Details for: LIFR

Gene ID: 3977

Symbol: LIFR

Ensembl ID: ENSG00000113594

Description: LIF receptor subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.02
    Marker Score: 64438
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.98
    Marker Score: 3188.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.95
    Marker Score: 1942
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.9
    Marker Score: 4221
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.66
    Marker Score: 5311
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.66
    Marker Score: 6754
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.62
    Marker Score: 2259
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.56
    Marker Score: 4920
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.53
    Marker Score: 1664
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.5
    Marker Score: 942
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.29
    Marker Score: 1982
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.22
    Marker Score: 1171
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.14
    Marker Score: 498
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.13
    Marker Score: 18690
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.08
    Marker Score: 442
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.05
    Marker Score: 1157
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.02
    Marker Score: 2713
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.99
    Marker Score: 4371.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.99
    Marker Score: 2120
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.96
    Marker Score: 1091
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.95
    Marker Score: 428
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.9
    Marker Score: 522
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.85
    Marker Score: 523
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.81
    Marker Score: 4857
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.8
    Marker Score: 1075
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.8
    Marker Score: 4301
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.79
    Marker Score: 6909
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.72
    Marker Score: 25735
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.71
    Marker Score: 2900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.71
    Marker Score: 1845
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.69
    Marker Score: 1529
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.67
    Marker Score: 402
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.66
    Marker Score: 694
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14137
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.64
    Marker Score: 1469
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.62
    Marker Score: 1741
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.61
    Marker Score: 503
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.59
    Marker Score: 576
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1150
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.57
    Marker Score: 1946
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.56
    Marker Score: 1205
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.56
    Marker Score: 6516
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.49
    Marker Score: 435
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.49
    Marker Score: 6194
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.48
    Marker Score: 1412
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.47
    Marker Score: 2262
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.43
    Marker Score: 1733
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.42
    Marker Score: 3234
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.4
    Marker Score: 2299
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.38
    Marker Score: 1400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 856
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.35
    Marker Score: 49748
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3166
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.34
    Marker Score: 2070
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.33
    Marker Score: 338
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.32
    Marker Score: 5474
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.32
    Marker Score: 427
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.27
    Marker Score: 43255
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.27
    Marker Score: 708
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.26
    Marker Score: 11947
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.25
    Marker Score: 27881
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19505
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.24
    Marker Score: 5042
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.22
    Marker Score: 512
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.21
    Marker Score: 11378
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.21
    Marker Score: 9253
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.19
    Marker Score: 45221
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.18
    Marker Score: 1115
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.18
    Marker Score: 12208
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.14
    Marker Score: 598.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.14
    Marker Score: 463
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4762
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.12
    Marker Score: 1585
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.12
    Marker Score: 322
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.11
    Marker Score: 5842
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1
    Marker Score: 17619
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.1
    Marker Score: 3891
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.09
    Marker Score: 636
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.09
    Marker Score: 2734
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.06
    Marker Score: 409
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.06
    Marker Score: 439
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.05
    Marker Score: 613
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.04
    Marker Score: 1102
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251711
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63222
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.02
    Marker Score: 3632
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.02
    Marker Score: 1192
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.02
    Marker Score: 2562
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.01
    Marker Score: 1420
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.01
    Marker Score: 489
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71729
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1
    Marker Score: 339
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47954
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.98
    Marker Score: 5272
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.98
    Marker Score: 1776
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.97
    Marker Score: 378
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 440

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Other Information

**Key characteristics:** - LIFR is a cell surface protein that is expressed on a variety of cell types. - It is a member of the cytokine receptor family. - It is a key regulator of the immune system, and its expression is associated with the regulation of inflammation and cell growth. **Pathways and functions:** - LIFR signaling is involved in a variety of cellular processes, including cell growth, differentiation, and survival. - It is a key regulator of the development and function of the immune system. - It is involved in the regulation of inflammation and cell death. - It is also involved in the regulation of cell growth and differentiation. **Clinical significance:** - Mutations in the LIFR gene have been linked to a number of human diseases, including leukemia and lymphoma. - LIFR inhibitors are being investigated as a treatment for these diseases. **Additional information:** - The LIFR gene is located on chromosome 17q21. - It is a single-exon gene that encodes a protein of 140 amino acids. - It is expressed in high levels in the brain, heart, and other organs. - It is a highly conserved protein, with similar sequences found in mammals.

Genular Protein ID: 3201650940

Symbol: LIFR_HUMAN

Name: Leukemia inhibitory factor receptor

UniProtKB Accession Codes:

P42702 Q6LCD9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 4 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1915266

Title: Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

PubMed ID: 1915266

DOI: 10.1002/j.1460-2075.1991.tb07833.x

PubMed ID: 9525740

Title: The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.

PubMed ID: 9525740

DOI: 10.1038/sj.onc.1201660

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18775332

Title: Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.

PubMed ID: 18775332

DOI: 10.1016/j.molcel.2008.08.011

PubMed ID: 14740318

Title: Null leukemia inhibitory factor receptor (LIFR) mutations in Stueve-Wiedemann/Schwartz-Jampel type 2 syndrome.

PubMed ID: 14740318

DOI: 10.1086/381715

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1097
  • Mass: 123743
  • Checksum: C8602897E359FCE5
  • Sequence:
    • MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL 
QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS 
STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE 
SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP 
VKNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK 
IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA 
LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ 
STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR 
NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD 
TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK 
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK 
WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE 
ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR 
SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI 
LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM 
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN 
PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE 
DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS 
NGGGWSFTNF FQNKPND

Genular Protein ID: 3966010311

Symbol: A8K1Z4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K1Z4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 1097
  • Mass: 123831
  • Checksum: 5E600CB2EE929FF6
  • Sequence:
    • MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL 
QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS 
STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE 
SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP 
VRNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK 
IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA 
LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ 
STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR 
NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD 
TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK 
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK 
WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE 
ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR 
SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI 
LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM 
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN 
PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE 
DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDFPKS 
NGGGWSFTNF FQNKPND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.