Details for: LIMS1

Gene ID: 3987

Symbol: LIMS1

Ensembl ID: ENSG00000169756

Description: LIM zinc finger domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 445.1438
    Cell Significance Index: -69.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 244.5954
    Cell Significance Index: -62.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 157.3320
    Cell Significance Index: -74.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 139.2050
    Cell Significance Index: -71.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.6648
    Cell Significance Index: -76.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.8306
    Cell Significance Index: -61.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.7328
    Cell Significance Index: -63.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5867
    Cell Significance Index: -77.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.3566
    Cell Significance Index: -40.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3191
    Cell Significance Index: 460.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3044
    Cell Significance Index: 176.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.2211
    Cell Significance Index: 639.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9055
    Cell Significance Index: 1040.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6673
    Cell Significance Index: 205.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5955
    Cell Significance Index: 38.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4973
    Cell Significance Index: 269.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3725
    Cell Significance Index: 39.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3608
    Cell Significance Index: 39.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2666
    Cell Significance Index: 254.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.2597
    Cell Significance Index: 32.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2029
    Cell Significance Index: 165.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1702
    Cell Significance Index: 55.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0823
    Cell Significance Index: 29.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0099
    Cell Significance Index: 19.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9867
    Cell Significance Index: 160.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9333
    Cell Significance Index: 52.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8419
    Cell Significance Index: 15.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8280
    Cell Significance Index: 23.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7782
    Cell Significance Index: 279.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6855
    Cell Significance Index: 18.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6588
    Cell Significance Index: 77.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6258
    Cell Significance Index: 40.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5506
    Cell Significance Index: 33.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5406
    Cell Significance Index: 69.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4581
    Cell Significance Index: 58.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4210
    Cell Significance Index: 7.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4004
    Cell Significance Index: 361.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3735
    Cell Significance Index: 165.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3065
    Cell Significance Index: 30.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2959
    Cell Significance Index: 557.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2724
    Cell Significance Index: 14.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2538
    Cell Significance Index: 161.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2231
    Cell Significance Index: 343.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2203
    Cell Significance Index: 41.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1712
    Cell Significance Index: 3.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1409
    Cell Significance Index: 6.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1408
    Cell Significance Index: 259.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1109
    Cell Significance Index: 0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0922
    Cell Significance Index: 41.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0637
    Cell Significance Index: 10.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0535
    Cell Significance Index: 1.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0316
    Cell Significance Index: 42.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0167
    Cell Significance Index: 0.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0215
    Cell Significance Index: -13.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0401
    Cell Significance Index: -29.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0466
    Cell Significance Index: -34.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0520
    Cell Significance Index: -0.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0536
    Cell Significance Index: -7.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0559
    Cell Significance Index: -42.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0573
    Cell Significance Index: -5.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0880
    Cell Significance Index: -49.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1329
    Cell Significance Index: -4.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1354
    Cell Significance Index: -5.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1683
    Cell Significance Index: -7.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1740
    Cell Significance Index: -12.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1900
    Cell Significance Index: -13.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1939
    Cell Significance Index: -40.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2282
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2912
    Cell Significance Index: -33.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3257
    Cell Significance Index: -24.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3436
    Cell Significance Index: -13.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3589
    Cell Significance Index: -41.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3978
    Cell Significance Index: -45.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4033
    Cell Significance Index: -11.6200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4249
    Cell Significance Index: -5.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5197
    Cell Significance Index: -7.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5317
    Cell Significance Index: -6.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5803
    Cell Significance Index: -60.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6330
    Cell Significance Index: -16.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6551
    Cell Significance Index: -17.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6989
    Cell Significance Index: -14.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7044
    Cell Significance Index: -10.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7198
    Cell Significance Index: -15.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7263
    Cell Significance Index: -48.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7559
    Cell Significance Index: -20.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7732
    Cell Significance Index: -61.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9156
    Cell Significance Index: -57.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9348
    Cell Significance Index: -29.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9678
    Cell Significance Index: -13.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0134
    Cell Significance Index: -62.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0589
    Cell Significance Index: -22.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0607
    Cell Significance Index: -53.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0798
    Cell Significance Index: -18.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0852
    Cell Significance Index: -26.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1262
    Cell Significance Index: -59.1300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.3991
    Cell Significance Index: -6.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.5047
    Cell Significance Index: -21.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.5480
    Cell Significance Index: -14.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5953
    Cell Significance Index: -52.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.6587
    Cell Significance Index: -28.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **LIM Zinc Finger Domain**: The protein's LIM domain is a key structural motif that mediates interactions with other proteins and regulates cellular processes. 2. **Multiple Cellular Localizations**: LIMS1 is expressed in various cell types, including the plasma membrane, cytosol, and nucleus, indicating its involvement in multiple cellular processes. 3. **Signaling Pathway Regulation**: LIMS1 interacts with various signaling pathways, including the NF-κB and TGF-β pathways, suggesting its role in regulating cellular responses to environmental cues. 4. **Cytoskeletal Organization**: LIMS1 regulates cytoskeletal remodeling and cell spreading by interacting with components of the IPP complex, indicating its involvement in cell migration and adhesion. **Pathways and Functions** 1. **Cell-Cell Adhesion**: LIMS1 regulates cell-substrate adhesion and focal adhesion assembly, indicating its role in maintaining tissue structure and cell-cell interactions. 2. **Cell-Cell Communication**: LIMS1 interacts with signaling pathways that regulate cell-cell communication, including the TGF-β and NF-κB pathways. 3. **Cytoskeletal Remodeling**: LIMS1 regulates cytoskeletal remodeling and cell spreading by interacting with components of the IPP complex, indicating its involvement in cell migration and adhesion. 4. **Epithelial to Mesenchymal Transition**: LIMS1 may play a role in regulating epithelial to mesenchymal transition (EMT), a process involved in tissue repair and disease progression. 5. **Immune Cell Function**: LIMS1 is expressed in immune cells, including macrophages and lymphocytes, suggesting its involvement in immune cell function and regulation. **Clinical Significance** 1. **Cancer Progression**: LIMS1 may play a role in cancer progression by regulating cell-cell adhesion, migration, and invasion in tumor cells. 2. **Inflammatory Diseases**: LIMS1's interaction with the NF-κB pathway may regulate inflammation in diseases such as arthritis and atherosclerosis. 3. **Neurological Disorders**: LIMS1's expression in the central nervous system may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regenerative Medicine**: LIMS1's role in regulating cytoskeletal remodeling and cell spreading may make it a potential target for regenerative therapies. In conclusion, LIMS1 is a multifunctional protein that plays critical roles in regulating cell-cell adhesion, signaling, and cytoskeletal organization. Its involvement in various cellular processes and diseases suggests its potential as a therapeutic target for various clinical applications.

Genular Protein ID: 4158183383

Symbol: LIMS1_HUMAN

Name: LIM and senescent cell antigen-like-containing domain protein 1

UniProtKB Accession Codes:

P48059 B2RAJ4 B7Z483 B7Z7R3 B7Z907 Q53TE0 Q9BS44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 5 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7517666

Title: A new LIM protein containing an autoepitope homologous to 'senescent cell antigen'.

PubMed ID: 7517666

DOI: 10.1006/bbrc.1994.1822

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9843575

Title: Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.

PubMed ID: 9843575

DOI: 10.1091/mbc.9.12.3367

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10022929

Title: The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells.

PubMed ID: 10022929

DOI: 10.1128/mcb.19.3.2425

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 11078733

Title: Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain.

PubMed ID: 11078733

DOI: 10.1074/jbc.m007632200

PubMed ID: 12794636

Title: Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling.

PubMed ID: 12794636

DOI: 10.1038/nsb938

PubMed ID: 19074270

Title: The structural basis of integrin-linked kinase-PINCH interactions.

PubMed ID: 19074270

DOI: 10.1073/pnas.0811415106

PubMed ID: 19117955

Title: Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase.

PubMed ID: 19117955

DOI: 10.1074/jbc.m805319200

Sequence Information:

  • Length: 325
  • Mass: 37251
  • Checksum: E665FEB11D849CAE
  • Sequence:
    • MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE 
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP 
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY 
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC 
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC 
KKCYEKFPLE LKKRLKKLAE TLGRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.