Details for: LEPR

Gene ID: 3953

Symbol: LEPR

Ensembl ID: ENSG00000116678

Description: leptin receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.6232
    Cell Significance Index: -20.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.0012
    Cell Significance Index: -21.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.2221
    Cell Significance Index: -21.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.6361
    Cell Significance Index: -18.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4607
    Cell Significance Index: -18.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.4864
    Cell Significance Index: -21.5600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 8.5110
    Cell Significance Index: 50.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8800
    Cell Significance Index: -18.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.4102
    Cell Significance Index: 91.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0962
    Cell Significance Index: -20.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.3605
    Cell Significance Index: 46.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2653
    Cell Significance Index: 449.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.9233
    Cell Significance Index: 41.1100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2606
    Cell Significance Index: 18.1300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.2529
    Cell Significance Index: 7.8500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.1364
    Cell Significance Index: 4.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0549
    Cell Significance Index: 30.2400
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.0421
    Cell Significance Index: 5.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0196
    Cell Significance Index: 194.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8974
    Cell Significance Index: 60.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6701
    Cell Significance Index: 134.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6369
    Cell Significance Index: 9.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6242
    Cell Significance Index: 61.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5779
    Cell Significance Index: 521.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5343
    Cell Significance Index: 32.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5332
    Cell Significance Index: 15.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5247
    Cell Significance Index: 19.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5177
    Cell Significance Index: 60.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4997
    Cell Significance Index: 179.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4611
    Cell Significance Index: 24.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4467
    Cell Significance Index: 19.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4038
    Cell Significance Index: 20.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3463
    Cell Significance Index: 50.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3338
    Cell Significance Index: 54.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2602
    Cell Significance Index: 6.2400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2455
    Cell Significance Index: 3.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2391
    Cell Significance Index: 26.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1648
    Cell Significance Index: 4.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0971
    Cell Significance Index: 53.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0749
    Cell Significance Index: 5.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0465
    Cell Significance Index: 0.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0286
    Cell Significance Index: 0.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0265
    Cell Significance Index: 0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0248
    Cell Significance Index: 1.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0238
    Cell Significance Index: 44.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0205
    Cell Significance Index: 9.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0192
    Cell Significance Index: 1.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0180
    Cell Significance Index: 24.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0134
    Cell Significance Index: 20.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0127
    Cell Significance Index: 1.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0102
    Cell Significance Index: 6.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0077
    Cell Significance Index: 0.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0062
    Cell Significance Index: 4.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.1800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0052
    Cell Significance Index: -0.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0063
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0090
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0097
    Cell Significance Index: -6.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0105
    Cell Significance Index: -0.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0147
    Cell Significance Index: -1.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0156
    Cell Significance Index: -0.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0176
    Cell Significance Index: -1.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0220
    Cell Significance Index: -16.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0268
    Cell Significance Index: -15.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0275
    Cell Significance Index: -20.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0283
    Cell Significance Index: -5.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0307
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0321
    Cell Significance Index: -9.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0384
    Cell Significance Index: -1.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0384
    Cell Significance Index: -16.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0444
    Cell Significance Index: -7.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0549
    Cell Significance Index: -2.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0561
    Cell Significance Index: -6.9000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0627
    Cell Significance Index: -0.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1052
    Cell Significance Index: -2.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1088
    Cell Significance Index: -11.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1363
    Cell Significance Index: -15.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1566
    Cell Significance Index: -20.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1579
    Cell Significance Index: -5.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1589
    Cell Significance Index: -3.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1618
    Cell Significance Index: -16.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1648
    Cell Significance Index: -18.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1815
    Cell Significance Index: -21.4100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1981
    Cell Significance Index: -1.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1983
    Cell Significance Index: -2.8400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2096
    Cell Significance Index: -3.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2121
    Cell Significance Index: -9.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2537
    Cell Significance Index: -20.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2552
    Cell Significance Index: -11.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2703
    Cell Significance Index: -20.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2781
    Cell Significance Index: -19.6700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2826
    Cell Significance Index: -2.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2875
    Cell Significance Index: -18.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2945
    Cell Significance Index: -19.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2950
    Cell Significance Index: -6.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3365
    Cell Significance Index: -17.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3505
    Cell Significance Index: -18.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3836
    Cell Significance Index: -10.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4094
    Cell Significance Index: -13.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The Leptin Receptor (LEPR) is a large transmembrane receptor, consisting of a ligand-binding extracellular domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. LEPR is highly expressed in various tissues, including adipose tissue, hypothalamus, and peripheral tissues, where it mediates the effects of leptin. The receptor is activated by binding of leptin to its extracellular domain, triggering a cascade of signaling events that regulate energy homeostasis, metabolism, and other physiological processes. **Pathways and Functions:** LEPR is involved in several key pathways, including: 1. **Leptin-mediated signaling pathway**: LEPR mediates the effects of leptin on energy balance, body weight regulation, and metabolism. 2. **Angiogenesis**: LEPR is involved in the regulation of angiogenesis, the formation of new blood vessels, which is critical for tissue growth and development. 3. **Cytokine-mediated signaling pathway**: LEPR interacts with various cytokines, including those involved in inflammation and immune responses. 4. **Energy homeostasis**: LEPR regulates energy balance by modulating glucose and lipid metabolism, as well as energy expenditure. 5. **Gluconeogenesis**: LEPR inhibits gluconeogenesis, the production of glucose from non-carbohydrate sources, which is critical for maintaining energy homeostasis. **Clinical Significance:** Dysregulation of LEPR has been implicated in various diseases, including: 1. **Obesity**: LEPR is involved in the regulation of energy balance and metabolism, making it a potential target for the treatment of obesity. 2. **Type 2 diabetes**: LEPR dysfunction has been linked to insulin resistance and impaired glucose metabolism. 3. **Cardiovascular disease**: LEPR is involved in the regulation of angiogenesis and vascular function, making it a potential target for the prevention and treatment of cardiovascular disease. 4. **Neurological disorders**: LEPR has been implicated in the regulation of energy homeostasis and metabolism in the brain, making it a potential target for the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, the Leptin Receptor (LEPR) is a crucial regulator of energy homeostasis and various physiological processes. Its dysregulation has been implicated in various diseases, highlighting the potential for LEPR as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 2126627489

Symbol: LEPR_HUMAN

Name: Leptin receptor

UniProtKB Accession Codes:

P48357 Q13592 Q13593 Q13594 Q92919 Q92920 Q92921

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 23 EMDB 3 Ensembl 6 EvolutionaryTrace 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8548812

Title: Identification and expression cloning of a leptin receptor, OB-R.

PubMed ID: 8548812

DOI: 10.1016/0092-8674(95)90151-5

PubMed ID: 8805376

Title: A role for leptin and its cognate receptor in hematopoiesis.

PubMed ID: 8805376

DOI: 10.1016/s0960-9822(02)70684-2

PubMed ID: 8616721

Title: Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.

PubMed ID: 8616721

DOI: 10.1038/nm0596-585

PubMed ID: 9158141

Title: Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.

PubMed ID: 9158141

DOI: 10.1093/hmg/6.5.675

PubMed ID: 9061609

Title: Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.

PubMed ID: 9061609

DOI: 10.1677/jme.0.0180077

PubMed ID: 9537324

Title: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.

PubMed ID: 9537324

DOI: 10.1038/32911

PubMed ID: 9929394

Title: The long terminal repeat of an endogenous retrovirus induces alternative splicing and encodes an additional carboxy-terminal sequence in the human leptin receptor.

PubMed ID: 9929394

DOI: 10.1007/pl00013153

PubMed ID: 9600917

Title: Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.

PubMed ID: 9600917

DOI: 10.1073/pnas.95.11.6061

PubMed ID: 9786864

Title: Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.

PubMed ID: 9786864

DOI: 10.1074/jbc.273.44.28691

PubMed ID: 10896907

Title: Leptin secretion and leptin receptor in the human stomach.

PubMed ID: 10896907

DOI: 10.1136/gut.47.2.178

PubMed ID: 12504075

Title: Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines.

PubMed ID: 12504075

DOI: 10.1016/s0006-291x(02)02838-3

PubMed ID: 16052473

Title: Leptin expression in human primary skeletal muscle cells is reduced during differentiation.

PubMed ID: 16052473

DOI: 10.1002/jcb.20521

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25060689

Title: Leptin modulates autophagy in human CD4+CD25- conventional T cells.

PubMed ID: 25060689

DOI: 10.1016/j.metabol.2014.06.010

PubMed ID: 22405007

Title: Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.

PubMed ID: 22405007

DOI: 10.1016/j.str.2012.01.019

PubMed ID: 8666155

Title: The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.

PubMed ID: 8666155

DOI: 10.2337/diab.45.7.992

PubMed ID: 9144432

Title: Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.

PubMed ID: 9144432

DOI: 10.1006/bbrc.1997.6430

PubMed ID: 9287054

Title: Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).

PubMed ID: 9287054

DOI: 10.2337/diab.46.9.1509

PubMed ID: 9175732

Title: Leptin receptor gene variation and obesity: lack of association in a white British male population.

PubMed ID: 9175732

DOI: 10.1093/hmg/6.6.869

PubMed ID: 9860295

Title: Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents.

PubMed ID: 9860295

DOI: 10.1007/s004390050867

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

PubMed ID: 25751111

Title: Seven novel deleterious LEPR mutations found in early-onset obesity: a DeltaExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect.

PubMed ID: 25751111

DOI: 10.1210/jc.2015-1036

Sequence Information:

  • Length: 1165
  • Mass: 132494
  • Checksum: CAA03BEAF2602D0A
  • Sequence:
    • MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS 
NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF 
QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS 
FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP 
LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP 
GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI 
VPSKEIVWWM NLAEKIPQSQ YDVVSDHVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH 
RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH 
PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP 
SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV 
PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKEKNV 
TLLWKPLMKN DSLCSVQRYV INHHTSCNGT WSEDVGNHTK FTFLWTEQAH TVTVLAINSI 
GASVANFNLT FSWPMSKVNI VQSLSAYPLN SSCVIVSWIL SPSDYKLMYF IIEWKNLNED 
GEIKWLRISS SVKKYYIHDH FIPIEKYQFS LYPIFMEGVG KPKIINSFTQ DDIEKHQSDA 
GLYVIVPVII SSSILLLGTL LISHQRMKKL FWEDVPNPKN CSWAQGLNFQ KPETFEHLFI 
KHTASVTCGP LLLEPETISE DISVDTSWKN KDEMMPTTVV SLLSTTDLEK GSVCISDQFN 
SVNFSEAEGT EVTYEDESQR QPFVKYATLI SNSKPSETGE EQGLINSSVT KCFSSKNSPL 
KDSFSNSSWE IEAQAFFILS DQHPNIISPH LTFSEGLDEL LKLEGNFPEE NNDKKSIYYL 
GVTSIKKRES GVLLTDKSRV SCPFPAPCLF TDIRVLQDSC SHFVENNINL GTSSKKTFAS 
YMPQFQTCST QTHKIMENKM CDLTV

Genular Protein ID: 3296656622

Symbol: Q4G138_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4G138

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 3 RefSeq 3 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 659
  • Mass: 75220
  • Checksum: 5DDFABBED8321A78
  • Sequence:
    • MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS 
NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF 
QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS 
FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP 
LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP 
GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI 
VPSKEIVWWM NLAEKIPQSQ YDVVSDNVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH 
RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH 
PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP 
SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV 
PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.