD PYSSRIQNLL KITNLRVNLT RLHTLGDNLL DPRREIREKY YYALYELVVR GNCFCYGHAS ECAPAPGAPA HAEGMVHGAC ICKHNTRGLN CEQCQDFYRD LPWRPAEDGH SHACRKCECH GHTHSCHFDM AVYLASGNVS GGVCDGCQHN TAGRHCELCR PFFYRDPTKD LRDPAVCRSC DCDPMGSQDG GRCDSHDDPA LGLVSGQCRC KEHVVGTRCQ QCRDGFFGLS ISDRLGCRRC QCNARGTVPG STPCDPNSGS CYCKRLVTGR GCDRCLPGHW GLSHDLLGCR PCDCDVGGAL DPQCDEGTGQ CHCRQHMVGR RCEQVQPGYF RPFLDHLIWE AEDTRGQVLD VVERLVTPGE TPSWTGSGFV RLQEGQTLEF LVASVPKAMD YDLLLRLEPQ VPEQWAELEL IVQRPGPVPA HSLCGHLVPK DDRIQGTLQP HARYLIFPNP VCLEPGISYK LHLKLVRTGG SAQPETPYSG PGLLIDSLVL LPRVLVLEMF SGGDAAALER QATFERYQCH EEGLVPSKTS PSEACAPLLI SLSTLIYNGA LPCQCNPQGS LSSECNPHGG QCLCKPGVVG RRCDLCAPGY YGFGPTGCQA CQCSHEGALS SLCEKTSGQC LCRTGAFGLR CDRCQRGQWG FPSCRPCVCN GHADECNTHT GACLGCRDHT GGEHCERCIA GFHGDPRLPY GGQCRPCPCP EGPGSQRHFA TSCHQDEYSQ QIVCHCRAGY TGLRCEACAP GHFGDPSRPG GRCQLCECSG NIDPMDPDAC DPHTGQCLRC LHHTEGPHCA HCKPGFHGQA ARQSCHRCTC NLLGTNPQQC PSPDQCHCDP SSGQCPCLPN VQGPSCDRCA PNFWNLTSGH GCQPCACHPS RARGPTCNEF TGQCHCRAGF GGRTCSECQE LHWGDPGLQC HACDCDSRGI DTPQCHRFTG HCSCRPGVSG VRCDQCARGF SGIFPACHPC HACFGDWDRV VQDLAARTQR LEQRAQELQQ TGVLGAFESS FWHMQEKLGI VQGIVGARNT SAASTAQLVE ATEELRREIG EATEHLTQLE ADLTDVQDEN FNANHALSGL ERDRLALNLT LRQLDQHLDL LKHSNFLGAY DSIRHAHSQS AEAERRANTS ALAVPSPVSN SASARHRTEA LMDAQKEDFN SKHMANQRAL GKLSAHTHTL SLTDINELVC GAPGDAPCAT SPCGGAGCRD EDGQPRCGGL SCNGAAATAD LALGRARHTQ AELQRALAEG GSILSRVAET RRQASEAQQR AQAALDKANA SRGQVEQANQ ELQELIQSVK DFLNQEGADP DSIEMVATRV LELSIPASAE QIQHLAGAIA ERVRSLADVD AILARTVGDV RRAEQLLQDA RRARSWAEDE KQKAETVQAA LEEAQRAQGI AQGAIRGAVA DTRDTEQTLY QVQERMAGAE RALSSAGERA RQLDALLEAL KLKRAGNSLA ASTAEETAGS AQGRAQEAEQ LLRGPLGDQY QTVKALAERK AQGVLAAQAR AEQLRDEARD LLQAAQDKLQ RLQELEGTYE ENERALESKA AQLDGLEARM RSVLQAINLQ VQIYNTCQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.