Details for: LAMB2

Gene ID: 3913

Symbol: LAMB2

Ensembl ID: ENSG00000172037

Description: laminin subunit beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 190.0412
    Cell Significance Index: -29.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.6294
    Cell Significance Index: -29.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.2007
    Cell Significance Index: -27.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.4851
    Cell Significance Index: -23.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.7763
    Cell Significance Index: -23.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9911
    Cell Significance Index: -29.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9321
    Cell Significance Index: -17.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4784
    Cell Significance Index: -29.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4977
    Cell Significance Index: 130.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2245
    Cell Significance Index: 30.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7806
    Cell Significance Index: 338.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7158
    Cell Significance Index: 45.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.2348
    Cell Significance Index: 19.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0894
    Cell Significance Index: 139.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9947
    Cell Significance Index: 11.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9851
    Cell Significance Index: 889.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9264
    Cell Significance Index: 18.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8781
    Cell Significance Index: 25.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7498
    Cell Significance Index: 409.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6712
    Cell Significance Index: 92.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5442
    Cell Significance Index: 14.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4858
    Cell Significance Index: 36.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4563
    Cell Significance Index: 49.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4549
    Cell Significance Index: 20.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4463
    Cell Significance Index: 72.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4136
    Cell Significance Index: 8.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3997
    Cell Significance Index: 49.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3894
    Cell Significance Index: 10.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3447
    Cell Significance Index: 68.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3142
    Cell Significance Index: 14.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3101
    Cell Significance Index: 8.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3051
    Cell Significance Index: 23.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2913
    Cell Significance Index: 8.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2819
    Cell Significance Index: 3.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2394
    Cell Significance Index: 43.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2393
    Cell Significance Index: 14.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2142
    Cell Significance Index: 21.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1439
    Cell Significance Index: 6.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1357
    Cell Significance Index: 0.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1333
    Cell Significance Index: 58.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1242
    Cell Significance Index: 6.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0947
    Cell Significance Index: 12.2400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0364
    Cell Significance Index: 0.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0200
    Cell Significance Index: 0.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0144
    Cell Significance Index: 0.3600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0095
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0087
    Cell Significance Index: 16.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0108
    Cell Significance Index: -7.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0113
    Cell Significance Index: -8.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0150
    Cell Significance Index: -20.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0196
    Cell Significance Index: -8.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0287
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0408
    Cell Significance Index: -30.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0507
    Cell Significance Index: -28.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0667
    Cell Significance Index: -11.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0749
    Cell Significance Index: -26.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0905
    Cell Significance Index: -26.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0982
    Cell Significance Index: -1.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0999
    Cell Significance Index: -2.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1088
    Cell Significance Index: -15.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1179
    Cell Significance Index: -13.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1195
    Cell Significance Index: -2.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1239
    Cell Significance Index: -14.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1309
    Cell Significance Index: -9.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1368
    Cell Significance Index: -27.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1480
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1499
    Cell Significance Index: -31.5800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1609
    Cell Significance Index: -1.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2279
    Cell Significance Index: -12.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2310
    Cell Significance Index: -3.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2323
    Cell Significance Index: -5.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2421
    Cell Significance Index: -28.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2544
    Cell Significance Index: -26.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2662
    Cell Significance Index: -5.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2907
    Cell Significance Index: -15.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3061
    Cell Significance Index: -6.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3168
    Cell Significance Index: -25.0900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3195
    Cell Significance Index: -2.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3474
    Cell Significance Index: -21.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3594
    Cell Significance Index: -11.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3860
    Cell Significance Index: -15.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3993
    Cell Significance Index: -10.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4249
    Cell Significance Index: -27.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4278
    Cell Significance Index: -26.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4337
    Cell Significance Index: -29.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4484
    Cell Significance Index: -27.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4581
    Cell Significance Index: -15.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4675
    Cell Significance Index: -4.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4923
    Cell Significance Index: -3.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5872
    Cell Significance Index: -30.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5872
    Cell Significance Index: -12.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6202
    Cell Significance Index: -27.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6390
    Cell Significance Index: -9.6300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6648
    Cell Significance Index: -16.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6773
    Cell Significance Index: -19.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6833
    Cell Significance Index: -25.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LAMB2 is a type II transmembrane protein that belongs to the laminin family, which is composed of three subunits: alpha, beta, and gamma. The beta subunit, LAMB2, is the most abundant subunit and is responsible for the majority of the protein's interactions with other ECM components and cell surface receptors. LAMB2 is highly glycosylated, which enhances its ability to interact with other proteins and cells. The protein is also phosphorylated, which modulates its activity and interactions. **Pathways and Functions** LAMB2 plays a central role in various cellular processes, including: 1. **Cell adhesion**: LAMB2 interacts with integrins, cadherins, and other ECM components to regulate cell adhesion and migration. 2. **Cell migration**: LAMB2 regulates cell migration by interacting with cytoskeletal proteins and signaling molecules. 3. **Differentiation**: LAMB2 is involved in the differentiation of various cell types, including neural progenitor cells and muscle satellite stem cells. 4. **Signaling**: LAMB2 interacts with signaling molecules, such as the Met receptor tyrosine kinase, to regulate cellular responses to growth factors and cytokines. 5. **ECM organization**: LAMB2 is essential for the organization and maintenance of the ECM, including the formation of the basement membrane. **Clinical Significance** Dysregulation of LAMB2 has been implicated in various diseases and disorders, including: 1. **Muscular dystrophy**: Mutations in the LAMB2 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Neurological disorders**: LAMB2 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer**: LAMB2 has been found to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. 4. **Kidney disease**: LAMB2 has been implicated in the pathogenesis of kidney disease, including diabetic nephropathy and chronic kidney disease. In summary, LAMB2 is a critical component of the extracellular matrix that plays a central role in various cellular processes, including cell adhesion, migration, and differentiation. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 172199374

Symbol: LAMB2_HUMAN

Name: Laminin subunit beta-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7698745

Title: Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas.

PubMed ID: 7698745

DOI: 10.1006/geno.1994.1612

PubMed ID: 7795887

Title: The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene.

PubMed ID: 7795887

DOI: 10.1016/0945-053x(95)90006-3

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 15367484

Title: Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.

PubMed ID: 15367484

DOI: 10.1093/hmg/ddh284

PubMed ID: 16912710

Title: Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders.

PubMed ID: 16912710

DOI: 10.1038/sj.ki.5001679

PubMed ID: 20798252

Title: Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome.

PubMed ID: 20798252

DOI: 10.2215/cjn.01190210

PubMed ID: 21236492

Title: A novel mutation of LAMB2 in a multigenerational mennonite family reveals a new phenotypic variant of Pierson syndrome.

PubMed ID: 21236492

DOI: 10.1016/j.ophtha.2010.10.009

PubMed ID: 23595123

Title: A molecular genetic analysis of childhood nephrotic syndrome in a cohort of Saudi Arabian families.

PubMed ID: 23595123

DOI: 10.1038/jhg.2013.27

Sequence Information:

  • Length: 1798
  • Mass: 195981
  • Checksum: FFB3531AD13E1486
  • Sequence:
  • MELTSRERGR GQPLPWELRL GLLLSVLAAT LAQAPAPDVP GCSRGSCYPA TGDLLVGRAD 
    RLTASSTCGL NGPQPYCIVS HLQDEKKCFL CDSRRPFSAR DNPHSHRIQN VVTSFAPQRR 
    AAWWQSENGI PAVTIQLDLE AEFHFTHLIM TFKTFRPAAM LVERSADFGR TWHVYRYFSY 
    DCGADFPGVP LAPPRHWDDV VCESRYSEIE PSTEGEVIYR VLDPAIPIPD PYSSRIQNLL 
    KITNLRVNLT RLHTLGDNLL DPRREIREKY YYALYELVVR GNCFCYGHAS ECAPAPGAPA 
    HAEGMVHGAC ICKHNTRGLN CEQCQDFYRD LPWRPAEDGH SHACRKCECH GHTHSCHFDM 
    AVYLASGNVS GGVCDGCQHN TAGRHCELCR PFFYRDPTKD LRDPAVCRSC DCDPMGSQDG 
    GRCDSHDDPA LGLVSGQCRC KEHVVGTRCQ QCRDGFFGLS ISDRLGCRRC QCNARGTVPG 
    STPCDPNSGS CYCKRLVTGR GCDRCLPGHW GLSHDLLGCR PCDCDVGGAL DPQCDEGTGQ 
    CHCRQHMVGR RCEQVQPGYF RPFLDHLIWE AEDTRGQVLD VVERLVTPGE TPSWTGSGFV 
    RLQEGQTLEF LVASVPKAMD YDLLLRLEPQ VPEQWAELEL IVQRPGPVPA HSLCGHLVPK 
    DDRIQGTLQP HARYLIFPNP VCLEPGISYK LHLKLVRTGG SAQPETPYSG PGLLIDSLVL 
    LPRVLVLEMF SGGDAAALER QATFERYQCH EEGLVPSKTS PSEACAPLLI SLSTLIYNGA 
    LPCQCNPQGS LSSECNPHGG QCLCKPGVVG RRCDLCAPGY YGFGPTGCQA CQCSHEGALS 
    SLCEKTSGQC LCRTGAFGLR CDRCQRGQWG FPSCRPCVCN GHADECNTHT GACLGCRDHT 
    GGEHCERCIA GFHGDPRLPY GGQCRPCPCP EGPGSQRHFA TSCHQDEYSQ QIVCHCRAGY 
    TGLRCEACAP GHFGDPSRPG GRCQLCECSG NIDPMDPDAC DPHTGQCLRC LHHTEGPHCA 
    HCKPGFHGQA ARQSCHRCTC NLLGTNPQQC PSPDQCHCDP SSGQCPCLPN VQGPSCDRCA 
    PNFWNLTSGH GCQPCACHPS RARGPTCNEF TGQCHCRAGF GGRTCSECQE LHWGDPGLQC 
    HACDCDSRGI DTPQCHRFTG HCSCRPGVSG VRCDQCARGF SGIFPACHPC HACFGDWDRV 
    VQDLAARTQR LEQRAQELQQ TGVLGAFESS FWHMQEKLGI VQGIVGARNT SAASTAQLVE 
    ATEELRREIG EATEHLTQLE ADLTDVQDEN FNANHALSGL ERDRLALNLT LRQLDQHLDL 
    LKHSNFLGAY DSIRHAHSQS AEAERRANTS ALAVPSPVSN SASARHRTEA LMDAQKEDFN 
    SKHMANQRAL GKLSAHTHTL SLTDINELVC GAPGDAPCAT SPCGGAGCRD EDGQPRCGGL 
    SCNGAAATAD LALGRARHTQ AELQRALAEG GSILSRVAET RRQASEAQQR AQAALDKANA 
    SRGQVEQANQ ELQELIQSVK DFLNQEGADP DSIEMVATRV LELSIPASAE QIQHLAGAIA 
    ERVRSLADVD AILARTVGDV RRAEQLLQDA RRARSWAEDE KQKAETVQAA LEEAQRAQGI 
    AQGAIRGAVA DTRDTEQTLY QVQERMAGAE RALSSAGERA RQLDALLEAL KLKRAGNSLA 
    ASTAEETAGS AQGRAQEAEQ LLRGPLGDQY QTVKALAERK AQGVLAAQAR AEQLRDEARD 
    LLQAAQDKLQ RLQELEGTYE ENERALESKA AQLDGLEARM RSVLQAINLQ VQIYNTCQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.