Details for: LBR

Gene ID: 3930

Symbol: LBR

Ensembl ID: ENSG00000143815

Description: lamin B receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.88
    Marker Score: 2304
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2
    Marker Score: 6530
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.85
    Marker Score: 1484
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.83
    Marker Score: 1140
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.78
    Marker Score: 4836.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.72
    Marker Score: 740
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.71
    Marker Score: 844
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.71
    Marker Score: 4261
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.69
    Marker Score: 19698
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.62
    Marker Score: 2111
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.59
    Marker Score: 398
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.58
    Marker Score: 599.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.58
    Marker Score: 13829
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.52
    Marker Score: 4264
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.51
    Marker Score: 2140
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.51
    Marker Score: 2633
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.49
    Marker Score: 3497.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.47
    Marker Score: 19741
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.45
    Marker Score: 1363
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.44
    Marker Score: 1129.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.41
    Marker Score: 610
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.41
    Marker Score: 9020.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.4
    Marker Score: 954
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.4
    Marker Score: 1858.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.39
    Marker Score: 3422
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.38
    Marker Score: 914
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.36
    Marker Score: 1470
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.32
    Marker Score: 1274
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.31
    Marker Score: 1363
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.31
    Marker Score: 12983
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.31
    Marker Score: 585
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.3
    Marker Score: 643
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.3
    Marker Score: 1386
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.3
    Marker Score: 2541
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.28
    Marker Score: 1888
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.27
    Marker Score: 303
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.27
    Marker Score: 635
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.27
    Marker Score: 1746
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.26
    Marker Score: 613
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.25
    Marker Score: 1479
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.24
    Marker Score: 286
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.23
    Marker Score: 68645
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.21
    Marker Score: 425
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.2
    Marker Score: 1063
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.19
    Marker Score: 369
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.19
    Marker Score: 302
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.18
    Marker Score: 12008
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.18
    Marker Score: 3729
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.18
    Marker Score: 411.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.18
    Marker Score: 281
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.17
    Marker Score: 478
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.17
    Marker Score: 721
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.17
    Marker Score: 323
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.17
    Marker Score: 1233
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.17
    Marker Score: 1461.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.16
    Marker Score: 334
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.16
    Marker Score: 772
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.16
    Marker Score: 665
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.15
    Marker Score: 786
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.15
    Marker Score: 1651
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.15
    Marker Score: 940
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.15
    Marker Score: 859
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.14
    Marker Score: 1076
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.14
    Marker Score: 267
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.13
    Marker Score: 1115
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.13
    Marker Score: 686
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.13
    Marker Score: 1361
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.12
    Marker Score: 1057
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.12
    Marker Score: 822.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.12
    Marker Score: 387
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.12
    Marker Score: 417
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.11
    Marker Score: 2647
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.11
    Marker Score: 1984
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.11
    Marker Score: 1207
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.11
    Marker Score: 2314
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.11
    Marker Score: 247
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.1
    Marker Score: 671
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.1
    Marker Score: 222
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.1
    Marker Score: 729
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 1.09
    Marker Score: 268
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.09
    Marker Score: 1202
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.08
    Marker Score: 645
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.08
    Marker Score: 594
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.07
    Marker Score: 721
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.07
    Marker Score: 628
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.07
    Marker Score: 403
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.06
    Marker Score: 275
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.06
    Marker Score: 261
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.06
    Marker Score: 295
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.06
    Marker Score: 953
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.05
    Marker Score: 333
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.05
    Marker Score: 279
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.05
    Marker Score: 797
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.05
    Marker Score: 631
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.05
    Marker Score: 791
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2125
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.04
    Marker Score: 1046
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 1.04
    Marker Score: 290
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.04
    Marker Score: 762

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Other Information

**Key characteristics:** * LBR is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including early promyelocytes, tonsil germinal center B cells, pulmonary interstitial fibroblasts, erythroblasts, large pre-B-II cells, CD8+ T cells, centroblast, and blood cells. * It is a key regulator of cell cycle progression and differentiation. **Pathways and functions:** * LBR is a key regulator of the cell cycle. It is expressed in cells that are in the G1 phase of the cell cycle. When LBR is present, it blocks the activation of cyclin-dependent kinase 4 (CDK4), which is an enzyme that is responsible for promoting cell cycle progression. * In the absence of LBR, CDK4 is activated and cell cycle progression is initiated. * LBR also plays a role in differentiation. It is expressed in cells that are committed to becoming a specific cell type. When LBR is present, it prevents the cells from differentiating into a different cell type. **Clinical significance:** * Mutations in the LBR gene have been linked to a number of human diseases, including cancer and developmental disorders. * In cancer, mutations in LBR can lead to the activation of cyclin-dependent kinase 4 (CDK4), which can promote cell cycle progression and tumor growth. * LBR inhibitors are being investigated as a treatment for cancer.

Genular Protein ID: 79681096

Symbol: LBR_HUMAN

Name: Delta(14)-sterol reductase LBR

UniProtKB Accession Codes:

Q14739 B2R5P3 Q14740 Q53GU7 Q59FE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 3 Rhea 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8157662

Title: Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane.

PubMed ID: 8157662

DOI: 10.1016/s0021-9258(19)78126-5

PubMed ID: 8157663

Title: Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane.

PubMed ID: 8157663

DOI: 10.1016/s0021-9258(19)78127-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9169472

Title: Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.

PubMed ID: 9169472

DOI: 10.1074/jbc.272.23.14983

PubMed ID: 9630650

Title: Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae.

PubMed ID: 9630650

DOI: 10.1016/s0005-2760(98)00041-1

PubMed ID: 10049757

Title: SRPK1 and LBR protein kinases show identical substrate specificities.

PubMed ID: 10049757

DOI: 10.1006/bbrc.1999.0249

PubMed ID: 10828963

Title: Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker.

PubMed ID: 10828963

DOI: 10.1021/bi992908b

PubMed ID: 12118250

Title: Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly).

PubMed ID: 12118250

DOI: 10.1038/ng925

PubMed ID: 12618959

Title: Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene.

PubMed ID: 12618959

DOI: 10.1086/373938

PubMed ID: 15882967

Title: The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.

PubMed ID: 15882967

DOI: 10.1016/j.bbrc.2005.04.016

PubMed ID: 16784888

Title: Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

PubMed ID: 16784888

DOI: 10.1016/j.bbalip.2006.05.004

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21795390

Title: Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor.

PubMed ID: 21795390

DOI: 10.1091/mbc.e11-03-0199

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26009488

Title: Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.

PubMed ID: 26009488

DOI: 10.1016/j.bbrc.2015.05.046

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32694168

Title: TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis.

PubMed ID: 32694168

DOI: 10.1242/jcs.245357

PubMed ID: 14617022

Title: Lamin B-receptor mutations in Pelger-Huet anomaly.

PubMed ID: 14617022

DOI: 10.1046/j.1365-2141.2003.04621.x

PubMed ID: 20522425

Title: LBR mutation and nuclear envelope defects in a patient affected with Reynolds syndrome.

PubMed ID: 20522425

DOI: 10.1136/jmg.2009.071696

PubMed ID: 21327084

Title: Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein.

PubMed ID: 21327084

DOI: 10.4161/nucl.1.4.12435

PubMed ID: 23824842

Title: Pelger-huet anomaly and a mild skeletal phenotype secondary to mutations in LBR.

PubMed ID: 23824842

DOI: 10.1002/ajmg.a.36019

PubMed ID: 25348816

Title: An anadysplasia-like, spontaneously remitting spondylometaphyseal dysplasia secondary to lamin B receptor (LBR) gene mutations: further definition of the phenotypic heterogeneity of LBR-bone dysplasias.

PubMed ID: 25348816

DOI: 10.1002/ajmg.a.36808

PubMed ID: 27336722

Title: The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.

PubMed ID: 27336722

DOI: 10.7554/elife.16011

Sequence Information:

  • Length: 615
  • Mass: 70703
  • Checksum: 5A7388776F43C66D
  • Sequence:
    • MPSRKFADGE VVRGRWPGSS LYYEVEILSH DSTSQLYTVK YKDGTELELK ENDIKPLTSF 
RQRKGGSTSS SPSRRRGSRS RSRSRSPGRP PKSARRSASA SHQADIKEAR REVEVKLTPL 
ILKPFGNSIS RYNGEPEHIE RNDAPHKNTQ EKFSLSQESS YIATQYSLRP RREEVKLKEI 
DSKEEKYVAK ELAVRTFEVT PIRAKDLEFG GVPGVFLIMF GLPVFLFLLL LMCKQKDPSL 
LNFPPPLPAL YELWETRVFG VYLLWFLIQV LFYLLPIGKV VEGTPLIDGR RLKYRLNGFY 
AFILTSAVIG TSLFQGVEFH YVYSHFLQFA LAATVFCVVL SVYLYMRSLK APRNDLSPAS 
SGNAVYDFFI GRELNPRIGT FDLKYFCELR PGLIGWVVIN LVMLLAEMKI QDRAVPSLAM 
ILVNSFQLLY VVDALWNEEA LLTTMDIIHD GFGFMLAFGD LVWVPFIYSF QAFYLVSHPN 
EVSWPMASLI IVLKLCGYVI FRGANSQKNA FRKNPSDPKL AHLKTIHTST GKNLLVSGWW 
GFVRHPNYLG DLIMALAWSL PCGFNHILPY FYIIYFTMLL VHREARDEYH CKKKYGVAWE 
KYCQRVPYRI FPYIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.