LIFR | ENSG00000113594 | NCBI 3977

Details for: LIFR

Gene ID: 3977

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: LIFR

Ensembl ID: ENSG00000113594

Description: LIF receptor subunit alpha

Cell Significance Landscape

Display Count:

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Il-6-type cytokine receptor ligand interactions
(R-HSA-6788467)
Immune system
(R-HSA-168256)
Interleukin-6 family signaling
(R-HSA-6783589)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in interleukin signaling
(R-HSA-8939247)
Signaling by interleukins
(R-HSA-449147)
Transcriptional regulation by runx1
(R-HSA-8878171)
Cell surface receptor signaling pathway
(GO:0007166)
Ciliary neurotrophic factor-mediated signaling pathway
(GO:0070120)
Ciliary neurotrophic factor receptor activity
(GO:0004897)
Ciliary neurotrophic factor receptor binding
(GO:0005127)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Growth factor binding
(GO:0019838)
Leukemia inhibitory factor receptor activity
(GO:0004923)
Leukemia inhibitory factor signaling pathway
(GO:0048861)
Oncostatin-m-mediated signaling pathway
(GO:0038165)
Oncostatin-m receptor activity
(GO:0004924)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Response to cytokine
(GO:0034097)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

Bergmann glial cell CL0000644

CSI 34.45

rCSI 47.14%

PRS 57.67
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 24.64

rCSI 75.93%

PRS 72.43
astrocyte of the cerebral cortex CL0002605

CSI 24.56

rCSI 55.06%

PRS 46.67
astrocyte CL0000127

CSI 22.07

rCSI 47.02%

PRS 36.36
extravillous trophoblast CL0008036

CSI 20.27

rCSI 25.07%

PRS 61.26
macroglial cell CL0000126

CSI 20.17

rCSI 51.85%

PRS 63.54
myoepithelial cell CL0000185

CSI 17.86

rCSI 45.18%

PRS 72.28
retinal blood vessel endothelial cell CL0002585

CSI 16.82

rCSI 26.85%

PRS 68.78
neural crest cell CL0011012

CSI 16.65

rCSI 13.16%

PRS 51.39
blood vessel endothelial cell CL0000071

CSI 14.52

rCSI 30.14%

PRS 61.68
endothelial cell of artery CL1000413

CSI 12.42

rCSI 18.2%

PRS 80.35
pulmonary artery endothelial cell CL1001568

CSI 11.02

rCSI 15%

PRS 75.84
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 10.54

rCSI 14.94%

PRS 60.91
fallopian tube secretory epithelial cell CL4030006

CSI 10.19

rCSI 9.81%

PRS 64.45
ependymal cell CL0000065

CSI 10.05

rCSI 20.39%

PRS 43.51
pulmonary ionocyte CL0017000

CSI 9.56

rCSI 11.64%

PRS 72.03
vein endothelial cell CL0002543

CSI 9.35

rCSI 25.53%

PRS 80.9
pulmonary alveolar type 1 cell CL0002062

CSI 8.87

rCSI 51.13%

PRS 62.93
endothelial cell of placenta CL0009092

CSI 8.84

rCSI 43.57%

PRS 75.35
renal alpha-intercalated cell CL0005011

CSI 8.84

rCSI 11.82%

PRS 73.4
vascular leptomeningeal cell CL4023051

CSI 8.69

rCSI 15.23%

PRS 56.54
retinal rod cell CL0000604

CSI 8.63

rCSI 15.21%

PRS 61.11
lamp5 GABAergic cortical interneuron CL4023011

CSI 8.31

rCSI 13.94%

PRS 45.98
cardiac endothelial cell CL0010008

CSI 8.12

rCSI 32.74%

PRS 63.45
glutamatergic neuron CL0000679

CSI 8.11

rCSI 16.66%

PRS 54.37
endothelial cell of arteriole CL1000412

CSI 8.02

rCSI 44.48%

PRS 79.18
vein endothelial cell of respiratory system CL4033008

CSI 7.7

rCSI 52.86%

PRS 76.66
Mueller cell CL0000636

CSI 7.41

rCSI 16.92%

PRS 56.13
Schwann cell CL0002573

CSI 7.29

rCSI 20.73%

PRS 62.45
glioblast CL0000030

CSI 7.28

rCSI 11.62%

PRS 56.88
capillary endothelial cell CL0002144

CSI 7.07

rCSI 12.95%

PRS 74.8
syncytiotrophoblast cell CL0000525

CSI 7.05

rCSI 20.3%

PRS 77.11
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 6.77

rCSI 24.37%

PRS 44.29
pvalb GABAergic cortical interneuron CL4023018

CSI 6.73

rCSI 8.37%

PRS 44.16
GABAergic neuron CL0000617

CSI 6.71

rCSI 22.48%

PRS 49.38
inhibitory interneuron CL0000498

CSI 6.7

rCSI 15.47%

PRS 53.19
perivascular cell CL4033054

CSI 6.65

rCSI 9.09%

PRS 70.41
pulmonary capillary endothelial cell CL4028001

CSI 6.54

rCSI 12.46%

PRS 78.85
vasa recta ascending limb cell CL1001131

CSI 6.53

rCSI 29.54%

PRS 79.87
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 6.5

rCSI 15.8%

PRS 44.46
secretory cell CL0000151

CSI 6.5

rCSI 6.78%

PRS 64.88
cardiac blood vessel endothelial cell CL0010006

CSI 6.19

rCSI 43.77%

PRS 56.45
cerebral cortex endothelial cell CL1001602

CSI 6.03

rCSI 10.43%

PRS 54.63
epithelial cell of proximal tubule CL0002306

CSI 5.92

rCSI 14.45%

PRS 57.69
alveolar type 1 fibroblast cell CL4028004

CSI 5.83

rCSI 6.39%

PRS 68.24
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 5.79

rCSI 10.22%

PRS 45.07
adipocyte CL0000136

CSI 5.72

rCSI 7.35%

PRS 56.83
fibroblast of lung CL0002553

CSI 5.67

rCSI 5.27%

PRS 65.2
mesenchymal cell CL0008019

CSI 5.64

rCSI 14.33%

PRS 58.62
hepatic stellate cell CL0000632

CSI 5.62

rCSI 21.06%

PRS 56.46
kidney interstitial alternatively activated macrophage CL1000695

CSI 5.19

rCSI 13.54%

PRS 64.28
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 5.04

rCSI 15.77%

PRS 50.07
keratocyte CL0002363

CSI 4.85

rCSI 11.65%

PRS 71.72
L6b glutamatergic cortical neuron CL4023038

CSI 4.76

rCSI 14.89%

PRS 47.63
oligodendrocyte precursor cell CL0002453

CSI 4.73

rCSI 10.41%

PRS 47.22
cerebral cortex neuron CL0010012

CSI 4.65

rCSI 18.93%

PRS 58.28
vascular associated smooth muscle cell CL0000359

CSI 4.64

rCSI 15.04%

PRS 64.39
ciliated epithelial cell CL0000067

CSI 4.61

rCSI 4.05%

PRS 52.46
melanocyte CL0000148

CSI 4.54

rCSI 3.36%

PRS 57.08
skin fibroblast CL0002620

CSI 4.35

rCSI 3.75%

PRS 69.46
sst GABAergic cortical interneuron CL4023017

CSI 4.3

rCSI 5.54%

PRS 47.26
near-projecting glutamatergic cortical neuron CL4023012

CSI 4.19

rCSI 15.84%

PRS 46.66
choroid plexus epithelial cell CL0000706

CSI 4.17

rCSI 6.83%

PRS 53.64
oligodendrocyte CL0000128

CSI 4.13

rCSI 12.2%

PRS 54.39
Kupffer cell CL0000091

CSI 4.1

rCSI 9.37%

PRS 64.56
amacrine cell CL0000561

CSI 4.06

rCSI 11.77%

PRS 54.04
endothelial cell of venule CL1000414

CSI 3.62

rCSI 32.09%

PRS 79.75
differentiation-committed oligodendrocyte precursor CL4023059

CSI 3.57

rCSI 6.49%

PRS 56.24
brush cell of tracheobronchial tree CL0002075

CSI 3.57

rCSI 10.59%

PRS 74.22
conjunctival epithelial cell CL1000432

CSI 3.41

rCSI 5.2%

PRS 65.27
placental villous trophoblast CL2000060

CSI 3.39

rCSI 5.24%

PRS 63.01
mature astrocyte CL0002627

CSI 3.34

rCSI 14.2%

PRS 57.63
retinal ganglion cell CL0000740

CSI 3.24

rCSI 7.15%

PRS 50.52
cardiac neuron CL0010022

CSI 3.21

rCSI 10.28%

PRS 61.63
epithelial cell of lung CL0000082

CSI 3.18

rCSI 2.64%

PRS 64
basal cell CL0000646

CSI 3.18

rCSI 4.25%

PRS 64.79
fibroblast of cardiac tissue CL0002548

CSI 3.17

rCSI 15.18%

PRS 64.52
multi-ciliated epithelial cell CL0005012

CSI 3.14

rCSI 3.14%

PRS 57.95
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.13

rCSI 8.08%

PRS 59.53
endothelial cell of uterus CL0009095

CSI 3.04

rCSI 22.22%

PRS 79.91
cardiac muscle cell CL0000746

CSI 3.02

rCSI 4.33%

PRS 54.12
bronchus fibroblast of lung CL2000093

CSI 2.94

rCSI 2.39%

PRS 64.88
luminal cell of prostate epithelium CL0002340

CSI 2.91

rCSI 15.67%

PRS 75.95
stromal cell CL0000499

CSI 2.86

rCSI 8.04%

PRS 61.02
basal-myoepithelial cell of mammary gland CL0002324

CSI 2.85

rCSI 5.38%

PRS 81.89
kidney collecting duct intercalated cell CL1001432

CSI 2.84

rCSI 20.3%

PRS 64.43
epithelial cell of lower respiratory tract CL0002632

CSI 2.83

rCSI 2.19%

PRS 66.99
cerebellar granule cell CL0001031

CSI 2.83

rCSI 4.15%

PRS 57.81
OFF midget ganglion cell CL4033047

CSI 2.74

rCSI 55.73%

PRS 56.58
lung endothelial cell CL1001567

CSI 2.71

rCSI 6.32%

PRS 81.51
pulmonary alveolar type 2 cell CL0002063

CSI 2.7

rCSI 4.18%

PRS 71.64
endocardial cell CL0002350

CSI 2.68

rCSI 12.82%

PRS 62.75
renal principal cell CL0005009

CSI 2.63

rCSI 6.84%

PRS 67.91
regular atrial cardiac myocyte CL0002129

CSI 2.62

rCSI 8.42%

PRS 62.41
vasa recta descending limb cell CL1001285

CSI 2.56

rCSI 20.42%

PRS 81.32
alveolar adventitial fibroblast CL4028006

CSI 2.55

rCSI 4.03%

PRS 67.05
renal beta-intercalated cell CL0002201

CSI 2.53

rCSI 6.04%

PRS 65.13
VIP GABAergic cortical interneuron CL4023016

CSI 2.53

rCSI 3.02%

PRS 45.79
interneuron CL0000099

CSI 2.51

rCSI 5.04%

PRS 53.53
GABAergic amacrine cell CL4030027

CSI 2.49

rCSI 8.54%

PRS 53.06

peptic cell CL0000155

CSI 0.2

rCSI 1.9%

PRS 81.7%
mesenchymal stem cell CL0000134

CSI 0.5

rCSI 5.1%

PRS 76.0%
ON parasol ganglion cell CL4033052

CSI 0.5

rCSI 6.8%

PRS 55.5%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.6

rCSI 1.4%

PRS 51.6%
collagen secreting cell CL0000667

CSI 0.7

rCSI 3.8%

PRS 77.7%
regular ventricular cardiac myocyte CL0002131

CSI 0.7

rCSI 4.5%

PRS 56.3%
parietal cell CL0000162

CSI 0.8

rCSI 7.0%

PRS 87.6%
neuroendocrine cell CL0000165

CSI 0.8

rCSI 3.2%

PRS 78.4%
central nervous system neuron CL2000029

CSI 0.9

rCSI 6.5%

PRS 51.0%
podocyte CL0000653

CSI 0.9

rCSI 4.0%

PRS 64.4%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.0

rCSI 10.1%

PRS 62.6%
airway submucosal gland duct basal cell CL4033024

CSI 1.1

rCSI 6.8%

PRS 73.6%
mesangial cell CL0000650

CSI 1.1

rCSI 4.5%

PRS 76.3%
smooth muscle cell of the pulmonary artery CL0002591

CSI 1.1

rCSI 8.5%

PRS 70.3%
pancreatic acinar cell CL0002064

CSI 1.3

rCSI 1.8%

PRS 70.9%
medium spiny neuron CL1001474

CSI 1.3

rCSI 11.4%

PRS 51.6%
mesenchymal stem cell of adipose tissue CL0002570

CSI 1.4

rCSI 7.6%

PRS 73.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.5

rCSI 8.9%

PRS 47.1%
stromal cell of ovary CL0002132

CSI 1.5

rCSI 4.2%

PRS 76.6%
ON midget ganglion cell CL4033046

CSI 1.6

rCSI 31.7%

PRS 55.1%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.6

rCSI 13.7%

PRS 61.2%
forebrain radial glial cell CL0013000

CSI 1.6

rCSI 5.2%

PRS 69.2%
indirect pathway medium spiny neuron CL4023029

CSI 1.6

rCSI 39.5%

PRS 45.8%
type EC enteroendocrine cell CL0000577

CSI 1.7

rCSI 6.1%

PRS 72.5%
lung ciliated cell CL1000271

CSI 1.8

rCSI 2.0%

PRS 54.9%
hepatocyte CL0000182

CSI 1.8

rCSI 3.2%

PRS 63.7%
adventitial cell CL0002503

CSI 1.8

rCSI 4.3%

PRS 72.7%
direct pathway medium spiny neuron CL4023026

CSI 1.9

rCSI 46.3%

PRS 45.0%
respiratory suprabasal cell CL4033048

CSI 2.0

rCSI 2.5%

PRS 69.3%
mesodermal cell CL0000222

CSI 2.0

rCSI 2.5%

PRS 62.7%
parietal epithelial cell CL1000452

CSI 2.1

rCSI 5.6%

PRS 55.5%
lung secretory cell CL1000272

CSI 2.1

rCSI 5.2%

PRS 63.1%
stem cell CL0000034

CSI 2.1

rCSI 2.1%

PRS 55.4%
endothelial cell of vascular tree CL0002139

CSI 2.2

rCSI 11.9%

PRS 62.7%
sncg GABAergic cortical interneuron CL4023015

CSI 2.2

rCSI 3.6%

PRS 47.9%
lung microvascular endothelial cell CL2000016

CSI 2.2

rCSI 43.3%

PRS 78.9%
kidney connecting tubule epithelial cell CL1000768

CSI 2.3

rCSI 5.7%

PRS 53.9%
mucous neck cell CL0000651

CSI 2.3

rCSI 3.3%

PRS 74.9%
chondrocyte CL0000138

CSI 2.3

rCSI 3.7%

PRS 57.0%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 2.4

rCSI 11.0%

PRS 74.9%
renal interstitial pericyte CL1001318

CSI 2.4

rCSI 6.7%

PRS 59.9%
GABAergic amacrine cell CL4030027

CSI 2.5

rCSI 8.5%

PRS 53.1%
interneuron CL0000099

CSI 2.5

rCSI 5.0%

PRS 53.5%
VIP GABAergic cortical interneuron CL4023016

CSI 2.5

rCSI 3.0%

PRS 45.8%
renal beta-intercalated cell CL0002201

CSI 2.5

rCSI 6.0%

PRS 65.1%
alveolar adventitial fibroblast CL4028006

CSI 2.6

rCSI 4.0%

PRS 67.1%
vasa recta descending limb cell CL1001285

CSI 2.6

rCSI 20.4%

PRS 81.3%
regular atrial cardiac myocyte CL0002129

CSI 2.6

rCSI 8.4%

PRS 62.4%
renal principal cell CL0005009

CSI 2.6

rCSI 6.8%

PRS 67.9%
endocardial cell CL0002350

CSI 2.7

rCSI 12.8%

PRS 62.8%
pulmonary alveolar type 2 cell CL0002063

CSI 2.7

rCSI 4.2%

PRS 71.6%
lung endothelial cell CL1001567

CSI 2.7

rCSI 6.3%

PRS 81.5%
OFF midget ganglion cell CL4033047

CSI 2.7

rCSI 55.7%

PRS 56.6%
cerebellar granule cell CL0001031

CSI 2.8

rCSI 4.2%

PRS 57.8%
epithelial cell of lower respiratory tract CL0002632

CSI 2.8

rCSI 2.2%

PRS 67.0%
kidney collecting duct intercalated cell CL1001432

CSI 2.8

rCSI 20.3%

PRS 64.4%
basal-myoepithelial cell of mammary gland CL0002324

CSI 2.9

rCSI 5.4%

PRS 81.9%
stromal cell CL0000499

CSI 2.9

rCSI 8.0%

PRS 61.0%
luminal cell of prostate epithelium CL0002340

CSI 2.9

rCSI 15.7%

PRS 76.0%
bronchus fibroblast of lung CL2000093

CSI 2.9

rCSI 2.4%

PRS 64.9%
cardiac muscle cell CL0000746

CSI 3.0

rCSI 4.3%

PRS 54.1%
endothelial cell of uterus CL0009095

CSI 3.0

rCSI 22.2%

PRS 79.9%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.1

rCSI 8.1%

PRS 59.5%
multi-ciliated epithelial cell CL0005012

CSI 3.1

rCSI 3.1%

PRS 58.0%
fibroblast of cardiac tissue CL0002548

CSI 3.2

rCSI 15.2%

PRS 64.5%
basal cell CL0000646

CSI 3.2

rCSI 4.3%

PRS 64.8%
epithelial cell of lung CL0000082

CSI 3.2

rCSI 2.6%

PRS 64.0%
cardiac neuron CL0010022

CSI 3.2

rCSI 10.3%

PRS 61.6%
retinal ganglion cell CL0000740

CSI 3.2

rCSI 7.2%

PRS 50.5%
mature astrocyte CL0002627

CSI 3.3

rCSI 14.2%

PRS 57.6%
placental villous trophoblast CL2000060

CSI 3.4

rCSI 5.2%

PRS 63.0%
conjunctival epithelial cell CL1000432

CSI 3.4

rCSI 5.2%

PRS 65.3%
brush cell of tracheobronchial tree CL0002075

CSI 3.6

rCSI 10.6%

PRS 74.2%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 3.6

rCSI 6.5%

PRS 56.2%
endothelial cell of venule CL1000414

CSI 3.6

rCSI 32.1%

PRS 79.8%
amacrine cell CL0000561

CSI 4.1

rCSI 11.8%

PRS 54.0%
Kupffer cell CL0000091

CSI 4.1

rCSI 9.4%

PRS 64.6%
oligodendrocyte CL0000128

CSI 4.1

rCSI 12.2%

PRS 54.4%
choroid plexus epithelial cell CL0000706

CSI 4.2

rCSI 6.8%

PRS 53.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI 4.2

rCSI 15.8%

PRS 46.7%
sst GABAergic cortical interneuron CL4023017

CSI 4.3

rCSI 5.5%

PRS 47.3%
skin fibroblast CL0002620

CSI 4.4

rCSI 3.8%

PRS 69.5%
melanocyte CL0000148

CSI 4.5

rCSI 3.4%

PRS 57.1%
ciliated epithelial cell CL0000067

CSI 4.6

rCSI 4.1%

PRS 52.5%
vascular associated smooth muscle cell CL0000359

CSI 4.6

rCSI 15.0%

PRS 64.4%
cerebral cortex neuron CL0010012

CSI 4.7

rCSI 18.9%

PRS 58.3%
oligodendrocyte precursor cell CL0002453

CSI 4.7

rCSI 10.4%

PRS 47.2%
L6b glutamatergic cortical neuron CL4023038

CSI 4.8

rCSI 14.9%

PRS 47.6%
keratocyte CL0002363

CSI 4.9

rCSI 11.7%

PRS 71.7%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 5.0

rCSI 15.8%

PRS 50.1%
kidney interstitial alternatively activated macrophage CL1000695

CSI 5.2

rCSI 13.5%

PRS 64.3%
hepatic stellate cell CL0000632

CSI 5.6

rCSI 21.1%

PRS 56.5%
mesenchymal cell CL0008019

CSI 5.6

rCSI 14.3%

PRS 58.6%
fibroblast of lung CL0002553

CSI 5.7

rCSI 5.3%

PRS 65.2%
adipocyte CL0000136

CSI 5.7

rCSI 7.4%

PRS 56.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 5.8

rCSI 10.2%

PRS 45.1%
alveolar type 1 fibroblast cell CL4028004

CSI 5.8

rCSI 6.4%

PRS 68.2%
epithelial cell of proximal tubule CL0002306

CSI 5.9

rCSI 14.5%

PRS 57.7%
cerebral cortex endothelial cell CL1001602

CSI 6.0

rCSI 10.4%

PRS 54.6%
cardiac blood vessel endothelial cell CL0010006

CSI 6.2

rCSI 43.8%

PRS 56.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [LIFR](/details-gene/3977) (Leukemia Inhibitory Factor Receptor Subunit Alpha) is a protein-coding gene located on chromosome 5p13.1. It encodes the alpha subunit of the receptor for leukemia inhibitory factor (LIF), a pleiotropic cytokine belonging to the interleukin-6 family. This receptor, upon binding LIF, forms a high-affinity signaling complex with the common signal transducer gp130, initiating intracellular signaling cascades, primarily the JAK/STAT and MAPK pathways ([Link](https://doi.org/10.1002/j.1460-2075.1991.tb07833.x)). The expression profile of [LIFR](/details-gene/3977) indicates a significant role in the central nervous system and vascular endothelium. **Overall**, it shows the highest significance in glial cells, including [Bergmann glial cell](/details-cell/CL0000644) and [astrocyte of the cerebral cortex](/details-cell/CL0002605), as well as in various endothelial cell populations such as [endothelial cell of pericentral hepatic sinusoid](/details-cell/CL0019022). Clinically, null mutations in [LIFR](/details-gene/3977) are associated with Stueve-Wiedemann/Schwartz-Jampel type 2 syndrome ([151443](https://omim.org/entry/151443), [601559](https://omim.org/entry/601559)), a severe congenital skeletal dysplasia syndrome ([Link](https://doi.org/10.1086/381715)). ## Cellular Roles and Expression Landscape The expression pattern of [LIFR](/details-gene/3977) highlights its importance in non-neuronal cells of the central nervous system and in the lining of the vasculature. **Overall**, the gene demonstrates its highest significance in glial cell populations. It is a top marker for [Bergmann glial cell](/details-cell/CL0000644) (CSI: 34.45), [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 24.56), and the broader [astrocyte](/details-cell/CL0000127) category (CSI: 22.07), suggesting a fundamental role in glial function, which may include neuronal support, synaptic modulation, and response to injury. Its high CSI in [ependymal cell](/details-cell/CL0000065) further supports its relevance within the CNS. A second major expression domain is the vascular endothelium. [LIFR](/details-gene/3977) is highly significant in [endothelial cell of pericentral hepatic sinusoid](/details-cell/CL0019022) (CSI: 24.64), [retinal blood vessel endothelial cell](/details-cell/CL0002585) (CSI: 16.82), and [pulmonary artery endothelial cell](/details-cell/CL1001568) (CSI: 11.02). This widespread expression across different endothelial beds points towards a role in regulating vascular homeostasis, inflammation, or angiogenesis in response to circulating cytokines. Beyond these two primary domains, [LIFR](/details-gene/3977) also shows notable significance in specialized epithelial and developmental cell types, including [extravillous trophoblast](/details-cell/CL0008036) (CSI: 20.27), [myoepithelial cell](/details-cell/CL0000185) (CSI: 17.86), and [neural crest cell](/details-cell/CL0011012) (CSI: 16.65), indicating diverse functional roles in tissue development and maintenance. ## Pathways and Molecular Function Functionally, [LIFR](/details-gene/3977) is a quintessential cytokine receptor. Its molecular functions are dominated by activities such as '[cytokine receptor activity](/details-ontology/GO0004896)', '[leukemia inhibitory factor receptor activity](/details-ontology/GO0004923)', and '[oncostatin-m receptor activity](/details-ontology/GO0004924)'. As a component of the '[receptor complex](/details-ontology/GO0043235)' on the '[external side of plasma membrane](/details-ontology/GO0009897)', it is poised to respond to extracellular signals. The biological processes it mediates are consistent with its receptor function, primarily the '[cytokine-mediated signaling pathway](/details-ontology/GO0019221)' and more specifically, the '[leukemia inhibitory factor signaling pathway](/details-ontology/GO0048861)'. Its involvement in '[positive regulation of cell population proliferation](/details-ontology/GO0008284)' aligns with the known roles of the IL-6 cytokine family in cell growth and differentiation. Reactome pathway analysis further elaborates on its signaling context, placing it centrally within '[Interleukin-6 family signaling](/details-pathway/R-HSA-6783589)' and the broader '[Cytokine signaling in immune system](/details-pathway/R-HSA-1280215)'. The downstream consequences of [LIFR](/details-gene/3977) activation are reflected in its association with transcriptional regulation pathways, including '[Generic transcription pathway](/details-pathway/R-HSA-212436)' and '[Transcriptional regulation by runx1](/details-pathway/R-HSA-8878171)', indicating that its primary output is the modulation of gene expression programs. This signaling activity likely underpins its functional roles in the glial and endothelial cells where it is most prominently expressed. ## Research Directions The expression profile and functional annotation of [LIFR](/details-gene/3977) suggest several avenues for future investigation, particularly concerning its roles in tissue homeostasis and pathology. The known association with Stueve-Wiedemann syndrome from loss-of-function mutations highlights its critical, non-redundant role in human development. Furthermore, its involvement in pleomorphic adenomas through chromosomal translocation resulting in promoter swapping suggests it can act as a proto-oncogene when its expression is deregulated ([Link](https://doi.org/10.1038/sj.onc.1201660)). ### Testable Hypotheses 1. **Glial-Mediated Neuroinflammation:** Given its high expression in astrocytes, [LIFR](/details-gene/3977) signaling may be a key regulator of astrogliosis and the neuroinflammatory response following CNS injury or in neurodegenerative diseases. Dysregulation of this pathway in [astrocytes](/details-cell/CL0000127) could either exacerbate or mitigate neuronal damage depending on the context. 2. **Endothelial Barrier Regulation:** The prominent expression of [LIFR](/details-gene/3977) across various endothelial beds suggests a role in modulating vascular permeability and leukocyte trafficking in response to inflammatory cytokines like LIF and Oncostatin M. This function could be critical in inflammatory conditions and tumor angiogenesis. ### Proposed Experimental Approach To test the second hypothesis regarding endothelial barrier regulation, a conditional knockout mouse model could be employed. Specifically, crossing mice with floxed [LIFR](/details-gene/3977) alleles to a Cdh5-CreERT2 line would allow for inducible, endothelium-specific deletion of the receptor in adult animals. These knockout mice and their littermate controls could then be subjected to inflammatory challenges, such as systemic LPS administration or a localized skin inflammation model. Vascular permeability could be quantified using Evans blue dye extravasation assays. Furthermore, in a tumor implantation model (e.g., B16 melanoma), the role of endothelial [LIFR](/details-gene/3977) in tumor angiogenesis and metastasis could be assessed by measuring tumor growth, microvessel density, and the extravasation of circulating tumor cells. ### Therapeutic Potential As a cell surface receptor that signals for cell proliferation, [LIFR](/details-gene/3977) represents a plausible therapeutic target. In cancers where its pathway is aberrantly activated, such as pleomorphic adenomas driven by the *PLAG1* fusion, **inhibition** would be the desired strategy. This could be achieved through the development of monoclonal antibodies that block ligand binding or receptor dimerization, or with small molecule inhibitors targeting downstream effectors like JAK kinases. Given its specific expression pattern, such therapies might offer a targeted approach with a potentially favorable therapeutic window, though its role in normal glial and endothelial function would need to be carefully considered.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Leukemia inhibitory factor receptor
A8K1Z4_HUMAN

Genular Protein ID: 3201650940

Symbol: LIFR_HUMAN

Name: Leukemia inhibitory factor receptor

UniProtKB Accession Codes:

P42702 Q6LCD9

Database IDs:

Citations:

PubMed ID: 1915266

Title: Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

PubMed ID: 1915266

DOI: 10.1002/j.1460-2075.1991.tb07833.x

PubMed ID: 9525740

Title: The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.

PubMed ID: 9525740

DOI: 10.1038/sj.onc.1201660

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18775332

Title: Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.

PubMed ID: 18775332

DOI: 10.1016/j.molcel.2008.08.011

PubMed ID: 14740318

Title: Null leukemia inhibitory factor receptor (LIFR) mutations in Stueve-Wiedemann/Schwartz-Jampel type 2 syndrome.

PubMed ID: 14740318

DOI: 10.1086/381715

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 1097
Mass: 123743
Checksum: C8602897E359FCE5
Sequence:

MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL 
QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS 
STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE 
SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP 
VKNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK 
IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA 
LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ 
STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR 
NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD 
TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK 
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK 
WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE 
ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR 
SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI 
LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM 
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN 
PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE 
DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS 
NGGGWSFTNF FQNKPND

Genular Protein ID: 3966010311

Symbol: A8K1Z4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K1Z4