Details for: LEPR
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: endocardial cell (CL0002350)
Fold Change: 6.51
Marker Score: 3677 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2.34
Marker Score: 7666 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.29
Marker Score: 4576 - Cell Name: keratocyte (CL0002363)
Fold Change: 2.2
Marker Score: 506 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.07
Marker Score: 1237 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.93
Marker Score: 1660 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.77
Marker Score: 2573.5 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.71
Marker Score: 4353 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.53
Marker Score: 3103 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.5
Marker Score: 15495 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168694 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.44
Marker Score: 6224.5 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.42
Marker Score: 7650 - Cell Name: peptic cell (CL0000155)
Fold Change: 1.4
Marker Score: 588 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.27
Marker Score: 3003 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.27
Marker Score: 1357 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.25
Marker Score: 393 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.23
Marker Score: 1898 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.21
Marker Score: 824 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.16
Marker Score: 11003 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4782 - Cell Name: neuron (CL0000540)
Fold Change: 1.14
Marker Score: 4626 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.13
Marker Score: 1297 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.12
Marker Score: 17583 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.11
Marker Score: 23741 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.09
Marker Score: 7008 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.07
Marker Score: 4154 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.07
Marker Score: 2804 - Cell Name: erythroblast (CL0000765)
Fold Change: 1.06
Marker Score: 661 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.05
Marker Score: 521 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.02
Marker Score: 62771 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.02
Marker Score: 328 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.01
Marker Score: 34261 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1
Marker Score: 390 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71788 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48013 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1
Marker Score: 598 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405 - Cell Name: podocyte (CL0000653)
Fold Change: 0.98
Marker Score: 362 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.97
Marker Score: 654 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.96
Marker Score: 9070 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.95
Marker Score: 853 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.95
Marker Score: 8169 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.92
Marker Score: 18251 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 365.5 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2732 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5109 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319 - Cell Name: reticular cell (CL0000432)
Fold Change: 0.88
Marker Score: 322 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.87
Marker Score: 5241 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.86
Marker Score: 923 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.86
Marker Score: 368 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.86
Marker Score: 31548 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.85
Marker Score: 220 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.84
Marker Score: 3263 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.84
Marker Score: 32018 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.83
Marker Score: 200 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.8
Marker Score: 303 - Cell Name: interneuron (CL0000099)
Fold Change: 0.8
Marker Score: 367 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.8
Marker Score: 1546 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.8
Marker Score: 336 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.8
Marker Score: 198 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.8
Marker Score: 11972 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 595 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.77
Marker Score: 529 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1251 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.77
Marker Score: 1687 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.77
Marker Score: 3202 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.76
Marker Score: 363.5 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.75
Marker Score: 806 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 388 - Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 670 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.72
Marker Score: 360 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.72
Marker Score: 625 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.72
Marker Score: 230 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.7
Marker Score: 5359.5 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.69
Marker Score: 147 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.68
Marker Score: 448 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.68
Marker Score: 447 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.67
Marker Score: 1650 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.67
Marker Score: 601 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.65
Marker Score: 658 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.65
Marker Score: 236 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.65
Marker Score: 177 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.63
Marker Score: 1798 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.63
Marker Score: 634 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.61
Marker Score: 159 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.6
Marker Score: 353 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.6
Marker Score: 311 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6
Marker Score: 5237 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.58
Marker Score: 564 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 369 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.57
Marker Score: 439 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.56
Marker Score: 216 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.56
Marker Score: 232
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Other Information
Genular Protein ID: 2126627489
Symbol: LEPR_HUMAN
Name: Leptin receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8548812
Title: Identification and expression cloning of a leptin receptor, OB-R.
PubMed ID: 8548812
PubMed ID: 8805376
Title: A role for leptin and its cognate receptor in hematopoiesis.
PubMed ID: 8805376
PubMed ID: 8616721
Title: Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.
PubMed ID: 8616721
DOI: 10.1038/nm0596-585
PubMed ID: 9158141
Title: Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.
PubMed ID: 9158141
DOI: 10.1093/hmg/6.5.675
PubMed ID: 9061609
Title: Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.
PubMed ID: 9061609
PubMed ID: 9537324
Title: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.
PubMed ID: 9537324
DOI: 10.1038/32911
PubMed ID: 9929394
Title: The long terminal repeat of an endogenous retrovirus induces alternative splicing and encodes an additional carboxy-terminal sequence in the human leptin receptor.
PubMed ID: 9929394
DOI: 10.1007/pl00013153
PubMed ID: 9600917
Title: Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.
PubMed ID: 9600917
PubMed ID: 9786864
Title: Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.
PubMed ID: 9786864
PubMed ID: 10896907
Title: Leptin secretion and leptin receptor in the human stomach.
PubMed ID: 10896907
DOI: 10.1136/gut.47.2.178
PubMed ID: 12504075
Title: Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines.
PubMed ID: 12504075
PubMed ID: 16052473
Title: Leptin expression in human primary skeletal muscle cells is reduced during differentiation.
PubMed ID: 16052473
DOI: 10.1002/jcb.20521
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 25232147
Title: 20 years of leptin: connecting leptin signaling to biological function.
PubMed ID: 25232147
DOI: 10.1530/joe-14-0404
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25060689
Title: Leptin modulates autophagy in human CD4+CD25- conventional T cells.
PubMed ID: 25060689
PubMed ID: 22405007
Title: Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.
PubMed ID: 22405007
PubMed ID: 8666155
Title: The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.
PubMed ID: 8666155
PubMed ID: 9144432
Title: Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.
PubMed ID: 9144432
PubMed ID: 9287054
Title: Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).
PubMed ID: 9287054
PubMed ID: 9175732
Title: Leptin receptor gene variation and obesity: lack of association in a white British male population.
PubMed ID: 9175732
DOI: 10.1093/hmg/6.6.869
PubMed ID: 9860295
Title: Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents.
PubMed ID: 9860295
PubMed ID: 18987736
Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
PubMed ID: 18987736
DOI: 10.1038/nature07485
PubMed ID: 25751111
Title: Seven novel deleterious LEPR mutations found in early-onset obesity: a DeltaExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect.
PubMed ID: 25751111
DOI: 10.1210/jc.2015-1036
Sequence Information:
- Length: 1165
- Mass: 132494
- Checksum: CAA03BEAF2602D0A
- Sequence:
MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI VPSKEIVWWM NLAEKIPQSQ YDVVSDHVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKEKNV TLLWKPLMKN DSLCSVQRYV INHHTSCNGT WSEDVGNHTK FTFLWTEQAH TVTVLAINSI GASVANFNLT FSWPMSKVNI VQSLSAYPLN SSCVIVSWIL SPSDYKLMYF IIEWKNLNED GEIKWLRISS SVKKYYIHDH FIPIEKYQFS LYPIFMEGVG KPKIINSFTQ DDIEKHQSDA GLYVIVPVII SSSILLLGTL LISHQRMKKL FWEDVPNPKN CSWAQGLNFQ KPETFEHLFI KHTASVTCGP LLLEPETISE DISVDTSWKN KDEMMPTTVV SLLSTTDLEK GSVCISDQFN SVNFSEAEGT EVTYEDESQR QPFVKYATLI SNSKPSETGE EQGLINSSVT KCFSSKNSPL KDSFSNSSWE IEAQAFFILS DQHPNIISPH LTFSEGLDEL LKLEGNFPEE NNDKKSIYYL GVTSIKKRES GVLLTDKSRV SCPFPAPCLF TDIRVLQDSC SHFVENNINL GTSSKKTFAS YMPQFQTCST QTHKIMENKM CDLTV
Genular Protein ID: 3296656622
Symbol: Q4G138_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 659
- Mass: 75220
- Checksum: 5DDFABBED8321A78
- Sequence:
MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI VPSKEIVWWM NLAEKIPQSQ YDVVSDNVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKKKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.