Details for: LIMS1

Gene ID: 3987

Symbol: LIMS1

Ensembl ID: ENSG00000169756

Description: LIM zinc finger domain containing 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.71
    Marker Score: 1425
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.66
    Marker Score: 1480.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.5
    Marker Score: 44308
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.42
    Marker Score: 2586
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.36
    Marker Score: 986.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.35
    Marker Score: 2694
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.35
    Marker Score: 52622
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.35
    Marker Score: 978
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.29
    Marker Score: 936
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.28
    Marker Score: 1133
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.25
    Marker Score: 76675
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.25
    Marker Score: 1255
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.22
    Marker Score: 4443.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.22
    Marker Score: 76858
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.19
    Marker Score: 4219
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.16
    Marker Score: 1047
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.11
    Marker Score: 1798
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.11
    Marker Score: 5085
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.1
    Marker Score: 769
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.09
    Marker Score: 1190
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.04
    Marker Score: 5274
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.02
    Marker Score: 43096
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.02
    Marker Score: 2125
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.99
    Marker Score: 903
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.99
    Marker Score: 695
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.97
    Marker Score: 1226
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.96
    Marker Score: 109410
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.94
    Marker Score: 3541
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.94
    Marker Score: 7173
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.93
    Marker Score: 1008
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.91
    Marker Score: 1207
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.9
    Marker Score: 48629
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.88
    Marker Score: 11454
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.87
    Marker Score: 11942.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.86
    Marker Score: 1052
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.85
    Marker Score: 460
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.84
    Marker Score: 3581
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.83
    Marker Score: 460
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.82
    Marker Score: 2098
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.82
    Marker Score: 2206
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.82
    Marker Score: 20505
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.81
    Marker Score: 655
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.81
    Marker Score: 933
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.8
    Marker Score: 525
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.8
    Marker Score: 4498
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.79
    Marker Score: 1978
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.78
    Marker Score: 1259
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.78
    Marker Score: 1545
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.77
    Marker Score: 2429
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.76
    Marker Score: 891
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.76
    Marker Score: 2276
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.76
    Marker Score: 1273
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.75
    Marker Score: 1095
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.75
    Marker Score: 2580
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.75
    Marker Score: 1023
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.75
    Marker Score: 418
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.74
    Marker Score: 1448
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.72
    Marker Score: 1329
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.72
    Marker Score: 1858
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.7
    Marker Score: 847.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.69
    Marker Score: 2456
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.69
    Marker Score: 486
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.68
    Marker Score: 887
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.68
    Marker Score: 7046
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.68
    Marker Score: 831
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.68
    Marker Score: 26999
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.68
    Marker Score: 14589
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.66
    Marker Score: 1582
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.63
    Marker Score: 928
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.63
    Marker Score: 1806.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.62
    Marker Score: 521
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.62
    Marker Score: 3560
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.62
    Marker Score: 519
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.62
    Marker Score: 344
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.61
    Marker Score: 412
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.61
    Marker Score: 2670
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.61
    Marker Score: 2279
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.61
    Marker Score: 960
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.6
    Marker Score: 650
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.6
    Marker Score: 1600
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.6
    Marker Score: 580
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.59
    Marker Score: 1377
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.59
    Marker Score: 1689
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.59
    Marker Score: 588
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.58
    Marker Score: 4143.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.58
    Marker Score: 1418
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.58
    Marker Score: 358
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.57
    Marker Score: 18283
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.57
    Marker Score: 416
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.57
    Marker Score: 1939
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.57
    Marker Score: 1440.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.56
    Marker Score: 339
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.55
    Marker Score: 349
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.55
    Marker Score: 350
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.55
    Marker Score: 6424
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.54
    Marker Score: 489
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.54
    Marker Score: 2923
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.53
    Marker Score: 2713
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.53
    Marker Score: 5261
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.52
    Marker Score: 2579

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Other Information

**Key characteristics** - LIMS1 is a transmembrane protein with a predicted molecular weight of approximately 120 kDa. - It contains a conserved LIM domain, which is responsible for its cell adhesion and signaling properties. - LIMS1 is a key regulator of epithelial cell proliferation, tumor necrosis factor-mediated signaling pathway, and cell-substrate adhesion. **Pathways and functions** - LIMS1 is involved in cell-cell adhesion through its interaction with cadherins and integrins on neighboring cells. - It also regulates cell signaling pathways, including the epithelial-to-mesenchymal transition and cell junction organization. - LIMS1 is crucial for the proper development and maintenance of epithelial tissues, as it is expressed in various epithelial cell types. **Clinical significance** - Mutations in the LIMS1 gene have been linked to various human diseases, including cancer, cardiovascular disease, and kidney disease. - Targeting LIMS1 signaling has emerged as a potential therapeutic strategy for these diseases. **Additional points** - LIMS1 is a highly conserved protein, with a similar gene found in other mammals. - It is a promising target for cancer immunotherapy due to its involvement in tumor growth and metastasis. - Further research is needed to fully understand the role of LIMS1 in human health and disease.

Genular Protein ID: 4158183383

Symbol: LIMS1_HUMAN

Name: LIM and senescent cell antigen-like-containing domain protein 1

UniProtKB Accession Codes:

P48059 B2RAJ4 B7Z483 B7Z7R3 B7Z907 Q53TE0 Q9BS44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 5 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 14 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7517666

Title: A new LIM protein containing an autoepitope homologous to 'senescent cell antigen'.

PubMed ID: 7517666

DOI: 10.1006/bbrc.1994.1822

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9843575

Title: Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.

PubMed ID: 9843575

DOI: 10.1091/mbc.9.12.3367

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10022929

Title: The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells.

PubMed ID: 10022929

DOI: 10.1128/mcb.19.3.2425

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 11078733

Title: Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain.

PubMed ID: 11078733

DOI: 10.1074/jbc.m007632200

PubMed ID: 12794636

Title: Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling.

PubMed ID: 12794636

DOI: 10.1038/nsb938

PubMed ID: 19074270

Title: The structural basis of integrin-linked kinase-PINCH interactions.

PubMed ID: 19074270

DOI: 10.1073/pnas.0811415106

PubMed ID: 19117955

Title: Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase.

PubMed ID: 19117955

DOI: 10.1074/jbc.m805319200

Sequence Information:

  • Length: 325
  • Mass: 37251
  • Checksum: E665FEB11D849CAE
  • Sequence:
    • MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE 
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP 
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY 
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC 
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC 
KKCYEKFPLE LKKRLKKLAE TLGRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.