Details for: LIG1

Gene ID: 3978

Symbol: LIG1

Ensembl ID: ENSG00000105486

Description: DNA ligase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.71
    Marker Score: 4734
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.7
    Marker Score: 6574
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168697
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.23
    Marker Score: 837
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.22
    Marker Score: 3318
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.21
    Marker Score: 2302
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.15
    Marker Score: 3417
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.15
    Marker Score: 1647
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.13
    Marker Score: 849.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1722
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.11
    Marker Score: 1387
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71753
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47977
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.99
    Marker Score: 286
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15518
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.95
    Marker Score: 892
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.94
    Marker Score: 945
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.89
    Marker Score: 278
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4949
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.85
    Marker Score: 618
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.83
    Marker Score: 3459
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.8
    Marker Score: 1061
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.8
    Marker Score: 850
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.79
    Marker Score: 1336
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.78
    Marker Score: 3187
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.75
    Marker Score: 2946
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.75
    Marker Score: 450
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1509
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.74
    Marker Score: 183
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.73
    Marker Score: 1518
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.72
    Marker Score: 353
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.71
    Marker Score: 2619
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.7
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 619
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.68
    Marker Score: 6980
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2822.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 302
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.62
    Marker Score: 308
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.61
    Marker Score: 2095
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 196
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.61
    Marker Score: 1427
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.59
    Marker Score: 709
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.57
    Marker Score: 316
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.56
    Marker Score: 350
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.56
    Marker Score: 195
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.55
    Marker Score: 1499
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.54
    Marker Score: 561
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.53
    Marker Score: 258
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.53
    Marker Score: 386
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.51
    Marker Score: 10203
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 209
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.51
    Marker Score: 347
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.51
    Marker Score: 4826
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 334
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.5
    Marker Score: 989
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.5
    Marker Score: 4375
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.5
    Marker Score: 954
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.5
    Marker Score: 4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.5
    Marker Score: 643
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.49
    Marker Score: 806
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.49
    Marker Score: 307
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.49
    Marker Score: 553
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.48
    Marker Score: 1141
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.47
    Marker Score: 29163
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.47
    Marker Score: 234
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.47
    Marker Score: 334
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 428
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.46
    Marker Score: 461
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 194
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.46
    Marker Score: 3445
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.46
    Marker Score: 5339
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.46
    Marker Score: 431
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.46
    Marker Score: 501
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.46
    Marker Score: 208
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.46
    Marker Score: 3488
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.45
    Marker Score: 222
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.45
    Marker Score: 1848
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.45
    Marker Score: 134
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.45
    Marker Score: 402
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.45
    Marker Score: 227
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.45
    Marker Score: 3848
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.44
    Marker Score: 2868
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 425

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * The LIG1 gene is located on chromosome 19p13.2. * It is a large gene with a complex structure. * It is expressed in a variety of cell types. * It is involved in a variety of DNA repair pathways, including base excision repair, mismatch repair, and nucleotide excision repair. **Pathways and functions** * **Base excision repair:** LIG1 is responsible for repairing double-strand breaks (DSBs) in DNA. It is one of the most important DNA repair proteins in mammalian cells. * **Mismatch repair:** LIG1 is also involved in repairing mismatches in DNA. * **Nucleotide excision repair:** LIG1 is involved in repairing a variety of DNA lesions, including ap sites (apurinic base sites) and DNA strand breaks. * **Resolution of abasic sites:** LIG1 is involved in repairing abasic lesions in DNA by repairing the damage and then ligating the broken ends together. * **Resolution of ap sites via the multiple-nucleotide patch replacement pathway:** LIG1 is involved in repairing DNA damage by replacing the damaged nucleotides with undamaged nucleotides. * **S phase:** LIG1 is involved in repairing DNA damage that occurs during DNA replication. * **Telomere maintenance:** LIG1 is involved in maintaining the integrity of telomeres, which are protective caps at the ends of chromosomes. * **Transcription-coupled nucleotide excision repair (tc-ner):** LIG1 is involved in repairing DNA damage that occurs during transcription. **Clinical significance** Mutations in the LIG1 gene have been linked to a number of human diseases, including cancer, developmental disorders, and neurodegenerative diseases. LIG1 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 2234658791

Symbol: DNLI1_HUMAN

Name: DNA ligase 1

UniProtKB Accession Codes:

P18858 B2RAI8 B4DTU4 Q2TB12 Q32P23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 ELM 1 EMBL 9 EMDB 3 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 19 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2204063

Title: Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae.

PubMed ID: 2204063

DOI: 10.1073/pnas.87.17.6679

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1881902

Title: A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells.

PubMed ID: 1881902

DOI: 10.1073/pnas.88.17.7615

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19336415

Title: Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

PubMed ID: 19336415

DOI: 10.1093/nar/gkp201

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24911150

Title: Hypomorphic PCNA mutation underlies a human DNA repair disorder.

PubMed ID: 24911150

DOI: 10.1172/jci74593

PubMed ID: 15565146

Title: Human DNA ligase I completely encircles and partially unwinds nicked DNA.

PubMed ID: 15565146

DOI: 10.1038/nature03082

PubMed ID: 1581963

Title: Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.

PubMed ID: 1581963

DOI: 10.1016/0092-8674(92)90450-q

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30395541

Title: Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies.

PubMed ID: 30395541

DOI: 10.1172/jci99629

Sequence Information:

  • Length: 919
  • Mass: 101736
  • Checksum: B2854DAE38A8D4AD
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEEETP KESLTEAEVA TEKEGEDGDQ 
PTTPPKPLKT SKAETPTESV SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK 
KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE 
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ 
ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT ASGVFSKFRD IARLTGSAST 
AKKIDIIKGL FVACRHSEAR FIARSLSGRL RLGLAEQSVL AALSQAVSLT PPGQEFPPAM 
VDAGKGKTAE ARKTWLEEQG MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL 
KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD 
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE IQVQVCLYAF 
DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD TKDIEQIAEF LEQSVKDSCE 
GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL 
ASYDEDSEEL QAICKLGTGF SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA 
VWEVKCADLS LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ 
SQIQNQQGED SGSDPEDTY

Genular Protein ID: 550725440

Symbol: F5GZ28_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GZ28 M0R1G7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SMR 1 SUPFAM 3 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.M700120-MCP200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 851
  • Mass: 93948
  • Checksum: 962BAEBE37E672CA
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTEAETPTE SVSEPEVATK QELQEEEEQT KPPRRAPKTL SSFFTPRKPA VKKEVKEEEP 
GAPGKEGAAE GPLDPSGYNP AKNNYHPVED ACWKPGQKVP YLAVARTFEK IEEVSARLRM 
VETLSNLLRS VVALSPPDLL PVLYLSLNHL GPPQQGLELG VGDGVLLKAV AQATGRQLES 
VRAEAAEKGD VGLVAENSRS TQRLMLPPPP LTASGVFSKF RDIARLTGSA STAKKIDIIK 
GLFVACRHSE ARFIARSLSG RLRLGLAEQS VLAALSQAVS LTPPGQEFPP AMVDAGKGKT 
AEARKTWLEE QGMILKQTFC EVPDLDRIIP VLLEHGLERL PEHCKLSPGI PLKPMLAHPT 
RGISEVLKRF EEAAFTCEYK YDGQRAQIHA LEGGEVKIFS RNQEDNTGKY PDIISRIPKI 
KLPSVTSFIL DTEAVAWDRE KKQIQPFQVL TTRKRKEVDA SEIQVQVCLY AFDLIYLNGE 
SLVREPLSRR RQLLRENFVE TEGEFVFATS LDTKDIEQIA EFLEQSVKDS CEGLMVKTLD 
VDATYEIAKR SHNWLKLKKD YLDGVGDTLD LVVIGAYLGR GKRAGRYGGF LLASYDEDSE 
ELQAICKLGT GFSDEELEEH HQSLKALVLP SPRPYVRIDG AVIPDHWLDP SAVWEVKCAD 
LSLSPIYPAA RGLVDSDKGI SLRFPRFIRV REDKQPEQAT TSAQVACLYR KQSQIQNQQG 
EDSGSDPEDT Y

Genular Protein ID: 918861446

Symbol: A0A8V8TQC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TQC4

Database IDs:

ARBA 6 CDD 2 CTD 1 EC 1 EMBL 2 EPD 1 Ensembl 2 GO 7 Gene3D 4 GeneTree 1 HGNC 1 InterPro 7 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PROSITE 4 Pfam 3 Proteomes 2 RefSeq 1 RuleBase 2 SAM 1 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 918
  • Mass: 101607
  • Checksum: 65548DBC15E72691
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEETPK ESLTEAEVAT EKEGEDGDQP 
TTPPKPLKTS KAETPTESVS EPEVATKQEL QEEEEQTKPP RRAPKTLSSF FTPRKPAVKK 
EVKEEEPGAP GKEGAAEGPL DPSGYNPAKN NYHPVEDACW KPGQKVPYLA VARTFEKIEE 
VSARLRMVET LSNLLRSVVA LSPPDLLPVL YLSLNHLGPP QQGLELGVGD GVLLKAVAQA 
TGRQLESVRA EAAEKGDVGL VAENSRSTQR LMLPPPPLTA SGVFSKFRDI ARLTGSASTA 
KKIDIIKGLF VACRHSEARF IARSLSGRLR LGLAEQSVLA ALSQAVSLTP PGQEFPPAMV 
DAGKGKTAEA RKTWLEEQGM ILKQTFCEVP DLDRIIPVLL EHGLERLPEH CKLSPGIPLK 
PMLAHPTRGI SEVLKRFEEA AFTCEYKYDG QRAQIHALEG GEVKIFSRNQ EDNTGKYPDI 
ISRIPKIKLP SVTSFILDTE AVAWDREKKQ IQPFQVLTTR KRKEVDASEI QVQVCLYAFD 
LIYLNGESLV REPLSRRRQL LRENFVETEG EFVFATSLDT KDIEQIAEFL EQSVKDSCEG 
LMVKTLDVDA TYEIAKRSHN WLKLKKDYLD GVGDTLDLVV IGAYLGRGKR AGRYGGFLLA 
SYDEDSEELQ AICKLGTGFS DEELEEHHQS LKALVLPSPR PYVRIDGAVI PDHWLDPSAV 
WEVKCADLSL SPIYPAARGL VDSDKGISLR FPRFIRVRED KQPEQATTSA QVACLYRKQS 
QIQNQQGEDS GSDPEDTY

Genular Protein ID: 3789634815

Symbol: B4DM52_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DM52

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EC 1 EMBL 2 GO 7 Gene3D 4 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 2 SAM 1 SUPFAM 3

Sequence Information:

  • Length: 851
  • Mass: 94020
  • Checksum: 84EC1B7F5613ADED
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTEAETPTE SVSEPEVATK QELQEEEEQT KPPRRAPKTL SSFFTPRKPA VKKEVKEEEP 
EAPGKEGAAE GPLDPSGYNP AKNNYHPVED ACWKPGQKVP YLAVARTFEK IEEVSARLRM 
VETLSNLLRS VVALSPPDLL PVLYLSLNHL GPPQQGLELG VGDGVLLKAV AQATGRQLES 
VRAEAAEKGD VGLVAENSRS TQRLMLPPPP LTASGVFSKF RDIARLTGSA STAKKIDIIK 
GLFVACRHSE ARFIARSLSG RLRLGLAEQS VLAALSQAVS LTPPGQEFPP AMVDAGKGKT 
AEARKTWLEE QGMILKQTFC EVPDLDRIIP VLLEHGLERL PEHCKLSPGI PLKPMLAHPT 
RGISEVLKRF EEAAFTCEYK YDGQRAQIHA LEGGEVKIFS RNQEDNTGKY PDIISRIPKI 
KLPSVTSFIL DTEAVAWDRE KKQIQPFQVL TTRKRKEVDA SEIQVQVCLY AFDLIYLNGE 
SLVREPLSRR RQLLRENFVE TEGEFVFATS LDTKDIEQIA EFLEQSVKDS CEGLMVKTLD 
VDATYEIAKR SHNWLKLKKD YLDGVGDTLD LVVIGAYLGR GKRAGRYGGF LLASYDEDSE 
ELQAICKLGT GFSDEELEEH HQSLKALVLP SPRPYVRIDG AVIPDHWLDP SAVWEVKCAD 
LSLSPIYPAA RGLVDSDKGI SLRFPRFIRV REDKQPEQAT TSAQVACLYR KQSQIQNQQG 
EDSGSDPEDT Y

Genular Protein ID: 4089884975

Symbol: A0A8V8TPH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TPH8

Database IDs:

ARBA 6 CDD 2 CTD 1 EC 1 EMBL 4 EPD 1 Ensembl 2 GO 7 Gene3D 4 GeneTree 1 HGNC 1 InterPro 7 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PROSITE 4 Pfam 3 Proteomes 2 RefSeq 1 RuleBase 2 SAM 1 SUPFAM 3

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 889
  • Mass: 98357
  • Checksum: BAAA40FA13E11616
  • Sequence:
    • MQRSIMAALK EWNGVVSESD SPVKRPGRKA ARVLGSEGEE EDEALSPAKG QKPALDCSQV 
SPPRPATSPE NNASLSDTSP MDSSPSGIPK RRTARKQLPK RTIQEVLEEQ SEDEDREAKR 
KKEEEEEETP KESLTEAEVA TEKEGEDGDQ PTTPPKPLKT SKAETPTESV SEPEVATKQE 
LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK 
NNYHPVEDAC WKPGQKVPYL AVARTFEKIE EVSARLRMVE TLSNLLRSVV ALSPPDLLPV 
LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ ATGRQLESVR AEAAEKGDVG LVAENSRSTQ 
RLMLPPPPLT ASGVFSKFRD IARLTGSAST AKKIDIIKGL FVACRHSEAR FIARSLSGRL 
RLGLAEQSVL AALSQAVSLT PPGQEFPPAM VDAGKGKTAE ARKTWLEEQG MILKQTFCEV 
PDLDRIIPVL LEHGLERLPE HCKLSPGIPL KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD 
GQRAQIHALE GGEVKIFSRN QEDNTGKYPD IISRIPKIKL PSVTSFILDT EAVAWDREKK 
QIQPFQVLTT RKRKEVDASE IQVQVCLYAF DLIYLNGESL VREPLSRRRQ LLRENFVETE 
GEFVFATSLD TKDIEQIAEF LEQSVKDSCE GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL 
DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL ASYDEDSEEL QAICKLGTGF SDEELEEHHQ 
SLKALVLPSP RPYVRIDGAV IPDHWLDPSA VWEVKCADLS LSPIYPAARG LVDSDKGISL 
RFPRFIRVRE DKQPEQATTS AQVACLYRKQ SQIQNQQGED SGSDPEDTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.