Details for: LEPR

Gene ID: 3953

Symbol: LEPR

Ensembl ID: ENSG00000116678

Description: leptin receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 6.51
    Marker Score: 3677
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.34
    Marker Score: 7666
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.29
    Marker Score: 4576
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.2
    Marker Score: 506
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.07
    Marker Score: 1237
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.93
    Marker Score: 1660
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.77
    Marker Score: 2573.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.71
    Marker Score: 4353
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.53
    Marker Score: 3103
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5
    Marker Score: 15495
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168694
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.44
    Marker Score: 6224.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.42
    Marker Score: 7650
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.4
    Marker Score: 588
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.27
    Marker Score: 3003
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.27
    Marker Score: 1357
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.25
    Marker Score: 393
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1898
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.21
    Marker Score: 824
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.16
    Marker Score: 11003
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4782
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.14
    Marker Score: 4626
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.13
    Marker Score: 1297
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17583
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.11
    Marker Score: 23741
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.09
    Marker Score: 7008
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.07
    Marker Score: 4154
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.07
    Marker Score: 2804
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.06
    Marker Score: 661
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.05
    Marker Score: 521
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.02
    Marker Score: 62771
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.02
    Marker Score: 328
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.01
    Marker Score: 34261
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1
    Marker Score: 390
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 598
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 362
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 654
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.96
    Marker Score: 9070
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.95
    Marker Score: 853
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.95
    Marker Score: 8169
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.92
    Marker Score: 18251
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5109
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.88
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5241
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.86
    Marker Score: 923
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.86
    Marker Score: 368
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.86
    Marker Score: 31548
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.85
    Marker Score: 220
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.84
    Marker Score: 3263
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.84
    Marker Score: 32018
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.83
    Marker Score: 200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.8
    Marker Score: 303
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.8
    Marker Score: 367
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.8
    Marker Score: 1546
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.8
    Marker Score: 336
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.8
    Marker Score: 198
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.8
    Marker Score: 11972
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.77
    Marker Score: 529
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.77
    Marker Score: 1687
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.77
    Marker Score: 3202
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 363.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.75
    Marker Score: 806
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.72
    Marker Score: 360
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.72
    Marker Score: 625
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.72
    Marker Score: 230
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.7
    Marker Score: 5359.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.69
    Marker Score: 147
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.68
    Marker Score: 448
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 447
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1650
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.67
    Marker Score: 601
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.65
    Marker Score: 658
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.65
    Marker Score: 236
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.65
    Marker Score: 177
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.63
    Marker Score: 1798
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.63
    Marker Score: 634
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 159
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6
    Marker Score: 353
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.6
    Marker Score: 311
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6
    Marker Score: 5237
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.58
    Marker Score: 564
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 369
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.57
    Marker Score: 439
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.56
    Marker Score: 216
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 232

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Other Information

**Key characteristics:** - The LEPR gene is located on chromosome 17q21.1. - It is a single gene with a length of approximately 17,500 nucleotides. - The protein encoded by LEPR is a transmembrane receptor that belongs to the leptin receptor family. - It is a key regulator of energy expenditure and has been shown to play a role in obesity, diabetes, and metabolic syndrome. **Pathways and functions:** - The LEPR receptor is involved in various pathways, including angiogenesis, cell surface receptor signaling, cholesterol metabolic process, cytokine-mediated signaling pathway, and energy reserve metabolic process. - It is a key regulator of vascularization and plays a role in the regulation of body temperature. - It also regulates the metabolism of glucose, proteins, and lipids. **Clinical significance:** - Mutations in the LEPR gene have been linked to various human diseases, including obesity, type 2 diabetes, and metabolic syndrome. - The LEPR receptor is a potential therapeutic target for these diseases, as it can be used to improve energy balance and metabolism. **Additional information:** - The LEPR receptor is a highly conserved protein, with similar sequences found in mammals. - It is a member of the leptin receptor family, which also includes the leptin, leptin-like, and obestatin receptors. - The LEPR receptor is a transmembrane protein that is expressed on the surface of cells. - It is a ligand for the growth hormone receptor, which is also expressed on cells.

Genular Protein ID: 2126627489

Symbol: LEPR_HUMAN

Name: Leptin receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8548812

Title: Identification and expression cloning of a leptin receptor, OB-R.

PubMed ID: 8548812

DOI: 10.1016/0092-8674(95)90151-5

PubMed ID: 8805376

Title: A role for leptin and its cognate receptor in hematopoiesis.

PubMed ID: 8805376

DOI: 10.1016/s0960-9822(02)70684-2

PubMed ID: 8616721

Title: Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.

PubMed ID: 8616721

DOI: 10.1038/nm0596-585

PubMed ID: 9158141

Title: Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.

PubMed ID: 9158141

DOI: 10.1093/hmg/6.5.675

PubMed ID: 9061609

Title: Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.

PubMed ID: 9061609

DOI: 10.1677/jme.0.0180077

PubMed ID: 9537324

Title: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.

PubMed ID: 9537324

DOI: 10.1038/32911

PubMed ID: 9929394

Title: The long terminal repeat of an endogenous retrovirus induces alternative splicing and encodes an additional carboxy-terminal sequence in the human leptin receptor.

PubMed ID: 9929394

DOI: 10.1007/pl00013153

PubMed ID: 9600917

Title: Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.

PubMed ID: 9600917

DOI: 10.1073/pnas.95.11.6061

PubMed ID: 9786864

Title: Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.

PubMed ID: 9786864

DOI: 10.1074/jbc.273.44.28691

PubMed ID: 10896907

Title: Leptin secretion and leptin receptor in the human stomach.

PubMed ID: 10896907

DOI: 10.1136/gut.47.2.178

PubMed ID: 12504075

Title: Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines.

PubMed ID: 12504075

DOI: 10.1016/s0006-291x(02)02838-3

PubMed ID: 16052473

Title: Leptin expression in human primary skeletal muscle cells is reduced during differentiation.

PubMed ID: 16052473

DOI: 10.1002/jcb.20521

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25060689

Title: Leptin modulates autophagy in human CD4+CD25- conventional T cells.

PubMed ID: 25060689

DOI: 10.1016/j.metabol.2014.06.010

PubMed ID: 22405007

Title: Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.

PubMed ID: 22405007

DOI: 10.1016/j.str.2012.01.019

PubMed ID: 8666155

Title: The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.

PubMed ID: 8666155

DOI: 10.2337/diab.45.7.992

PubMed ID: 9144432

Title: Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.

PubMed ID: 9144432

DOI: 10.1006/bbrc.1997.6430

PubMed ID: 9287054

Title: Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).

PubMed ID: 9287054

DOI: 10.2337/diab.46.9.1509

PubMed ID: 9175732

Title: Leptin receptor gene variation and obesity: lack of association in a white British male population.

PubMed ID: 9175732

DOI: 10.1093/hmg/6.6.869

PubMed ID: 9860295

Title: Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents.

PubMed ID: 9860295

DOI: 10.1007/s004390050867

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

PubMed ID: 25751111

Title: Seven novel deleterious LEPR mutations found in early-onset obesity: a DeltaExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect.

PubMed ID: 25751111

DOI: 10.1210/jc.2015-1036

Sequence Information:

  • Length: 1165
  • Mass: 132494
  • Checksum: CAA03BEAF2602D0A
  • Sequence:
  • MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS 
    NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF 
    QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS 
    FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP 
    LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP 
    GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI 
    VPSKEIVWWM NLAEKIPQSQ YDVVSDHVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH 
    RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH 
    PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP 
    SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV 
    PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKEKNV 
    TLLWKPLMKN DSLCSVQRYV INHHTSCNGT WSEDVGNHTK FTFLWTEQAH TVTVLAINSI 
    GASVANFNLT FSWPMSKVNI VQSLSAYPLN SSCVIVSWIL SPSDYKLMYF IIEWKNLNED 
    GEIKWLRISS SVKKYYIHDH FIPIEKYQFS LYPIFMEGVG KPKIINSFTQ DDIEKHQSDA 
    GLYVIVPVII SSSILLLGTL LISHQRMKKL FWEDVPNPKN CSWAQGLNFQ KPETFEHLFI 
    KHTASVTCGP LLLEPETISE DISVDTSWKN KDEMMPTTVV SLLSTTDLEK GSVCISDQFN 
    SVNFSEAEGT EVTYEDESQR QPFVKYATLI SNSKPSETGE EQGLINSSVT KCFSSKNSPL 
    KDSFSNSSWE IEAQAFFILS DQHPNIISPH LTFSEGLDEL LKLEGNFPEE NNDKKSIYYL 
    GVTSIKKRES GVLLTDKSRV SCPFPAPCLF TDIRVLQDSC SHFVENNINL GTSSKKTFAS 
    YMPQFQTCST QTHKIMENKM CDLTV

Genular Protein ID: 3296656622

Symbol: Q4G138_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 659
  • Mass: 75220
  • Checksum: 5DDFABBED8321A78
  • Sequence:
  • MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS 
    NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF 
    QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS 
    FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP 
    LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP 
    GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI 
    VPSKEIVWWM NLAEKIPQSQ YDVVSDNVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH 
    RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH 
    PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP 
    SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV 
    PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.