Details for: LIFR
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 143.5220
Cell Significance Index: -67.7600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 138.9514
Cell Significance Index: -56.4500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 59.2254
Cell Significance Index: -56.5500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 23.1291
Cell Significance Index: -50.6200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.2296
Cell Significance Index: -52.9200 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 2.7600
Cell Significance Index: 38.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.7284
Cell Significance Index: 142.1200 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.5784
Cell Significance Index: 17.4700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.7841
Cell Significance Index: 34.8200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4966
Cell Significance Index: 536.8000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0496
Cell Significance Index: 80.5500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9600
Cell Significance Index: 192.5800 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.7480
Cell Significance Index: 5.9100 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.4982
Cell Significance Index: 5.1600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4370
Cell Significance Index: 302.2300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3259
Cell Significance Index: 37.9800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3236
Cell Significance Index: 64.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2013
Cell Significance Index: 127.8300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1772
Cell Significance Index: 326.8700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1573
Cell Significance Index: 296.1600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1544
Cell Significance Index: 2.2200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1457
Cell Significance Index: 0.8800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1327
Cell Significance Index: 60.2500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1028
Cell Significance Index: 158.2800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0813
Cell Significance Index: 10.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0412
Cell Significance Index: 37.2300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0071
Cell Significance Index: 0.1900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0034
Cell Significance Index: 1.8800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0023
Cell Significance Index: 1.6700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0044
Cell Significance Index: -6.0400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0177
Cell Significance Index: -11.0600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0584
Cell Significance Index: -43.2900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0733
Cell Significance Index: -32.3900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0742
Cell Significance Index: -56.1700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0850
Cell Significance Index: -14.5200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0995
Cell Significance Index: -5.0300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1040
Cell Significance Index: -58.6700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1288
Cell Significance Index: -23.2200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1443
Cell Significance Index: -19.8100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1526
Cell Significance Index: -6.7500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1538
Cell Significance Index: -10.3400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1682
Cell Significance Index: -6.3700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1782
Cell Significance Index: -10.9300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1841
Cell Significance Index: -52.9800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1949
Cell Significance Index: -28.3300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.2319
Cell Significance Index: -44.1300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2420
Cell Significance Index: -50.9800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2557
Cell Significance Index: -31.4400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2899
Cell Significance Index: -17.8200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2902
Cell Significance Index: -7.4600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3002
Cell Significance Index: -5.3100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3138
Cell Significance Index: -19.7800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3178
Cell Significance Index: -9.1100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.3212
Cell Significance Index: -52.2400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3512
Cell Significance Index: -35.8700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3897
Cell Significance Index: -50.3500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.5115
Cell Significance Index: -50.6000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5383
Cell Significance Index: -25.1000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5509
Cell Significance Index: -62.8800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.5623
Cell Significance Index: -13.7200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5798
Cell Significance Index: -60.3700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5901
Cell Significance Index: -67.6000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.5949
Cell Significance Index: -64.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6394
Cell Significance Index: -35.8800 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.6738
Cell Significance Index: -11.6500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.7025
Cell Significance Index: -52.3600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7491
Cell Significance Index: -59.3300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.7518
Cell Significance Index: -9.3800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.7559
Cell Significance Index: -35.5300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.8050
Cell Significance Index: -11.5600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.8321
Cell Significance Index: -58.8500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.8965
Cell Significance Index: -31.5000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.9029
Cell Significance Index: -15.1100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.9636
Cell Significance Index: -66.6400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.0117
Cell Significance Index: -65.2700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.1399
Cell Significance Index: -51.6700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.1462
Cell Significance Index: -60.1800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.1774
Cell Significance Index: -61.1700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.2355
Cell Significance Index: -18.2400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2397
Cell Significance Index: -43.0800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.3771
Cell Significance Index: -36.2100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.3891
Cell Significance Index: -45.4800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.4261
Cell Significance Index: -49.9600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4855
Cell Significance Index: -47.3100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.5100
Cell Significance Index: -43.0900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.5205
Cell Significance Index: -32.5000 - Cell Name: astrocyte (CL0000127)
Fold Change: -1.5485
Cell Significance Index: -17.7200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.6363
Cell Significance Index: -45.7300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.6527
Cell Significance Index: -60.6700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.7033
Cell Significance Index: -40.8500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.7605
Cell Significance Index: -30.1700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.7839
Cell Significance Index: -37.3400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.7970
Cell Significance Index: -38.1400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.8259
Cell Significance Index: -39.4500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.8362
Cell Significance Index: -54.0900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.9169
Cell Significance Index: -55.2300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -2.0089
Cell Significance Index: -50.1100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -2.0094
Cell Significance Index: -54.7000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -2.0246
Cell Significance Index: -23.0000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -2.0450
Cell Significance Index: -25.8100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3201650940
Symbol: LIFR_HUMAN
Name: Leukemia inhibitory factor receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1915266
Title: Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.
PubMed ID: 1915266
PubMed ID: 9525740
Title: The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.
PubMed ID: 9525740
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18775332
Title: Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.
PubMed ID: 18775332
PubMed ID: 14740318
Title: Null leukemia inhibitory factor receptor (LIFR) mutations in Stueve-Wiedemann/Schwartz-Jampel type 2 syndrome.
PubMed ID: 14740318
DOI: 10.1086/381715
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 1097
- Mass: 123743
- Checksum: C8602897E359FCE5
- Sequence:
MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP VKNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS NGGGWSFTNF FQNKPND
Genular Protein ID: 3966010311
Symbol: A8K1Z4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1097
- Mass: 123831
- Checksum: 5E600CB2EE929FF6
- Sequence:
MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP VRNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDFPKS NGGGWSFTNF FQNKPND
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.