Details for: LNPEP

Gene ID: 4012

Symbol: LNPEP

Ensembl ID: ENSG00000113441

Description: leucyl and cystinyl aminopeptidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 311.0671
    Cell Significance Index: -48.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 183.0917
    Cell Significance Index: -46.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.4688
    Cell Significance Index: -45.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.4888
    Cell Significance Index: -51.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.5813
    Cell Significance Index: -49.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.5625
    Cell Significance Index: -45.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.4759
    Cell Significance Index: -49.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.6301
    Cell Significance Index: -54.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.5224
    Cell Significance Index: -46.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7773
    Cell Significance Index: -50.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5678
    Cell Significance Index: -20.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6550
    Cell Significance Index: 183.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8498
    Cell Significance Index: 141.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4940
    Cell Significance Index: 96.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4729
    Cell Significance Index: 160.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4604
    Cell Significance Index: 289.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4052
    Cell Significance Index: 228.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3692
    Cell Significance Index: 274.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3222
    Cell Significance Index: 18.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2440
    Cell Significance Index: 146.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2372
    Cell Significance Index: 74.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1722
    Cell Significance Index: 30.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1362
    Cell Significance Index: 407.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0298
    Cell Significance Index: 126.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9317
    Cell Significance Index: 167.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9048
    Cell Significance Index: 50.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6453
    Cell Significance Index: 12.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5873
    Cell Significance Index: 406.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5786
    Cell Significance Index: 16.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5583
    Cell Significance Index: 504.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4318
    Cell Significance Index: 190.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4299
    Cell Significance Index: 9.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3939
    Cell Significance Index: 215.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3901
    Cell Significance Index: 23.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3799
    Cell Significance Index: 9.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3751
    Cell Significance Index: 5.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3228
    Cell Significance Index: 44.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2416
    Cell Significance Index: 4.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1829
    Cell Significance Index: 34.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1795
    Cell Significance Index: 12.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1691
    Cell Significance Index: 16.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1645
    Cell Significance Index: 309.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1610
    Cell Significance Index: 4.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1554
    Cell Significance Index: 98.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0581
    Cell Significance Index: 26.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0503
    Cell Significance Index: 3.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0429
    Cell Significance Index: 79.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0415
    Cell Significance Index: 63.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0399
    Cell Significance Index: 1.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0093
    Cell Significance Index: 6.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0074
    Cell Significance Index: 0.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0389
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0453
    Cell Significance Index: -6.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0484
    Cell Significance Index: -35.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0548
    Cell Significance Index: -41.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0614
    Cell Significance Index: -1.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0862
    Cell Significance Index: -48.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0952
    Cell Significance Index: -59.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0968
    Cell Significance Index: -9.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1068
    Cell Significance Index: -4.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1138
    Cell Significance Index: -5.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1378
    Cell Significance Index: -23.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1395
    Cell Significance Index: -6.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1417
    Cell Significance Index: -3.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1510
    Cell Significance Index: -43.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1654
    Cell Significance Index: -7.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1778
    Cell Significance Index: -20.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2306
    Cell Significance Index: -5.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2618
    Cell Significance Index: -33.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2627
    Cell Significance Index: -55.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2658
    Cell Significance Index: -16.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2951
    Cell Significance Index: -30.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3232
    Cell Significance Index: -37.0300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3555
    Cell Significance Index: -2.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3830
    Cell Significance Index: -10.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4189
    Cell Significance Index: -11.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4354
    Cell Significance Index: -10.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4413
    Cell Significance Index: -12.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4478
    Cell Significance Index: -12.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4677
    Cell Significance Index: -9.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5030
    Cell Significance Index: -37.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5361
    Cell Significance Index: -17.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5755
    Cell Significance Index: -15.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5780
    Cell Significance Index: -45.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5985
    Cell Significance Index: -31.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6556
    Cell Significance Index: -34.4200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.6685
    Cell Significance Index: -2.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7045
    Cell Significance Index: -43.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7396
    Cell Significance Index: -13.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7827
    Cell Significance Index: -9.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8140
    Cell Significance Index: -10.1500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.9014
    Cell Significance Index: -11.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9131
    Cell Significance Index: -13.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9490
    Cell Significance Index: -31.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9758
    Cell Significance Index: -20.7100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9888
    Cell Significance Index: -12.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0128
    Cell Significance Index: -16.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0401
    Cell Significance Index: -33.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0515
    Cell Significance Index: -36.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LNPEP is a metalloaminopeptidase enzyme that belongs to the M18 family of peptidases. It is a bifunctional enzyme that catalyzes the removal of leucine and cysteine residues from the N-terminus of peptides, resulting in the generation of short peptides that can be presented by Major Histocompatibility Complex (MHC) class I molecules to CD8+ T cells. LNPEP is unique in its ability to process and present antigens in a tap-independent manner, which is distinct from other antigen-presenting cells. **Pathways and Functions** LNPEP is involved in several key pathways, including: 1. **Adaptive Immune System**: LNPEP plays a crucial role in the processing and presentation of antigens to CD8+ T cells, which is essential for the adaptive immune response. 2. **Antigen Processing and Presentation**: LNPEP is involved in the degradation of proteins and peptides, and its product is presented by MHC class I molecules to CD8+ T cells. 3. **Cell-Cell Signaling**: LNPEP is expressed in various cell types, including immune cells and neurons, suggesting its involvement in cell-cell signaling pathways. 4. **Protein Catabolic Process**: LNPEP is involved in the degradation of proteins and peptides, which is essential for protein homeostasis. **Clinical Significance** Dysregulation of LNPEP has been implicated in various diseases, including: 1. **Cancer**: LNPEP overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor. 2. **Autoimmune Disorders**: LNPEP has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where its dysregulation can lead to immune dysregulation and tissue damage. 3. **Neurological Disorders**: LNPEP has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can lead to neuronal damage and dysfunction. In conclusion, LNPEP is a critical enzyme involved in the processing and presentation of antigens to the immune system, and its dysregulation has been implicated in various diseases. Further studies are needed to fully understand the mechanisms of LNPEP and its role in human disease. **Significantly Expressed Cells** LNPEP is highly expressed in various cell types, including: 1. **Kidney Loop of Henle Thin Ascending Limb Epithelial Cells**: LNPEP is highly expressed in these cells, which are involved in the regulation of electrolyte balance and fluid homeostasis. 2. **CD8-Positive, Alpha-Beta Cytokine Secreting Effector T Cells**: LNPEP is expressed in these cells, which are critical for the adaptive immune response. 3. **Astrocytes of the Cerebral Cortex**: LNPEP is expressed in these cells, which are involved in the regulation of neuronal homeostasis and synaptic plasticity. 4. **Regular Ventricular Cardiac Myocytes**: LNPEP is expressed in these cells, which are involved in the regulation of cardiac function and homeostasis. **Proteins** LNPEP is encoded by the LCAP_HUMAN gene, which is a single gene that encodes for the LNPEP enzyme.

Genular Protein ID: 3223605661

Symbol: LCAP_HUMAN

Name: Leucyl-cystinyl aminopeptidase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8550619

Title: Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family.

PubMed ID: 8550619

DOI: 10.1074/jbc.271.1.56

PubMed ID: 9177475

Title: The complete amino acid sequence of human placental oxytocinase.

PubMed ID: 9177475

DOI: 10.1016/s0167-4781(97)00036-5

PubMed ID: 10759854

Title: Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21.

PubMed ID: 10759854

DOI: 10.1046/j.1432-1327.2000.01234.x

PubMed ID: 11389728

Title: Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides.

PubMed ID: 11389728

DOI: 10.1046/j.1432-1327.2001.02221.x

PubMed ID: 8119729

Title: Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules.

PubMed ID: 8119729

DOI: 10.1007/bf00188785

PubMed ID: 1731608

Title: Identification of human placental leucine aminopeptidase as oxytocinase.

PubMed ID: 1731608

DOI: 10.1016/0003-9861(92)90007-j

PubMed ID: 11707427

Title: Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase.

PubMed ID: 11707427

DOI: 10.1074/jbc.c100512200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1025
  • Mass: 117349
  • Checksum: F84C0EA9D48DC2C0
  • Sequence:
  • MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG SRLLVRGLGE 
    HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD GACSVPSART MVVCAFVIVV 
    AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL IQPFATNGKL FPWAQIRLPT AVVPLRYELS 
    LHPNLTSMTF RGSVTISVQA LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH 
    GQIAIVAPEA LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR 
    SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE SVKMSTYLVA 
    FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL LEFFQNYFEI QYPLKKLDLV 
    AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS SMADRKLVTK IIAHELAHQW FGNLVTMKWW 
    NDLWLNEGFA TFMEYFSLEK IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI 
    EEMFDSLSYF KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT 
    LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY LWHIPLSYVT 
    EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY IVHYADDDWE ALIHQLKINP 
    YVLSDKDRAN LINNIFELAG LGKVPLKRAF DLINYLGNEN HTAPITEALF QTDLIYNLLE 
    KLGYMDLASR LVTRVFKLLQ NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM 
    KLFDDWMASN GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS 
    EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN KLVQKFPLGS 
    YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV QEALEVIQLN IQWMEKNLKS 
    LTWWL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.