Details for: LAMB2

Gene ID: 3913

Symbol: LAMB2

Ensembl ID: ENSG00000172037

Description: laminin subunit beta 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.94
    Marker Score: 1377
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.89
    Marker Score: 436
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.88
    Marker Score: 16478
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.72
    Marker Score: 1637
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.65
    Marker Score: 1987
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.62
    Marker Score: 914
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.57
    Marker Score: 1680
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.5
    Marker Score: 5821
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.33
    Marker Score: 319
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.32
    Marker Score: 3445
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.3
    Marker Score: 2599
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.29
    Marker Score: 1343
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.25
    Marker Score: 3162
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.25
    Marker Score: 42627
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.23
    Marker Score: 1158
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.22
    Marker Score: 806
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.22
    Marker Score: 283
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.21
    Marker Score: 300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.21
    Marker Score: 343
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2
    Marker Score: 41606
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.19
    Marker Score: 1022
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.18
    Marker Score: 787
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.18
    Marker Score: 250
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.17
    Marker Score: 8732
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.17
    Marker Score: 1258
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.16
    Marker Score: 1682
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.16
    Marker Score: 1590
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.13
    Marker Score: 2866
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.12
    Marker Score: 650
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.11
    Marker Score: 289
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.11
    Marker Score: 1002
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.1
    Marker Score: 1165
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.09
    Marker Score: 2932.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.09
    Marker Score: 1580
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.09
    Marker Score: 598
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.08
    Marker Score: 1246
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.08
    Marker Score: 661
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.07
    Marker Score: 2017
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.07
    Marker Score: 3783
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.06
    Marker Score: 6907
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.06
    Marker Score: 10662
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.02
    Marker Score: 18072
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.02
    Marker Score: 982
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1
    Marker Score: 897
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71752
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1
    Marker Score: 320
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47977
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.98
    Marker Score: 4095
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.97
    Marker Score: 608
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15155
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.97
    Marker Score: 279
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.96
    Marker Score: 3684
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.95
    Marker Score: 242
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.94
    Marker Score: 551
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.94
    Marker Score: 423
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.94
    Marker Score: 440
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.94
    Marker Score: 1328
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.94
    Marker Score: 985
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.92
    Marker Score: 990
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.92
    Marker Score: 2090
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.92
    Marker Score: 334
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.91
    Marker Score: 377
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.91
    Marker Score: 918
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.9
    Marker Score: 1596
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.89
    Marker Score: 14257
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.88
    Marker Score: 2401
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.88
    Marker Score: 748
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.87
    Marker Score: 5164
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.86
    Marker Score: 218
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.86
    Marker Score: 1361
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.85
    Marker Score: 507
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.85
    Marker Score: 321
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4828
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1371
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 644
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.84
    Marker Score: 1039
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.83
    Marker Score: 236
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 328
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.81
    Marker Score: 947
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8
    Marker Score: 9055
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.8
    Marker Score: 4223
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.8
    Marker Score: 254
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.8
    Marker Score: 1541
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1623.5
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.78
    Marker Score: 219
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1463
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.77
    Marker Score: 506
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.77
    Marker Score: 1269
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.75
    Marker Score: 757
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.75
    Marker Score: 370
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.74
    Marker Score: 180
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.74
    Marker Score: 217

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Other Information

**Key characteristics:** * Type: Protein * Ensembl ID: ENSG00000172037 * Protein length: 113 amino acids * Cellular location: Extracellular matrix * Function: Cell adhesion, cell migration, and signaling **Pathways and functions:** * Cell adhesion: Lambda-2 is a key component of cell adhesion molecules, interacting with other ECM proteins to form stable cell-cell contacts. * Ecm proteoglycans: It is a major component of the extracellular matrix (ECM) and interacts with Ecm proteoglycans, which are involved in cell adhesion and signaling. * Extracellular matrix structural constituent: Lambda-2 contributes to the structural integrity and organization of the ECM, influencing cell migration and adhesion. * Integrin binding: Lambda-2 is a core integrin receptor, interacting with the integrin molecule on the cell surface. * Laminin interactions: Lambda-2 forms heterodimers with other laminin subunits to form the extracellular matrix. * Metabolism of proteins: Lambda-2 is involved in the metabolism of proteins, potentially regulating the turnover of ECM components. * Met activates ptk2 signaling: Lambda-2 is a substrate for the Met receptor, which is involved in cell signaling pathways. * Met promotes cell motility: It is a key regulator of cell motility, influencing cell migration and invasion. * Non-integrin membrane-ECM interactions: Lambda-2 also interacts with non-integrin membrane proteins, which are involved in cell adhesion and signaling. * Post-translational protein modification: Lambda-2 undergoes various post-translational modifications that regulate its activity and cell behavior. * Post-translational protein phosphorylation: It is phosphorylated by various kinases, which can affect its stability, localization, and function. * Protein binding: Lambda-2 can bind to various proteins involved in cell adhesion, migration, and signaling. **Clinical significance:** * Mutations in the LAMB2 gene have been linked to various diseases, including kidney disease, cancer, and cardiovascular disorders. * Lambda-2 inhibitors are being investigated as potential therapeutic agents for these diseases, targeting cell adhesion and migration. * Understanding the role of LAMB2 in cell adhesion and signaling is crucial for developing novel therapeutic strategies for various diseases.

Genular Protein ID: 172199374

Symbol: LAMB2_HUMAN

Name: Laminin subunit beta-2

UniProtKB Accession Codes:

P55268 Q16321

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 28 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7698745

Title: Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas.

PubMed ID: 7698745

DOI: 10.1006/geno.1994.1612

PubMed ID: 7795887

Title: The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene.

PubMed ID: 7795887

DOI: 10.1016/0945-053x(95)90006-3

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 15367484

Title: Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.

PubMed ID: 15367484

DOI: 10.1093/hmg/ddh284

PubMed ID: 16912710

Title: Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders.

PubMed ID: 16912710

DOI: 10.1038/sj.ki.5001679

PubMed ID: 20798252

Title: Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome.

PubMed ID: 20798252

DOI: 10.2215/cjn.01190210

PubMed ID: 21236492

Title: A novel mutation of LAMB2 in a multigenerational mennonite family reveals a new phenotypic variant of Pierson syndrome.

PubMed ID: 21236492

DOI: 10.1016/j.ophtha.2010.10.009

PubMed ID: 23595123

Title: A molecular genetic analysis of childhood nephrotic syndrome in a cohort of Saudi Arabian families.

PubMed ID: 23595123

DOI: 10.1038/jhg.2013.27

Sequence Information:

  • Length: 1798
  • Mass: 195981
  • Checksum: FFB3531AD13E1486
  • Sequence:
    • MELTSRERGR GQPLPWELRL GLLLSVLAAT LAQAPAPDVP GCSRGSCYPA TGDLLVGRAD 
RLTASSTCGL NGPQPYCIVS HLQDEKKCFL CDSRRPFSAR DNPHSHRIQN VVTSFAPQRR 
AAWWQSENGI PAVTIQLDLE AEFHFTHLIM TFKTFRPAAM LVERSADFGR TWHVYRYFSY 
DCGADFPGVP LAPPRHWDDV VCESRYSEIE PSTEGEVIYR VLDPAIPIPD PYSSRIQNLL 
KITNLRVNLT RLHTLGDNLL DPRREIREKY YYALYELVVR GNCFCYGHAS ECAPAPGAPA 
HAEGMVHGAC ICKHNTRGLN CEQCQDFYRD LPWRPAEDGH SHACRKCECH GHTHSCHFDM 
AVYLASGNVS GGVCDGCQHN TAGRHCELCR PFFYRDPTKD LRDPAVCRSC DCDPMGSQDG 
GRCDSHDDPA LGLVSGQCRC KEHVVGTRCQ QCRDGFFGLS ISDRLGCRRC QCNARGTVPG 
STPCDPNSGS CYCKRLVTGR GCDRCLPGHW GLSHDLLGCR PCDCDVGGAL DPQCDEGTGQ 
CHCRQHMVGR RCEQVQPGYF RPFLDHLIWE AEDTRGQVLD VVERLVTPGE TPSWTGSGFV 
RLQEGQTLEF LVASVPKAMD YDLLLRLEPQ VPEQWAELEL IVQRPGPVPA HSLCGHLVPK 
DDRIQGTLQP HARYLIFPNP VCLEPGISYK LHLKLVRTGG SAQPETPYSG PGLLIDSLVL 
LPRVLVLEMF SGGDAAALER QATFERYQCH EEGLVPSKTS PSEACAPLLI SLSTLIYNGA 
LPCQCNPQGS LSSECNPHGG QCLCKPGVVG RRCDLCAPGY YGFGPTGCQA CQCSHEGALS 
SLCEKTSGQC LCRTGAFGLR CDRCQRGQWG FPSCRPCVCN GHADECNTHT GACLGCRDHT 
GGEHCERCIA GFHGDPRLPY GGQCRPCPCP EGPGSQRHFA TSCHQDEYSQ QIVCHCRAGY 
TGLRCEACAP GHFGDPSRPG GRCQLCECSG NIDPMDPDAC DPHTGQCLRC LHHTEGPHCA 
HCKPGFHGQA ARQSCHRCTC NLLGTNPQQC PSPDQCHCDP SSGQCPCLPN VQGPSCDRCA 
PNFWNLTSGH GCQPCACHPS RARGPTCNEF TGQCHCRAGF GGRTCSECQE LHWGDPGLQC 
HACDCDSRGI DTPQCHRFTG HCSCRPGVSG VRCDQCARGF SGIFPACHPC HACFGDWDRV 
VQDLAARTQR LEQRAQELQQ TGVLGAFESS FWHMQEKLGI VQGIVGARNT SAASTAQLVE 
ATEELRREIG EATEHLTQLE ADLTDVQDEN FNANHALSGL ERDRLALNLT LRQLDQHLDL 
LKHSNFLGAY DSIRHAHSQS AEAERRANTS ALAVPSPVSN SASARHRTEA LMDAQKEDFN 
SKHMANQRAL GKLSAHTHTL SLTDINELVC GAPGDAPCAT SPCGGAGCRD EDGQPRCGGL 
SCNGAAATAD LALGRARHTQ AELQRALAEG GSILSRVAET RRQASEAQQR AQAALDKANA 
SRGQVEQANQ ELQELIQSVK DFLNQEGADP DSIEMVATRV LELSIPASAE QIQHLAGAIA 
ERVRSLADVD AILARTVGDV RRAEQLLQDA RRARSWAEDE KQKAETVQAA LEEAQRAQGI 
AQGAIRGAVA DTRDTEQTLY QVQERMAGAE RALSSAGERA RQLDALLEAL KLKRAGNSLA 
ASTAEETAGS AQGRAQEAEQ LLRGPLGDQY QTVKALAERK AQGVLAAQAR AEQLRDEARD 
LLQAAQDKLQ RLQELEGTYE ENERALESKA AQLDGLEARM RSVLQAINLQ VQIYNTCQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.