Details for: LIG1

Gene ID: 3978

Symbol: LIG1

Ensembl ID: ENSG00000105486

Description: DNA ligase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.6259
    Cell Significance Index: -12.0800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.8598
    Cell Significance Index: -6.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.9748
    Cell Significance Index: -12.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.6581
    Cell Significance Index: -13.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1521
    Cell Significance Index: -13.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5322
    Cell Significance Index: -14.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6682
    Cell Significance Index: -14.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2343
    Cell Significance Index: -4.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6633
    Cell Significance Index: 164.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4148
    Cell Significance Index: 269.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0124
    Cell Significance Index: 27.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9990
    Cell Significance Index: 25.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9160
    Cell Significance Index: 108.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9006
    Cell Significance Index: 54.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8502
    Cell Significance Index: 92.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8286
    Cell Significance Index: 164.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7933
    Cell Significance Index: 129.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7667
    Cell Significance Index: 10.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7409
    Cell Significance Index: 86.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5979
    Cell Significance Index: 16.7100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5589
    Cell Significance Index: 4.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5072
    Cell Significance Index: 28.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4507
    Cell Significance Index: 4.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4142
    Cell Significance Index: 11.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3791
    Cell Significance Index: 342.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3738
    Cell Significance Index: 12.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3452
    Cell Significance Index: 17.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3374
    Cell Significance Index: 10.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3254
    Cell Significance Index: 14.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2631
    Cell Significance Index: 52.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2551
    Cell Significance Index: 17.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2471
    Cell Significance Index: 109.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2241
    Cell Significance Index: 122.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2035
    Cell Significance Index: 12.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1885
    Cell Significance Index: 23.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1765
    Cell Significance Index: 11.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1726
    Cell Significance Index: 31.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1574
    Cell Significance Index: 11.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1463
    Cell Significance Index: 101.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1340
    Cell Significance Index: 6.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1236
    Cell Significance Index: 3.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1222
    Cell Significance Index: 43.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0997
    Cell Significance Index: 2.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0899
    Cell Significance Index: 12.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0834
    Cell Significance Index: 2.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0827
    Cell Significance Index: 1.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0794
    Cell Significance Index: 5.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0464
    Cell Significance Index: 1.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0420
    Cell Significance Index: 1.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0219
    Cell Significance Index: 41.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0170
    Cell Significance Index: 26.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0148
    Cell Significance Index: 27.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0099
    Cell Significance Index: 1.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0209
    Cell Significance Index: -9.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0260
    Cell Significance Index: -16.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0262
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0269
    Cell Significance Index: -4.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0295
    Cell Significance Index: -0.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0315
    Cell Significance Index: -0.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0329
    Cell Significance Index: -3.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0358
    Cell Significance Index: -1.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0389
    Cell Significance Index: -11.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0424
    Cell Significance Index: -0.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0643
    Cell Significance Index: -1.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0690
    Cell Significance Index: -3.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0692
    Cell Significance Index: -4.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0730
    Cell Significance Index: -3.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0750
    Cell Significance Index: -5.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0766
    Cell Significance Index: -16.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0872
    Cell Significance Index: -9.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0896
    Cell Significance Index: -2.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1004
    Cell Significance Index: -3.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1086
    Cell Significance Index: -1.5600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1211
    Cell Significance Index: -1.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1301
    Cell Significance Index: -13.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1359
    Cell Significance Index: -8.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1359
    Cell Significance Index: -10.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1363
    Cell Significance Index: -3.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1525
    Cell Significance Index: -4.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1718
    Cell Significance Index: -13.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1998
    Cell Significance Index: -1.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2357
    Cell Significance Index: -2.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2378
    Cell Significance Index: -3.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2544
    Cell Significance Index: -7.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2589
    Cell Significance Index: -5.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2690
    Cell Significance Index: -7.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3137
    Cell Significance Index: -9.2400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3258
    Cell Significance Index: -4.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3394
    Cell Significance Index: -11.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3473
    Cell Significance Index: -12.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3478
    Cell Significance Index: -8.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LIG1 is a member of the DNA ligase family, specifically belonging to the ATP-dependent DNA ligase class. It is characterized by its ability to form high-energy phosphoanhydride bonds, which are necessary for DNA ligation. The enzyme has a high processivity, allowing it to synthesize long DNA strands. LIG1 is also capable of recognizing and repairing different types of DNA damage, including ap sites, abasic sites, and mismatched bases. **Pathways and Functions** LIG1 plays a central role in various cellular processes, including: 1. **Base Excision Repair (BER)**: LIG1 is the primary enzyme responsible for repairing DNA damage caused by oxidative stress, alkylation, and other types of damage. 2. **DNA Replication**: LIG1 is involved in the replication of DNA, particularly on the lagging strand, where it helps to seal gaps between Okazaki fragments. 3. **Telomere Maintenance**: LIG1 contributes to the maintenance of telomeres by facilitating the synthesis of the lagging strand. 4. **Mismatch Repair**: LIG1 works in conjunction with mismatch repair proteins to correct errors in DNA replication and recombination. 5. **V(D)J Recombination**: LIG1 is involved in the process of V(D)J recombination, which is essential for the development of the immune system. **Clinical Significance** Dysregulation of LIG1 has been implicated in various diseases, including: 1. **Cancer**: Mutations in LIG1 have been associated with several types of cancer, including breast, ovarian, and colon cancer. 2. **Neurological Disorders**: LIG1 dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Immunodeficiency**: LIG1 plays a critical role in the development and function of the immune system, and its dysfunction can lead to immunodeficiency disorders. 4. **Aging and Telomere Shortening**: LIG1 is involved in telomere maintenance, and its dysfunction may contribute to telomere shortening and aging. In conclusion, LIG1 is a vital enzyme that plays a central role in maintaining genome stability and preventing mutations. Its dysregulation has been implicated in various diseases, highlighting the importance of LIG1 in human health and disease.

Genular Protein ID: 2234658791

Symbol: DNLI1_HUMAN

Name: DNA ligase 1

UniProtKB Accession Codes:

P18858 B2RAI8 B4DTU4 Q2TB12 Q32P23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 ELM 1 EMBL 9 EMDB 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2204063

Title: Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae.

PubMed ID: 2204063

DOI: 10.1073/pnas.87.17.6679

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1881902

Title: A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells.

PubMed ID: 1881902

DOI: 10.1073/pnas.88.17.7615

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19336415

Title: Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

PubMed ID: 19336415

DOI: 10.1093/nar/gkp201

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24911150

Title: Hypomorphic PCNA mutation underlies a human DNA repair disorder.

PubMed ID: 24911150

DOI: 10.1172/jci74593

PubMed ID: 15565146

Title: Human DNA ligase I completely encircles and partially unwinds nicked DNA.

PubMed ID: 15565146

DOI: 10.1038/nature03082

PubMed ID: 1581963

Title: Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.

PubMed ID: 1581963

DOI: 10.1016/0092-8674(92)90450-q

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30395541

Title: Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies.

PubMed ID: 30395541

DOI: 10.1172/jci99629

Sequence Information:

  • Length: 919
  • Mass: 101736
  • Checksum: B2854DAE38A8D4AD
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEEETP KESLTEAEVA TEKEGEDGDQ 
PTTPPKPLKT SKAETPTESV SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK 
KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE 
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ 
ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT ASGVFSKFRD IARLTGSAST 
AKKIDIIKGL FVACRHSEAR FIARSLSGRL RLGLAEQSVL AALSQAVSLT PPGQEFPPAM 
VDAGKGKTAE ARKTWLEEQG MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL 
KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD 
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE IQVQVCLYAF 
DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD TKDIEQIAEF LEQSVKDSCE 
GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL 
ASYDEDSEEL QAICKLGTGF SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA 
VWEVKCADLS LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ 
SQIQNQQGED SGSDPEDTY

Genular Protein ID: 550725440

Symbol: F5GZ28_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GZ28 M0R1G7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SMR 1 SUPFAM 3 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.M700120-MCP200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 851
  • Mass: 93948
  • Checksum: 962BAEBE37E672CA
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTEAETPTE SVSEPEVATK QELQEEEEQT KPPRRAPKTL SSFFTPRKPA VKKEVKEEEP 
GAPGKEGAAE GPLDPSGYNP AKNNYHPVED ACWKPGQKVP YLAVARTFEK IEEVSARLRM 
VETLSNLLRS VVALSPPDLL PVLYLSLNHL GPPQQGLELG VGDGVLLKAV AQATGRQLES 
VRAEAAEKGD VGLVAENSRS TQRLMLPPPP LTASGVFSKF RDIARLTGSA STAKKIDIIK 
GLFVACRHSE ARFIARSLSG RLRLGLAEQS VLAALSQAVS LTPPGQEFPP AMVDAGKGKT 
AEARKTWLEE QGMILKQTFC EVPDLDRIIP VLLEHGLERL PEHCKLSPGI PLKPMLAHPT 
RGISEVLKRF EEAAFTCEYK YDGQRAQIHA LEGGEVKIFS RNQEDNTGKY PDIISRIPKI 
KLPSVTSFIL DTEAVAWDRE KKQIQPFQVL TTRKRKEVDA SEIQVQVCLY AFDLIYLNGE 
SLVREPLSRR RQLLRENFVE TEGEFVFATS LDTKDIEQIA EFLEQSVKDS CEGLMVKTLD 
VDATYEIAKR SHNWLKLKKD YLDGVGDTLD LVVIGAYLGR GKRAGRYGGF LLASYDEDSE 
ELQAICKLGT GFSDEELEEH HQSLKALVLP SPRPYVRIDG AVIPDHWLDP SAVWEVKCAD 
LSLSPIYPAA RGLVDSDKGI SLRFPRFIRV REDKQPEQAT TSAQVACLYR KQSQIQNQQG 
EDSGSDPEDT Y

Genular Protein ID: 918861446

Symbol: A0A8V8TQC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TQC4

Database IDs:

ARBA 6 CDD 2 CTD 1 EC 1 EMBL 2 Ensembl 2 GO 7 Gene3D 4 GeneTree 1 HGNC 1 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SAM 1 SMR 1 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 918
  • Mass: 101607
  • Checksum: 65548DBC15E72691
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEETPK ESLTEAEVAT EKEGEDGDQP 
TTPPKPLKTS KAETPTESVS EPEVATKQEL QEEEEQTKPP RRAPKTLSSF FTPRKPAVKK 
EVKEEEPGAP GKEGAAEGPL DPSGYNPAKN NYHPVEDACW KPGQKVPYLA VARTFEKIEE 
VSARLRMVET LSNLLRSVVA LSPPDLLPVL YLSLNHLGPP QQGLELGVGD GVLLKAVAQA 
TGRQLESVRA EAAEKGDVGL VAENSRSTQR LMLPPPPLTA SGVFSKFRDI ARLTGSASTA 
KKIDIIKGLF VACRHSEARF IARSLSGRLR LGLAEQSVLA ALSQAVSLTP PGQEFPPAMV 
DAGKGKTAEA RKTWLEEQGM ILKQTFCEVP DLDRIIPVLL EHGLERLPEH CKLSPGIPLK 
PMLAHPTRGI SEVLKRFEEA AFTCEYKYDG QRAQIHALEG GEVKIFSRNQ EDNTGKYPDI 
ISRIPKIKLP SVTSFILDTE AVAWDREKKQ IQPFQVLTTR KRKEVDASEI QVQVCLYAFD 
LIYLNGESLV REPLSRRRQL LRENFVETEG EFVFATSLDT KDIEQIAEFL EQSVKDSCEG 
LMVKTLDVDA TYEIAKRSHN WLKLKKDYLD GVGDTLDLVV IGAYLGRGKR AGRYGGFLLA 
SYDEDSEELQ AICKLGTGFS DEELEEHHQS LKALVLPSPR PYVRIDGAVI PDHWLDPSAV 
WEVKCADLSL SPIYPAARGL VDSDKGISLR FPRFIRVRED KQPEQATTSA QVACLYRKQS 
QIQNQQGEDS GSDPEDTY

Genular Protein ID: 4089884975

Symbol: A0A8V8TPH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TPH8

Database IDs:

ARBA 6 CDD 2 CTD 1 EC 1 EMBL 4 Ensembl 2 GO 7 Gene3D 4 GeneTree 1 HGNC 1 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SAM 1 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 889
  • Mass: 98357
  • Checksum: BAAA40FA13E11616
  • Sequence:
    • MQRSIMAALK EWNGVVSESD SPVKRPGRKA ARVLGSEGEE EDEALSPAKG QKPALDCSQV 
SPPRPATSPE NNASLSDTSP MDSSPSGIPK RRTARKQLPK RTIQEVLEEQ SEDEDREAKR 
KKEEEEEETP KESLTEAEVA TEKEGEDGDQ PTTPPKPLKT SKAETPTESV SEPEVATKQE 
LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK 
NNYHPVEDAC WKPGQKVPYL AVARTFEKIE EVSARLRMVE TLSNLLRSVV ALSPPDLLPV 
LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ ATGRQLESVR AEAAEKGDVG LVAENSRSTQ 
RLMLPPPPLT ASGVFSKFRD IARLTGSAST AKKIDIIKGL FVACRHSEAR FIARSLSGRL 
RLGLAEQSVL AALSQAVSLT PPGQEFPPAM VDAGKGKTAE ARKTWLEEQG MILKQTFCEV 
PDLDRIIPVL LEHGLERLPE HCKLSPGIPL KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD 
GQRAQIHALE GGEVKIFSRN QEDNTGKYPD IISRIPKIKL PSVTSFILDT EAVAWDREKK 
QIQPFQVLTT RKRKEVDASE IQVQVCLYAF DLIYLNGESL VREPLSRRRQ LLRENFVETE 
GEFVFATSLD TKDIEQIAEF LEQSVKDSCE GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL 
DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL ASYDEDSEEL QAICKLGTGF SDEELEEHHQ 
SLKALVLPSP RPYVRIDGAV IPDHWLDPSA VWEVKCADLS LSPIYPAARG LVDSDKGISL 
RFPRFIRVRE DKQPEQATTS AQVACLYRKQ SQIQNQQGED SGSDPEDTY

Genular Protein ID: 3789634815

Symbol: B4DM52_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DM52

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 10 Gene3D 4 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 2 SAM 1 SUPFAM 3

Sequence Information:

  • Length: 851
  • Mass: 94020
  • Checksum: 84EC1B7F5613ADED
  • Sequence:
    • MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 
RRTEAETPTE SVSEPEVATK QELQEEEEQT KPPRRAPKTL SSFFTPRKPA VKKEVKEEEP 
EAPGKEGAAE GPLDPSGYNP AKNNYHPVED ACWKPGQKVP YLAVARTFEK IEEVSARLRM 
VETLSNLLRS VVALSPPDLL PVLYLSLNHL GPPQQGLELG VGDGVLLKAV AQATGRQLES 
VRAEAAEKGD VGLVAENSRS TQRLMLPPPP LTASGVFSKF RDIARLTGSA STAKKIDIIK 
GLFVACRHSE ARFIARSLSG RLRLGLAEQS VLAALSQAVS LTPPGQEFPP AMVDAGKGKT 
AEARKTWLEE QGMILKQTFC EVPDLDRIIP VLLEHGLERL PEHCKLSPGI PLKPMLAHPT 
RGISEVLKRF EEAAFTCEYK YDGQRAQIHA LEGGEVKIFS RNQEDNTGKY PDIISRIPKI 
KLPSVTSFIL DTEAVAWDRE KKQIQPFQVL TTRKRKEVDA SEIQVQVCLY AFDLIYLNGE 
SLVREPLSRR RQLLRENFVE TEGEFVFATS LDTKDIEQIA EFLEQSVKDS CEGLMVKTLD 
VDATYEIAKR SHNWLKLKKD YLDGVGDTLD LVVIGAYLGR GKRAGRYGGF LLASYDEDSE 
ELQAICKLGT GFSDEELEEH HQSLKALVLP SPRPYVRIDG AVIPDHWLDP SAVWEVKCAD 
LSLSPIYPAA RGLVDSDKGI SLRFPRFIRV REDKQPEQAT TSAQVACLYR KQSQIQNQQG 
EDSGSDPEDT Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.