Details for: LNPEP

Gene ID: 4012

Symbol: LNPEP

Ensembl ID: ENSG00000113441

Description: leucyl and cystinyl aminopeptidase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.31
    Marker Score: 2342
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.08
    Marker Score: 899
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.85
    Marker Score: 39585
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.83
    Marker Score: 40914
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.8
    Marker Score: 658
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.78
    Marker Score: 4774
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.71
    Marker Score: 500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.71
    Marker Score: 25549
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.7
    Marker Score: 1834
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7
    Marker Score: 17547
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.69
    Marker Score: 1511
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14468
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.67
    Marker Score: 16915
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.65
    Marker Score: 800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.65
    Marker Score: 3612
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.64
    Marker Score: 1887
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.64
    Marker Score: 32589
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.64
    Marker Score: 862
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.61
    Marker Score: 902
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.61
    Marker Score: 1782
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6
    Marker Score: 98610
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.6
    Marker Score: 6627
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.59
    Marker Score: 6659
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.59
    Marker Score: 58548
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.58
    Marker Score: 15052
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.58
    Marker Score: 12140
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.57
    Marker Score: 818
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.55
    Marker Score: 4606
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.54
    Marker Score: 5955
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.49
    Marker Score: 56618
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.49
    Marker Score: 2469
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.48
    Marker Score: 1122
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.48
    Marker Score: 1647
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.46
    Marker Score: 2559
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.44
    Marker Score: 1093.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.44
    Marker Score: 712
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.43
    Marker Score: 452
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.42
    Marker Score: 14103
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.42
    Marker Score: 709
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.41
    Marker Score: 1499
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.4
    Marker Score: 4421
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.39
    Marker Score: 1184
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.39
    Marker Score: 693
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.39
    Marker Score: 3900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.38
    Marker Score: 352
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.38
    Marker Score: 12974
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.37
    Marker Score: 1445
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.36
    Marker Score: 1182.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.36
    Marker Score: 571
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.36
    Marker Score: 993
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.35
    Marker Score: 1991
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.35
    Marker Score: 5491
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.34
    Marker Score: 497
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.34
    Marker Score: 1281
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.34
    Marker Score: 816
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.34
    Marker Score: 4762
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2057
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.33
    Marker Score: 15484
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.33
    Marker Score: 775
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.32
    Marker Score: 1080
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.32
    Marker Score: 534
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.32
    Marker Score: 2351
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.32
    Marker Score: 3318
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.28
    Marker Score: 1764
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.27
    Marker Score: 67227
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.27
    Marker Score: 1166
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.26
    Marker Score: 392
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.26
    Marker Score: 302
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.26
    Marker Score: 441
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.26
    Marker Score: 1788
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.25
    Marker Score: 1617
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.25
    Marker Score: 3399
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.24
    Marker Score: 765
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.24
    Marker Score: 1087
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.23
    Marker Score: 737
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.23
    Marker Score: 349
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.23
    Marker Score: 405
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.23
    Marker Score: 2988
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19140
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.21
    Marker Score: 278
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.21
    Marker Score: 2102
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.2
    Marker Score: 808
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.2
    Marker Score: 261
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.2
    Marker Score: 3311
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.2
    Marker Score: 8917
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.19
    Marker Score: 362
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.19
    Marker Score: 587
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.19
    Marker Score: 449
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.19
    Marker Score: 303
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.19
    Marker Score: 313
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.19
    Marker Score: 2284.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.19
    Marker Score: 265
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.18
    Marker Score: 688
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.18
    Marker Score: 1047
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.18
    Marker Score: 1260
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 706
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.17
    Marker Score: 404.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.17
    Marker Score: 1125
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.16
    Marker Score: 335
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.15
    Marker Score: 284

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Other Information

**Key characteristics:** * LNPEP is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in the kidney, where it is involved in the processing of peptides derived from extracellular proteins. * LNPEP is also expressed in other tissues, including the brain, heart, and liver. * It is a ubiquitin-dependent protein that is degraded by the proteasome. * It is a key regulator of the adaptive immune response. **Pathways and functions:** * LNPEP is involved in the adaptive immune response by processing peptides derived from extracellular proteins. * These peptides are then presented on the surface of antigen-presenting cells, where they can be recognized by T cells. * This process is essential for the activation of T cells and the initiation of an adaptive immune response. **Clinical significance:** * Mutations in the LNPEP gene have been linked to several human diseases, including renal failure and cancer. * In renal failure, mutations in LNPEP can result in the accumulation of misfolded or truncated proteins, which can lead to kidney damage. * In cancer, mutations in LNPEP can lead to the production of abnormal proteins that can promote tumor growth and metastasis. * Therefore, LNPEP is a promising target for the development of new therapies for renal failure and cancer. **Additional notes:** * LNPEP is a member of the metallopeptidase family of enzymes. * It is regulated by a variety of signaling pathways, including the adaptive immune system, the ubiquitin-proteasome pathway, and the endoplasmic reticulum pathway. * It is a highly conserved protein that is found in organisms from yeast to humans.

Genular Protein ID: 3223605661

Symbol: LCAP_HUMAN

Name: Leucyl-cystinyl aminopeptidase

UniProtKB Accession Codes:

Q9UIQ6 O00769 Q15145 Q59H76 Q9TNQ2 Q9TNQ3 Q9UIQ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 ELM 1 EMBL 35 EPD 1 Ensembl 2 GO 25 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 7 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8550619

Title: Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family.

PubMed ID: 8550619

DOI: 10.1074/jbc.271.1.56

PubMed ID: 9177475

Title: The complete amino acid sequence of human placental oxytocinase.

PubMed ID: 9177475

DOI: 10.1016/s0167-4781(97)00036-5

PubMed ID: 10759854

Title: Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21.

PubMed ID: 10759854

DOI: 10.1046/j.1432-1327.2000.01234.x

PubMed ID: 11389728

Title: Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides.

PubMed ID: 11389728

DOI: 10.1046/j.1432-1327.2001.02221.x

PubMed ID: 8119729

Title: Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules.

PubMed ID: 8119729

DOI: 10.1007/bf00188785

PubMed ID: 1731608

Title: Identification of human placental leucine aminopeptidase as oxytocinase.

PubMed ID: 1731608

DOI: 10.1016/0003-9861(92)90007-j

PubMed ID: 11707427

Title: Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase.

PubMed ID: 11707427

DOI: 10.1074/jbc.c100512200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1025
  • Mass: 117349
  • Checksum: F84C0EA9D48DC2C0
  • Sequence:
    • MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG SRLLVRGLGE 
HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD GACSVPSART MVVCAFVIVV 
AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL IQPFATNGKL FPWAQIRLPT AVVPLRYELS 
LHPNLTSMTF RGSVTISVQA LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH 
GQIAIVAPEA LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR 
SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE SVKMSTYLVA 
FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL LEFFQNYFEI QYPLKKLDLV 
AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS SMADRKLVTK IIAHELAHQW FGNLVTMKWW 
NDLWLNEGFA TFMEYFSLEK IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI 
EEMFDSLSYF KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT 
LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY LWHIPLSYVT 
EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY IVHYADDDWE ALIHQLKINP 
YVLSDKDRAN LINNIFELAG LGKVPLKRAF DLINYLGNEN HTAPITEALF QTDLIYNLLE 
KLGYMDLASR LVTRVFKLLQ NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM 
KLFDDWMASN GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS 
EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN KLVQKFPLGS 
YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV QEALEVIQLN IQWMEKNLKS 
LTWWL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.