Details for: LIFR

Gene ID: 3977

Symbol: LIFR

Ensembl ID: ENSG00000113594

Description: LIF receptor subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.5220
    Cell Significance Index: -67.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 138.9514
    Cell Significance Index: -56.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.2254
    Cell Significance Index: -56.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.1291
    Cell Significance Index: -50.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.2296
    Cell Significance Index: -52.9200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.7600
    Cell Significance Index: 38.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.7284
    Cell Significance Index: 142.1200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.5784
    Cell Significance Index: 17.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7841
    Cell Significance Index: 34.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4966
    Cell Significance Index: 536.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0496
    Cell Significance Index: 80.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9600
    Cell Significance Index: 192.5800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.7480
    Cell Significance Index: 5.9100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4982
    Cell Significance Index: 5.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4370
    Cell Significance Index: 302.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3259
    Cell Significance Index: 37.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3236
    Cell Significance Index: 64.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2013
    Cell Significance Index: 127.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1772
    Cell Significance Index: 326.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1573
    Cell Significance Index: 296.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1544
    Cell Significance Index: 2.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1457
    Cell Significance Index: 0.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1327
    Cell Significance Index: 60.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1028
    Cell Significance Index: 158.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0813
    Cell Significance Index: 10.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0412
    Cell Significance Index: 37.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0071
    Cell Significance Index: 0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0034
    Cell Significance Index: 1.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0023
    Cell Significance Index: 1.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0177
    Cell Significance Index: -11.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0584
    Cell Significance Index: -43.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0733
    Cell Significance Index: -32.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0742
    Cell Significance Index: -56.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0850
    Cell Significance Index: -14.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0995
    Cell Significance Index: -5.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1040
    Cell Significance Index: -58.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1288
    Cell Significance Index: -23.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1443
    Cell Significance Index: -19.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1526
    Cell Significance Index: -6.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1538
    Cell Significance Index: -10.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1682
    Cell Significance Index: -6.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1782
    Cell Significance Index: -10.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1841
    Cell Significance Index: -52.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1949
    Cell Significance Index: -28.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.2319
    Cell Significance Index: -44.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2420
    Cell Significance Index: -50.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2557
    Cell Significance Index: -31.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2899
    Cell Significance Index: -17.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2902
    Cell Significance Index: -7.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3002
    Cell Significance Index: -5.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3138
    Cell Significance Index: -19.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3178
    Cell Significance Index: -9.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3212
    Cell Significance Index: -52.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3512
    Cell Significance Index: -35.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3897
    Cell Significance Index: -50.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.5115
    Cell Significance Index: -50.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5383
    Cell Significance Index: -25.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5509
    Cell Significance Index: -62.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5623
    Cell Significance Index: -13.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5798
    Cell Significance Index: -60.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5901
    Cell Significance Index: -67.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5949
    Cell Significance Index: -64.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6394
    Cell Significance Index: -35.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6738
    Cell Significance Index: -11.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7025
    Cell Significance Index: -52.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7491
    Cell Significance Index: -59.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7518
    Cell Significance Index: -9.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7559
    Cell Significance Index: -35.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8050
    Cell Significance Index: -11.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8321
    Cell Significance Index: -58.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8965
    Cell Significance Index: -31.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9029
    Cell Significance Index: -15.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9636
    Cell Significance Index: -66.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0117
    Cell Significance Index: -65.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1399
    Cell Significance Index: -51.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1462
    Cell Significance Index: -60.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1774
    Cell Significance Index: -61.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2355
    Cell Significance Index: -18.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2397
    Cell Significance Index: -43.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3771
    Cell Significance Index: -36.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3891
    Cell Significance Index: -45.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4261
    Cell Significance Index: -49.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4855
    Cell Significance Index: -47.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5100
    Cell Significance Index: -43.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.5205
    Cell Significance Index: -32.5000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.5485
    Cell Significance Index: -17.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.6363
    Cell Significance Index: -45.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6527
    Cell Significance Index: -60.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.7033
    Cell Significance Index: -40.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.7605
    Cell Significance Index: -30.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.7839
    Cell Significance Index: -37.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.7970
    Cell Significance Index: -38.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.8259
    Cell Significance Index: -39.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8362
    Cell Significance Index: -54.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.9169
    Cell Significance Index: -55.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.0089
    Cell Significance Index: -50.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.0094
    Cell Significance Index: -54.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -2.0246
    Cell Significance Index: -23.0000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -2.0450
    Cell Significance Index: -25.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor:** LIFR is a transmembrane receptor with an extracellular domain that binds to LIF, a member of the interleukin-6 (IL-6) family of cytokines. 2. **Signaling Pathway:** LIFR activation triggers a signaling cascade that involves the phosphorylation and activation of various downstream kinases, including JAK2 and STAT3. 3. **Cellular Expression:** LIFR is highly expressed in cells of the immune system, including astrocytes, endothelial cells, and fibroblasts. 4. **Regulatory Function:** LIFR plays a critical role in regulating immune responses, cell proliferation, and differentiation. **Pathways and Functions:** 1. **Cytokine Signaling:** LIFR is involved in cytokine signaling pathways, including the IL-6 family signaling pathway, which regulates immune responses and inflammation. 2. **Cell Proliferation and Differentiation:** LIFR signaling regulates cell proliferation and differentiation in various cell types, including immune cells and fibroblasts. 3. **Immune System Regulation:** LIFR plays a crucial role in regulating immune responses, including the activation of immune cells and the production of cytokines. 4. **Tissue Homeostasis:** LIFR is involved in maintaining tissue homeostasis by regulating cell growth, differentiation, and survival in various cell types. **Clinical Significance:** Dysregulation of LIFR signaling has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Alterations in LIFR signaling have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** LIFR overexpression has been observed in certain types of cancer, including leukemia and lymphoma. 3. **Inflammatory Diseases:** LIFR signaling is involved in the regulation of inflammation, and dysregulation of this pathway has been implicated in inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, the Leukemia Inhibitory Factor Receptor Subunit Alpha (LIFR) is a critical component of the LIF signaling pathway, playing a significant role in regulating immune responses, cell proliferation, and differentiation. Understanding the mechanisms of LIFR signaling and its dysregulation in disease can provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3201650940

Symbol: LIFR_HUMAN

Name: Leukemia inhibitory factor receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1915266

Title: Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

PubMed ID: 1915266

DOI: 10.1002/j.1460-2075.1991.tb07833.x

PubMed ID: 9525740

Title: The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.

PubMed ID: 9525740

DOI: 10.1038/sj.onc.1201660

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18775332

Title: Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.

PubMed ID: 18775332

DOI: 10.1016/j.molcel.2008.08.011

PubMed ID: 14740318

Title: Null leukemia inhibitory factor receptor (LIFR) mutations in Stueve-Wiedemann/Schwartz-Jampel type 2 syndrome.

PubMed ID: 14740318

DOI: 10.1086/381715

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1097
  • Mass: 123743
  • Checksum: C8602897E359FCE5
  • Sequence:
  • MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL 
    QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS 
    STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE 
    SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP 
    VKNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK 
    IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA 
    LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ 
    STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR 
    NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD 
    TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK 
    NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK 
    WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE 
    ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR 
    SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI 
    LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM 
    NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN 
    PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE 
    DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS 
    NGGGWSFTNF FQNKPND

Genular Protein ID: 3966010311

Symbol: A8K1Z4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1097
  • Mass: 123831
  • Checksum: 5E600CB2EE929FF6
  • Sequence:
  • MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL 
    QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS 
    STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE 
    SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP 
    VRNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK 
    IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA 
    LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ 
    STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR 
    NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD 
    TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK 
    NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK 
    WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE 
    ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR 
    SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI 
    LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM 
    NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN 
    PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE 
    DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDFPKS 
    NGGGWSFTNF FQNKPND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.